Ethical assessment of privacy breaches in epidemiological investigations and information disclosure in the internet age: safeguarding identity information for infectious patients

While the Internet has brought convenience and speed to human life, it has also led to frequent privacy violations. In the context of epidemiological investigations and information disclosure regarding confirmed Covid-19 patients, many individuals have utilized the Internet as a means to disseminate information and engage in cyber manhunts, resulting in breaches of privacy for those involved. This phenomenon is particularly prevalent within the realm of the Internet, where the boundaries of privacy invasion become blurred. Various types of privacy infringements, both active and passive negligence, are evident on social networking platforms. The juxtaposition of the virtual world of the Internet with real-life scenarios presents novel challenges in the realm of privacy violations. The Internet era, coupled with the widespread use and integration of big data, has diminished the absolute right to privacy on the Internet. This paper examines the challenge of safeguarding the identity information of infectious patients through the lens of two theoretical frameworks -Kantianism and Utilitarianism- in an effort to address this ethical dilemma.

Aunque Internet ha aportado comodidad y rapidez a la vida humana, también ha dado lugar a frecuentes violaciones de la intimidad. En el contexto de las investigaciones epidemiológicas y la divulgación de información relativa a pacientes confirmados de covid-19, muchas personas han utilizado Internet como medio para difundir información y participar en cibercacerías, lo que ha dado lugar a violaciones en la intimidad de los implicados. Este fenómeno prevalece en el ámbito de Internet, donde los límites de la invasión de la intimidad se vuelven vagos. En las redes sociales, se manifiestan diversos tipos de violaciones de la intimidad, tanto por negligencia activa como pasiva. La yuxtaposición entre el mundo virtual de Internet con escenarios de la vida real plantea nuevos retos en el ámbito de las violaciones de la intimidad. La era de Internet, junto con el uso generalizado y la integración del bigdata, han mermado el derecho absoluto a la privacidad. Este artículo examina el reto de salvaguardar la información sobre la identidad de los pacientes infecciosos a través de la lente de dos marcos teóricos -el kantianismo y el utilitarismo- en un esfuerzo por abordar este dilema ético.

Enquanto a Internet trouxe conveniência e velocidade à vida humana, ela também levou a frequentes violações da privacidade. No contexto de investigações epidemiológicas e divulgação de informações em relação a pacientes confirmados de Covid-19, muitos indivíduos utilizaram a Internet como um meio para disseminar informação e participar de uma caçada cibernética, resultando em violações da privacidade para aqueles envolvidos. Esse fenômeno é particularmente prevalente no âmbito da Internet, onde os limites de invasão da privacidade se tornaram borrados. Vários tipos de infrações da privacidade, tanto negligências ativa como passiva, são evidentes em plataformas de redes sociais. A justaposição do mundo virtual da Internet com cenários da vida real apresenta novos desafios no âmbito das violações da privacidade. A era da Internet, juntamente com o amplo uso e integração de megadados (big data), diminuiu o direito absoluto à privacidade na Internet. Esse artigo examina o desafio de proteger a informação de identidade de pacientes infectantes através das lentes de dois enquadres teóricos -Kantianismo e Utilitarismo- em um esforço para abordar esse dilema ético.

The impact of basic pension for urban and rural residents on the subjective well-being of the older adult in Chinese rural areas.

Introduction: As an important component of the social security system, basic pension insurance for urban and rural residents is expected to improve the quality of life of rural older adult people and make their lives better and happier. This article mainly studies the relationship between the basic pension for urban and rural residents and the subjective well-being of older adult people in rural China. Methods: This paper uses data from the China Health and Retirement Longitudinal Study (CHARLS) for the years 2018 and 2020. It selected samples of rural older adult people aged 60 and above, ultimately obtaining 9,310 samples. The impact of the basic pension for urban and rural residents on the subjective well-being of rural older adult people was estimated by constructing Ordinary Least Squares (OLS) estimation methods and ordered logistic regression models. The robustness of the results was verified by changing the regression methods, and the samples were divided into different groups for heterogeneity analysis according to three different standards. Results: The results show that the basic pension for urban and rural residents significantly improves the life satisfaction of rural older adult, reduces their degrees of depression, and thereby enhances their subjective well-being. The impact of the basic pension for urban and rural residents is more significant for older adult individuals in areas with a higher gender ratio, those suffering from chronic diseases, and those in the eastern regions of the country. Further verification indicates that the basic pension for urban and rural residents enhances the subjective well-being of the rural older adult by improving their health status and reducing their labor supply. Discussion: Most of the existing research on basic pension insurance for urban and rural residents and subjective well-being has been conducted from the perspective of whether individuals are enrolled in the pension scheme or whether they received a pension. However, there are few studies analyzing from the perspective of the amount of pension benefits received by residents. The results of this study help to enrich the research perspective on the basic pension insurance system for urban and rural residents in China and expand the understanding of the impact and value of the basic pension for urban and rural residents.

