Major congenital heart defects are rarely diagnosed after newborns' hospital discharge with modern screening.

AIM: Our aim was to assess undiagnosed congenital heart defects (CHD) after newborns' hospital discharge in patients with a murmur or CHD suspicion, to find out the signs that predict CHDs and to estimate the costs of the examinations. METHODS: We reviewed retrospective medical records of patients (n = 490) referred for the evaluation of CHD suspicion during 2017-2018. RESULTS: The median age of the patients was 2.5 (IQR 0.5-7.4) years. Sixty-three (13%) patients had an abnormal echocardiography. Neither ductal-dependent nor cyanotic CHDs were found. Cardiac interventions were performed for 14 out of 63 (22%) patients. Clinical signs indicating CHDs were murmur grade ≥3 (10/11 [91%] vs. 53/479 [11%], p < 0.001) and harsh murmur (15/44 [34%] vs. 48/446 [11%], p < 0.001). Abnormal electrocardiography did not indicate CHD (8/40 [20%] vs. 55/447 [12%], p = 0.165). The total cost of the examinations was 259 700€. The share of the cost of studies assessed as benign was 59%. CONCLUSION: Only a few CHDs were found after newborn hospital discharge among patients who received foetal and newborn screening and were examined due to CHD suspicion. The high number of benign murmurs in children leads to many referrals, resulting in unnecessary healthcare costs.

Contribution of vaginal scanning to sonographic evaluation of endometrial cancer invasion.

Vaginal sonography was compared to abdominal sonography in predicting myometrial invasion in 23 women (mean age 59 +/- 9 years) undergoing hysterectomy due to endometrial cancer. Vaginal scanning prediction corresponded to histological findings in 87% (20/23) of the cases. In 2 cases the degree of invasion was underestimated and in 1 case overestimated by vaginal sonography. Abdominal sonography was accurate in 78% (18/23) of the cases. Vaginal scanning also improved the sonographic visualization of endometrium and cervical canal. However, in one case a superficial invasion of the cervix was missed by both methods of scanning. Furthermore, in another patient an ovarian cyst of 5 cm located in the upper pelvis was seen by abdominal but not vaginal sonography. We suggest that a sonographic work-up to assess endometrial cancer spread should include both methods of scanning.