Higher-Order Topological In-Bulk Corner State in Pure Diffusion Systems.

Compared with conventional topological insulator that carries topological state at its boundaries, the higher-order topological insulator exhibits lower-dimensional gapless boundary states at its corners and hinges. Leveraging the form similarity between Schrödinger equation and diffusion equation, research on higher-order topological insulators has been extended from condensed matter physics to thermal diffusion. Unfortunately, all the corner states of thermal higher-order topological insulator reside within the band gap. Another kind of corner state, which is embedded in the bulk states, has not been realized in pure diffusion systems so far. Here, we construct higher-dimensional Su-Schrieffer-Heeger models based on sphere-rod structure to elucidate these corner states, which we term "in-bulk corner states." Because of the anti-Hermitian properties of diffusive Hamiltonian, we investigate the thermal behavior of these corner states through theoretical calculation, simulation, and experiment. Furthermore, we study the different thermal behaviors of in-bulk corner state and in-gap corner state. Our results would open a different gate for diffusive topological states and provide a distinct application for efficient heat dissipation.

Nonreciprocal Heat Circulation Metadevices.

Thermal nonreciprocity typically stems from nonlinearity or spatiotemporal variation of parameters. However, constrained by the inherent temperature-dependent properties and the law of mass conservation, previous works have been compelled to treat dynamic and steady-state cases separately. Here, by establishing a unified thermal scattering theory, the creation of a convection-based thermal metadevice which supports both dynamic and steady-state nonreciprocal heat circulation is reported. The nontrivial dependence between the nonreciprocal resonance peaks and the dynamic parameters is observed and the unique nonreciprocal mechanism of multiple scattering is revealed at steady state. This mechanism enables thermal nonreciprocity in the initially quasi-symmetric scattering matrix of the three-port metadevice and has been experimentally validated with a significant isolation ratio of heat fluxes. The findings establish a framework for thermal nonreciprocity that can be smoothly modulated for dynamic and steady-state heat signals, it may also offer insight into other heat-transfer-related problems or even other fields such as acoustics and mechanics.

Deep Learning-Assisted Active Metamaterials with Heat-Enhanced Thermal Transport.

Heat management is crucial for state-of-the-art applications such as passive radiative cooling, thermally adjustable wearables, and camouflage systems. Their adaptive versions, to cater to varied requirements, lean on the potential of adaptive metamaterials. Existing efforts, however, feature with highly anisotropic parameters, narrow working-temperature ranges, and the need for manual intervention, which remain long-term and tricky obstacles for the most advanced self-adaptive metamaterials. To surmount these barriers, heat-enhanced thermal diffusion metamaterials powered by deep learning is introduced. Such active metamaterials can automatically sense ambient temperatures and swiftly, as well as continuously, adjust their thermal functions with a high degree of tunability. They maintain robust thermal performance even when external thermal fields change direction, and both simulations and experiments demonstrate exceptional results. Furthermore, two metadevices with on-demand adaptability, performing distinctive features with isotropic materials, wide working temperatures, and spontaneous response are designed. This work offers a framework for the design of intelligent thermal diffusion metamaterials and can be expanded to other diffusion fields, adapting to increasingly complex and dynamic environments.

Investigation of the Relationship between Aptamers' Targeting Functions and Human Plasma Proteins.

