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Soft tissue integration around titanium (Ti) implants is weaker than that around natural teeth, compromising long-term success of Ti implants. Carbon monoxide (CO) possesses distinctive therapeutic properties, rendering it as a highly promising candidate for enhancing STI. However, achieving controlled CO generation at the STI interface remains challenging. Herein, a controlled CO-releasing dual-function coating was constructed on Ti surfaces. Under near-infrared (NIR) irradiation, the designed surface could actively accelerate CO generation for antibiosis against both aerobic and anaerobic bacteria. More importantly, in the absence of NIR, the slow release of CO induces macrophage polarization from pro-inflammatory phenotype towards pro-regenerative phenotype. In a rat implantation model with induced infection, the designed surface effectively controlled the bacterial infection, alleviates accompanying inflammation and modulated immune microenvironment, leading to enhanced STI. Single-cell sequencing revealed that the coating alters the cytokine profile within the soft tissue, thereby influencing cellular functions. Differentially expressed genes in macrophages are highly enriched in the PIK3-Akt pathway. Furthermore, the cellular communication between fibroblasts and macrophages was significantly enhanced through the CXCL12/CXCL14/CXCR4 and CSF1-CSF1R ligand-receptor pair. These findings indicate that our coating showed an appealing prospect for enhancing STI around Ti implants, which would ultimately contribute to the improved long-term success of Ti implants.
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Background: Immune checkpoint inhibitors (ICIs) enhance the immune system's ability to target and destroy cancer cells by blocking inhibitory pathways. Despite their efficacy, these treatments can trigger immune-related adverse events (irAEs), such as acute kidney injury (ICI-AKI), complicating patient management. The genetic predispositions to ICI-AKI are not well understood, necessitating comprehensive genomic studies to identify risk factors and improve therapeutic strategies. Objective: To identify genetic predispositions for ICI-AKI using large-scale real-world data. Methods: A systematic literature search led to 14 candidate variants related to irAEs. We performed a candidate variant association study with these 14 variants using the All of Us cohort (AoU, v7, cutoff date: 7/1/2022). A cohort for cancer patients receiving ICI and a general cohort were established to evaluate ICI-AKI risk. Logistic regression, adjusted for sex, was used to evaluate the impact of each candidate genotype, separately for self-reported and ancestry-estimated race. Kaplan-Meier survival analysis assessed the genetic effects on AKI-free survival. Results: The ICI cohort (n=414) showed a one-year AKI incidence rate of 23.2%, significantly higher than the general cohort (6.5%, n=213,282). The rs16957301 variant (chr13:100324308, T>C) in the PCCA gene was a significant risk genotype for ICI-AKI among self-reported Caucasians (Beta=0.93, Bonferroni-corrected P-value=0.047) and ancestry estimated Caucasians (Beta = 0.94, Bonferroni-corrected P-value=0.044). Self-reported Caucasians with the rs16957301 risk genotypes (TC/CC) developed AKI significantly earlier (3.6 months) compared to the reference genotype (TT, 7.0 months, log-rank P=0.04). Consistent results were found in ancestry-estimated Caucasians. This variant did not present significant AKI risks in the general cohort (Beta: -0.008-0.035, FDR: 0.75-0.99). Conclusion: Real-world evidence from the All of Us cohort suggests that, in Caucasians, PCCA variant rs16957301 is a novel AKI risk genotype specific to ICI treatment. Additional studies are warranted to validate rs16957301 as risk marker for AKI in Caucasian patients treated with ICIs and to assess its risk in other ancestral populations.
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Background: Falcotentorial meningiomas (FM) are surgical challenges for protecting sinus, and the technique notes on the management of superior sagittal or transverse sinus are required for good results. Methods: We improved the technique notes on the management of superior sagittal or transverse sinus in three FM patients with signs of increased intracranial pressure or chronic headache. Results: All patients underwent surgeries in the prone position, and occipital/sup-occipital/sub-occipital craniotomy was performed. In one patient, the skull was removed traditionally with exposure of the confluence of sinuses, superior sagittal, and transverse sinus, while the longitudinal skull bridge was left to suspend the dura for protecting the superior sagittal sinus in one patient, and the transverse skull bridge was left to suspend the dura for protecting the transverse sinus in one patient. The dura was opened infratentorially or supratentorially to spare the sinus and then the "skull bridge" was suspended. The tumor was then removed completely without brain swelling or significant venous bleeding. Complete tumor resection was confirmed by early postoperative imaging, and all patients recovered well without postoperative morbidity. Conclusion: The authors recommend the "skull bridge" to suspend the dura for optimal control of the venous sinuses during FM surgery (less venous bleeding).
