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1.
Zhen Ci Yan Jiu ; 44(9): 668-71, 2019.
Artigo em Chinês | MEDLINE | ID: mdl-31532137

RESUMO

OBJECTIVE: To investigate the effective of acupoint thread-embedding therapy for ataxia children with cerebral palsy. METHODS: A total of 70 ataxia children with cerebral palsy and a Gross Motor Function Measure (GMFM, Dimension B) score of <35 were enrolled and randomly divided into thread-embedding group and control group, with 35 children in each group, and 2 children in the thread-embedding group were lost to follow-up. The children in the control group were given routine rehabilitation treatment, including physical therapy, spleen-strengthening, kidney-nourishing, and Governor Vessel-regulating massage, vibroacoustic therapy, and scalp acupuncture, and those in the thread-embedding group were given thread-embedding therapy at the acupoints of Jianyu (LI15), Jianliao (SJ14), Tianzong (SI11), Tianshu (ST25), and HuatuoJiaji points (C4, L1 and L4) in addition to the treatment in the control group, with 6-8 acupoints selected each time, once a week. Each course of treatment was 4 weeks, with an interval of one week between two courses of treatment, and the children were treated for 3 courses. Level of sitting scale (LSS), incurvation reflex, and GMFM score were recorded to evaluate the improvement in sitting ability and clinical outcome. RESULTS: Both groups had significant improvements in LSS, incurvation reflex, and GMFM (Dimension A and B) score after treatment (P<0.01), and the thread-embedding group had significantly greater improvements than the control group (P<0.01). The thread-embedding group had a significantly higher overall response rate than the control group (90.9% [30/33] vs 68.5% [24/35], P<0.01). CONCLUSION: In addition to routine rehabilitation treatment, acupoint thread-embedding therapy can effectively suppress primitive reflex in ataxia children with cerebral palsy and significantly promote their sitting ability, and therefore, it is an effective acupuncture treatment method for ataxia children with cerebral palsy.


Assuntos
Pontos de Acupuntura , Paralisia Cerebral , Ataxia , Paralisia Cerebral/terapia , Criança , Humanos , Postura Sentada
2.
Int J Biol Macromol ; 109: 407-416, 2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29274420

RESUMO

A large number of archaeological wooden building poles have been excavated from the Hai Menkou site (Yunnan province, China). Lignin can be transformed and altered accompanied with significant loss of carbohydrates during this process. Elucidation of chemical and structural transformations of lignin is of primary importance for understanding both the nature of degradation processes and the structure of waterlogged archaeological wood, and crucial for developing proper consolidation technology and restoring artifacts of historical and cultural value. In this study, state-of-the-art analytical techniques, including SEM, FT-IR, XRD, CP-MAS 13C NMR, 2D-HSQC NMR, 31P-NMR, CRM, GPC and TG analysis, were all employed to elucidate the structural characteristics of lignin in waterlogged and reference Pinus wood. The results interpreted by NMR analysis demonstrated the depolymerization of lignin via cleavage of ß-O-4, ß-5, -OCH3 and some LCC linkages, leading to a higher amount of free phenol OH groups in the lignin from the ancient waterlogged wood as compared to that of the reference wood. Microscopically, it was found that extensive degradation of carbohydrates in cell walls was mainly occurred in secondary cell walls, while the lignin concentrations were relatively increased in CCML and S regions in the plant cell wall of the ancient wood.


Assuntos
Arqueologia , Lignina/química , Madeira/química , Artefatos , Peso Molecular , Temperatura , Água/química
3.
Zhongguo Dang Dai Er Ke Za Zhi ; 17(12): 1338-41, 2015 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-26695676

RESUMO

OBJECTIVE: To investigate the clinical symptoms and features of interictal epileptiform discharges (IED) on electroencephalogram (EEG) in children with spastic hemiplegic cerebral palsy (CP) and to analyze the risk factors for IED. METHODS: Eighty-three children with spastic hemiplegic CP were recruited, and their clinical data, results of video-electroencephalogram, imaging findings, and cognitive levels were collected. The influencing factors for IED were determined by multiple logistic regression analysis. RESULTS: The incidence of epilepsy was 13% in children with spastic hemiplegic CP; 34% of these cases had IED. The incidence of epilepsy in children with IED (32%) was significantly higher than that in those without IED (4%) (P<0.01). The incidence of IED in children with complications and brain cortex impairment increased significantly (P<0.01). The incidence of IED varied significantly between patients with different cognitive levels (P<0.01). Brain cortex impairment (OR=11.521) and low cognitive level (OR=2.238)were risk factors for IED in children with spastic hemiplegic CP (P<0.05). CONCLUSIONS: Spastic hemiplegic CP is often found with IED on EEG, and the incidence of epilepsy is higher in children with IED than in those without IED. Brain cortex impairment and low cognitive level have predictive values for IED in children with spastic hemiplegic CP.


