Fluoride affects bone repair differently in mice models with distinct bone densities.

We grouped mice [strains: C57BL/6J (n=32) and C3H/HeJ (n=32)] to address the influence of bone density on fluoride's (F's) biological effects. These animals received low-fluoride food and water containing 0 (control group) or 50ppm of F for up to 28days. The upper left central incisor was extracted, and the left maxilla was collected at 7, 14, 21, and 28days for histological and histomorphometric analysis to estimate bone neoformation. Our results showed bone neoformation in all of the evaluated groups, with the presence of bone islets invading the center of the alveoli when replacing the existing connective tissue. Curiously, this biological phenomenon was more evident in the C57BL/6J strain. The histomorphometric analysis confirmed the histological findings in relation to the amount of new bone tissue and showed a decrease in C3H/HeJ mice (control group). Altogether, our results showed differential effects of fluoride bone metabolism, confirming a genetic component in susceptibility to the effects of fluoride.

[Integrated approach to the oral health of drug-addicted undergoing rehabilitation]. / Abordagem integrada da saúde bucal de droga-dependentes em processo de recuperação.

Considering the current context of increasing and early utilization of licit or illicit drugs (habit-forming substances), the aim of this study was to evaluate the oral health conditions of 102 males from the Esquadrão da Vida rehabilitation center, in Bauru, São Paulo, Brazil. The evaluation was carried out by means of the assessment of caries experience (DMFT), dental plaque (PHP), gingival index and salivary flow. This study also aimed at instituting an educational-preventive program and evaluating its efficacy. The subjects' mean age was 29.17 years (sd = 11.40; n = 95). From all subjects (n = 102), 72.54% had the habit of eating between meals, and 69.60% did not utilize dental floss. The observed DMFT was 14.88 (sd = 6.38; n = 86). The initial PHP was 2.34 (sd = 0.69; n = 14) and, after 3 months, it was reduced to 1.91 (sd = 0.74; n = 14). The initial salivary flow was 1.31 ml/min (sd = 0.7; n = 97). Due to the fluctuation of this group, only 13 of the original subjects were reevaluated after 3 months, when a salivary flow of 1.13 ml/min (sd = 0.49) was registered. The initial gingival index and PHP presented r = 0.30 (p = 0.002 - statistically significant). The objective need for treatment and the subjective importance given to oral health were negatively correlated (r = -0.26; p = 0.019 - statistically significant), which indicates that the value attributed to oral health influences health care and affects the oral health-sickness process.

Abordagem integrada da saúde bucal de droga-dependentes em processo de recuperaçäo / Integrated approach to the oral health of drug-addicted undergoing rehabilitation

No atual contexto de uso crescente e precoce de drogas (fármacos recreacionais), legais ou näo, a finalidade deste trabalho foi avaliar as condiçöes de saúde bucal de 102 indivíduos, do sexo masculino, da instituiçäo de recuperaçäo Esquadräo da Vida, em Bauru-SP. O diagnóstico desta condi;äo foi feito por meio da experiência de cárie (CPOD), placa bacteriana (PHP), índice gengival e teste de fluxo salivar. Objetivou-se também a implantaçäo e verificaçäo da eficácia de um programa educativo-preventivo. A idade média dos internos foi de 29,17 anos (d.p=11,40/ N=95). Dos internos (N=102), 72,54 por cento tinham o hábito de comer entre as refeiçöes e 69,60 por cento näo utilizavam fio dental. O CPOD observado foi de 14,88 (d.p=6,38; N=86) e, quando correlacionado à idade, obteve-se r=0,55 (p<0,001*). O PHP inicial foi de 2,34 (d.p=0,69; N=14) e, decorridos 3 meses, reduziu para 1,91 (d.p=0,74/ N=14). O fluxo salivar inicial foi de 1,31 mLmin (d.p=0,7/ N=97), sendo apenas 13 reavaliados após 3 meses, devido à flutuaçäo deste grupo populacional, obtendo-se 1,13mLmin (d.p=0,49). O índice gengival e o PHP iniciais apresentaram r=0,30 (p=0,002*). A necessidade objetiva de tratamento verificada e a importância subjetiva conferida à saúde bucal apresentaram correlaçäo negativa (r= -0,26; p=0,019*), indicando que a valorizaçäo da saúde bucal repercute sobre os cuidados em saúde e tem reflexos sobre o processo saúde-doença bucal