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1.
Indian J Cancer ; 2023 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-38090957

RESUMO

BACKGROUND: Current markers (carcinoembryonic antigen [CEA] and carbohydrate antigen 15-3 [CA15-3]) lack sensitivity in diagnosis of breast cancer. The aberrantly expressed circulating miRNAs were shown as diagnostic markers in breast cancer. However, there are very few studies from the Indian population. We studied the diagnostic utility of miRNA-21, miRNA-155 and miRNA-205 compared to CEA and CA15-3 in stage I and II breast cancer patients. MATERIALS AND METHODS: Sixty newly diagnosed women with stage I/II breast cancer and 20 healthy controls were recruited. Expression of circulating miRNAs was studied using reverse transcription-polymerase chain reaction, whereas CEA and CA 15-3 were analyzed by enzyme-linked immunosorbent assay. RESULTS: miRNA-21 and miRNA-155 were upregulated, miRNA-205 down-regulated (P < 0.05) and serum CEA and CA15-3 levels increased in breast cancer patients (P < 0.001). Receiver operating characteristic curve analysis showed significant area under curve (AUC) for all markers (0.656 to 0.993; P = 0.015 to <0.001) validating their diagnostic potential. Unlike CEA and CA15-3, miRNAs retained their sensitivity even at higher cut-offs (95% CI of mean). Logistic regression analysis showed significant association between disease and marker positivity for miRNA-21 and miRNA-205 but not for miRNA-155. Combining CA15-3 with miRNAs did not improve their diagnostic performance. However, combining CEA with either miRNA-21 (AUC = 0.742; P < 0.001 versus AUC = 0.656; P = 0.018) or miRNA-205 (AUC = 0.733; P < 0.001 versus AUC = 0.700; P < 0.001) increased its diagnostic performance. CONCLUSION: Our study shows miRNA-21 and miRNA-205, are useful as diagnostic markers for breast cancer in the Indian population and combination of these miRNAs with CEA but not with CA 15-3 improved their diagnostic performance.

2.
Mol Biol Rep ; 46(6): 6287-6297, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31538300

RESUMO

Single nucleotide polymorphisms (SNPs) in adiponectin gene [rs1501299 (+276G/T) and rs266729 (-11377C/G)] and one SNP of leptin gene [rs7799039 (-2548G/A)] are known to influence plasma levels of adiponectin and leptin respectively. Literature is scarce on the association of adiponectin gene polymorphism rs266729 with breast cancer. The present study was taken up to study these polymorphisms and their association with breast cancer. Ninety-three patients diagnosed with malignant breast cancer were included as cases along with 186 age matched healthy controls. Adiponectin +276G/T, -11377C/G and leptin -2548G/A polymorphism were studied using polymerase chain reaction (PCR) based restriction fragment length polymorphism (RFLP). Adipokine levels in blood were measured using enzyme linked immunosorbent assay. Adiponectin +276G/T and leptin -2548G/A showed a significant increased risk for breast cancer even after adjusting for confounding variables like present age, age at menarche, age at first child birth and age at menopause. In the subset analysis, based on menopausal state, stronger association was observed between SNP in adiponectin gene +276G/T with the breast cancer in post-menopausal women after adjusting for all other variables. No association was found with adiponectin -11377C/G. No association of the gene polymorphisms with adipokine levels was observed. Also, no significant association was seen for the effect of gene-environment interaction i.e. presence of polymorphism with obesity and menopausal state for any of the SNPs studied. Adiponectin +276G/T is strongly associated with breast cancer in postmenopausal women while leptin -2548G/A polymorphisms is significantly associated with breast cancer irrespective of the menopausal state in south Indian subjects.


