The Emergence of Organized Emotion Dynamics in Childhood.

Emotions change from one moment to the next. They have a duration from seconds to hours and then transition to other emotions. Here, we describe the early ontology of these key aspects of emotion dynamics. In five cross-sectional studies (N = 904) combining parent surveys and ecological momentary assessment, we characterize how caregivers' perceptions of children's emotion duration and transitions change over the first 5 years of life and how they relate to children's language development. Across these ages, the duration of children's emotions increased, and emotion transitions became increasingly organized by valence, such that children were more likely to transition between similarly valenced emotions. Children with more mature emotion profiles also had larger vocabularies and could produce more emotion labels. These findings advance our understanding of emotion and communication by highlighting their intertwined nature in development and by charting how dynamic features of emotion experiences change over the first years of life. Supplementary Information: The online version contains supplementary material available at 10.1007/s42761-024-00248-y.

Testing the relationship between preferences for infant-directed speech and vocabulary development: A multi-lab study.

From early on, infants show a preference for infant-directed speech (IDS) over adult-directed speech (ADS), and exposure to IDS has been correlated with language outcome measures such as vocabulary. The present multi-laboratory study explores this issue by investigating whether there is a link between early preference for IDS and later vocabulary size. Infants' preference for IDS was tested as part of the ManyBabies 1 project, and follow-up CDI data were collected from a subsample of this dataset at 18 and 24 months. A total of 341 (18 months) and 327 (24 months) infants were tested across 21 laboratories. In neither preregistered analyses with North American and UK English, nor exploratory analyses with a larger sample did we find evidence for a relation between IDS preference and later vocabulary. We discuss implications of this finding in light of recent work suggesting that IDS preference measured in the laboratory has low test-retest reliability.

Language development in children's natural environments: People, places, and things.

Our goal in this chapter is to describe young children's experiences with language by examining three domains-people, places, and things-that define and influence their language input. We highlight how features of each of these three domains could provide useful learning opportunities, as well as how differences in infants' and toddlers' experiences may affect their long-term language skills. However, we ultimately suggest that a full understanding of early environments must move beyond a focus on individual experiences and include the broader systems that shape young children's lives, including both tangible aspects of the environment, such as physical resources or locations, and more hidden factors, such as cultural considerations, community health, or economic constraints.

Infants and toddlers in the United States with more close relationships have larger vocabularies.

Young children learn language from their caregivers, family members, and friends. However, with few exceptions, contemporary developmental scientists have studied language input and language learning through the lens of the primary caregiver and the nuclear family, rather than the infants' broader communities. In many communities-and increasingly in the United States-nonnuclear family structures are common, and extended kin, fictive kin, and intergenerational relationships are relied upon for child care. Understanding children's relationships within kinship networks can allow for more inclusive depictions of children's social interactions and their language experiences. We drew upon methods used by researchers studying social networks to assess U.S. infants' and toddlers' network composition. Results showed that young children with a greater number of close relationships (but not those with larger networks overall) had larger vocabularies, after controlling for age and socioeconomic status. These findings suggest that distributed models of child-rearing are an influential factor in early language growth and call for increased attention to social networks for understanding children's developmental trajectories. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Infant-directed communication: Examining the many dimensions of everyday caregiver-infant interactions.

Everyday caregiver-infant interactions are dynamic and multidimensional. However, existing research underestimates the dimensionality of infants' experiences, often focusing on one or two communicative signals (e.g., speech alone, or speech and gesture together). Here, we introduce "infant-directed communication" (IDC): the suite of communicative signals from caregivers to infants including speech, action, gesture, emotion, and touch. We recorded 10 min of at-home play between 44 caregivers and their 18- to 24-month-old infants from predominantly white, middle-class, English-speaking families in the United States. Interactions were coded for five dimensions of IDC as well as infants' gestures and vocalizations. Most caregivers used all five dimensions of IDC throughout the interaction, and these dimensions frequently overlapped. For example, over 60% of the speech that infants heard was accompanied by one or more non-verbal communicative cues. However, we saw marked variation across caregivers in their use of IDC, likely reflecting tailored communication to the behaviors and abilities of their infant. Moreover, caregivers systematically increased the dimensionality of IDC, using more overlapping cues in response to infant gestures and vocalizations, and more IDC with infants who had smaller vocabularies. Understanding how and when caregivers use all five signals-together and separately-in interactions with infants has the potential to redefine how developmental scientists conceive of infants' communicative environments, and enhance our understanding of the relations between caregiver input and early learning. RESEARCH HIGHLIGHTS: Infants' everyday interactions with caregivers are dynamic and multimodal, but existing research has underestimated the multidimensionality (i.e., the diversity of simultaneously occurring communicative cues) inherent in infant-directed communication. Over 60% of the speech that infants encounter during at-home, free play interactions overlap with one or more of a variety of non-speech communicative cues. The multidimensionality of caregivers' communicative cues increases in response to infants' gestures and vocalizations, providing new information about how infants' own behaviors shape their input. These findings emphasize the importance of understanding how caregivers use a diverse set of communicative behaviors-both separately and together-during everyday interactions with infants.

