Necrolytic migratory erythema caused by pancreatic hyperglycemia with emphasis on therapeutic and prognosis: A case report.

BACKGROUND: With the incidence of pancreatic diseases increasing year by year, pancreatic hyperglycemia, as one of the common complications, is gradually gaining attention for its impact on the skin health of patients. CASE SUMMARY: This was the case of an elderly female with clinical manifestations of necrolytic migratory erythema, "three more and one less," diabetes mellitus, hypertension, anemia, hypoproteinemia, and other syndromes, which had been misdiagnosed as eczema. Abdominal computed tomography showed a pancreatic caudal space-occupying lesion, and the magnetic resonance scanning of the epigastric region with dynamic enhancement and diffusion-weighted imaging suggested a tumor of the pancreatic tail, which was considered to be a neuroendocrine tumor or cystadenoma. The patient was referred to a more equipped hospital for laparoscopic pancreatic tail resection. Post-surgery diagnosis revealed a neuroendocrine tumor in the tail of the pancreas. To date, the patient's general condition is good, and she is still under close follow-up. CONCLUSION: Necrolytic migratory erythema can be induced by endocrine system tumors or endocrine metabolic abnormalities, with complex clinical manifestations, difficult diagnosis, and easy misdiagnosis by dermatologists. The initial treatment principles in dermatology include symptomatic supportive therapy and effective drugs to relieve skin lesions. After clarifying the etiology of glucagonoma, comprehensive treatment in collaboration with endocrinologists, general surgeons, and oncologists can help provide individualized treatment for patients and improve their prognosis.

Organophosphorus-Catalyzed Direct Dehydroxylative Thioetherification of Alcohols with Hypervalent Organosulfur Compounds.

A metal-free and thiol-free organophosphorus-catalyzed method for forming thioethers was disclosed, driven by PIII/PV═O redox cycling. In this work, one-step dehydroxylative thioetherification of alcohols was fulfilled with various hypervalent organosulfur compounds. This established strategy features an excellent functional group tolerance and broad substrate scope, especially inactivated alcohols. The scale-up reaction and further transformation of the product were also successful. Additionally, this method offers a protecting-group-free and step-efficient approach for synthesizing peroxisome proliferator-activated receptor agonists which exhibited promising potential for treating osteoporosis in mammals.

[Synthesis and white light emission upconversion of Tm3+, Ho3+, Yb3+ co-doped YPO4 micro-nano tubes].

Tm3+, Ho3+, Yb3+ co-doped YPO4 micro-nano tubes were synthesized by hydrothermal method. Under the 980 nm near infrared (NI) excitation, the micro-nano tubes emitted red, green, blue visible light and a near infrared emission centered at 795 nm. The optical properties and structure of the synthesized Tm3+, Ho3+, Yb3+ co-doped YPO4 micro-nano tubes were characterized by testing the TEM, XRD and fluorescence spectra. The results showed that the micro-nano tubes are pure hexagonal phase. The hydrothermal temperature had obvious effect on fluorescence spectra but little effect on phase. The intensity of the emission peaks didn't increase with the concentration of doping ions monotonously under the same reaction temperature, but changed non-monotonously due to the concentration quenching and cross relation. The possible upconversion (UC) mechanism was discussed in this paper. This UC emission intensity controllable fluorescent material has potential application in three dimension solid display, UC illumination, fluorescence detection and some other fields.