Aptamers are single-stranded DNA or RNA molecules capable of recognizing targets via specific three-dimensional structures. Taking advantage of this unique targeting function, aptamers have been extensively applied to bioanalysis and disease theranostics. However, the targeting functionality of aptamers in the physiological milieu is greatly impeded compared with their in vitro applications. To investigate the physiological factors that adversely affect the in vivo targeting ability of aptamers, we herein systematically studied the interactions between human plasma proteins and aptamers and the specific effects of plasma proteins on aptamer targeting. Microscale thermophoresis and flow cytometry analysis showed that plasma interacted with aptamers, restricting their affinity toward targeted tumor cells. Further pull-down assay and proteomic identification verified that the interactions between aptamers and plasma proteins were mainly involved in complement activation and immune response as well as showed structure-selective and sequence-specific features. Particularly, the fibronectin 1 (FN1) protein showed dramatically specific interactions with nucleolin (NCL) targeting aptamer AS1411. The competitive binding between FN1 and NCL almost deprived the AS1411 aptamer's targeting ability in vivo. In order to maintain the targeting function in the physiological milieu, a series of optimizations were performed via the chemical modifications of AS1411 aptamer, and 3'-terminal pegylation was demonstrated to be resistant to the interaction with FN1, leading to improved tumor-targeting effects. This work emphasizes the physiological environment influences on aptamers targeting functionality and suggests that rational design and modification of aptamers to minimize the nonspecific interaction with plasma proteins might be effective to maintain aptamer functionality in future clinical uses.

Tunable thermal conduction force without macroscopic temperature gradients.

Ubiquitous thermal conduction makes its force effect particularly important in diverse fields, such as electronic engineering and biochemistry. However, regulating thermal conduction force is still challenging due to two stringent restrictions. First, a temperature gradient is essential for inducing the force effect. Second, the force direction is fixed to the temperature gradient in a specific material. Here, we demonstrate that thermal conduction force can exist unexpectedly at a zero average temperature gradient in dielectric crystals. The wavelike feature of thermal conduction is considered, i.e., the second sound mode. Based on the momentum conservation law for phonon gases, we analyze thermal conduction force with the plane, zeroth-order Bessel, and first-order Bessel second sounds. Remarkably, the force direction is highly tunable to be along or against the second sound direction. These results provide valuable insights into thermal conduction force in those environments with temperature fluctuations, and they open up possibilities for practical applications in manipulating the local thermal conductivity of crystals.

Giant, magnet-free, and room-temperature Hall-like heat transfer.

Thermal chirality, generically referring to the handedness of heat flux, provides a significant possibility for modern heat control. It may be realized with the thermal Hall effect yet at the high cost of strong magnetic fields and extremely low temperatures. Here, we reveal magnet-free and room-temperature Hall-like heat transfer in an active thermal lattice composed of a stationary solid matrix and rotating solid particles. Rotation breaks the Onsager reciprocity relation and generates giant thermal chirality about two orders of magnitude larger than ever reported at the optimal rotation velocity. We further achieve anisotropic thermal chirality by breaking the rotation invariance of the active lattice, bringing effective thermal conductivity to a region unreachable by the thermal Hall effect. These results could enlighten topological and non-Hermitian heat transfer and efficient heat utilization in ways distinct from phonons.

Black-hole-inspired thermal trapping with graded heat-conduction metadevices.

The curved space-time produced by black holes leads to the intriguing trapping effect. So far, metadevices have enabled analogous black holes to trap light or sound in laboratory spacetime. However, trapping heat in a conductive environment is still challenging because diffusive behaviors are directionless. Inspired by black holes, we construct graded heat-conduction metadevices to achieve thermal trapping, resorting to the imitated advection produced by graded thermal conductivities rather than the trivial solution of using insulation materials to confine thermal diffusion. We experimentally demonstrate thermal trapping for guiding hot spots to diffuse towards the center. Graded heat-conduction metadevices have advantages in energy-efficient thermal regulation because the imitated advection has a similar temperature field effect to the realistic advection that is usually driven by external energy sources. These results also provide an insight into correlating transformation thermotics with other disciplines, such as cosmology, for emerging heat control schemes.

Tunable liquid-solid hybrid thermal metamaterials with a topology transition.

