Adsorption of insulin onto infusion sets used in adult intensive care unit and neonatal care settings.

INTRODUCTION: Insulin adsorption onto infusion equipment may affect glycaemic control. METHODS: The change in insulin concentration during delivery through tubing employed for adult ICU and neonatal patients was determined using continuous flow UV analysis. RESULTS: Insulin adsorption depended on tubing composition, dimensions and flow rate, being highest for neonatal polyvinylchloride tubing at low flow rates. CONCLUSION: In continuous insulin therapy, we should consider the nature of the infusion set and flow rate.