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Catalytic conversion of biomass-derived value-added chemicals was of great significance for the utilization of renewable biomass resources to instead of fossil chemicals. Biomass-derived lignin was regarded as an important support and 5-hydroxymethylfurfural (HMF) was a vital platform chemical derived from cellulose. Herein, a series of lignin-MOF hybrid catalysts were prepared and modified with different heteropolyacids (HPAs), which were then successfully introduced into the selective conversion of HMF to 5-hydroxymethylfurfuryl alcohol (MFA). The effect of different HPA, calcination temperature, etc. were all studied, and all catalysts were well characterized. It was confirmed that silicotungstic acid modified catalyst (Ni3Co-MOF-LS@HSiW) exhibited the best catalytic performance, while the highest conversion of HMF was up to 100%, with the best MFA yield of 86.5%. The finding in this study could provide novel insights for the utilization of lignin and preparation of value-added biomass-derived chemicals.
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BACKGROUND: Although many risk factors for residual pain following percutaneous vertebroplasty or kyphoplasty (PVP or PKP) have been reported in many studies, research methods and cohorts differ greatly. A previous meta-analysis identified patient- and operation-specific risk factors for residual pain. This study aimed to examine the available data and identify significant risk factors for residual pain after PVP or PKP. METHODS: PubMed, EMBASE, Web of Science, and the Chinese Wanfang Database were searched for relevant research in English and Chinese, and full-text publications including patients with and without residual pain were compared. Only studies presenting odds ratios from multivariate analysis of residual pain data were considered. To evaluate the impact of the results of the selected articles, Review Manager 5.4 was used. RESULTS: Twelve publications including a total of 3120 patients met the requirements. The meta-analysis examined 10 factors associated with residual pain and categorized them as either patient- or operation-associated factors. Thoracolumbar fascia injury, intravertebral vacuum cleft, depression, and number of fractured vertebrae were all significant patient-associated parameters for residual pain. Significant operation-associated risk factors included bone cement distribution and intraoperative facet joint injury. CONCLUSIONS: In this meta-analysis, we identified several significant risk factors for residual pain after PVP or PKP. These findings may be helpful for patient counseling and surgical planning.
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Cifoplastia , Vertebroplastia , Humanos , Cifoplastia/efeitos adversos , Fatores de Risco , Vertebroplastia/efeitos adversos , Dor Pós-Operatória/etiologia , Fraturas da Coluna Vertebral/cirurgiaRESUMO
Production of 2,6-dihydroxybenzoic acid (2,6-DHBA) via enzymatic carboxylation of resorcinol by decarboxylases is of great promising but shows depressed equilibrium conversion. In this study, 2,3-dihydroxybenzoic acid decarboxylase from Aspergillus oryzae (2,3-DHBD_Ao) pushing the conversion towards carboxylation for efficient 2,6-DHBA biosynthesis was achieved. Meanwhile, a novel amino-modified and lignin-doped cellulose nanocrystal aerogel (A-LCNCA) with high specific surface area and prominent CO2 capture was prepared for 2,3-DHBD_Ao immobilization. 2,3-DHBD_Ao@A-LCNC contributed a further enhanced conversion of carboxylation with the maximal conversion of 76.2 %, which was correlated to both the activity of 2,3-DHBD_Ao and the high CO2 loading capacity of A-LCNCA. Moreover, 2,3-DHBD_Ao@A-LCNC exhibited superior performances in a wider range of temperature and higher concentrations of substrate, with a prolonged storage period longer than 30 days. After seven cycles reuse, 2,3-DHBD_Ao@A-LCNCA could retain 85.3 % of its original activity. These results suggest a considerable potential of 2,3-DHBD_Ao@A-LCNCA in the selective biosynthesis of 2,6-DHBA.
