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Two-layered metal oxides (LiCoO2 and cobalt-doped K n MnO2, n < 1) were explored as precatalysts for nanoconfined cobalt-based Fischer-Tropsch catalysts for conversion of syngas (CO and H2) to hydrocarbons. Ex situ, in situ, and PDF XRD analyses are presented. Based on in situ XRD analysis, LiCoO2 underwent reduction to predominantly cubic and hexagonal phases of cobalt metal. Reaction with syngas resulted in the generation of carbon, cobalt carbide, and lithium carbonate, in addition to the metallic cobalt phases. In the case of cobalt-doped birnessite, catalyst activation converted the birnessite phase to manganite and the cobalt to elemental cobalt, along with similar lithium and carbon phases. Conversion of syngas to C1 through C7 products was observed. The best conversions were observed for the LiCoO2 precursor catalyst, with generally a low olefin-to-paraffin ratio. While the conversions for the cobalt-doped birnessite precatalyst were generally lower, with lower chain lengths (up to C5), these catalysts gave a strikingly high olefin-to-paraffin ratio: in the best case, greater than 20:1.
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Cationic biocides play a crucial role in the disinfection of domestic and healthcare surfaces. Due to the rise of bacterial resistance towards common cationic disinfectants like quaternary ammonium compounds (QACs), the development of novel actives is necessary for effective infection prevention and control. Toward this end, a series of 15 chimeric biscationic amphiphilic compounds, bearing both ammonium and phosphonium residues, were prepared to probe the structure and efficacy of mixed cationic ammonium-phosphonium structures. Compounds were obtained in two steps and good yields, with straightforward and chromatography-free purifications. Antibacterial activity evaluation of these compounds against a panel of seven bacterial strains, including two MRSA strains as well as opportunistic pathogen A. baumannii, were encouraging, as low micromolar inhibitory activity was observed for multiple structures. Alkyl chain length on the ammonium group was, as expected, a major determinant of bioactivity. In addition, high therapeutic indexes (up to 125-fold) for triphenyl phosphonium-bearing amphiphiles were observed when comparing antimicrobial activity to mammalian cell lysis activity.
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Antibacterianos , Desinfetantes , Testes de Sensibilidade Microbiana , Compostos Organofosforados , Compostos de Amônio Quaternário , Compostos de Amônio Quaternário/química , Compostos de Amônio Quaternário/farmacologia , Compostos de Amônio Quaternário/síntese química , Desinfetantes/farmacologia , Desinfetantes/química , Desinfetantes/síntese química , Compostos Organofosforados/química , Compostos Organofosforados/farmacologia , Compostos Organofosforados/síntese química , Antibacterianos/farmacologia , Antibacterianos/química , Antibacterianos/síntese química , Relação Estrutura-Atividade , Estrutura Molecular , Tensoativos/química , Tensoativos/farmacologia , Tensoativos/síntese química , Humanos , Acinetobacter baumannii/efeitos dos fármacos , Relação Dose-Resposta a DrogaRESUMO
Preparation of a redox-frustrated high-energy-density energetic material is achieved by gentle protolysis of Mn[N(SiMe3)2]2 with the perchlorate salt of the tetrazolamide [H2NtBuMeTz]ClO4 (Tz = tetrazole), yielding the Mn6N6 hexagonal prismatic cluster, Mn6(µ3-NTztBuMe)6(ClO4)6. Quantum mechanics-based molecular dynamics simulations of the decomposition of this molecule predict that magnetic ordering of the d5 Mn2+ ions influences the pathway and rates of decomposition, suggesting that the initiation of decomposition of the bulk material might be significantly retarded by an applied magnetic field. We report here experimental tests of the prediction showing that the presence of a 0.5 T magnetic field modulates the ignition onset temperature by +10.4 ± 3.9 °C (from 414 ± 4 °C), demonstrating the first example of a magnetically modulated explosive.
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Crystallization of the reaction mixture of 2-amino-4,6-diazido-1,3,5-triazine and excess tert-butylamine results in the isolation of tert-butylammonium N,N-[1'H-(1,5'-bitetrazol)-5-yl]cyanamidate, suggesting a complex decyclization/cyclization rearrangement involving breakage of the six-membered aromatic ring and the formation of two new five-membered azole rings mediated by deprotonation of the precursor by the amine. The addition of tert-butylamine to 2-amino-4,6-diazido-1,3,5-triazine gives spectroscopic indication of thermodynamically unfavorable reactivity in low-dielectric solvents, and high-level quantum chemical computations also suggest its formation to be unfavorable. A computed interconversion pathway describes the likely reaction mechanism and supports the general thermodynamic unfavorability of the reaction and the requirement for a high-dielectric environment to template formation of the ionic product and its trapping by crystallization.