Open Science Considerations for Descriptive Research in Developmental Science.

Descriptive developmental research seeks to document, describe, and analyze the conditions under which infants and children live and learn. Here, we articulate how open-science practices can be incorporated into descriptive research to increase its transparency, reliability, and replicability. To date, most open-science practices have been oriented toward experimental rather than descriptive studies, and it can be confusing to figure out how to translate open-science practices (e.g., preregistration) for research that is more descriptive in nature. We discuss a number of unique considerations for descriptive developmental research, taking inspiration from existing open-science practices and providing examples from recent and ongoing studies. By embracing a scientific culture where descriptive research and open science coexist productively, developmental science will be better positioned to generate comprehensive theories of development and understand variability in development across communities and cultures.

Comparing apples to manzanas and oranges to naranjas: A new measure of English-Spanish vocabulary for dual language learners.

The valid assessment of vocabulary development in dual-language-learning infants is critical to developmental science. We developed the Dual Language Learners English-Spanish (DLL-ES) Inventories to measure vocabularies of U.S. English-Spanish DLLs. The inventories provide translation equivalents for all Spanish and English items on Communicative Development Inventory (CDI) short forms; extended inventories based on CDI long forms; and Spanish language-variety options. Item-Response Theory analyses applied to Wordbank and Web-CDI data (n = 2603, 12-18 months; n = 6722, 16-36 months; half female; 1% Asian, 3% Black, 2% Hispanic, 30% White, 64% unknown) showed near-perfect associations between DLL-ES and CDI long-form scores. Interviews with 10 Hispanic mothers of 18- to 24-month-olds (2 White, 1 Black, 7 multi-racial; 6 female) provide a proof of concept for the value of the DLL-ES for assessing the vocabularies of DLLs.

A unified approach to demographic data collection for research with young children across diverse cultures.

Culture is a key determinant of children's development both in its own right and as a measure of generalizability of developmental phenomena. Studying the role of culture in development requires information about participants' demographic backgrounds. However, both reporting and treatment of demographic data are limited and inconsistent in child development research. A barrier to reporting demographic data in a consistent fashion is that no standardized tool currently exists to collect these data. Variation in cultural expectations, family structures, and life circumstances across communities make the creation of a unifying instrument challenging. Here, we present a framework to standardize demographic reporting for early child development (birth to 3 years of age), focusing on six core sociodemographic construct categories: biological information, gestational status, health status, community of descent, caregiving environment, and socioeconomic status. For each category, we discuss potential constructs and measurement items and provide guidance for their use and adaptation to diverse contexts. These items are stored in an open repository of context-adapted questionnaires that provide a consistent approach to obtaining and reporting demographic information so that these data can be archived and shared in a more standardized format. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

The Influence of Memory on Visual Perception in Infants, Children, and Adults.

Perception is not an independent, in-the-moment event. Instead, perceiving involves integrating prior expectations with current observations. How does this ability develop from infancy through adulthood? We examined how prior visual experience shapes visual perception in infants, children, and adults. Using an identical task across age groups, we exposed participants to pairs of colorful stimuli and implicitly measured their ability to discriminate relative saturation levels. Results showed that adult participants were biased by previously experienced exemplars, and exhibited weakened in-the-moment discrimination between different levels of saturation. In contrast, infants and children showed less influence of memory in their perception, and they actually outperformed adults in discriminating between current levels of saturation. Our findings suggest that as humans develop, their perception relies more on prior experience and less on current observation.