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Carboxiliases , Hidroxibenzoatos , Nanopartículas , Lignina , Dióxido de Carbono , CeluloseRESUMO
Cyclopentanol (CPL) was an eco-friendly solvent as well as important platform chemical which could be generated from biomass-derived furfural (FFA). In this paper, a series of Ni, Cu, Mo, Co bimetallic catalysts with different metals loadings supported on carbon nanotubes (CNT) were synthesized by an impregnation method for aqueous-phase hydrogenation of FFA to obtain CPL. Various effects of reaction parameters such as reaction solvent, reaction temperature, reaction time and different loading amounts of Ni over bimetallic Ni-based CNT catalysts were fully investigated. Among the catalysts studied, (15 + 5)â wt% NiCu/CNT catalysts showed a high conversion of FFA and 88% selectivity towards CPL in water and 96% selectivity towards acetal in methanol at the mild condition of 160â, 2â MPa hydrogen and 4â h reaction time. NiCu bimetallic synergistic effect was interpreted through H2-TPR and NH3-TPD measurement and a possible pathway was proposed. The features of the CNT-supported catalysts were investigated via XRD, XPS, TEM, H2-TPR and NH3-TPD. The Ni and bimetallic NiCu catalysts synthesized in this work were inexpensive and simple, which made them a promising candidate for the conversion of biomass-derived FFA to CPL.
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Soft-tissue integration (STI) plays an essential role in the long-term success of percutaneous Ti implants since it acts as a biological barrier that protects the soft and hard tissue around implants. Surface modification of Ti implants with drug-release properties to achieve soft-tissue regeneration has been proven to be effective in STI. However, the short-acting effect caused by the uncontrolled drug release of the topical delivery system limits long-term STI enhancement. Herein, a long-acting protein delivery system for Ti implants that involved micro-arc oxidation of Ti surfaces (MAO-Ti) and localized immobilization of cellular communication network factor 2 (CCN2) bearing mesoporous silica nanoparticles (MSNs) on MAO-Ti was prepared, namely, CCN2@MSNs-Ti. The CCN2 release study of CCN2@MSNs-Ti demonstrated a sustained-release profile for 21 days, which was able to maintain long-term stable STI. In addition, in vitro cell behavior evaluation results indicated that CCN2@MSNs-Ti could promote the STI-related biological response of human dermal fibroblasts via the FAK-MAPK pathway. More importantly, the system could effectively enhance STI after 4 weeks and proinflammatory factors in the soft tissue decreased significantly in a rat model of implantation. These results denote that CCN2@MSNs-Ti showed an appealing application prospect for enhanced STI around transcutaneous Ti implants, which would ultimately result in an increased success rate of percutaneous Ti implants.
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Próteses e Implantes , Titânio , Ratos , Humanos , Animais , Titânio/farmacologia , Oxirredução , Propriedades de SuperfícieRESUMO
Few studies have focused on the growth, soil quality and sustainability of medicinal plants under different soil conditions. In this study, the spatial heterogeneity of soil physical and chemical properties, the diversity of rhizosphere soil microbial community structure, and the characteristics of growth of the wild and cultivated medicinal plant, Siberian fritillary (Fritillaria pallidiflora Schrek) were analyzed, and the soil quality and ecosystem sustainability were comprehensively evaluated. The results showed that there was significant spatial variability of soil nutrients in the different habitats. Nitrate nitrogen (NO3-N) was strongly variable, while those of the soil organic carbon (SOC) and available phosphorus (AP) were moderately variable. There was little variability among the soil available potassium (AK), electrical conductivity (EC), pH and ammonium nitrogen (NH4-N). Inverse Distance Weighting spatial interpolation showed that SOC, NO3-N, NH4-H and EC were highly distributed in the southeastern part of the wild area, and the soil was more acidic in the original habitat than in the planting habitat. There was little AK and AP in the native habitat, and there was a high content in the planting habitat. Simultaneously, the soil microbial communities of the two soils also differed. The wild-type soil showed a "fungal" type, while the planted soil showed a "bacterial" type. Pathogenic bacteria were among the primary microflora in the planting area. In general, it is difficult to maintain the sustainable development and geo-herbalism of F. pallidiflora in today's cultivation mode because of the significant differences in soil nature, spatial heterogeneity and microbial community structure for the growth of F. pallidiflora. Therefore, future planting should focus on transforming it from intensive to mountain forest planting. This is highly significant for improving the planting efficiency of F. pallidiflora, protecting their geo-herbalism and germplasm resources, and maintaining the stability and sustainable development of the ecosystem.