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The single-crystal-to-single-crystal phase transition is determined by using X-ray crystallography on LiBF4, resolving a longstanding ambiguity in the existence of a high-temperature polymorph of LiBF4. LiBF4 possesses an endothermic phase change at 28.2 °C with ΔH = 1180 J mol-1 and ΔS = 3.92 J mol-1K-1 based on DSC. Single-crystal X-ray diffraction shows that the low-temperature phase collected at 200 K is a twinned trigonal P system with a twin law indicating reflection through the 110 plane. The same crystal collected above the phase transition temperature at 313 K is a C-centered orthorhombic system, describable as the superposition of the two low-temperature twin geometries undergoing interconversion. The geometries of the high- and low-temperature phases are consistent with the calorimetry experiments and with previous NMR findings indicating BF4 geometric reorientations above 300 K.
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The energetic content of the compounds MgTp2, FeTp2, MnTp2, and TiTp2 is measured by bomb calorimetry and compared to theoretical calculations (Tp = trispyrazoylborate). TiTp2 had the largest heat of combustion of the four compounds. Comparison of the heat of combustion of the Ti complex to those of Mg and Mn complexes suggests an effective combustion energy of TiII of between 1400 and 3000 kJ/mol, affirming the role of TiII as a strong fuel atom.
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Alternative solid electrolytes are the next key step in advancing lithium batteries with better thermal and chemical stability. A soft solid electrolyte, (Adpn)2LiPF6 (Adpn, adiponitrile), is synthesized and characterized that exhibits high thermal and electrochemical stability and good ionic conductivity, overcoming several limitations of conventional organic and ceramic materials. The surface of the electrolyte possesses a liquid nano-layer of Adpn that links grains for a facile ionic conduction without high pressure/temperature treatments. Further, the material can quickly self-heal if fractured and provides liquid-like conduction paths via the grain boundaries. A substantially high ion conductivity (~10-4 S cm-1) and lithium-ion transference number (0.54) are obtained due to weak interactions between 'hard' (charge dense) Li+ ions and the 'soft' (electronically polarizable) -C≡N group of Adpn. Molecular simulations predict that Li+ ions migrate at the co-crystal grain boundaries with a (preferentially) lower activation energy Ea and within the interstitial regions between the co-crystals with higher Ea values, where the bulk conductivity is a smaller but extant contribution. These co-crystals establish a special concept of crystal design to increase the thermal stability of LiPF6 by separating ions in the Adpn solvent matrix, and also exhibit a unique mechanism of ion conduction via low-resistance grain boundaries, which contrasts with ceramics or gel electrolytes.
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N-Butyl-2,3-bis-(di-cyclo-hexyl-amino)-cyclo-propenimine (1) crystallizes from benzene and hexa-nes in the presence of HCl as a mono-benzene solvate of the hydro-chloride salt, [1H]Cl·C6H6 or C31H54N3 +·Cl-·C6H6, in the P21/n space group. The protonation of 1 results in the generation of an aromatic structure based upon the delocalization of the cyclo-propene double bond around the cyclo-propene ring, giving three inter-mediate C-C bond lengths of â¼1.41â Å, and the delocalization of the imine-type C-N double bond, giving three inter-mediate C-N bond lengths of â¼1.32â Å. Ion-ion and ion-benzene packing inter-actions are described and illustrated.
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A series of Ca-Mn clusters with the ligand 2-pyridinemethoxide (Py-CH2O) have been prepared with varying degrees of topological similarity to the biological oxygen-evolving complex. These clusters activate water as a substrate in the oxidative degradation of propylene carbonate, with activity correlated with topological similarity to the OEC, lowering the onset potential of the oxidation by as much as 700 mV.
