RESUMO
In acute dendritic keratitis, the lacrimal flow is increased in the affected eye but not in the normal fellow eye. After recovery the tearflow returns to normal. The lysozyme concentration in the affected and the normal fellow eye do not differ statistically significantly nor do they differ significantly from values of an age- and sex-matched control group. There is no correlation between tearflow and lysozyme concentration. These findings support the view of a constant composition of stimulated tear fluid, irrespective of tear volume produced.
Assuntos
Ceratite Dendrítica/metabolismo , Muramidase/análise , Lágrimas/metabolismo , Doença Aguda , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Ceratite Dendrítica/enzimologia , Masculino , Pessoa de Meia-Idade , Lágrimas/enzimologiaRESUMO
Fifty-nine patients with superficial herpetic keratitis were treated with 3% acyclovir ointment five times a day in combination with alpha-interferon (30 million IU/mL) or albumin-placebo once a day in a stratified double-masked clinical trial. All patients had minimal wiping of the superficial lesion to isolate virus. The healing time of the corneal ulcers was substantially lower with the combination of acyclovir and interferon than with the combination of acyclovir and placebo. Only minor toxic effects were observed. The combination of acyclovir and interferon appears to be the best presently known treatment for dendritic keratitis.