RESUMO
Morphological research of the esophagogastric transition mucosa at 35 fetuses and newborns was done. The esophagogastric transition was lined by high columnar epithelium and mucos glands. At fetuses of 22-24 week gestational age studied zone didn't have any glands. Histochemical features of the epithelium, particularly MUC5AC positive staining, corresponded to cardial type of the Barrett esophagus, defined at adults. We have revealed that mucosa of the esophagogastric transition has gastric origin and arises before birth. We found out the islets of columnar epithelium on the surface of the laminated pavement epithelium, indicated about its uneven development up to the birth. The sites of immature epithelium could be considered as transformation zones both of laminated pavement epithelium or columnar one.
Assuntos
Junção Esofagogástrica , Desenvolvimento Fetal , Feto/anatomia & histologia , Autopsia , Esôfago de Barrett/patologia , Cárdia/embriologia , Cárdia/crescimento & desenvolvimento , Epitélio/embriologia , Epitélio/crescimento & desenvolvimento , Junção Esofagogástrica/embriologia , Junção Esofagogástrica/crescimento & desenvolvimento , Feminino , Mucosa Gástrica/embriologia , Mucosa Gástrica/crescimento & desenvolvimento , Humanos , Recém-Nascido , Mucosa/embriologia , Mucosa/crescimento & desenvolvimento , GravidezRESUMO
Cardiomyopathies in children are rather rare, but extremely severe disorders that are little known in practical healthcare. Many of them are a cause of sudden death and they are familial. By using their findings and the data available in the literature, the authors describe the etiology, pathogenesis, morphology, and clinical presentation of dilated, hypertrophic, arhythmogenic right ventricular, histiocytoid cardiomyopathies, as well as the non-compact myocardium, and a type of cardiac connective tissue dysplasia. By keeping in mind the frequency of inheritance of cardiomyopathies, it is necessary to improve the diagnosis of these diseases not only for timely treatment, but also medical genetic counseling.
Assuntos
Cardiomiopatias/diagnóstico , Cardiomiopatias/patologia , Cardiopatias Congênitas/diagnóstico , Cardiopatias Congênitas/patologia , Miocárdio/patologia , Cardiomiopatias/etiologia , Cardiomiopatias/fisiopatologia , Feminino , Coração/fisiopatologia , Cardiopatias Congênitas/etiologia , Cardiopatias Congênitas/fisiopatologia , Humanos , MasculinoRESUMO
Preparation of autopsy material for a histological study for correct diagnosis is not less important than that of a biopsy specimen. Based on their accumulated experience, the authors propose a number of modernizations to prepare autopsy material for the study of lung, bone marrow, and intestinal abnormalities, which require no higher work intensity, but at the same time contribute to a unified approach to investigating tissues and organs in certain pathological processes in pediatric care.