Assuntos
Minas de Carvão , Peróxidos/uso terapêutico , Pneumoconiose/complicações , Insuficiência Respiratória/tratamento farmacológico , Ureia/análogos & derivados , Idoso , Peróxido de Carbamida , Combinação de Medicamentos , Humanos , Masculino , Pessoa de Meia-Idade , Peróxidos/administração & dosagem , Pneumoconiose/tratamento farmacológico , Insuficiência Respiratória/etiologia , Ureia/administração & dosagem , Ureia/uso terapêuticoAssuntos
Infecção Hospitalar/microbiologia , Quimioterapia Combinada/uso terapêutico , Pneumonia/tratamento farmacológico , Staphylococcus aureus/efeitos dos fármacos , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/farmacologia , Minas de Carvão , Infecção Hospitalar/complicações , Humanos , Masculino , Meticilina/farmacologia , Resistência a Meticilina , Testes de Sensibilidade Microbiana , Pessoa de Meia-Idade , Pneumonia/etiologia , Silicose/classificação , Silicose/complicações , Resultado do TratamentoRESUMO
OBJECTIVE: To study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer, and its relation to clinical pathology. METHOD: Measuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry. RESULTS: The positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.13% whereas that in 30 cases of single pulmonary cancer was 26.67% (P < 0.05); the positive expressions of C-erbB-2 in patients with lymph node metastasis (70.59% in pneumoconiosis group, 50.00% in controls) were significantly different from those without lymph node metastasis (33.33% in pneumoconiosis group, 11.11% in controls) (P < 0.05). The prognosis on patients with positive expressions of C-erbB-2 was poor, and was not related to pathologic category. CONCLUSION: C-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer, and as a reference index to determine lymph node metastasis and prognosis.
Assuntos
Minas de Carvão , Neoplasias Pulmonares/genética , Pneumoconiose/genética , Receptor ErbB-2/genética , Idoso , China , Expressão Gênica , Genes erbB-2 , Genótipo , Humanos , Neoplasias Pulmonares/complicações , Neoplasias Pulmonares/patologia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Pneumoconiose/complicações , Pneumoconiose/patologia , Prognóstico , Receptor ErbB-2/metabolismo , Análise de SobrevidaRESUMO
OBJECTIVE: To study lumbar vertebral degenerations of coal miners with low back pain. METHODS: 40 underground miners with low back pain, aged from 30 to 50 years and employed for a length from 10 to 30 years, were taken as observation group. 30 ground workers without low back pain but with almost the same age, employment length and height etc. were selected as control group. Intervertebral discs at L3/L4, L4/L5, L5/S1 were scanned with computerized tomography, comparing herniated discs, sagittal diameter of vertebral canal, height of lateral recess, vertebral hypertostosis, ligament hypertrophy and calcification between two groups. RESULTS: L3/L4, L4/L5, L5/S1 herniated discs and narrow lateral recess in observation group(0.33 +/- 0.15, 0.53 +/- 0.25, 0.45 +/- 0.18 and 0.40 +/- 0.08, 0.31 +/- 0.05, 0.37 +/- 0.07) were more serious than that in control group(0.28 +/- 0.11, 0.32 +/- 0.21, 0.37 +/- 0.19 and 0.42 +/- 0.10, 0.43 +/- 0.07, 0.40 +/- 0.06), but only with significant difference at L4/L5 (P < 0.01). Sagittal diameter of vertebral canal in observation group is narrower than that in control group but of little significance(P > 0.05). Cases of vertebral hyperostosis, ligament hypertrophy and calcification were found more frequent in observation group(45.00%, 42.50%, 22.50%) than in control group(23.33%, 16.67%, 16.67%), but only ligament hypertrophy was remarkable(P < 0.05). CONCLUSIONS: As compared with control group lumbar vertebral degenerations are more serious in underground miners with manifestations like herniated disc and narrow lateral recess mainly at L4/L5.