Assuntos
Disfunção Erétil/etiologia , Pênis/efeitos da radiação , Radioterapia Conformacional/efeitos adversos , Humanos , Masculino , Ereção Peniana/fisiologia , Pênis/anatomia & histologia , Neoplasias da Próstata/radioterapia , Inquéritos e Questionários , Uretra/anatomia & histologia , Uretra/efeitos da radiaçãoRESUMO
Metastatic renal cancer is responsive in some cases to immunotherapeutic agents. Indications for nephrectomy in the face of metastatic disease have traditionally included palliation of symptoms caused by the primary tumor, and nephrectomy combined with metastatectomy in patients with resectable metastases. Recent findings from a Southwest Oncology Group trial strongly suggest that cytoreductive nephrectomy, combined with immunotherapy, may also result in improved survival in patients with unresectable metastases.
Assuntos
Carcinoma de Células Renais/cirurgia , Imunoterapia , Neoplasias Renais/cirurgia , Nefrectomia , Carcinoma de Células Renais/imunologia , Carcinoma de Células Renais/secundário , Terapia Combinada , Humanos , Infarto/imunologia , Rim/irrigação sanguínea , Neoplasias Renais/imunologia , Neoplasias Renais/patologia , PrognósticoRESUMO
The role of cytoreductive surgery in patients with metastatic renal cancer remains controversial. Recent data from our Southwest Oncology Group trial suggest that cytoreduction confers an approximately 50% increase in median survival for such patients when they are treated with interferon-alfa-2b immunotherapy. The timing of cytoreduction, and in which patients it may be most applicable, are discussed herein.
Assuntos
Carcinoma de Células Renais/patologia , Carcinoma de Células Renais/cirurgia , Neoplasias Renais/cirurgia , Nefrectomia , Carcinoma de Células Renais/mortalidade , Humanos , Neoplasias Renais/mortalidade , Neoplasias Renais/patologia , Metástase Neoplásica , Prognóstico , Taxa de SobrevidaRESUMO
The role of cytoreductive nephrectomy in the management of metastatic renal cancer remains controversial. Recent trials, like SWOG 8949 have suggested the usefulness of this approach at least in selected patients with good performance status and other favorable indicators. The timing of cytoreductive nephrectomy has also been controversial and remains so to this time.
Assuntos
Carcinoma de Células Renais/cirurgia , Neoplasias Renais/cirurgia , Nefrectomia , Carcinoma de Células Renais/patologia , Humanos , Imunoterapia , Neoplasias Renais/patologia , Metástase Neoplásica , Prognóstico , Fatores de TempoRESUMO
An 83-year-old man had episodic dizziness, visual disturbance, and facial and extremity weakness associated with eating. Occlusion of the ipsilateral common carotid artery and stenosis or occlusion of the major collateral sources were demonstrated. We believe this anatomic configuration, combined with increases in demand for external carotid artery blood flow necessitated by the act of chewing, resulted in a vascular steal syndrome. An extended carotid endarterectomy was performed, and there were no additional episodes.