Assuntos
Adiponectina/genética , Neoplasias da Mama/genética , Predisposição Genética para Doença , Leptina/genética , Polimorfismo de Nucleotídeo Único , Adulto , Idoso , Alelos , Biomarcadores Tumorais , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/metabolismo , Estudos de Casos e Controles , Feminino , Frequência do Gene , Interação Gene-Ambiente , Estudos de Associação Genética , Genótipo , Humanos , Mamografia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Fatores de Risco
3.
Malays J Pathol ; 32(1): 65-8, 2010 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-20614729

RESUMO

Cervical ectopic thymus (CET), a common embryological anomaly detected incidentally at autopsy, is rarely described in clinical patients. Furthermore, aberrant cervical thymic tissue is an infrequently reported cause of paediatric neck masses. We report a 12-year-old female presenting with multinodular thyroid swelling since seven years of age. FNAC revealed adenomatous goitre with suspicious cystic papillary neoplastic foci, for which she underwent total thyroidectomy along with excision of a nodular swelling near the lower pole of the right thyroid lobe which was per-operatively suspected to be a lymph node. Histopathological examination revealed a follicular variant papillary carcinoma of the thyroid with background thyroiditis, and a nodule of ectopic thymic tissue. Though the presence of CET is rare, one should be aware of this entity, especially in children because it may be confused with lymph node metastasis which may lead to morbid radical neck dissection.


Assuntos
Carcinoma Papilar/complicações , Metástase Linfática/patologia , Disgenesia da Tireoide/complicações , Disgenesia da Tireoide/patologia , Neoplasias da Glândula Tireoide/complicações , Biópsia por Agulha Fina , Carcinoma Papilar/patologia , Carcinoma Papilar/cirurgia , Criança , Diagnóstico Diferencial , Feminino , Humanos , Disgenesia da Tireoide/cirurgia , Neoplasias da Glândula Tireoide/patologia , Neoplasias da Glândula Tireoide/cirurgia , Tireoidectomia , Tireoidite/complicações , Tireoidite/patologia
5.
JOP ; 9(3): 332-4, 2008 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-18469449

RESUMO

CONTEXT: Synchronous malignancies affecting both the major and minor papilla are rare and are usually of endocrine origin. CASE REPORT: A 60-year-old female presented with a two-week history of progressive jaundice and pruritus. Evaluation revealed features of a periampullary malignancy. A Whipple pancreaticoduodenectomy was done. There was a growth in the ampulla of Vater and another in the region of the minor duodenal papilla. On histopathology, both lesions were adenocarcinomas. CONCLUSION: Although rare, synchronous adenocarcinomas can occur in the major and minor papilla.


Assuntos
Adenocarcinoma/diagnóstico , Ampola Hepatopancreática , Carcinoma Ductal Pancreático/complicações , Carcinoma Ductal Pancreático/diagnóstico , Neoplasias do Ducto Colédoco/complicações , Neoplasias do Ducto Colédoco/diagnóstico , Neoplasias Primárias Múltiplas/diagnóstico , Ductos Pancreáticos , Adenocarcinoma/complicações , Ampola Hepatopancreática/patologia , Feminino , Humanos , Icterícia/diagnóstico , Icterícia/etiologia , Pessoa de Meia-Idade , Ductos Pancreáticos/patologia
8.
Nepal Med Coll J ; 9(2): 125-8, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17899964

RESUMO

Dressing or preparation of the diabetic foot ulcer is very essential not only to reduce or prevent infection but also for the preparation for definite surgery, if necessary. Present article is about our experience in the evaluation of effectiveness of super oxidized solution in local treatment of diabetic foot ulcers. Out of 20 cases super oxidized solution helped in total healing in 8 cases, and prepared wounds for definite cover by reducing infection and promoting granulations which are pre requisites for definitive surgery in remaining 12 cases.


Assuntos
Antibacterianos/uso terapêutico , Pé Diabético/tratamento farmacológico , Oxidantes/uso terapêutico , Cicatrização , Adolescente , Adulto , Antibacterianos/administração & dosagem , Criança , Pé Diabético/prevenção & controle , Feminino , Humanos , Peróxido de Hidrogênio , Masculino , Pessoa de Meia-Idade , Oxidantes/farmacologia , Projetos Piloto
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