Assuntos
Paralisia Cerebral/fisiopatologia , Eletroencefalografia , Epilepsia/epidemiologia , Hemiplegia/fisiopatologia , Córtex Cerebral/fisiopatologia , Criança , Pré-Escolar , Epilepsia/etiologia , Feminino , Humanos , Incidência , Lactente , Masculino , Fatores de Risco
4.
J Zhejiang Univ Sci B ; 16(3): 191-7, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25743120

RESUMO

Tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization (WHO), and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate and testosterone undecanoate in infertile men with idiopathic oligozoospermia, and whether the results would be affected by polymorphisms of CYP2D6*10. A total of 230 infertile men and 147 controls were included in the study. Patients were treated with tamoxifen citrate and testosterone undecanoate. Sex hormone, sperm parameters, and incidence of spontaneous pregnancy were detected. There were no significant differences between the control and patient groups with respect to CYP2D6*10 genotype frequencies (P>0.05). The follicle-stimulation hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were raised, and sperm concentration and motility were increased at 3 months and became significant at 6 months, and they were higher in the wild-type allele (C/C) than in the heterozygous variant allele (C/T) or homozygous variant allele (T/T) subgroups (P<0.05). In addition, the percentage of normal morphology was raised at 6 months, and represented the highest percentage in the C/C subgroup (P<0.05). The incidence of spontaneous pregnancy in the C/C subgroup was higher than that in the C/T or T/T subgroups (P<0.01). This study showed that the CYP2D6*10 variant genotype demonstrated worse clinical effects in infertile men with idiopathic oligozoospermia.


Assuntos
Citocromo P-450 CYP2D6/genética , Oligospermia/tratamento farmacológico , Oligospermia/genética , Polimorfismo Genético , Tamoxifeno/administração & dosagem , Testosterona/análogos & derivados , Adulto , Substituição de Aminoácidos , Estudos de Casos e Controles , Citocromo P-450 CYP2D6/metabolismo , Quimioterapia Combinada , Feminino , Hormônio Foliculoestimulante/sangue , Frequência do Gene , Humanos , Hormônio Luteinizante/sangue , Masculino , Oligospermia/enzimologia , Polimorfismo de Nucleotídeo Único , Gravidez , Contagem de Espermatozoides , Motilidade dos Espermatozoides/efeitos dos fármacos , Testosterona/administração & dosagem , Testosterona/sangue , Resultado do Tratamento , Adulto Jovem
5.
Hepatogastroenterology ; 61(132): 978-83, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26158152

RESUMO

BACKGROUND/AIMS: Endorectal endoscopic ultrasound (EUS) can provide accurate and reliable information for initial staging of locally advanced rectal cancer (LARC) in both the depth of rectal cancer penetration (T-stage) and regional lymph node involvement (N-stage). However, there is still no consensus about its accuracy in retagging LARC after neoadjuvant chemoradiotherapy (NAT). METHODOLOGY: In this study, we retrieved previous studies and performed a meta-analysis for assessing the accuracy of EUS for retagging of LARC after NAT. RESULTS: It was found the accuracy of EUS for T restaging of LARC was relatively low and over-staging was common, although the accuracy for assessing T3/4 was significantly higher than T0-T2 stage. The specificity of EUS for assessing N stage was relatively high, but the sensitivity was relatively low. CONCLUSIONS: Data obtained in this study confirmed the overall accuracy of EUS is not sufficient to serve as a basis for decisions on restaging Exploring the possible application of new techniques is necessary for better restaging.


Assuntos
Quimiorradioterapia Adjuvante , Endossonografia , Terapia Neoadjuvante , Estadiamento de Neoplasias/métodos , Neoplasias Retais/terapia , Distribuição de Qui-Quadrado , Humanos , Razão de Chances , Valor Preditivo dos Testes , Neoplasias Retais/diagnóstico por imagem , Neoplasias Retais/patologia , Reprodutibilidade dos Testes , Resultado do Tratamento
6.
Guang Pu Xue Yu Guang Pu Fen Xi ; 31(2): 422-6, 2011 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-21510395

RESUMO

From 0.5 to 5.0 generation PAMAM dendrimers were synthesized with ethylenediamine core by Michael addition reaction and aminolysis reaction two repeated steps. The structure of dendrimers were confirmed by FTIR 1H NMR 13C NMR MS and all of these measurements showed that they were successfully synthesized. Furthermore, The authors studied the UV and fluorescence properties of different generation dendrimers. Because of diffenent terminal groups, it was found that the whole generation and half generation show different ultraviolet absorption peaks and the intensity of ultraviolet absorption is closely related to the molecular skeleton. There is no traditional fluorescence emission groups, but PAMAM dendrimers show the peculiar phenomenon. In this paper we detailedly studied the factors which affect PAMAM dendrimers fluorescence properties.

7.
Eur Rev Med Pharmacol Sci ; 10(2): 41-6, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16705946

RESUMO

OBJECTIVES: To identify the risk factors of postoperative pulmonary complications (PPC) after surgery for gallstone disease. METHODS: A total of 544 patients undergoing open surgery for gallstone disease were retrospectively studied. Univariate and multivariate logistic regression were used to analyze each factor. RESULTS: There were 24 factors relating to PPC in univariate logistic analysis. And multivariate logistic analysis identified 5 independent risk factors associated with PPC, including perioperative aerosol therapy (OR = 5.906), duration of postoperative antacids therapy (OR = 1.145), duration of operation (OR = 1.011), preoperative serum albumin (OR = 0.689), postoperative analgesia (OR = 0.059), Logistic regression equation for predicting the risk of PPC was P(1) = 1/[1 + e-(- 9.803 + 1.776 x A + 0.135 x B + 0.011 x C - 0.372 x D - 2.835 x E)]. CONCLUSION: Perioperative aerosol therapy, duration of postoperative antacids therapy, duration of operation, preoperative serum albumin and postoperative analgesia were independent risk factors associated with PPC in patients undergoing surgery for gallstone disease.


Assuntos
Procedimentos Cirúrgicos do Sistema Biliar , Colelitíase/cirurgia , Pneumopatias/etiologia , Complicações Pós-Operatórias/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Modelos Logísticos , Pneumopatias/sangue , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/sangue , Estudos Retrospectivos , Fatores de Risco
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