RESUMO
The mechanical loading environment encountered by articular cartilage in situ makes frictional-shear testing an invaluable technique for assessing engineered cartilage. Despite the important information that is gained from this testing, it remains under-utilized, especially for determining damage behavior. Currently, extensive visual inspection is required to assess damage; this is cumbersome and subjective. Tools to simplify, automate, and remove subjectivity from the analysis may increase the accessibility and usefulness of frictional-shear testing as an evaluation method. The objective of this study was to determine if the friction signal could be used to detect damage that occurred during the testing. This study proceeded in two phases: first, a simplified model of biphasic lubrication that does not require knowledge of interstitial fluid pressure was developed. In the second phase, frictional-shear tests were performed on 74 cartilage samples, and the simplified model was used to extract characteristic features from the friction signals. Using support vector machine classifiers, the extracted features were able to detect damage with a median accuracy of approximately 90%. The accuracy remained high even in samples with minimal damage. In conclusion, the friction signal acquired during frictional-shear testing can be used to detect resultant damage to a high level of accuracy.
Assuntos
Cartilagem/fisiologia , Fricção , Modelos Biológicos , Máquina de Vetores de Suporte , Animais , Coelhos , Resistência ao Cisalhamento/fisiologia , Estresse Mecânico , Engenharia Tecidual , Suporte de Carga/fisiologiaRESUMO
In conclusion, it should be kept in mind that family-centered practice is not merely a theoretical construct or philosophical position. Its practical implementation assumes that virtually any variety of options for how the family, child, and professionals will interface and collaborate will be possible, based on the needs and wishes of the family, community make-up, and the complexity of issues involved. As providers of service in a critical area of development, communication, we must be mindful of the many individual, social, and political factors, such as cultural and racial background, poverty, prejudice, mental and other health issues, managed care in medical practice, outcomes-based service models, and funding sources, that will impinge on this relationship. Key to our success is the focus on achieving mutual goals for the child: optimal communication skills in a positive, healthy family context.