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Fritillaria , Microbiota , Plantas Medicinais , Solo/química , Fritillaria/química , Carbono , Bactérias , Nitrogênio/análise , Microbiologia do SoloRESUMO
To improve the flame retardancy of phenolic foam from the perspective of sustainable development, it is a feasible way to add bio-based flame retardants into phenolic foam. Lignin has a similar structure to phenol, which provides a possibility to replace part of phenol. In this paper, we prepared a kind of reactive bio-based flame retardant based on enzymatic hydrolyzed lignin, in which side chain was chemically grafted with phosphorus and nitrogen and benzene ring would participate in the phenolic condensation reaction. According to elemental analysis and ICP-OES data, the content of nitrogen and phosphorus in modified lignin (NP-L) increased to 2.95% and 3.55% respectively. Compared with original lignin, the carbon residue rate of NP-L increased from 3.25% to 12.13% because of the presence of flame retardant elements N and P. Then lignin-based flame retardant was used to replace phenol for modifying phenolic foams (NPLPFX). The limited oxygen index (LOI) and compressive strength of phenolic foam were improved effectively by adding modified lignin when the substitution rate was less than 25%. The LOI and compressive strength of the modified phenolic foam with 5% replacement amount (NPLPF5) are 55.6% and 0.24 MPa, which increased by 88% and 60% compared with pure phenolic foam. The cone calorimetric data also showed that NPLPF5 had good flame retardancy, and the peak heat release rate and total heat release were significantly lower than PF. This work suggests a novel green strategy for improving the flame retardancy performance of phenolic foam and promoting the utilization of lignin.
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The identification of coal gangue is of great significance for its intelligent separation. To overcome the interference of visible light, we propose coal gangue recognition based on multispectral imaging and Extreme Gradient Boosting (XGBoost). The data acquisition system is built in the laboratory, and 280 groups of spectral data of coal and coal gangue are collected respectively through the imager. The spectral intensities of all channels of each group of spectral data are averaged, and then the dimensionality is reduced by principal component analysis. XGBoost is used to identify coal and coal gangue based on the reduced dimension spectral data. The results show that PCA combined with XGBoost has the relatively best classification performance, and its recognition accuracy of coal and coal gangue is 98.33%. In this paper, the ensemble-learning algorithm XGBoost is combined with spectral imaging technology to realize the rapid and accurate identification of coal and coal gangue, which is of great significance to the intelligent separation of coal gangue and the intelligent construction of coal mines.
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Carvão MineralRESUMO
Baicalin (BG) is a bioactive flavonoid extracted from the dried root of the medicinal plant, Scutellaria radix (SR) (dicotyledonous family, Labiatae), and has several biological activities. Polyethylene glycol 400 (PEG400) has been used as a suitable solvent for several traditional Chinese medicines (TCM) and is often used as an excipient for the compound preparation of SR. However, the drug-excipient interactions between BG and PEG400 are still unknown. Herein, we evaluated the effect of a single intravenous PEG400 administration on the BG levels of rats using pharmacokinetic and tissue distribution studies. A liver microsome and recombinant enzyme incubation system were used to further confirm the interaction mechanism between PEG400 and UDP-glucuronosyltransferases (UGTs) (UGT1A8 and UGT1A9). The pharmacokinetic study demonstrated that following the co-intravenous administration of PEG400 and BG, the total clearance (CLz) of BG in the rat plasma decreased by 101.60% (p < 0.05), whereas the area under the plasma concentration-time curve (AUC)0-t and AUC0-inf increased by 144.59% (p < 0.05) and 140.05% (p < 0.05), respectively. Additionally, the tissue distribution study showed that the concentration of BG and baicalein-6-O-ß-D-glucuronide (B6G) in the tissues increased, whereas baicalein (B) in the tissues decreased, and the total amount of BG and its metabolites in tissues altered following the intravenous administration of PEG400. We further found that PEG400 induced the UGT1A8 and UGT1A9 enzyme activities by affecting the maximum enzymatic velocity (Vmax) and Michaelis-Menten constant (Km) values of UGT1A8 and UGT1A9. In conclusion, our results demonstrated that PEG400 interaction with UGTs altered the pharmacokinetic behaviors and tissue distribution characteristics of BG and its metabolites in rats.
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Flavonoides , Polietilenoglicóis , UDP-Glucuronosiltransferase 1A , Animais , Ratos , Flavonoides/administração & dosagem , Flavonoides/química , Flavonoides/farmacocinética , Microssomos Hepáticos/metabolismo , Polietilenoglicóis/química , Distribuição Tecidual , Injeções Intravenosas , UDP-Glucuronosiltransferase 1A/metabolismoRESUMO
Dental implants are widely used to restore missing teeth because of their stability and comfort characteristics. Peri-implant infection may lead to implant failure and other profound consequences. It is believed that peri-implantitis is closely related to the formation of biofilms, which are difficult to remove once formed. Therefore, endowing titanium implants with anti-adhesion properties is an effective method to prevent peri-implant infection. Moreover, anti-adhesion strategies for titanium implant surfaces are critical steps for resisting bacterial adherence. This article reviews the process of bacterial adhesion, the material properties that may affect the process, and the anti-adhesion strategies that have been proven effective and promising in practice. This article intends to be a reference for further improvement of the antibacterial adhesion strategy in clinical application and for related research on titanium implant surfaces.