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Energetic materials (EMs) are central to construction, space exploration, and defense, but over the past 100 years, their capabilities have improved only minimally as they approach the CHNO energetic ceiling, the maximum energy density possible for EMs based on molecular carbon-hydrogen-nitrogen-oxygen compounds. To breach this ceiling, we experimentally explored redox-frustrated hybrid energetic materials (RFH EMs) in which metal atoms covalently connect a strongly reducing fuel ligand (e.g., tetrazole) to a strong oxidizer (e.g., ClO4). In this Article, we examine the reaction mechanisms involved in the thermal decomposition of an RFH EM, [Mn(Me2TzN)(ClO4]4 (3, Tz = tetrazole). We use quantum-mechanical molecular reaction dynamics simulations to uncover the atomistic reaction mechanisms underlying this decomposition. We discover a novel initiation mechanism involving oxygen atom transfer from perchlorate to manganese, generating energy that promotes the fission of tetrazole into chemically stable species such as diazomethane, diazenes, triazenes, and methyl azides, which further undergo exothermic decomposition to finally form stable N2, H2O, CO, CO2, Mn-based clusters, and additional incompletely combusted products.
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A new type of crystalline solid, termed "solvate sponge crystal", is presented, and the chemical basis of its properties are explained for a melt- and press-castable solid sodium ion conductor. X-ray crystallography and atomistic simulations reveal details of atomic interactions and clustering in (DMF)3NaClO4 and (DMF)2NaClO4 (DMF = N-N'-dimethylformamide). External pressure or heating results in reversible expulsion of liquid DMF from (DMF)3NaClO4 to generate (DMF)2NaClO4. The process reverses upon the release of pressure or cooling. Simulations reveal the mechanism of crystal "juicing," as well as melting. In particular, cation-solvent clusters form a chain of octahedrally coordinated Na+-DMF networks, which have perchlorate ions present in a separate sublattice space in 3 : 1 stoichiometry. Upon heating and/or pressing, the Na+â¯DMF chains break and the replacement of a DMF molecule with a ClO4 - anion per Na+ ion leads to the conversion of the 3 : 1 stoichiometry to a 2 : 1 stoichiometry. The simulations reveal the anisotropic nature of pressure induced stoichiometric conversion. The results provide molecular level understanding of a solvate sponge crystal with novel and desirable physical castability properties for device fabrication.
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We introduce the efficient Fmoc-SPPS and peptoid synthesis of Q-proline-based, metal-binding macrocycles (QPMs), which bind metal cations and display nine functional groups. Metal-free QPMs are disordered, evidenced by NMR and a crystal structure of QPM-3 obtained through racemic crystallization. Upon addition of metal cations, QPMs adopt ordered structures. Notably, the addition of a second functional group at the hydantoin amide position (R2) converts the proline ring from Cγ-endo to Cγ-exo, due to steric interactions.
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Prolina , Cristalização , Espectroscopia de Ressonância Magnética , Modelos MolecularesRESUMO
The synthesis of manganese cluster complexes templated by polyhedral oligomeric silsesquioxane-derived ligands is described. MnII3(Ph7Si7O12)2Pyr4 (1) and MnII4(Ph4Si4O8)2(Bpy)2(Py)2 (3) are prepared by replacement of the amide ligands of Mn(NR2)2 (R = SiMe3) via ligand protolysis by the acidic proton of the respective silsesquioxane-derived silanols. Complex 1 is shown to undergo ligand rearrangement by reaction with O2, which results in oxidation of the cluster to a mixed MnII/III cluster, concomitant with cleavage of the Si-O bonds of the ligand, releasing a [Ph2Si-O]+ unit, opening a new ligating siloxide group, and resulting in the formation of Mn3(Ph6Si6O11)2Pyr4 (2). The ligand framework of 1 can also be perturbed by a base. The addition of LiOH/BuLi delivers a soluble equivalent of Li2O to 1, resulting in cleavage of the Si-O bonds and linkage of the resulting exposed silicon atoms by the new oxide, giving a linked ligand variant that templates a Li2Mn3 cluster, Mn3Li2(Ph7Si7O12OPh7Si7O12)DMF5Pyr (4). These systems are characterized by single-crystal X-ray diffraction, absorption spectroscopy, Fourier transform infrared, cyclic voltammetry, and CHN combustion analysis. Mechanistic implications for the Si-O bond cleavage events are discussed.
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The properties of catenated nitrogen molecules, molecules containing internal chains of bonded nitrogen atoms, is of fundamental scientific interest in chemical structure and bonding, as nitrogen is uniquely situated in the periodic table to form kinetically stable compounds often with chemically stable N-N bonds but which are thermodynamically unstable in that the formation of stable multiply bonded N2 is usually thermodynamically preferable. This unique placement in the periodic table makes catenated nitrogen compounds of interest for development of high-energy-density materials, including explosives for defense and construction purposes, as well as propellants for missile propulsion and for space exploration. This review, designed for a chemical audience, describes foundational subjects, methods, and metrics relevant to the energetic materials community and provides an overview of important classes of catenated nitrogen compounds ranging from theoretical investigation of hypothetical molecules to the practical application of real-world energetic materials. The review is intended to provide detailed chemical insight into the synthesis and decomposition of such materials as well as foundational knowledge of energetic science new to most chemists.
