1.
Chem Commun (Camb)
; 60(52): 6671-6674, 2024 Jun 25.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38860640
RESUMO
Thioesters are a common class of biologically active fragments and synthetically useful building blocks. An attractive synthetic approach would be to use simple and bench-stable carboxylic acids as a coupling partner. Herein, we present a 4-bromo pyridine-borane complex as a catalyst for the direct coupling of carboxylic acids with thiols. A wide range of thioesters with good functional group compatibility could be prepared via this metal-free approach. The merit of this strategy is exemplified by the modification of carboxylic acid-containing drugs.