Thermal metamaterials provide rich control of heat transport which is becoming the foundation of cutting-edge applications ranging from chip cooling to biomedical. However, due to the fundamental laws of physics, the manipulation of heat is much more constrained in conventional thermal metamaterials where effective heat conduction with Onsager reciprocity dominates. Here, through the inclusion of thermal convection and breaking the Onsager reciprocity, we unveil a regime in thermal metamaterials and transformation thermotics that goes beyond effective heat conduction. By designing a liquid-solid hybrid thermal metamaterial, we demonstrate a continuous switch from thermal cloaking to thermal concentration in one device with external tuning. Underlying such a switch is a topology transition in the virtual space of the thermotic transformation which is achieved by tuning the liquid flow via external control. These findings illustrate the extraordinary heat transport in complex multicomponent thermal metamaterials and pave the way toward an unprecedented regime of heat manipulation.

Convective Thermal Metamaterials: Exploring High-Efficiency, Directional, and Wave-Like Heat Transfer.

Convective thermal metamaterials are artificial structures where convection dominates in the thermal process. Due to the field coupling between velocity and temperature, convection provides a new knob for controlling heat transfer beyond pure conduction, thus allowing active and robust thermal modulations. With the introduced convective effects, the original parabolic Fourier heat equation for pure conduction can be transformed to hyperbolic. Therefore, the hybrid diffusive system can be interpreted in a wave-like fashion, reviving many wave phenomena in dissipative diffusion. Here, recent advancements in convective thermal metamaterials are reviewed and the state-of-the-art discoveries are classified into the following four aspects, enhancing heat transfer, porous-media-based thermal effects, nonreciprocal heat transfer, and non-Hermitian phenomena. Finally, a prospect is cast on convective thermal metamaterials from two aspects. One is to utilize the convective parameter space to explore topological thermal effects. The other is to further broaden the convective parameter space with spatiotemporal modulation and multi-physical effects.

Thermal Willis Coupling in Spatiotemporal Diffusive Metamaterials.

Willis coupling generically stems from bianisotropy or chirality in wave systems. Nevertheless, those schemes are naturally unavailable in diffusion systems described by a single constitutive relation governed by the Fourier law. Here, we report spatiotemporal diffusive metamaterials by modulating thermal conductivity and mass density in heat transfer. The Fourier law should be modified after homogenizing spatiotemporal parameters, featuring thermal Willis coupling between heat flux and temperature change rate. Thermal Willis coupling drives asymmetric heat diffusion, and the diffusion direction is reversible at a critical point determined by the degree of spatiotemporal modulation. Moreover, thermal Willis coupling stands robustly even when only thermal conductivity is modulated. These results may have potential applications for directional diffusion and offer insights into asymmetric manipulation of nonequilibrium mass and energy transfer.

Diffusive Fizeau Drag in Spatiotemporal Thermal Metamaterials.

Fizeau drag means that the speed of light can be regulated by the flow of water, owing to the momentum interaction between photons and moving media. However, the dragging of heat is intrinsically elusive, due to the absence of momentum in thermal diffusion. Here, we design a spatiotemporal thermal metamaterial based on heat transfer in porous media to demonstrate the diffusive analog to Fizeau drag. The space-related inhomogeneity and time-related advection enable the diffusive Fizeau drag effect. Thanks to the spatiotemporal coupling, different propagating speeds of temperature fields can be observed in two opposite directions, thus facilitating nonreciprocal thermal profiles. The phenomenon of diffusive Fizeau drag stands robustly even when the direction of advection is perpendicular to the propagation of temperature fields. These results could pave an unexpected way toward realizing the nonreciprocal and directional transport of mass and energy.

Manipulation of Multiple Cell-Cell Interactions by Tunable DNA Scaffold Networks.

Manipulation of cell-cell interactions via cell surface engineering has potential biomedical applications in tissue engineering and cell therapy. However, manipulation of the comprehensive and multiple intercellular interactions remains a challenge and missing elements. Herein, utilizing a DNA triangular prism (TP) and a branched polymer (BP) as functional modules, we fabricate tunable DNA scaffold networks on the cell surface. The responsiveness of cell-cell recognition, aggregation and dissociation could be modulated by aptamer-functionalized DNA scaffold networks with high accuracy and specificity. By regulating the DNA scaffold networks coated on the cell surface, controlled intercellular molecular transportation is achieved. Our tunable network provides a simple and extendible strategy which addresses a current need in cell surface engineering to precisely manipulate cell-cell interactions and shows promise as a general tool for controllable cell behavior.

