RESUMO
Perineuronal nets comprise chondroitin sulfate moieties and their core proteins, and their neuropathological alterations have been implicated in schizophrenia. To explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. Immunoblotting for chondroitin 4-sulfate and chondroitin 6-sulfate moieties revealed a significant increase in intensity of a 180â¯kD band of chondroitin 4-sulfate immunoreactivity in the hippocampus of patients, although we detected no significant alteration in their immunoreactivities with any other molecular sizes or in other brain regions. The levels of immunoreactivity were not correlated with postmortem interval, age, or storage time. We failed to find such an increase in a similar molecular range of the chondroitin 4-sulfate immunoreactivity in the hippocampus of the rats chronically treated with haloperidol. These results suggest that the level alteration of the chondroitin 4-sulfate moiety might contribute to the perineuronal net abnormality found in patients with schizophrenia.
Assuntos
Sulfatos de Condroitina/metabolismo , Hipocampo/metabolismo , Esquizofrenia/metabolismo , Idoso , Animais , Estudos de Casos e Controles , Núcleo Caudado/metabolismo , Núcleo Caudado/patologia , Matriz Extracelular/metabolismo , Feminino , Hipocampo/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Córtex Pré-Frontal/metabolismo , Córtex Pré-Frontal/patologia , Ratos , Esquizofrenia/patologiaAssuntos
Anticonvulsivantes/efeitos adversos , Transtorno Bipolar/induzido quimicamente , Transtorno Conversivo/tratamento farmacológico , Ácido gama-Aminobutírico/análogos & derivados , Transtorno Bipolar/complicações , Transtorno Conversivo/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Pregabalina , Ácido gama-Aminobutírico/efeitos adversosRESUMO
We reported a 28-year-old woman who had Guillain-Barré syndrome (GBS). Eight days after fever up and abdominal pain, she had weakness and dysesthesia of both hands and feet. Campylobacter jejuni (C. jejuni) was isolated from her stool culture without diarrhea. IgG anti-GM1 antibody was detected in her serum. Nerve conduction studies revealed a predominantly axonal neuropathy. After intravenous immunoglobulin therapy, her symptoms promptly improved. Penner 19 of C. jejuni was isolated more frequently from the GBS patients than from sporadic enteritis patients. In this case, C. jejuni with the serogroup Penner A was isolated. The serogroup is detected rarely in GBS.
