Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study.

OBJECTIVE: The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population. METHODS: The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models. RESULTS: A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices). CONCLUSION: An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women.

High-resolution observation and analysis of the I2+ A2Π(3/2,u)-X2Π(3/2,g) system.

Rotationally resolved absorption spectra of I(2)(+) were recorded in 12,065-13,062 cm(-1) region by employing optical heterodyne velocity modulation absorption spectroscopy. In total, 4054 lines were assigned to 24 bands in the A(2)Π(3/2,u)-X(2)Π(3/2,g) system spanning the vibrational levels υ'' = 1-4 and υ(n)' = 11-19. The assigned lines were globally fitted and an error of 0.003 cm(-1) was obtained. Rotational constants, B(υ), were used to derive equilibrium parameters B(e)'' = 0.03977725(77) cm(-1), a(e)'' = 1.1819(24)×10(-4) cm(-1), r(e)'' = 2.584386(25) Å of the X(2)Π(3/2,g) state, and B(e)' = 0.0305787(37) cm(-1), a(e)' = 1.2353(23)×10(-4) cm(-1), r(e)' = 2.94758(18) Å of the A(2)Π(3/2,u) state. Vibrational energies were used to derive ω(e)'' = 239.0397(55) cm(-1), ω(e)x(e)'' = 0.64951(87) cm(-1) of the X(2)Π(3/2,g) state and ω(e)' = 138.103(11) cm(-1), ω(e)x(e)' = 0.45027(34) cm(-1) of the A(2)Π(3/2,u) state. The A(2)Π(3/2,u) (υ(n) = 13) state was found to be rotationally perturbed by the a(4)Σ(1/2,u)(-) (υ(n) = 17) state through second-order spin-orbit coupling.