1.
Bioorg Med Chem Lett
; 18(16): 4593-6, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18656351
RESUMO
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.