Ascertaining the Inconsistency of AEC Students' Perceptions and Behaviors Regarding Sustainability by Mixed Methods.

University students in architecture, engineering, and construction (AEC) are the main force and future leaders of the construction industry, and their values shape the model and direction of the industry's future development. The construction industry is the largest contributor of waste and greenhouse gas emissions. However, there is an inconsistency between AEC university students' perceptions and behaviors regarding sustainability, which has received little attention. This study attempts to shed light on the root causes of the inconsistency from the psychological perspective, incorporating construal level (CL) theory and psychological distance (PD) theory into situational settings of the experiment. We recruited 556 AEC students from 20 different universities to participate in data collection. Research findings revealed that PD has a significant influence on AEC students' recycling behavior with variance in the effect of different dimensions, even though CL has no significant impact. Furthermore, findings show that spatial distance poses the greatest impact on AEC student recycling behavior, followed by information distance, temporal distance, experience distance, hypothetical distance, and social distance. This study contributes to the body of knowledge by introducing CL and PD into sustainability perception and behavior research in construction and has practical implications for universities with sustainability curricula in AEC.

Oxygen Vacancy-Driven Reversible Free Radical Catalysis for Environment-Adaptive Cancer Chemodynamic Therapy.

Amplifying free radical production by chemical dynamic catalysis to cause oxidative damage to cancer cells has received extensive interest for cancer-specific therapy. The major challenge is inevitable negative modulation on the tumor microenvironment (TME) by these species, hindering durable effectiveness. Here we show for the first time an oxygen vacancy-rich Bi-based regulator that allows environment-adaptive free radical catalysis. Specifically, the regulator catalyzes production of highly toxic O2.- and . OH in cancer cells via logic enzymatic reactions yet scavenges accumulation of free radicals and immunosuppressive mediators in TME-associated noncancerous cells. Atomic-level mechanistic studies reveal that such dual-modal regulating behavior is dominated by oxygen vacancies that well fit for free radical catalytic kinetics, along with distinguished cellular fates of this regulator. With this smart regulator, a "two birds with one shot" cancer dynamic therapy can be expected.

Tunable thermal wave nonreciprocity by spatiotemporal modulation.

Nonreciprocity is of particular importance to realize one-way propagation, thus attracting intensive research interest in various fields. Thermal waves, essentially originating from periodic temperature fluctuations, are also expected to achieve one-way propagation, but the related mechanism is still lacking. To solve the problem, we introduce spatiotemporal modulation to realize thermal wave nonreciprocity. Since thermal waves are completely transient, both the convective term and the Willis term induced by spatiotemporal modulation should be considered. We also analytically study the phase difference between two spatiotemporally modulated parameters, which offers a tunable parameter to control nonreciprocity. We further define a rectification ratio based on the reciprocal of spatial decay rate and discuss nonreciprocity conditions accordingly. Finite-element simulations are performed to confirm theoretical predictions, and experimental suggestions are provided to ensure the feasibility of spatiotemporal modulation. These results have potential applications in realizing thermal detection and thermal stabilization simultaneously.

A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels.

Cell-cell communication plays a vital role in biological activities; in particular, membrane-protein interactions are profoundly significant. In order to explore the underlying mechanism of intercellular signaling pathways, a full range of artificial systems have been explored. However, many of them are complicated and uncontrollable. Herein we designed an artificial signal transduction system able to control the influx of environmental ions by triggering the activation of synthetic transmembrane channels immobilized on giant membrane vesicles (GMVs). A membrane protein-like stimulator from one GMV community (GMVB) stimulates a receptor on another GMV community (GMVA) to release ssDNA messengers, resulting in the activation of synthetic transmembrane channels to enable the influx of ions. This event, in turn, triggers signal responses encapsulated in the GMVA protocell model. By mimicking natural signal transduction pathways, this novel prototype provides a workable tool for investigating cell-cell communication and expands biological signaling systems in general as well as explores useful platforms for addressing scientific problems which involve materials science, chemistry, and medicine.