Moving beyond "nouns in the lab": Using naturalistic data to understand why infants' first words include uh-oh and hi.

Why do infants learn some words earlier than others? Many theories of early word learning focus on explaining how infants map labels onto concrete objects. However, words that are more abstract than object nouns, such as uh-oh, hi, more, up, and all-gone, are typically among the first to appear in infants' vocabularies. We combined a behavioral experiment with naturalistic observational research to explore how infants learn and represent this understudied category of high-frequency, routine-based non-nouns, which we term "everyday words." In Study 1, we found that a conventional eye-tracking measure of comprehension was insufficient to capture U.S.-based English-learning 10- to 16-month-old infants' emerging understanding of everyday words. In Study 2, we analyzed the visual and social scenes surrounding caregivers' and infants' use of everyday words in a naturalistic video corpus. This ecologically motivated research revealed that everyday words rarely co-occurred with consistent visual referents, making their early learnability difficult to reconcile with dominant word learning theories. Our findings instead point to complex patterns in the types of situations associated with everyday words that could contribute to their early representation in infants' vocabularies. By leveraging both experimental and observational methods, this investigation underscores the value of using naturalistic data to broaden theories of early learning. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

iCatcher+: Robust and Automated Annotation of Infants' and Young Children's Gaze Behavior From Videos Collected in Laboratory, Field, and Online Studies.

Technological advances in psychological research have enabled large-scale studies of human behavior and streamlined pipelines for automatic processing of data. However, studies of infants and children have not fully reaped these benefits because the behaviors of interest, such as gaze duration and direction, still have to be extracted from video through a laborious process of manual annotation, even when these data are collected online. Recent advances in computer vision raise the possibility of automated annotation of these video data. In this article, we built on a system for automatic gaze annotation in young children, iCatcher, by engineering improvements and then training and testing the system (referred to hereafter as iCatcher+) on three data sets with substantial video and participant variability (214 videos collected in U.S. lab and field sites, 143 videos collected in Senegal field sites, and 265 videos collected via webcams in homes; participant age range = 4 months-3.5 years). When trained on each of these data sets, iCatcher+ performed with near human-level accuracy on held-out videos on distinguishing "LEFT" versus "RIGHT" and "ON" versus "OFF" looking behavior across all data sets. This high performance was achieved at the level of individual frames, experimental trials, and study videos; held across participant demographics (e.g., age, race/ethnicity), participant behavior (e.g., movement, head position), and video characteristics (e.g., luminance); and generalized to a fourth, entirely held-out online data set. We close by discussing next steps required to fully automate the life cycle of online infant and child behavioral studies, representing a key step toward enabling robust and high-throughput developmental research.

A phase 1 evaluation of the safety and tolerability of niraparib in combination with everolimus in advanced ovarian and breast cancers.

OBJECTIVES: Phase 1 trial to determine the safety and tolerability of everolimus and niraparib in patients with advanced ovarian and breast malignancies. RESULTS: Fourteen heavily pretreated patients were enrolled (12 high-grade serous ovarian cancer, 1 clear cell ovarian cancer, and 1 triple negative breast cancer). All patients were PARP naïve and received comprehensive genomic profiling prior to enrollment. Two DLTs were experienced in cohort 2 (niraparib 200 mg daily and everolimus 5 mg 3 days per week) with one patient experiencing prolonged thrombocytopenia and the other experiencing severe hypertension. Four additional patients were enrolled after dose de-escalation with one patient again experiencing severe hypertension leading to conclusion of the study. The most frequent grade 3 or greater adverse events were thrombocytopenia, hypertension, anemia, fatigue, neutropenia, and elevated alkaline phosphatase. Two patients had a PR and five patients had SD. ORR was 18% and the CBR was 45% in 11 evaluable patients. Median PFS was 6 months, and median OS is approximately 18 months with three patients still alive at the data cutoff. CONCLUSIONS: The combination of everolimus and niraparib demonstrated significant toxicity at lower doses and is not feasible due to rapid onset and severe hypertension. This limitation possibly blunted the efficacy of the combination as PFS was modest, but OS was surprisingly robust due to three patients with ovarian cancer remaining alive with platinum refractory disease. Further investigation of multiagent blockade of the PI3K pathway combined with PARP is warranted.

Frequent vs. infrequent words shape toddlers' real-time sentence comprehension.