[Value of High-Frequency Ultrasound in the Diagnosis of Pronator Teres Syndrome].

Objective To investigate the clinical value of high-frequency ultrasound in the diagnosis of pronator teres syndrome (PTS). Methods The high-frequency ultrasound was employed to examine and measure the median nerve of the pronator teres muscle in 30 patients with PTS and 30 healthy volunteers (control group).The long-axis diameter (LA),short-axis diameter (SA) and cross-sectional area (CSA) of the median nerve were measured.The receiver operating characteristic curve of the median nerve ultrasonic measurement results was established,and the area under the curve (AUC) was calculated.The diagnostic efficiency of each index for PTS was compared with the surgical results as a reference. Results The PTS group showed larger LA[(5.02±0.50) mm vs.(3.89±0.41) mm;t=4.38,P=0.013],SA[(2.55±0.46) mm vs.(1.70±0.41) mm;t=5.19,P=0.009],and CSA[(11.13±3.72) mm2 vs.(6.88±2.68) mm2;t=8.42,P=0.008] of the median nerve than the control group.The AUC of CSA,SA,and LA was 94.3% (95%CI=0.912-0.972,Z=3.586,P=0.001),77.7% (95%CI=0.734-0.815,Z=2.855, P=0.006),and 78.8% (95%CI=0.752-0.821,Z=3.091,P=0.004),respectively.With 8.63 mm2 as the cutoff value,the sensitivity and specificity of CSA in diagnosing PTS were 93.3% and 90.0%,respectively. Conclusion High-frequency ultrasound is a practical method for diagnosing PTS,and the CSA of median nerve has a high diagnostic value.

A bioethical examination of the use of human emotions as a film marketing tool on short video platforms: normative morality applicable to film marketing matrix / Un examen bioético del uso de las emociones humanas como herramienta de marketing cinematográfico en plataformas de vídeo de corta duración: moralidad normativa aplicable a la matriz de marketing cinematográfico / Um exame bioético do uso de emoções humanas como uma ferramenta de marketing em plataformas de vídeos curtos: moralidade normativa aplicável à matriz de marketing

Abstract: The marketing matrix on a short video platform is an intriguing research topic. It is a novel film marketing strategy on the short video platform that successfully stimulates the audience's emotion in the film marketing process, but it must also be ethically tested.To address this desire, we examine the problem using normative ethics (consequentialism, deontology, and virtue ethics). The marketing matrix will be addressed within the framework of philosophical ethics, whose emotional marketing can be tested, in what follows, through reviews of literature and content analysis. First and foremost, a matrix standpoint will be adopted in order to provide a preliminary conceptualization along with its emotional techniques of the marketing matrix; then, the marketing matrix will be addressed within the framework of philosophical ethics, whose emotional marketing can be tested. In the future, when creating a moral marketing matrix, the author proposes that numerous ethical concepts be taken into account comprehensively.

Resumen: La matriz de marketing en una plataforma de vídeo de corta duración es un tema de investigación intrigante. Se trata de una novedosa estrategia de marketing cinematográfico en la plataforma de vídeos cortos que estimula con éxito la emoción de la audiencia en el proceso de marketing cinematográfico, pero también debe ponerse a prueba desde el punto de vista ético. Para hacerlo, examinamos el problema utilizando la ética normativa (consecuencialismo, deontología y ética de la virtud). La matriz de marketing se abordará en el marco de la ética filosófica, cuyo marketing emocional puede ponerse a prueba, en lo que sigue, mediante revisiones de la literatura y análisis de contenido. En primer lugar, se adoptará un punto de vista matricial para proporcionar una conceptualización preliminar junto con sus técnicas emocionales de la matriz de marketing; a continuación, se abordará la matriz de marketing en el marco de la ética filosófica, cuyo marketing emocional puede ponerse a prueba. En el futuro, a la hora de crear una matriz de marketing moral, el autor propone que se tengan en cuenta numerosos conceptos éticos de forma exhaustiva.

Resumo: A matriz de marketing em plataforma de vídeos curtos é um tópico de pesquisa intrigante. É uma nova estratégia de marketing em plataforma de vídeos curtos que estimula com sucesso as emoções da audiência no processo de marketing, mas deve ser também eticamente testada. Visando esse propósito, nós examinamos o problema usando ética normativa (consequencialismo, deontologia e ética da virtude). A matriz de marketing será abordada na perspectiva da ética filosófica, cujo marketing emocional pode ser testado através de revisões da literatura e de análise de conteúdo. Em primeiro lugar, um ponto de vista de matriz será adotado de forma a fornecer uma conceitualização juntamente com suas técnicas emocionais de matriz de marketing; em seguida, a matriz de marketing será abordada na perspectiva da ética filosófica, cujo marketing emocional pode ser testado. No futuro, ao criar uma matriz de marketing moral, o autor propõe que inúmeros conceitos éticos sejam levados em consideração de forma abrangente.

