[Research on early warning model of the hearing loss of workers exposed to noise].

Objective: To explore the change of hearing threshold of workers exposed to noise, establish an individual-based hearing loss early warning model, accurately and differentiated the health of workers exposed to noise. Methods: In September 2019, all physical examination data of 561 workers exposed to noise from an enterprise were collected since their employment. Three indicators of average hearing threshold of the better ear, namely, at high frequency, 4000 Hz and speech frequency, were constructed. The generalized estimating equation (GEE) was used to adjust gender and age and establish the warning model of each indicator. Finally, sensitive indicators and warning models were screened according to AUC and Yoden index. Results: Among the 561 workers exposed to noise, 26 (4.6%) workers had hearing loss. The sensitivity indicators were the average hearing threshold at speech frequency ≥20 dB, high frequency ≥30 dB and 4000 Hz ≥25 dB. The AUC of each index was 0.602, 0.794 and 0.804, and the Youden indexes were 0.204, 0.588 and 0.608, respectively. In GEE of hearing loss warning models, high-frequency hearing threshold ≥20 dB and 4000 Hz hearing threshold ≥25 dB were the optimal models, with AUC of 0.862. Conclusion: Combined with the changes of individual hearing threshold over the years, can accurately assess the risk of individual hearing loss of workers exposed to noise.

[Discussion on the application of ventilatory threshold in classification of physical workload in plateau].

Objective: To explore the application of the first ventilatory threshold (VT1) and the second ventilatory threshold (VT2) in the classification of physical workload for plateau workers, to provide reference for formulating the classification in plateau. Methods: In August 2018, 88 male workers from substations at different altitudes (500 m, 2000 m, 3000 m and 4000 m) of a company were selected as study subjects by cluster sampling. They were divided into plain group and plateau groups.The intensities of workload were simulated by power bicycle, and physiologic parameters, including VO(2), heart rate (HR) and energy metabolic rate per body surface area (E/BSA) , were recorded in test system when reaching VT1, VT2 and peak oxygen uptake (VO(2)Peak) . The ratios of VT1, VT2 and VO(2)Peak to the quiet and work potential at different altitudes were compared. Results: In a quiet state, compared with the plain group, the HR and E/BSA of the workers in the 2000 m and 3000 m groups increased, and the differences were statistically significant (P<0.05) . At VT2, compared with the plain group, the HR of the workers in the 4000 m group decreased, the difference was statistically significant (P<0.05) . VO(2) and E/BSA of workers in each plateau group were lower than those in the plain group at VO(2)Peak, and the differences were statistically significant (P<0.05) . At VT2 and VO(2)Peak, the ratios of VO(2), HR, and E/BSA relative to the quiet state of the workers in each plateau group were lower than those of the plain group, and the differences were statistically significant (P<0.05) . In the quiet state and VT1, compared with the plain group, the remaining percentages of VO(2) and E/BSA of workers in each plateau group decreased, and the differences were statistically significant (P<0.05) . Taking VT1, VT2 and VO(2)Peak as cut-off points and VO(2), HR and E/BSA as indicators, the physical workload in plateau could be divided into four levels, namely medium, heavy, extremely heavy and extreme physical workload. Conclusion: It is practicable to use ventilatory threshold to classification of physical workload. VT1 and VT2 can be applied to the classification in plateau to supplement and optimize current national standard of physical workload.

Deterministic Coherence Distillation.

Coherence distillation is one of the central problems in the resource theory of coherence. In this Letter, we complete the deterministic distillation of quantum coherence for a finite number of coherent states under strictly incoherent operations. Specifically, we find the necessary and sufficient condition for the transformation from a mixed coherent state into a pure state via strictly incoherent operations, which recovers a connection between the resource theory of coherence and the algebraic theory of majorization lattice. With the help of this condition, we present the deterministic coherence distillation scheme and derive the maximum number of maximally coherent states obtained via this scheme.

[The effect of miR-155 on HBV replication and PTEN expression in vivo].

