RESUMO
Branched oligohexamethyleneguanidine hydrochloride (OHMG) possesses great potential for the development of novel drugs for the treatment of diseases caused by bacteria. This study aimed at evaluating the antimicrobial activity of OHMG against potential causative agents of oral and pharyngeal mucosa infections, specifically, the activity against 56 clinical strains, 5 of which were antibiotics-resistant. Also, a preliminary in vivo study of the specific activity of OHMG based on a traumatic stomatitis and gingivitis model in rabbits was carried out. In vitro antimicrobial activity of OHMG was determined by testing the minimal inhibitory concentration (MIC). OHMG displayed excellent activity against Streptococcus pneumoniae, Streptococcus pyogenes (MIC was 0.002-0.25 µg/ml), Moraxella catarrhalis (0.03-0.06 µg/ml), Neisseria gonorrhoeae (0.125-2 µg/ml). Almost complete healing of defects in the groups of animals within the 7-day application of 'OHMG hydrochloride' at concentrations of 0.1% and 0.3% after the thermal formation of the stomatitis and gingivitis model was observed.