The impact of medical students' attitudes towards group ethical norms on their academic achievement and classroom deviant behaviour: An empirical study from China / El impacto de las actitudes de los estudiantes de medicina hacia las normas éticas de grupo en su rendimiento académico y el comportamiento desviado en el aula: un estudio empírico de China / O impacto de atitudes de estudantes de medicine em relação a normas éticas grupais em suas conquistas acadêmicas e comportamentos desviantes em sala de aula: um estudo empírico da China

Abstract: In recent years, medical students' absenteeism has been investigated in depth. Classroom deviant behavior is a richer concept than truancy behavior, but there are few researchers on this aspect in China. There are still many issues worth discussing about deviant classroom behavior. In this paper, questionnaires were given to 977 medical students to collect relevant data. After classifying the data, correlation analysis and multilevel linear regression analysis were used to conclude that academic performance and group ethical norms have a negative impact on medical students' deviant behaviors in class. Group ethical norms have a significant positive influence on academic performance, and descriptive ethical norms and imperative ethical norms of group ethical norms have a significant influence on academic performance. The four dimensions of academic performance: academic performance, task performance, interpersonal promotion, and social comparison have a negative influence on medical students' deviant behaviors in class. Descriptive ethical norms have an inverse effect on medical students' deviant behaviors, while imperative ethical norms have no significant effect on deviant behaviors in class. Group ethical norms as a category of ethical norms clearly have significant implications for improving academic performance and reducing their transgressions in class. Reinforcing group ethics in medical students will not only contribute to their professional ethics upon graduation, but also to their academic performance.

Resumen: En los últimos años, se ha investigado en profundidad el absentismo de los estudiantes de medicina. El comportamiento desviado en el aula es un concepto más rico que el comportamiento de absentismo escolar, pero hay pocos investigadores sobre este aspecto en China. Todavía hay muchas cuestiones que vale la pena discutir sobre el comportamiento desviado en el aula. En este trabajo, se entregaron cuestionarios a 977 estudiantes de medicina para recoger los datos pertinentes. Tras clasificar los datos, se utilizó el análisis de correlación y de regresión lineal multinivel para llegar a la conclusión de que el rendimiento académico y las normas éticas de grupo tienen un impacto negativo en los comportamientos desviados de los estudiantes de medicina en clase. Las normas éticas de grupo tienen una influencia positiva significativa en el rendimiento académico, y las normas éticas descriptivas y las normas éticas imperativas de las normas éticas de grupo tienen una influencia significativa en el rendimiento académico. Las cuatro dimensiones del rendimiento académico: rendimiento académico, rendimiento de la tarea, promoción interpersonal y comparación social tienen una influencia negativa en los comportamientos desviados de los estudiantes de medicina en clase. Las normas éticas descriptivas tienen un efecto inverso en las conductas desviadas de los estudiantes de medicina, mientras que las normas éticas imperativas no tienen un efecto significativo en las conductas desviadas en clase. Las normas éticas de grupo como categoría de normas éticas tienen claramente implicaciones significativas para mejorar el rendimiento académico y reducir sus transgresiones en clase. Reforzar la ética de grupo en los estudiantes de medicina no sólo contribuirá a su ética profesional al graduarse, sino también a su rendimiento académico.

Resumo: Nos últimos anos, o absenteísmo dos estudantes de medicina tem sido pesquisado em profundidade. O comportamento desviante na sala de aula é um conceito mais rico do que o comportamento de evasão escolar, mas há poucos pesquisadores sobre este aspecto na China. Ainda há muitas questões que vale a pena discutir sobre o comportamento desviante em sala de aula. Neste documento, foram entregues questionários a 977 estudantes de medicina para coletar dados relevantes. Após a classificação dos dados, análise de correlação e análise de regressão linear multinível foram utilizadas para concluir que o desempenho acadêmico e as normas éticas de grupo têm um impacto negativo sobre o comportamento desviante dos estudantes de medicina em sala de aula. Normas éticas de grupo têm uma influência positiva significativa no desempenho acadêmico, e normas éticas descritivas e normas éticas imperativas de normas éticas de grupo têm uma influência significativa no desempenho acadêmico. As quatro dimensões do desempenho acadêmico: desempenho acadêmico, desempenho de tarefas, promoção interpessoal e comparação social têm uma influência negativa sobre os comportamentos desviantes dos estudantes de medicina nas aulas. As normas éticas descritivas têm um efeito inverso sobre os comportamentos desviantes dos estudantes de medicina, enquanto as normas éticas imperativas não têm efeito significativo sobre os comportamentos desviantes nas aulas. Normas éticas de grupo como uma categoria de normas éticas têm claramente implicações significativas para melhorar o desempenho acadêmico e reduzir suas transgressões na classe. O reforço da ética de grupo em estudantes de medicina não só contribuirá para sua ética profissional ao se formarem, mas também para seu desempenho acadêmico.