Geometric phase and bilayer cloak in macroscopic particle-diffusion systems.

Particle diffusion is a fundamental process in various systems, so its effective manipulation is crucially important. For this purpose, here we design a basic structure composed of two moving rings with equal-but-opposite velocities and a stationary intermediate layer, which can realize multiple functions to control particle diffusion. On the one hand, the intermediate layer allows particle exchange between the two moving rings, which gives birth to an exceptional point of velocity. As a result, a geometric phase appears for a loop evolution of velocity containing the exceptional point. On the other hand, the two moving rings also enhance the effective diffusivity of the intermediate layer, which helps design a bilayer particle-diffusion cloak. The present cloak only requires homogeneous parameters and simple structures, and meanwhile, its on and off can be flexibly controlled by velocity. These results broaden the scope of geometric phase and provide hints for designing particle-diffusion metamaterials.

DNA-based artificial molecular signaling system that mimics basic elements of reception and response.

In order to maintain tissue homeostasis, cells communicate with the outside environment by receiving molecular signals, transmitting them, and responding accordingly with signaling pathways. Thus, one key challenge in engineering molecular signaling systems involves the design and construction of different modules into a rationally integrated system that mimics the cascade of molecular events. Herein, we rationally design a DNA-based artificial molecular signaling system that uses the confined microenvironment of a giant vesicle, derived from a living cell. This system consists of two main components. First, we build an adenosine triphosphate (ATP)-driven DNA nanogatekeeper. Second, we encapsulate a signaling network in the biomimetic vesicle, consisting of distinct modules, able to sequentially initiate a series of downstream reactions playing the roles of reception, transduction and response. Operationally, in the presence of ATP, nanogatekeeper switches from the closed to open state. The open state then triggers the sequential activation of confined downstream signaling modules.

Metathermotics: Nonlinear thermal responses of core-shell metamaterials.

Thermal metamaterials based on core-shell structures have aroused wide research interest, e.g., in thermal cloaks. However, almost all the relevant studies only discuss linear materials whose thermal conductivities are temperature-independent constants. Nonlinear materials (whose thermal conductivities depend on temperatures) have seldom been touched; however, they are important in practical applications. This situation largely results from the lack of a general theoretical framework for handling such nonlinear problems. Here we study the nonlinear responses of thermal metamaterials with a core-shell structure in two or three dimensions. By calculating the effective thermal conductivity, we derive the nonlinear modulation of a nonlinear core. Furthermore, we reveal two thermal coupling conditions, under which this nonlinear modulation can be efficiently manipulated. In particular, we reveal the phenomenon of nonlinearity enhancement. Then this theory helps us to design a kind of intelligent thermal transparency devices, which can respond to the direction of thermal fields. The theoretical results and finite-element simulations agree well with each other. This work not only offers a different mechanism to achieve nonlinearity modulation and enhancement in thermotics, but also suggests potential applications in thermal management, including illusion.

Designing effective thermal conductivity of materials of core-shell structure: Theory and simulation.

We introduce the phenomenon of golden touch from myth to thermotics. We define golden touch as extending the core property to a shell with an extremely small core fraction. We obtain the requirement of golden touch by making the effective thermal conductivity of the core-shell structure equal to the thermal conductivity of the core. We summarize three types (A, B, and C) of golden touch in two dimensions, and only two types (A and B) of golden touch in three dimensions. We theoretically analyze the distinct properties of different types of golden touch by delicately designing the anisotropic thermal conductivity of the shell. Golden touch is also validated by finite-element simulations which echo the theoretical analyses. Golden touch has potential applications in thermal camouflage, thermal management, etc. Our work not only lays the foundation for golden touch in thermotics, but also provides guidance for exploring golden touch in other diffusive fields like electrostatic and magnetostatic fields.