Objective: To construct the mmu-miR-155 eukaryotic overexpression vector pmR-155 and to investigate its effect on HBV replication and expression of PTEN in vivo. Methods: The mmu-mir-146a precursor gene fragment pre-mmu-mir-146a was amplified by PCR, then connected to the pmR-mCherry plasmid vector after double enzyme digestion, the accuracy of recombinant vector was verified by colony PCR、double enzyme digestion and sequencing; then the recombinant vector was transfected HBV transgene mice(Experimental Group)with hydrodynamics-based injection via vena caudalis, and pmR-mCherry plasmid、PBS were respectively transfected into the mice as Empty plasmid Group、Blank Group. The concentration of IFN-γ in the serum was detected by ELISA. The expression of SOCS1、PTEN mRNA in the liver was detected by qPCR at 30d post-transfectioned. The Western blot was performed to detect the changes in SOCS1、PTEN、HBX in the liver tissue at 30 d post-transfectioned. The results were analyzed with Student's t-test, or one-way analysis of variance and the least significant difference test. Results: the colony PCR、double enzyme digestion and sequencing verified that the gene was inserted into the pmR-mCherry vector. Compared with Blank Group, the expression of miR-155 in the Experimental Group was significantly increased(t = 8.90, P < 0.01); the concentration of IFN-γ in the Experimental Group was significantly increased(F = 26.58, P < 0.01); the mRNA(F(SOCS1 mRNA) = 19.72, P < 0.01; F(PTEN mRNA) = 7.38, P < 0.05) and protein(F(SOCS1) = 50.30, P < 0.01; F(PTEN) = 129.00, P < 0.01) expression of COCS1、PTEN was significantly decreased in the Experimental group and the protein of HBX was also significantly(F(HBX) = 77.97, P < 0.01). Conclusion: The pmR-155 eukaryotic overexpression vector is successfully constructed, this recombinant vector can express miR-155 stably; miR-155 can down-regulate cocs1、PTEN gene expression and up-regulate the expression of IFN-γ, it can inhibit the replication of HBV and a potential targets to treating hepatocellular carcinoma.

Graph states of prime-power dimension from generalized CNOT quantum circuit.

We construct multipartite graph states whose dimension is the power of a prime number. This is realized by the finite field, as well as the generalized controlled-NOT quantum circuit acting on two qudits. We propose the standard form of graph states up to local unitary transformations and particle permutations. The form greatly simplifies the classification of graph states as we illustrate up to five qudits. We also show that some graph states are multipartite maximally entangled states in the sense that any bipartition of the system produces a bipartite maximally entangled state. We further prove that 4-partite maximally entangled states exist when the dimension is an odd number at least three or a multiple of four.

Comparison of clinical outcomes of open, laparoscopic and single port appendicectomies.

INTRODUCTION: Appendicectomy is the most common surgical procedure performed in general surgery. This study aimed to compare the outcomes of open appendicectomy (OA), laparoscopic appendicectomy (LA) and single port laparoscopic appendicectomy (SPLA). METHODS: Fifty consecutive patients with suspected acute appendicitis were studied (OA: n=20, LA: n=20, SPLA: n=10). Clinical outcomes were compared between the three groups in terms of operative time, blood loss, postoperative complications, length of hospital stay and cost. RESULTS: Patient demographics were similar among groups (p>0.05). SPLA was characterised by longer operative time (88.1 minutes vs 35.6 minutes in OA and 33.4 minutes in LA) and higher costs (12.84 thousand Chinese yuan [RMB] vs 8.41 thousand RMB in LA and 4.99 thousand RMB in OA). OA was characterised by more blood loss (9.8ml vs 7.5ml in SPLA and 6.8ml in LA), longer hospital stay (7.5 days vs 3.5 days in LA and 3.4 days in SPLA) and lower costs. The total number of complications was higher for OA (n=2) than for LA and SPLA (n=0) although this was not statistically significant. CONCLUSIONS: Where feasible, LA should be undertaken as the initial treatment of choice for most cases of suspected appendicitis.

Irreducible multiparty correlations in quantum states without maximal rank.

The correlations of an n-partite quantum state are classified into a series of irreducible k-party ones (2

Dynamical instability and domain formation in a spin-1 Bose-Einstein condensate.

