1.
Org Biomol Chem
; 14(29): 7084-91, 2016 Aug 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27377480
RESUMO
3,5-Dialkyl indolizidines have been prepared in four linear steps from commercially available starting materials. The sequence involves two direct α-functionalization steps and a subsequent reductive amination and provides diastereoselective access to both C-3 epimers of the 5,9-trans-substituted indolizines. The naturally occurring indolizidines 195B and 223AB have been synthesized using this methodology.