Evaluation of nitrate tolerance in patients with coronary heart disease by vascular ultrasonography and treadmill exercise.

The aim of this study was to evaluate nitrate tolerance in patients with coronary heart diseases by vascular ultrasonography and treadmill exercise. According to the dosage interval of isosorbide dinitrate, 66 patients with coronary heart disease were divided into group A and group B in a random, control and double-blind method. Isosorbide dinitrate was given every 6 hours in group A and every 12 hours in group B for one week. Before and after the therapeutic period, the diameters of brachial arteries were measured by vascular ultrasonography at baseline and 5 min after sublingual administration of 10 mg isosorbide dinitrate, and the treadmill exercise test was performed in all subjects. The results showed that diameters of brachial arteries were increased significantly after sublingual isosorbide dinitrate in both groups before the therapeutic period. After the therapeutic period, dilation of brachial arteries induced by sublingual isosorbide dinitrate was more marked in group B than in group A. Compared with those before the therapeutic period, sigmaST segment depression decreased and treadmill walking time increased significantly in group B but not in group A after the therapeutic period. These findings suggest that less frequent doses of isosorbide dinitrate may prevent development of nitrate tolerance, which is confirmed by vascular ultrasonography combined with treadmill exercise in patients with coronary heart disease.

Clinical significance of QT dispersion after exercise in patients with previous myocardial infarction.

To evaluate the clinical significance of QT dispersion after exercise in patients with previous myocardial infarction, QT dispersion (QTd) and corrected QTd (QTcd) were assessed with standard 12 leads electrocardiogram in 90 patients with previous myocardial infarction and 30 healthy persons before and 3 min after a treadmill exercise test. In addition, 24 h ambulatory electrocardiogram and echo-cardiography were examined in all the subjects studied. Patients were followed up for 37.25 +/- 10.71 months. The results showed that there were no significant differences in the QTd and QTcd between the patients and the controls before exercise (36.11 +/- 13.42 ms versus 34.81 +/- 12.32 ms, P>0.05, 41.22 +/- 13.49 as versus 39.91 +/- 13.56 ms, P>0.05). Compared with those before exercise, QTd and QTcd were significantly increased in the patients 3 min after the exercise test (36.11 +/- 13.42 ms versus 47.20 +/- 14.41 ms, P<0.01, 41.22 +/- 13.49 ms versus 59.57 +/- 18.90 ms, P<0.01), but not in the controls (34.81 +/- 12.32 ms versus 38.76 +/- 12.09 ms, P>0.05, 39.91 +/- 13.56 ms versus 43.27 +/- 17.77 ms, P>0.05). The incidences of abnormal contraction of the left ventricular wall, aneurysms, NYHA III class, >III class of Lown's ventricular arrhythmia classification and cardiac sudden death were significantly higher in group A with QTcd >50 ms than that of group B with QTcd <50 ms (P<0.01). These findings indicate that the increased QT dispersion after exercise in 12 standard leads electrocardiogram might be associated with high incidences of sudden cardiac death and ventricular arrhythmia in the patients with previous myocardial infarction.