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With the wide application of autonomous mobile robots (AMRs), the visual inertial odometer (VIO) system that realizes the positioning function through the integration of a camera and inertial measurement unit (IMU) has developed rapidly, but it is still limited by the high complexity of the algorithm, the long development cycle of the dedicated accelerator, and the low power supply capacity of AMRs. This work designs a reconfigurable accelerated core that supports different VIO algorithms and has high area and energy efficiency, precision, and speed processing characteristics. Experimental results show that the loss of accuracy of the proposed accelerator is negligible on the most authoritative dataset. The on-chip memory usage of 70 KB is at least 10× smaller than the state-of-the-art works. Thus, the FPGA implementation's hardware-resource consumption, power dissipation, and synthesis in the 28 nm CMOS outperform the previous works with the same platform.
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Bacterial contamination and biofilm formation onpercutaneous implants can lead to device failure and be life-threatening. To solve this issue, we constructed a carboxymethyl dextran- (CMD-) based nanomicelle antibacterial coating on the microarc-oxidized titanium (MAO-Ti) surface (described in the supplementary file). The self-assembled CMD-based nanomicelles and octadecylamine (ODA) were developed as a drug carrier and loaded with minocycline (MC). The characterization and stability of the MC-loaded nanomicelles were determined. The surface roughness, hydrophilicity, and drug release property of the coatings were also investigated. Our findings showed that the cross-linked MC-loaded nanomicelles (MC@(ODA-CMD)CL) were more stable than the uncross-linked nanomicelles. Moreover, MC@(ODA-CMD)CL was successfully incorporated into the pores of MAO-Ti, which significantly increased the surface hydrophilicity of the coatings without influencing their surface roughness. In addition, the coatings demonstrated a sustained release time of 360 h, with a cumulative release rate reaching 86.6%. Staphylococcus aureus (S. aureus) was used to determine the antibacterial properties of the coatings, and human skin fibroblasts were seeded on them to investigate their biocompatibility. The results showed that the coatings significantly reduced the number of adhesive S. aureus and promoted the viability, adhesion, and morphology of the human skin fibroblasts compared to smooth titanium (S-Ti) sheets. In conclusion, MC-loaded CMD-based nanomicelles coated on MAO-Ti surface (MC@(ODA-CMD)CL-Ti) demonstrated sustained-release properties, excellent antibacterial properties and biocompatibility, and promising potential as coatings for percutaneous implants.
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Infecções Estafilocócicas , Titânio , Antibacterianos/farmacologia , Materiais Revestidos Biocompatíveis/farmacologia , Dextranos , Liberação Controlada de Fármacos , Humanos , Minociclina , Monoaminoxidase , Staphylococcus aureus , Propriedades de Superfície , Titânio/farmacologiaRESUMO
A prosthesis for a patient with a complete auricle defect can be fabricated with computer-aided design and computer-aided manufacturing, significantly reducing the number of patient visits and improving the efficiency of the production process. This technique provides a digital workflow for designing virtual patterns and negative molds for an auricular prosthesis.
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BACKGROUND: To estimate the effects of different intensities of intermittent pneumatic soft-tissue compression on bone defect repair in an animal model. METHODS: Five mm radial bone defect in length was made in 64 mature New Zealand rabbits and all animals randomly assigned into four groups: Group A (control group without compression), Group B (5-7 kPa intensity), Group C (8-10 kPa intensity) and Group D (11-13 kPa intensity). On the fourth day after surgery, their legs were intermittently pneumatic compressed for 4 weeks. The stimulation lasted 30 min every day and the frequency of compression was 15 Hz. New bone formation in 4 groups was evaluated by gross observation, X-ray, Micro-CT, and histological staining at 2 and 4 weeks after surgery. RESULT: There was more new bony callus in the bone defect in group C than in other groups by gross observation and X-ray radiography at 2 and 4 weeks. The Micro-CT results showed more new bony callus, bone trabecula and higher bone mineral density in group C. Fluorescent labeling results showed the speed of new bone formation in Group C was faster than that in other groups, among which the control group had the slowest speed of new bone formation. The result of histology had shown that the trabeculae in bone callus in group C had a regular form, the trabeculae were wide and had a more become osteoblast around them. CONCLUSION: The intermittent pneumatic soft-tissue compression can accelerate new bone formation of bone defects and the optimal intensity is 8-10 kPa for repairing the rabbit radial bone defect.