We interpret the recently observed spatial domain formation in spin-1 atomic condensates as a result of dynamical instability. Within the mean field theory, a homogeneous condensate is dynamically unstable (stable) for ferromagnetic (antiferromagnetic) atomic interactions. We find that this dynamical instability naturally leads to spontaneous domain formation as observed in several recent experiments for condensates with rather small numbers of atoms. For trapped condensates, our numerical simulations compare quantitatively to the experimental results, thus largely confirming the physical insight from our analysis of the homogeneous case.

Measuring the parity of an N-qubit state.

We present a scheme for a projective measurement of the parity operator Pz = Product(N)i=1 sigma(i)z of N qubits. Our protocol uses a single ancillary qubit, or a probe qubit, and involves manipulations of the total spin of the N qubits without requiring individual addressing. We illustrate our protocol in terms of an experimental implementation with atomic ions in a two-zone linear Paul trap, and further discuss its extensions to several more general cases.

Cloning and characterization of the rpfC gene of Xanthomonas oryzae pv. oryzae: involvement in exopolysaccharide production and virulence to rice.

rpfC is one of a cluster of genes which coordinately regulate the synthesis of extracellular enzymes and exopolysaccharide and pathogenicity in Xanthomonas campestris pv. campestris, the black rot pathogen of brassicas. An rpfC homolog which could functionally complement an rpfC mutant of X. campestris pv. campestris was identified in Xanthomonas oryzae pv. oryzae and the gene was characterized. Mutation of this gene in X. oryzae pv. oryzae had no effect on extracellular enzymes, but exopolysaccharide synthesis and virulence to rice were substantially reduced.

Long-term observation after radiotherapy for nasopharyngeal carcinoma (NPC).

One thousand one hundred twenty-seven cases of nasopharyngeal carcinoma were treated with routine radiotherapy from October 1969 to March 1976, of which 436 cases have survived for more than 5 years, 323 cases have survived for over 10 years. The follow-up rate was 98.4%. The present paper analyzes the factors involved in these 436 cases. All patients were treated with tele60Co unit, and in the neck some cases were treated with orthovoltage therapy. The total dose to the primary lesion was 60-75 Gy in 6-8 weeks and in a few cases over 80 Gy were needed, and 50 Gy were applied bilateral cervical lymphatic chain. In this series of cases the 10-year overall survival rate was 28.7%, with Stage I being 66.7%, Stage II 46.5%, Stage III 28.0%, and Stage IV 18.6%, respectively. Statistically, 68 cases died of cardiovascular and other diseases and should be eliminated for net survival calculations. Therefore, we could obtain an actual 10-year survival rate of 30.5%. However, it should be noted that most of these cases were advanced, with Stage III, IV accounting for 82.3%, thus at Stage I, II the 10-year survival rate was 48%, while at Stage III, IV rate was down to 24.5%, which was statistically significant (p less than 0.01). Local and cervical recurrence as well as distant spread of diseases, for these cases started from the fifth to the tenth year after radiotherapy, the mortality caused by the above-mentioned three sites together was 76.9%. According to these findings, we propose that follow-up after radiotherapy in NPC exceeds 10-years. Of the 323 NPC cases, 10 were nasopharyngeal local recurrence which were re-irradiated, accounting for 3.1%. This paper shows that the 3-year survival rate in the local recurrence which were re-irradiated was 34.5%, the 5-year survival rate was 14.8%, and the 10-year survival rate was 11.5%. The failure after re-irradiation was caused by local recurrence and metastasis with a mortality of 83.6%. These results emphasize that the success of initial irradiation is important.

[Research on the dose-response relationship of hand transmitted vibration and its hygienic standard].

According to ISO 5349-1986, the akw(4) was 9.04-41.47m/s2 which was measured and calculated in 5 types of instruments: chain saw, cleaner, rock driller, riveter & emery wheel. There were 170 cases with white finger through epidemiologic investigation on 5 types of workers in 1,675 persons. Based on the work mentioned above, a formula, which represented worker cumulative exposure to vibration was deduced: D = [(a2kw(4).T)1/2.Y.d]2 Furthermore, the dose-response relationship of hand transmitted vibration and prevalence of white finger was computed, the regression equation was: P = 1.0904X - 6.214 2 Under precondition of exposure to vibration for 20 years with 90% of workers having no white fingers, the limit of hygienic standard of hand transmitted vibration in china should be set at 4 hours and as akw(4) less than or equal to 5 m/s2 based on the regression equation.