The care types choice in filial culture: A cross-sectional study of disabled elderly in China.

For the past few decades, studies of care types choice have been restricted to the scope of individual characteristics and health status. Meanwhile, the historiography of the research largely ignores the role of filial culture within China. This study sets out to examine the influence of the factors in the cultural context of filial piety on the choice of care types for older people with disability in China. According to the characteristics of filial culture, the factors influencing the choice of care type for the older people in China are summarized as family endowment and support. The study concludes that gender, residence, living alone or not, family income, real estate, pension and community service have momentous effects on the choice of care type of older people with disability; informal care has a substitutive effect on formal care. The research was based on cross-sectional data of CLHLS 2018 and utilized binary logistic regression analysis to compare the factors influencing the choice of old disabled people between formal and informal care. The study implies that in the context of filial culture, the older people's choice of care types is affected by family endowment and community service supply for the older people in China. In the background of filial culture, the government should give informal care official support such as cash and services, so as to change its attribute of private domain of it and enhance the quality of long-term care.

Ethical dilemmas and principles in organ transplantation in China / Dilemas y principios éticos en el trasplante de órganos en China / Dilemas e princípios éticos no transplante de órgãos na China

Abstract In medical clinical practice, organ transplantation is mainly applied to patients with end-stage organ lesions and organ failure. However, with the development of organ transplantation, many ethical issues and controversies have arisen. From the perspective of bioethics, the article compares the relevant ethical and legal regulations of organ transplantation in various countries. Due to the complexity of the real situation, many ethical dilemmas arise in organ transplantation in China. The article analyzes and researches three aspects of organ donation, distribution, and trading, and finds that there are various ethical problems in these three aspects of organ transplantation in China, such as whether the principle of presumed consent is ethical, whether brain death is legalized, the selection and determination of transplant patients, and whether human organ trading is legalized, etc. With the help of the four principles of bioethics and the current development of organ transplantation in China, the article proposes that organ transplantation in China should follow four ethical principles: the principle of respect for life, the principle of do no harm/benefit, the principle of respect for autonomy, and the principle of justice, in order to provide a defense for the legitimacy of organ transplantation.

Resumen En la práctica clínica médica, el trasplante de órganos se aplica principalmente a los pacientes con lesiones orgánicas en fase terminal y con insuficiencia orgánica. Sin embargo, con el desarrollo del trasplante de órganos, han surgido muchas cuestiones éticas y controversias. Desde la perspectiva de la bioética, el artículo compara las normas éticas y jurídicas pertinentes del trasplante de órganos en varios países. Debido a la complejidad de la situación real, surgen muchos dilemas éticos en el trasplante de órganos en China. El artículo analiza e investiga tres aspectos de la donación, la distribución y el comercio de órganos, y constata que hay varios problemas éticos en estos tres aspectos del trasplante de órganos en China, como si el principio del consentimiento presunto es ético, si la muerte cerebral está legalizada, la selección y determinación de los pacientes de trasplante y si el comercio de órganos humanos está legalizado, etc. Con la ayuda de los cuatro principios de la bioética y el desarrollo actual del trasplante de órganos en China, el artículo propone que el trasplante de órganos en China debe seguir cuatro principios éticos: el principio de respeto a la vida, el principio de no hacer daño/beneficio, el principio de respeto a la autonomía y el principio de justicia, con el fin de proporcionar una defensa de la legitimidad del trasplante de órganos.

Resumo Na prática clínica médica, o transplante de órgãos é principalmente destinado a pacientes em estágio final de lesões e falência dos órgãos. Entretanto, com o desenvolvimento do transplante de órgãos, surgiram muitas questões e controvérsias éticas. O artigo compara, desde uma perspectiva bioética, as regulações éticas e legais relevantes sobre transplantes de órgãos em vários países. Devido à complexidade da situação real, muitos dilemas éticos surgiram no transplante de órgãos na China. O artigo analisa e investiga aspectos de doação, distribuição e comercialização de órgãos, e encontra que há vários problemas éticos nestes três aspectos do transplante de órgãos na China, tais como se o princípio do consentimento presumido é ético, se morte cerebral é legalizada, a seleção e determinação de pacientes que irão receber transplante, se a comercialização de órgãos humanos é legalizada, etc. O artigo propõe, com a ajuda de quatro princípios da bioética e o desenvolvimento atual de transplante de órgãos na China, que o transplante de órgãos na China deve seguir quatro princípios éticos: o princípio do respeito à vida, o princípio de beneficiar/não causar dano, o princípio do respeito pela autonomia e o princípio da justiça, de forma a possibilitar a defesa da legitimidade do transplante de órgãos.

