1.
J Org Chem
; 88(13): 9488-9495, 2023 Jul 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-37338541
RESUMO
A concise and efficient synthesis of fully substituted cyclobutane derivatives from 1,4-diyn-3-ols and anhydrides was developed. Mechanistic studies indicated that a tandem esterification, isomerization to give allenyl ester, and homointermolecular [2+2] cycloaddition might be involved. The features of this protocol are its operational practicality, mild reaction conditions, and high regio- and stereoselectivity, and it is a readily accessible gram-scale synthesis.