Short periodicity phase based on ceramide [AP] in the model lipid membranes of stratum corneum does not change during hydration.

Small angle X-ray scattering technique was used to determine electron density profiles of short periodicity phase in the model lipid membranes of stratum corneum at different pH. Basic quaternary system was prepared as used previously in the neutron experiments at partial hydration. It was shown that electron density profiles of partially hydrated and fully hydrated model lipid membranes with four basic components were quite similar and demonstrated almost no interbilayer water.

Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine.

Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2Å.