[Method of Identifying Male Lineages Based on Main Haplotype and Analysis of the Distribution of Y-STR Haplotype Mismatch Based on the Bayesian Theory].

OBJECTIVE: To establish a classification method to identify different male lineages in a large population, to study the distribution patterns of Y-STR loci mismatches among Han Chinese male lineage members and to explore the mismatch probability distribution among the members with different meiosis intervals in the family. METHODS: Peripheral blood samples of 269 male individuals from 12 lineages in Han Chinese population and 45 unrelated male individuals were collected. Then, Yfiler Plus TM and ZGWZ FSY or Yfiler Platinum amplification kits were used, obtaining 314 Y-STR haplotypes. The Y-STR haplotype with 3 or more repetitions were selected as the main haplotype, in which the largest number was selected as the first data center. According to the standard of Y-STR genotype, those with mismatches within five loci and six steps were clustered and merged. Then, the main haplotype of the largest number in the remaining data was taken as the second data center, and cluster analysis is carried out in turn until there is no main haplotype remained. Pair comparison was conducted between lineage members and unrelated individuals, and the mismatch distribution among lineage members and unrelated individuals was calculated respectively. The average mismatch rate of each locus was subsequently calculated, as well as the mismatch probability distribution among members with different meiosis intervals within the lineage. RESULTS: 269 out of the 314 individuals were divided into 12 groups by cluster analysis method, accomplishing 100% accuracy between the cluster groups thus identified and the 12 known lineages. The remaining 45 unrelated individuals were scattered. The mismatch loci was within 0-7 loci and 0-7 steps among lineage members and the mismatch between unrelated individuals was at least 11 loci and 15 steps. The mismatch loci with the largest number of one-step and two-step mismatch were different in each lineage and had features that were specific to each lineage. The minimum mutation count and average mismatch rate of each locus were significantly correlated with the mutation rate. Two individuals with no mismatch had a 19.7% probability of 1 meiosis interval and a 71.2% probability of less than 6 meiosis interval. Two individuals with 3 loci mismatches had a 65.2% probability of more than 10 meiosis intervals. CONCLUSION: The cluster analysis method based on main haplotypes provided in this paper can quickly and effectively differentiate large male lineage samples. The clustering method and the mismatch probability distribution of different meiosis intervals obtained thus can provide new ideas for research and screening instruments, and important reference for lineage investigation, data analysis and practical application of Y-STR database in the future.

How the gene-editing in medicine and public health practice could stand the test of bioethics / De qué forma la tecnología de edición génica en medicina y salud pública puede ser aceptada al someterse a la reflexión bioética / Como a edição de genes na prática médica e de saúde pública poderia apoiar o teste da bioética

Abstract: 13. In recent years, gene editing is increasingly used as one of the technical means to solve public health problems. The great progress made in the field of life science and gene-editing technology has made it possible for humans to control and alter human physiological characteristics through gene-editing technology and created a broad application prospect for this technology. However, gene-editing technology has faced with many significant ethical risks, and human gene editing experiments have been banned for a long time in the past. Realistic technological breakthroughs and the emergence of real cases force the ethics circle to re-examine this issue. Through the analysis and trade-off of the potential benefits and ethical risks of human gene-editing technology, it can be found that different applications of human gene editing for different purposes are considered to have different acceptability. Among them, human gene editing for medical purposes has no fundamental moral barriers, human gene editing for purposes of enhancement cannot be allowed by ethics and reality in the current social environment, and human gene editing for purposes of transformation fundamentally violates ethical norms. Therefore, gene editing can be allowed if it is only used to solve human medical and public health problems.

Resumen: 17. En años recientes, se usa cada vez más la edición génica como medio técnico para resolver problema de salud pública. El gran progreso realizado en el campo de las ciencias de la vida y la tecnología de edición génica ha hecho posible que el ser humano controle y altere las características fisiológicas humanas, usando esta tecnología y abriéndose una amplia perspectiva de aplicación. Sin embargo, esta tecnología enfrenta problemas éticos significativos, y los experimentos de edición génica en humanos han sido prohibidos por mucho tiempo en el pasado. Los avances tecnológicos realistas y la emergencia de casos reales ejerce presión sobre el círculo de reflexión ética para volver a examinar el tema. Mediante el análisis y balance de los potenciales beneficios y riesgos éticos de la tecnología de edición génica, se puede encontrar que las diferentes aplicaciones de ésta tecnología, para propósitos diferentes, tienen distinta aceptabilidad. Entre ellos, el uso de edición génica para propósitos médicos no tiene barreras morales fundamentales; la edición génica humana para propósitos de mejoramiento no debería permitirse en la realidad social actual, y la edición génica humana para propósitos de transformación viola fundamentalmente las normas éticas. Por lo tanto, la edición génica podría permitirse solamente para resolver problemas médicos y de salud pública en humanos.