We examined how noun frequency and the typicality of surrounding linguistic context contribute to children's real-time comprehension. Monolingual English-learning toddlers viewed pairs of pictures while hearing sentences with typical or atypical sentence frames (Look at the… vs. Examine the…), followed by nouns that were higher- or lower-frequency labels for a referent (horse vs. pony). Toddlers showed no significant differences in comprehension of nouns in typical and atypical sentence frames. However, they were less accurate in recognizing lower-frequency nouns, particularly among toddlers with smaller vocabularies. We conclude that toddlers can recognize nouns in diverse sentence contexts, but their representations develop gradually.

Caregiver speech predicts the emergence of children's emotion vocabulary.

Learning about emotions is an important part of children's social and communicative development. How does children's emotion-related vocabulary emerge over development? How may emotion-related information in caregiver input support learning of emotion labels and other emotion-related words? This investigation examined language production and input among English-speaking toddlers (16-30 months) using two datasets: Wordbank (N = 5520; 36% female, 38% male, and 26% unknown gender; 1% Asian, 4% Black, 2% Hispanic, 40% White, 2% others, and 50% unknown ethnicity; collected in North America; dates of data collection unknown) and Child Language Data Exchange System (N = 587; 46% female, 44% male, 9% unknown gender, all unknown ethnicity; collected in North America and the UK; data collection dates, were available between 1962 and 2009). First, we show that toddlers develop the vocabulary to express increasingly wide ranges of emotional information during the first 2 years of life. Computational measures of word valence showed that emotion labels are embedded in a rich network of words with related valence. Second, we show that caregivers leverage these semantic connections in ways that may scaffold children's learning of emotion and mental state labels. This research suggests that young children use the dynamics of language input to construct emotion word meanings, and provides new techniques for defining the quality of infant-directed speech.

Infants' lexical comprehension and lexical anticipation abilities are closely linked in early language development.

Theories across cognitive domains propose that anticipating upcoming sensory input supports information processing. In line with this view, prior findings indicate that adults and children anticipate upcoming words during real-time language processing, via such processes as prediction and priming. However, it is unclear if anticipatory processes are strictly an outcome of prior language development or are more entwined with language learning and development. We operationalized this theoretical question as whether developmental emergence of comprehension of lexical items occurs before or concurrently with the anticipation of these lexical items. To this end, we tested infants of ages 12, 15, 18, and 24 months (N = 67) on their abilities to comprehend and anticipate familiar nouns. In an eye-tracking task, infants viewed pairs of images and heard sentences with either informative words (e.g., eat) that allowed them to anticipate an upcoming noun (e.g., cookie), or uninformative words (e.g., see). Findings indicated that infants' comprehension and anticipation abilities are closely linked over developmental time and within individuals. Importantly, we do not find evidence for lexical comprehension in the absence of lexical anticipation. Thus, anticipatory processes are present early in infants' second year, suggesting they are a part of language development rather than solely an outcome of it.

Patterns of language switching and bilingual children's word learning: An experiment across two communities.

Language switching is common in bilingual environments, including those of many bilingual children. Some bilingual children hear rapid switching that involves immediate translation of words (an 'immediate-translation' pattern), while others hear their languages most often in long blocks of a single language (a 'one-language-at-a-time' pattern). Our two-site experimental study compared two groups of developing bilinguals from different communities, and investigated whether differences in the timing of language switching impose different demands on bilingual children's learning of novel nouns in their two languages: do children learn differently if they hear a translation immediately vs. if they hear translations more separated in time? Using an at-home online tablet word learning task, data were collected asynchronously from 3- to 5-year-old bilinguals from French-English bilingual families in Montreal, Canada (N = 31) and Spanish-English bilingual families in New Jersey, USA (N = 22). Results showed that bilingual children in both communities readily learned new words, and their performance was similar across the immediate-translation and one-language-at-a-time conditions. Our findings highlight that different types of bilingual interactions can provide equal learning opportunities for bilingual children's vocabulary development.

Phase I dose escalation study of dual PI3K/mTOR inhibition by Sapanisertib and Serabelisib in combination with paclitaxel in patients with advanced solid tumors.

