RESUMO
Aim of this study was to analyze the state of coronary arteries in patients with acute coronary syndrome according to polymorphism of integrin ß-3 (ITGB3) gene. All patients were divided into 2 groups: carries and non-carries of PLA2 allele. Carriers of PLA2 allele compared with noncarriers had lesser grades of coronary artery stenoses but greater number of involved arteries. Carriers had more repetitive acute coronary events.
Assuntos
Síndrome Coronariana Aguda , Vasos Coronários/patologia , Integrina beta3/genética , Síndrome Coronariana Aguda/diagnóstico , Síndrome Coronariana Aguda/genética , Síndrome Coronariana Aguda/fisiopatologia , Idoso , Angiografia Coronária , Feminino , Triagem de Portadores Genéticos , Heterozigoto , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo Genético , Recidiva , Índice de Gravidade de DoençaRESUMO
PLA polymorphism of platelet integrin receptor, GpIIIa glycoprotein, (PLA polymorphism of the ITGB3 gene) is associated with the risk of myocardial infarction and CHD especially in young subjects. We analyzed ITGB3 gene polymorphism in patients with acute coronary insufficiency. It was shown that increased AP and altered blood lipid spectrum in the acute period of disease in carriers of the PLA allele (PLA1/PLA2 and PLA2/PLA2 genotypes) can be regarded as manifestations of stress reaction. The data obtained indicate that the PLA2 allele is a predictor of complications of acute coronary insufficiency. This observation is of importance for the choice of adequate therapy for the patients with this disorder.
Assuntos
Síndrome Coronariana Aguda/genética , DNA/genética , Hipertensão/epidemiologia , Integrina beta3/genética , Polimorfismo Genético , Síndrome Coronariana Aguda/complicações , Idoso , Idoso de 80 Anos ou mais , Alelos , Feminino , Genótipo , Humanos , Hipertensão/complicações , Hipertensão/genética , Incidência , Integrina beta3/metabolismo , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Federação Russa/epidemiologiaRESUMO
This study showed that monitoring arterial pressure and heart rate during a few consecutive days allows for early diagnosis of cardiovascular disorders long before manifestation of its clinical symptoms. It is maintained that atrial fibrillation and fluttering are preceded by systemic disturbances of systolic pressure regulation.
Assuntos
Adaptação Fisiológica , Fibrilação Atrial/fisiopatologia , Pressão Sanguínea , Frequência Cardíaca , Fibrilação Atrial/diagnóstico , Fibrilação Atrial/terapia , Ritmo Circadiano , Diagnóstico Precoce , Cardioversão Elétrica , Eletrocardiografia Ambulatorial , Hemodinâmica , Humanos , MasculinoRESUMO
The authors analyse effect of GPIIIA gene (PI a allele) polymorphism on the frequency of complicated coronary heart disease in patients with dyslipidemia and hypertensive disease. Specific features of ventricular repolarization (T-wave variability) in patients with acute coronary syndrome are described.