Resumo: 21. Em anos recentes, a edição de genes é cada vez mais usada como um recurso técnico para resolver problemas de saúde pública. O grande progresso feito no campo das ciências da vida e da tecnologia de edição de genes tornou possível para os humanos controlarem e alterarem as características fisiológicas humanas através da tecnologia da edição de genes e criou uma ampla perspectiva de aplicação para esta tecnologia. Entretanto, a tecnologia de edição de genes enfrentou muitos riscos éticos significativos e os experimentos de edição de genes humanos foram banidos por muito tempo no passado. Avanços tecnológicos realísticos e a emergência de casos reais forçaram o círculo ético a reexaminar esta questão. Através da análise e do equilíbrio entre os benefícios potenciais e riscos éticos da tecnologia de edição de genes humanos, pode ser encontrado que diferentes aplicações da edição de genes humanos para diferentes propósitos são consideradas ter diferentes aceitações. Dentre elas, a edição de genes humanos com objetivos médicos não tem barreiras morais fundamentais, edição de genes humanos objetivando aprimoramento não pode ser permitida pela ética e realidade do ambiente social atual, e edição de genes humanos objetivando transformação fundamentalmente viola normas éticas. Portanto, edição de genes pode ser permitida somente se usada para resolver problemas médicos humanos e de saúde pública.

Occurrence and distribution of microplastics on recreational beaches of Haichow Bay, China.

As prime coastal recreational areas, beaches attract an increasing number of users worldwide. However, current studies have shown that beaches are subject to plastic pollution, one of the most significant global environmental threats. Considering the health of tourists and ecological environmental management of beaches, microplastics on recreational beaches are urgently being studied. This paper first focused on microplastics on the recreational beaches of Haichow Bay, which is located on the central coast of China and faces the Yellow Sea. The microplastic pollution level, occurrence, and distribution were investigated. Our study demonstrated that microplastics were consistently found on all studied beaches, which emphasized their extensive distribution throughout recreational beaches. The average microplastic abundance was 106.50 ± 34.41 items/kg, demonstrating that the microplastic pollution level on the studied beaches tended to be in the middle-to-low position compared with previous studies. In total, eight colors were found, more than 90% of microplastics were less than 1 mm in size, and fiber and fragments were the dominant shapes. Resort beaches contained the highest number of microplastics, indicating that the microplastic pollution level on recreational beaches was directly related to the tourism intensity. Five types of plastic were found in the samples, i.e., polyethylene (PE), polypropylene (PP), PS (polystyrene (PS), polyethylene terephthalate (PET) and nylon. Land inputs were the main source of pollution. This study provided baseline information on microplastic pollution that can be used for effective and comprehensive management of recreational beaches and suggests that the management of plastic use and recycling on beaches should be integrated into China's'coastal zone management practices.

Preliminary study of the source apportionment and diversity of microplastics: Taking floating microplastics in the South China Sea as an example.

At present, the study of microplastic sources is in a relatively preliminary stage due to the complexity of microplastic features in the environment. Based on a literature review, we developed a source-specific classification system for the quantitative analysis of microplastic sources. The classification system includes ten types of microplastics based on morphology and composition and can identify their main sources and the associated probabilities. To reflect the complexity of types and sources in the regional combination of microplastics, we first propose a microplastic diversity index (D1-D'(MP)). We use the South China Sea as an example to carry out quantitative source analysis and calculate the diversity index. Eight types of microplastics were found, mainly consisting of maritime coatings (type "Gran_coat") (33.0%) and synthetic fibers (type "Fib_thin") (29.6%). We also found that the diversity increased with offshore distance. In addition, we partitioned surface microplastics globally according to a two-dimensional microplastic abundance-diversity index. We believe that these indicators can effectively reflect pollution status and ultimately lead to different types of control measures. In the future, additional indicators for the characterization of microplastics must be included in the classification system to establish a one-to-one source analysis system for microplastic characteristics and source apportionment. In general, our study may provide new insights into the establishment of more accurate and quantitative source apportionment techniques and effective pollution control.

An approach based on M-AMBI for assessing benthic ecological status of a broad intertidal zone: A case study in the Jiangsu intertidal zone, China.

