1.
Org Lett
; 25(48): 8655-8660, 2023 Dec 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38062747
RESUMO
A novel protocol has been developed for the Cu-catalyzed synthesis of primary arylamines with meta-substituents using cyclohexenone oxime esters. Mechanistic insights suggest that the reaction proceeds via an intermolecular 1,5-H hydrogen atom transfer of an imine radical intermediate. This approach features high efficiency, a readily available catalyst system, and broad functional group tolerance.