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Cyanuric triazide reacts with several transition metal precursors, extruding one equivalent of N2 and reducing the putative diazidotriazeneylnitrene species by two electrons, which rearranges to N-(1'H-[1,5'-bitetrazol]-5-yl)methanediiminate (biTzI2-) dianionic ligand, which ligates the metal and dimerizes, and is isolated from pyridine as [M(biTzI)]2Py6 (M = Mn, Fe, Zn, Cu, Ni). Reagent scope, product analysis, and quantum chemical calculations were combined to elucidate the mechanism of formation as a two-electron reduction preceding ligand rearrangement.
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Reaction of 1,3-diazidopropane with an electron-rich Mn(II) precursor results in oxidation of the metal center to a Mn complex with concomitant assembly of the macrocyclic ligand into the 1,2,3,4,8,9,10,11-octaazacyclotetradeca-2,9-diene-1,4,8,11-tetraido (OIM) ligand. Although describable as a Werner Mn(V) complex, analysis by X-ray diffraction, magnetic measurements, X-ray photoelectron spectroscopy, cyclic voltammetry, and density functional theory calculations suggest an electronic structure consisting of a Mn(III) metal center with a noninnocent OIM diradical ligand. The resulting complex, (OIM)Mn(NH tBu), reacts via proton-coupled electron transfer (PCET) with phenols to form phenoxyl radicals, with dihydroanthracene to form anthracene, and with (2,4-di tert-butyltetrazolium-5-yl)amide to extrude a tetrazyl radical. PCET from the latter generates the isolable corresponding one-electron reduced compound with a neutral, zwitterionic axial 2,4-di tert-butyltetrazolium-5-yl)amido ligand. Electron paramagnetic resonance and density functional theoretical analyses suggest an electronic structure wherein the manganese atom remains Mn(III) and the OIM ligand has been reduced by one electron to a monoradical noninnocent ligand. The result indicates PCET processes whereby the proton is transferred to the axial ligand to extrude tBuNH2, the electron is transferred to the equatorial ligand, and the central metal remains relatively unperturbed.
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Complexos de Coordenação/química , Compostos Macrocíclicos/química , Manganês/química , Nitrogênio/química , Prótons , Transporte de Elétrons , Ligantes , Modelos Moleculares , Conformação MolecularRESUMO
The single-crystal X-ray structure of solvent-free (tmtaa)CoII reveals three different π-π intermacrocyclic interactions between tmtaa units (tmtaa = dibenzotetramethyltetraaza[14]annulene). Pairs of inequivalent (tmtaa)CoII units in the unit cell link into a one-dimensional π-π stacked array in the solid state. Magnetic susceptibility (χ) studies from 300 to 2 K reveal the effects of intermolecular interactions between (tmtaa)CoII units in the solid state. The effective magnetic moment per CoII center is constant at 2.83 µB from 300 to 100 K and begins to significantly decrease at lower temperatures. The magnetic data are fit to a singlet ( S = 0) ground state with a triplet ( S = 1) excited state that is 13 cm-1 higher in energy (-2 J = 13 cm-1). Toluene solutions of (tmtaa)CoII have 1H nuclear magnetic resonance (NMR) paramagnetic shifts, a solution-phase magnetic moment µeff (295 K) of 2.1 µB, and toluene glass electron paramagnetic resonance spectra that are most consistent with a low-spin ( S = 1/2) CoII with the unpaired electron located in the d yz orbital. Pyridine interacts with (tmtaa)CoII to form a five-coordinate monopyridine complex in which the unpaired electron is in the d z2 orbital. The five-coordinate complex has been structurally characterized by single-crystal X-ray diffraction, and the equilibrium constant for pyridine binding at 295 K has been evaluated by both electronic and 1H NMR spectra. Density functional theory computation using the UB3LYP hybrid functional places the unpaired electron for (tmtaa)CoII in the d yz orbital and that for the monopyridine complex in the d z2 orbital, consistent with spectroscopic observations.