Intensive anthropogenic activities have a serious negative effect on the Jiangsu coastal area of China, especially on the distinctive intertidal zone. Humans are trying to eliminate this effect by taking protection and eco-compensation measures. However, when trying to determine the ecological status and quantify the anthropogenic impact for this area, the complex relationship between ecosystems and environmental stress leads to difficulties in reflecting general environmental quality. This study assessed the benthic ecological status of 10 transects (three stations/transect) across six different typologies over six years (2007, 2009-2013) in the Jiangsu intertidal zone. A unitary assessment of each transect was conducted using the multivariate AZTI Marine Biotic Index (M-AMBI), along with a radar chart (and its parameters). In the Jiangsu intertidal zone, the ecological status was noted as good or moderate at most sampling stations. Among the six assessed years, 2010 had the highest ecological status, while 2007 had the lowest. As for transects, transect 1 had the highest ratings, and transect 3 had the lowest ratings. Various stresses and advantageous human intervention and contributed to the ecological status for the different areas. The M-AMBI could be used in the future as a suitable index to assess the benthic ecological status of the Jiangsu intertidal zone. In addition, the new unitary method validated in this study could be used to assess ecosystems with several small biotopes, while accurately reflecting environmental quality.

[Connotation characterization and evaluation of ecological well-being based on ecosystem service theory.] / åŸºäºŽç”Ÿæ€ç³»ç»ŸæœåŠ¡ç†è®ºçš„ç”Ÿæ€ç¦ç¥‰å† æ¶µè¡¨å¾ä¸Žè¯„ä»·.

China is advocating ecological civilization construction nowadays. Further researches on the relation between ecosystem service and humanity well-being are full of theoretical and practical significance. Combining related researches, this paper defined the concept and connotation of ecological well-being based on ecosystem service theory. Referencing theory of national economic accounting and relative researches, the evaluation indicators of ecological well-being supply and consumption were established. The quantitative characterization and evaluation method of red line of regional ecological well-being was proposed on the basis of location quotient. Then the evaluation of ecological well-being in mainland China in 2012 was set as an example for empirical research. The results showed that the net product values of 6 ecosystems, includingcultivated land, forest land, grassland, wetland, water area and unused land, were respectively 1481.925, 8194.806, 4176.277, 4245.760, 3177.084 and 133.762 billion CNY. Spatial heterogeneity of ecosystem net product in different provinces was distinct. Ecological well-being per capita of forest land, grassland, wetland, cultivated land and unused land in eastern and middle provinces were under the red line and less than the national average. The spatial distribution of 9 kinds of ecological well-being per capita split at Hu's line with high value in northwest and low value in southeast, and was aggravated by differences in density of population and land resources gift.

[Evaluation of wetland ecological benefit and restoration in the natural reserves of western Jilin Province, China].

In order to correctly evaluate wetland ecological benefit and restoration in the natural reserves of western Jilin Province, an index system of wetland ecological benefit assessment for nature reserves was established based on ecosystem service theory and catastrophe theory. Considering the diversity characteristics of ecological benefit, and consulting the research results of ecological benefit in study area in 2001, the analytic hierarchy process and entropy method were introduced to analyze the ecological benefit and restoration in 2005 and 2012. The results showed that the ecological benefit level was very high in Momoge Nature Reserve since 2005, high in Chaganhu and Xianghai nature reserves, and moderate in Dabusu Nature Reserve. This study showed that the assessment combining the catastrophe progression method with the analytic hierarchy process and entropy method could reveal the dynamics and the integrality of wetland ecological benefit, and accurately reflect the reality of the ecological restoration in study area. In recent years, some achievements in ecological protection and environmental remediation had been obtained in the west of Jilin Province, and the whole ecological benefit of the wetlands had been improved and enhanced by means of man-made effective interference.

Down-regulated expression of acid-sensing ion channel 1a in cortical lesions of patients with focal cortical dysplasia.

Focal cortical dysplasia (FCD) represents a well-recognized cause of medically intractable epilepsy. Previous studies have indicated that seizures can reduce brain pH and then eliminate seizure discharges. Acid-sensing ion channels (ASICs) are H(+)-gated cation channels that are widely expressed in the central and peripheral nervous systems. To understand the potential roles of ASIC1a in the epileptogenesis of FCD, we investigated the expression and distribution patterns of ASIC1a in surgical specimens from patients with FCD and age-matched normal cortices (CTX). Decreased ASIC1a messenger RNA (mRNA) and protein expression were detected in FCD compared with CTX. Moreover, the expression of ASIC1a was significantly lower in FCD type II than FCD type I. Immunohistochemistry results indicated that the overall immunoreactivity of the ASIC1a staining was diminished in the dysplastic cortices of FCD compared to the CTX samples. In FCD, ASIC1a immunoreactivity was mainly observed in reactive astrocytes and a minority of malformed cells, including hypertrophic neurons, dysmorphic neurons, and balloon cells. Confocal analysis demonstrated that most malformed cells expressing ASIC1a were co-labeled with neuronal rather than astrocytic markers, indicating a neuronal lineage. In conclusion, the downregulation and altered cellular distribution of ASIC1a in FCD suggest that ASIC1a may potentially contribute to the epileptogenesis of FCD.

