Image Restoration Quality Assessment Based on Regional Differential Information Entropy.

With the development of image recovery models, especially those based on adversarial and perceptual losses, the detailed texture portions of images are being recovered more naturally. However, these restored images are similar but not identical in detail texture to their reference images. With traditional image quality assessment methods, results with better subjective perceived quality often score lower in objective scoring. Assessment methods suffer from subjective and objective inconsistencies. This paper proposes a regional differential information entropy (RDIE) method for image quality assessment to address this problem. This approach allows better assessment of similar but not identical textural details and achieves good agreement with perceived quality. Neural networks are used to reshape the process of calculating information entropy, improving the speed and efficiency of the operation. Experiments conducted with this study's image quality assessment dataset and the PIPAL dataset show that the proposed RDIE method yields a high degree of agreement with people's average opinion scores compared with other image quality assessment metrics, proving that RDIE can better quantify the perceived quality of images.

UNC93B1 curbs cytosolic DNA signaling by promoting STING degradation.

UNC93B1 is a trafficking chaperone of endosomal Toll-like receptors (TLRs) and plays an essential role in the TLR-mediated innate signaling. However, whether it is also involved in other innate immune sensing or cellular pathways remains largely unexplored. Here we investigated the role of UNC93B1 in cytosolic DNA-triggered cGAS-STING signaling in mouse and human cell lines. We showed that while UNC93B1 deficiency blunts the signal transduction by TLR3, it augments innate immune responses to cytosolic DNA stimulation and DNA virus infection. Mechanistic study reveals a distinct action of UNC93B1 upon STING, but not other parts along the cGAS-STING-TBK1 axis, through regulating the protein level of STING at both resting and cytosolic DNA-stimulated conditions. UNC93B1 can directly interact and traffic along with STING, and the disruption of this interaction causes accumulation of STING that subsequently leads to augmented signaling responses upon its activation. These findings reveal a new function of UNC93B1 in negatively regulating STING-mediated signaling responses.

Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity.

MCM7, a subunit of mini-chromosome maintenance proteins (MCM) complex, plays an important role in initiating DNA replication during the G1 phase and extending DNA strands during the S phase. Here, we demonstrated that MCM7 is not only sustained but maintains association with chromatin during M phase. Remarkably, MCM7 siRNA can accelerate mitotic exit. MCM7 depletion leads to CDK1 inactivation and promotes subsequent cohesin/RAD21 cleavage, which eventually leads to sister chromatin segregation. Moreover, MCM7 is co-localized with tubulin in the mitotic cells and MCM7 depletion results in aberrant mitosis. Our results indicate that MCM7 may exert certain functions on spindle formation to prevent cytokinesis during early mitosis by regulating CDK1 activity.