BACKGROUND: Phase I trial to determine the safety and efficacy of paclitaxel, sapanisertib, and serabelisib. PATIENTS AND METHODS: Patients with previously treated advanced solid tumors were eligible for this open label, cohort study of sapanisertib (TAK-228) and serabelisib (TAK-117) with weekly paclitaxel. A traditional 3 + 3 dose escalation design with 5 dosing cohorts was used. Patient reported outcomes were also evaluated. RESULTS: 19 heavily pretreated patients were enrolled (10 ovarian, 3 breast, and 6 endometrial cancers). All patients received comprehensive genomic profiling prior to enrollment. RP2D is sapanisertib 3 or 4 mg, serabelisib 200 mg on days 2-4, 9-11, 16-18 and 23-25 with paclitaxel 80 mg/m2 on days 1, 8 and 15 every 28 days. All patients in Cohort 5 required dose reductions and one patient experienced a DLT. The most frequent grade 3 or 4 adverse events were decreased WBCs (20%), nonfebrile neutropenia (12%), anemia (9%), elevated liver enzymes (4%), and hyperglycemia (11%). 3 patients had a CR, 4 had a PR, and 4 patients had SD > six months. ORR was 47% and CBR was 73% in 15 evaluable patients. Including all 19 enrolled patients, the PFS was 11 months and OS is still ongoing at 17 months. CONCLUSIONS: The combination of sapanisertib, serabelisib, and paclitaxel was safe and generally well tolerated. Preliminary efficacy was remarkable in an area of unmet need, especially for patient with PI3K/AKT/mTOR pathway aberrations. Positive effects and sustained clinical benefit were even seen in patients that were refractory to platinum and had failed taxane, everolimus, or temsirolimus. CLINICAL TRIAL NUMBER: ClinicalTrials.gov, NCT03154294.

Effects of language mixing on bilingual children's word learning.

Language mixing is common in bilingual children's learning environments. Here, we investigated effects of language mixing on children's learning of new words. We tested two groups of 3-year-old bilinguals: French-English (Experiment 1) and Spanish-English (Experiment 2). Children were taught two novel words, one in single-language sentences ("Look! Do you see the dog on the teelo?") and one in mixed-language sentences with a mid-sentence language switch ("Look! Do you see the chien/perro on the walem?"). During the learning phase, children correctly identified novel targets when hearing both single-language and mixed-language sentences. However, at test, French-English bilinguals did not successfully recognize the word encountered in mixed-language sentences. Spanish-English bilinguals failed to recognize either word, which underscores the importance of examining multiple bilingual populations. This research suggests that language mixing may sometimes hinder children's encoding of novel words that occur downstream, but leaves open several possible underlying mechanisms.

iCatcher: A neural network approach for automated coding of young children's eye movements.

Infants' looking behaviors are often used for measuring attention, real-time processing, and learning-often using low-resolution videos. Despite the ubiquity of gaze-related methods in developmental science, current analysis techniques usually involve laborious post hoc coding, imprecise real-time coding, or expensive eye trackers that may increase data loss and require a calibration phase. As an alternative, we propose using computer vision methods to perform automatic gaze estimation from low-resolution videos. At the core of our approach is a neural network that classifies gaze directions in real time. We compared our method, called iCatcher, to manually annotated videos from a prior study in which infants looked at one of two pictures on a screen. We demonstrated that the accuracy of iCatcher approximates that of human annotators and that it replicates the prior study's results. Our method is publicly available as an open-source repository at https://github.com/yoterel/iCatcher.

Look at that: Spatial deixis reveals experience-related differences in prediction.

Prediction-based theories posit that interlocutors use prediction to process language efficiently and to coordinate dialogue. The present study evaluated whether listeners can use spatial deixis (i.e., this, that, these, and those) to predict the plurality and proximity of a speaker's upcoming referent. In two eye-tracking experiments with varying referential complexity (N = 168), native English-speaking adults, native English-learning 5-year-olds, and non-native English-learning adults viewed images while listening to sentences with or without informative deictic determiners, e.g., Look at the/this/that/these/those wonderful cookie(s). Results showed that all groups successfully exploited plurality information. However, they varied in using deixis to anticipate the proximity of the referent; specifically, L1 adults showed more robust prediction than L2 adults, and L1 children did not show evidence of prediction. By evaluating listeners with varied language experiences, this investigation helps refine proposed mechanisms of prediction, and suggests that linguistic experience is key to the development of such mechanisms.