Expression and cellular distribution of the interleukin 2 signaling system in cortical lesions from patients with focal cortical dysplasia.

Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs) in FCD and control samples that included epileptic neocortex from mesial temporal lobe epilepsy patients and nonepileptic normal cortex (CTX). Greater mRNA and protein levels of IL-2 and IL-2Rs were observed in FCD versus CTX samples. Moreover, the expression of IL-2 and IL-2Rs was significantly higher in FCD II than FCD I. In situ hybridization and immunohistochemistry results indicated that IL-2 and IL-2Rs were strongly expressed in hypertrophic neurons and neuronal microcolumns in FCD I and highly expressed in malformed cells in FCD II. In addition, the protein levels of Janus kinase 1, Janus kinase 3, phosphorylated signal transducer and activator of transcription 5, which are important downstream factors in the IL-2 signaling pathway, were increased in FCD lesions. Soluble IL-2R was decreased in FCD compared with that in CTX samples. These results suggest that upregulation of IL-2 and IL-2Rs combined with activation of IL-2-dependent signaling pathways may contribute to the pathogenesis of FCD.

Distortion product otoacoustic emissions at 6 months in term infants after perinatal hypoxia-ischaemia or with a low Apgar score.

Distortion product otoacoustic emissions (DPOAEs) were analyzed at 6 months of age in term infants who had perinatal hypoxia-ischaemia (HI) and those who had a low Agar score alone to detect any abnormalities in cochlear function and any difference between the two groups of infants. The f2 primary tone was presented at ten frequencies (0.5-10 kHz). Both the left and right ears were tested. Compared to normal term controls, both the infants after perinatal HI and those with a low Apgar score alone showed lower DPOAE pass rates, mainly at 1-4 kHz at which the pass rates were decreased significantly (P < 0.05-0.01). The general pattern of DPOAE pass rates at different frequencies was similar in the two groups of infants. The pass rates at 1, 5 and 6 kHz tended to be lower in the infants after perinatal HI than those with a low Apgar score alone, although not statistically significant. Conclusions At 6 months of age, infants after perinatal HI or with a low Apgar score alone had a relatively poor cochlear function, mainly at 1-4 kHz. There are no major differences between the two groups of infants.

3D architectures of iron molybdate: phase selective synthesis, growth mechanism, and magnetic properties.

Monoclinic and orthorhombic Fe(2)(MoO(4))(3) microsized particles with complex 3D architectures have been selectively prepared by a template-free hydrothermal process. The pH value, reaction time, temperature, and molybdenian source have crucial influence on the phase formation, shape evolution, and microstructures. Monoclinic Fe(2)(MoO(4))(3) particles obtained at pH 1 and pH 1.65 display ferromagnetic ordering at 10.4 K and 10.5 K, respectively, and the ferromagnetic component is determined to be 0.0458 mu(B) and 0.0349 mu(B) per Fe-ion at 10 K, respectively. For orthorhombic beta-Fe(2)(MoO(4))(3), antiferromagnetic ordering was observed about 12 K. At higher temperatures, beta-Fe(2)(MoO(4))(3) began to follow the Curie-Weiss law with theta=-70 K. Such 3D architectures of monoclinic and orthorhombic beta-Fe(2)(MoO(4))(3) microparticles with unique shapes and structural characteristics may find applications as catalysts and as well as in other fields.

Distortion product otoacoustic emissions during the first year in term infants: a longitudinal study.

Understanding of any age-related differences in distortion product otoacoustic emissions (DPOAEs) during infancy is important for the use of DPOAEs in detection of cochlear impairment in infants. We studied DPOAEs at 10 frequencies of f2 primary tone between 500 Hz to 10 kHz longitudinally during the first year of life in 70 ears of 35 normal term infants. On days 3-5 after birth DPOAE pass rates ranged between the highest 98.6% at f2 frequencies 6-10 kHz and the lowest 22.9% at 750 Hz. The higher the frequency, the higher was the pass rate. At 6 months the pass rates at various frequencies were generally similar to those on days 3-5, and were greater than 91% across the frequencies of 3-10 kHz. At 12 months the pass rates were 100% or near 100% across 3-10 kHz. During the first year the pass rate was always very low at 750 Hz (<40%) and tended to decrease at 1 kHz with the increase in age. DPOAE level at f2 frequencies 4kHz increased from birth to 6 months but then reduced slightly at 12 months. At lower frequencies the age-related DPOAE levels change was less significant. These results indicate that there are no major changes in DPOAE or cochlear function during the first year of life at most frequencies. However, the interpretation of DPOAE results in infants need to take into account the age-related difference in DPOAE pass rate at low-frequency and in DPOAE level at high-frequency.