Staging of hemodynamic parameters during development of experimental arterial hypertension in rabbits.

The study analyzed changes in parameters of the central and intracardiac hemodynamics during the development of experimental arterial hypertension, which were assessed as the adaptive in nature. The development of hypertension demonstrated staging of the adaptive processes. The development of the adaptive responses was characterized by changes in the magnitude and probabilistic distribution of the hemodynamic parameters.

System analysis of changes in cardiovascular circulatory dynamics in experimental diphtheria in rabbit.

Trivariate correlation analysis of hemodynamic indices of the cardiovascular system in rabbits with diphtheria showed that adaptation of this system to direct action of diphtherin can be visualized by analysis of trivariate correlation tightness for indices of intraventricular pressure in the left and right ventricles and indices of systemic blood pressure. Using empirical production functions for systemic blood pressure indices we found that the contribution of intraventricular pressure in the left and right ventricles on blood pressure values is changed in diphtheria compared to the control. Basing on entropy analysis we established that the regimen of control over values of working intraventricular pressure in both left and right ventricles in diphtheria is changed from quasidetermined to stochastic.

Seasonal adaptation of the cardiovascular system in rabbits.

Analysis of the effects of seasonal changes in the myocardium on variability of arterial and intraventricular pressure in both ventricles showed that the objects of homeostatic regulation were the values of these parameters and their probability distribution. The adaptation mechanisms are mainly visualized by the analysis of the characteristics of probability distribution of the parameters (asymmetry and excess coefficients).