RESUMO
Weaning stress is the most common issue in swine farms, which increases mortality and morbidity. The use of artificial light is an option for modifying the immune system and metabolic pathways. This study aimed to evaluate the influence of ultraweak light (Photonia) on growth performance, immune system and metabolism of weanling pigs, and the carry-over effect on the growth performance in postweanling growing stages. A total of 30 weaned pigs with an average initial body weight of 7.06 ± 0.11 kg (age: 21 days) were allotted two treatments (Control and Photonia) with 15 replicates. The pelleted form diets were prepared for pigs in three phases including phase 1 (Days 0-14), phase 2 (Days 15-28) and phase 3 (Days 29-48). The gain-to-feed ratio (G:F) of pigs was significantly greater in the Photonia treatment. On Day 28, a higher concentration of immunoglobin A (IgA) (p < 0.01) and IgG (p < 0.01) was observed in the Photonia pigs. On Day 48, the Photonia treatment showed a greater serum IgA (p < 0.01) and IgG (p < 0.05). The concentration of interleukin (IL)-6 was decreased (p < 0.05) in the Photonia treatment. At Day 48, the concentrations of tumour necrotic factor-α, IL-1ß and IL-6 in serum were decreased (p < 0.05) in pigs in the Photonia treatment. Metabolic pathways analysis showed that the Photonia treatment increased the d-glutamine, d-glutamate, alanine, aspartate, glutamate and phenylalanine compared with the control treatment. In conclusion, the use of Photonia for weanling pigs is recommended due to improved G:F, immune status and activation of amino acids metabolic pathways including d-glutamine, d-glutamate, alanine, aspartate, glutamate and phenylalanine.
Assuntos
Ácido Glutâmico , Glutamina , Suínos , Animais , Ácido Aspártico , Desmame , Dieta/veterinária , Alanina , Fenilalanina , Imunoglobulina A , Imunoglobulina G , Ração Animal/análiseRESUMO
Activity-directed isolation of the n-hexane and dichloromethane fractions of Capsosiphon fulvescens resulted in the identification of four new glycolipids (1-3): (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-2-O-(4Z,7Z,10Z,13Z-hexadecatetraenoyl)-3-O-ß-D-galactopyranosyl glycerol (1, capsofulvesin A), (2S)-l-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-(10Z,13Z-hexadecadienoyl)-3-O-ß-D-galactopyranosyl glycerol (2, capsofulvesin B), (2S)-1-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-ß-D-galacatopyranosyl glycerol (3, capsofulvesin C). Compounds 1-6 exhibited acetylcholinesterase (AChE) inhibitory activities with IC(50) values ranging from 50.90 to 82.83 µM, whereas 2-6 showed butyrylcholinesterase (BChE) inhibitory activities with IC(50) values of 114.75-185.55 µM. Although most of the compounds isolated lacked scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and peroxynitrite (ONOO(-)), compound 8 showed ONOO(-) scavenging activity with an IC(50) value of 26.23 µg/mL.
Assuntos
Clorófitas/química , Inibidores da Colinesterase/química , Sequestradores de Radicais Livres/química , Glicolipídeos/química , Acetilcolinesterase/metabolismo , Compostos de Bifenilo/metabolismo , Butirilcolinesterase/metabolismo , Inibidores da Colinesterase/isolamento & purificação , Inibidores da Colinesterase/farmacologia , Sequestradores de Radicais Livres/isolamento & purificação , Sequestradores de Radicais Livres/farmacologia , Radicais Livres/metabolismo , Glicolipídeos/isolamento & purificação , Glicolipídeos/farmacologia , Humanos , Concentração Inibidora 50 , Ácido Peroxinitroso/metabolismo , Picratos/metabolismoRESUMO
The optical transmission spectra of several samples of gold nanoparticle layers were examined using a modified Drude model proposed with a novel elastic scattering parameter, gamma'. Although the measured transmission spectra deviated from the simple calculation from Mie scattering, it was explained well by the modified model assuming elastic and inelastic scattering in the form of the collision frequency of free electrons within a metal particle due to the particle boundary. The particle-size and inter-particle-distance dependences of gamma' were extracted within the framework of the proposed model from the curve of best fit of the transmittance spectra.