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Procedimentos de Cirurgia Plástica , Rádio (Anatomia) , Animais , Artrodese , Calo Ósseo/diagnóstico por imagem , Humanos , Coelhos , Rádio (Anatomia)/diagnóstico por imagem , Rádio (Anatomia)/cirurgia , Microtomografia por Raio-XRESUMO
Multispectral and hyperspectral image fusion (MS/HS fusion) aims to fuse a high-resolution multispectral (HrMS) and a low-resolution hyperspectral (LrHS) images to generate a high-resolution hyperspectral (HrHS) image, which has become one of the most commonly addressed problems for hyperspectral image processing. In this paper, we specifically designed a network architecture for the MS/HS fusion task, called MHF-net, which not only contains clear interpretability, but also reasonably embeds the well studied linear mapping that links the HrHS image to HrMS and LrHS images. In particular, we first construct an MS/HS fusion model which merges the generalization models of low-resolution images and the low-rankness prior knowledge of HrHS image into a concise formulation, and then we build the proposed network by unfolding the proximal gradient algorithm for solving the proposed model. As a result of the careful design for the model and algorithm, all the fundamental modules in MHF-net have clear physical meanings and are thus easily interpretable. This not only greatly facilitates an easy intuitive observation and analysis on what happens inside the network, but also leads to its good generalization capability. Based on the architecture of MHF-net, we further design two deep learning regimes for two general cases in practice: consistent MHF-net and blind MHF-net. The former is suitable in the case that spectral and spatial responses of training and testing data are consistent, just as considered in most of the pervious general supervised MS/HS fusion researches. The latter ensures a good generalization in mismatch cases of spectral and spatial responses in training and testing data, and even across different sensors, which is generally considered to be a challenging issue for general supervised MS/HS fusion methods. Experimental results on simulated and real data substantiate the superiority of our method both visually and quantitatively as compared with state-of-the-art methods along this line of research.
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Enormous attention has been paid to upconverted circularly polarized luminescence (UC-CPL). However, so far, chiral species are still needed in UC-CPL materials, either through the covalent or noncovalent bond. Here, we report a general supramolecular coassembly approach for the fabrication of UC-CPL systems from completely achiral components. We have found that an achiral C3-symmetric molecule could form a chiral nanohelix through symmetry breaking, which could serve as a general helical platform to endow achiral guests with induced chirality and CPL activity. Two different photon upconversion systems, namely, triplet-triplet annihilation photon upconversion (TTA-UC) donor/acceptor pairs and inorganic lanthanide upconversion nanoparticles (UCNPs), are selected. When these two systems coassembled with the chiral nanohelix made from an achiral C3-symmetric molecule, hybrid nanohelix structures formed and UC-CPL activity was induced. Through such an approach, we demonstrated that the fabrication of the UC-CPL materials does not require any chiral molecules. Moreover, we have shown that the polarization of UC-CPL can be tuned by the helicity of the nanohelix, which could be controlled through the seeded vortex. Our work provides a general approach for designing tunable UC-CPL materials from completely achiral motifs, which largely expands the research scope of the CPL materials.
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As an attractive renewable carbon resource, lignocellulose could be exploited to produce high-value-added products. Notably, comprehensive utilization of lignocelluloses and lignin first exploitation is still a challenge during bio-refinery process. In this study, an environmentally benign extraction method via hydrothermal-deep eutectic solvents pretreatment was proposed to separate hemicelluloses and high purity of lignin simultaneously from moso bamboo with most of cellulose retaining in the residues. Hemicelluloses were firstly removed by hydrothermal pretreatment, following with lignin extraction by DESs which was prepared from choline chloride and lactic acid, betaine and lactic acid, respectively. Notably, 98.2 wt% of hemicelluloses were degraded and mainly converted into pentose. Meanwhile, 80.1 wt% of delignification was achieved under the optimum condition (CC/LA, 140â, 6 h), following with up to 99.49% of lignin purity. The mass balance evaluation demonstrated that the combined hydrothermal-deep eutectic solvents pretreatment is a potential method for efficient fractionation of lignocellulose.