1.
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro.
J Virol
; 88(1): 752-7, 2014 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24155390
RESUMO
We previously reported that exosomal transfer of hepatitis C virus (HCV) positive-strand RNA from human Huh-7 hepatoma cells to human plasmacytoid dendritic cells (pDCs) triggers pDC alpha/beta interferon (IFN-α/ß) production in a Toll-like receptor 7 (TLR7)-dependent, virus-independent manner. Here we show that human pDCs are also activated by a TLR7-dependent, virus-independent, exosomal RNA transfer mechanism by human and mouse hepatoma and nonhepatoma cells that replicate the negative-strand lymphocytic choriomeningitis virus (LCMV).