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The crystal structures of two closely related compounds, 1-cyclo-hexyl-2-(2-nitro-phen-yl)-1,3-thia-zolidin-4-one, C15H18N2O3S, (1) and 1-cyclo-hexyl-2-(2-nitro-phen-yl)-1,3-thia-zolidin-4-one 1,1-dioxide, C15H18N2O5S, (2), are presented. These compounds are comprised of three types of rings: thia-zolidinone, nitrophenyl and cyclo-hexyl. In both structures, the rings are close to mutually perpendicular, with inter-planar dihedral angles greater than 80° in each case. The thia-zol-idinone rings in both structures exhibit envelope puckering with the S atom as flap and the cyclo-hexyl rings are in their expected chair conformations. The two structures superpose fairly well, except for the orientation of the nitro groups with respect to their host phenyl ring, with a difference of about 10° between 1 and 2. The extended structure of 1 has two kinds of weak C-Hâ¯O inter-actions, giving rise to a closed ring formation involving three symmetry-related mol-ecules. Structure 2 has four C-Hâ¯O inter-actions, two of which are exclusively between symmetry-related thia-zolidinone dioxide moieties and have a parallel 'give-and-take-fashion' counterpart. In the other two inter-actions, the nitrophenyl ring and the cyclo-hexane ring each offer an H atom to the two O atoms on the sulfone group. Additionally, a C-Hâ¯π inter-action between a C-H group of the cyclo-hexane ring and the nitrophenyl ring of an adjacent mol-ecule helps to consolidate the structure.
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Tolnaftate, a classic antifungal compound, has been found to crystallize from 1:1 (v/v) acetone-water as large flat colorless needles in the centrosymmetric monoclinic space group P21/c. These crystals contain a 50:50 mixture of the (+ap,-sp,+ac,-ac) and (-ap,+sp,-ac,+ac) conformers. The bond lengths in the central CNOS unit are 1.3444â (19), 1.3556â (18) and 1.6567â (15)â Å for C-N, C-O and C-S, respectively, and the CNOS and C3N moieties are flat and nearly coplanar with each other, consistent with the C-N bond possessing partial double-bond character. Tolnaftate and the four most closely related N,N-disubstituted thiocarbamates in the Cambridge Structural Database (CSD) all exist as E-conformational isomers in the solid state. Among these five compounds, tolnaftate is the only one in which the N-tolyl moiety is positioned trans to the S atom, i.e. the N-aryl substituent in each of the other compounds is positioned cis to their respective S atom. Notably, and more importantly, our experimental X-ray structure is unlike all prior theoretical models available for tolnaftate. The implication, either directly or indirectly, is that some of those theoretical models used in earlier studies to explain the spectroscopic properties of tolnaftate and to suggest which protein-ligand interactions are responsible for the binding of tolnaftate to squalene epoxidase are either inappropriate or structurally unreasonable, i.e. the results and conclusions from those prior studies are in need of critical reassessment.
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The solid-state structures of the Na+, Li+, and NH4+ salts of the 4,5-di-hydroxy-benzene-1,3-di-sulfonate (tiron) dianion are reported, namely disodium 4,5-di-hydroxy-benzene-1,3-di-sulfonate, 2Na+·C6H4O8S22-, µ-4,5-di-hydroxy-benzene-1,3-di-sulfonato-bis-[aqua-lithium(I)] hemihydrate, [Li2(C6H4O8S2)(H2O)2]·0.5H2O, and di-ammonium 4,5-di-hydroxy-benzene-1,3-di-sulfonate monohydrate, 2NH4+·C6H4O8S22-·H2O. Inter-molecular inter-actions vary with the size of the cation, and the asymmetric unit cell, and the macromolecular features are also affected. The sodium in Na2(tiron) is coordinated in a distorted octa-hedral environment through the sulfonate oxygen and hydroxyl oxygen donors on tiron, as well as an inter-stitial water mol-ecule. Lithium, with its smaller ionic radius, is coordinated in a distorted tetra-hedral environment by sulfonic and phenolic O atoms, as well as water in Li2(tiron). The surrounding tiron anions coordinating to sodium or lithium in Na2(tiron) and Li2(tiron), respectively, result in a three-dimensional network held together by the coordinate bonds to the alkali metal cations. The formation of such a three-dimensional network for tiron salts is relatively rare and has not been observed with monovalent cations. Finally, (NH4)2(tiron) exhibits extensive hydrogen-bonding arrays between NH4+ and the surrounding tiron anions and inter-stitial water mol-ecules. This series of structures may be valuable for understanding charge transfer in a putative solid-state fuel cell utilizing tiron.