Comparative histological analysis of the alae nasi in French bulldogs with brachycephalic obstructive airway syndrome and unaffected non-brachycephalic dogs.

BACKGROUND: Brachycephalic dogs are characterised by a short and flat nose. This cranial conformation is associated with brachycephalic obstructive airway syndrome, a respiratory syndrome primarily characterised by stenotic nares, a hyperplastic soft palate and a hypoplastic trachea, among other malformations, with secondary abnormalities resulting in upper airway obstruction METHODS: In this study, we aimed to characterise and compare the histological features of tissue samples harvested from the alae nasi of French bulldogs and non-brachycephalic dogs. Samples from the alae nasi of 11 French bulldogs and 13 non-brachycephalic dogs were collected. Four-µm-thick, paraffin-embedded sections were obtained from each tissue sample and mounted on glass slides, followed by staining with haematoxylin and eosin, periodic acid-Schiff and toluidine blue for histological examination. RESULTS: The only variation observed between the samples obtained from French bulldogs and those obtained from non-brachycephalic dogs concerned the presence of cartilage in the specimens. Cartilage was absent in 10 of 11 French bulldogs but present in nine of 13 non-brachycephalic dogs; this difference was statistically significant (p < 0.05). LIMITATIONS: The findings of this study need further validation in future prospective studies. It would be useful to examine the entire nostril wing, to include additional brachycephalic breeds, a larger number of subjects spanning a wider age range and degree of stenotic nares severity, a larger tissue sample, and a broadening of the control group to include dolichocephalic and mesaticephalic dogs. CONCLUSION: This study found an absence of cartilage in French bulldog nare specimens compared to those from non-brachycephalic dogs. This absence of cartilage may contribute to brachycephalic obstructive airway syndrome, although histological examination of the entire wing of the nostrils is needed to confirm this hypothesis.

Practice patterns about the role of palliation in veterinary surgical oncology.

Whether surgical palliative therapy is appropriate for oncologic veterinary patients is an increasing concern as pet age increases because of improved care. In this study, an online survey (available for 30 days), comprising 100 questions with structured response options, was administered to 492 diplomates of the European College of Veterinary Surgeons (ECVS). The survey queried the technical, ethical, social, medical, and financial aspects of surgical palliative therapy for oncologic veterinary patients. Responses were received from 155 ECVS diplomates (31.5%, n = 155/492). Palliative surgery was a relatively common intervention in veterinary oncology, with 50% of respondents (n = 77.5/155) indicating that 75%-100% of oncological surgeries performed were palliative. The presence of metastasis was judged as a key determinant when deciding to perform palliative oncological surgery by 41% of the respondents (n = 63.5/155). The survey revealed that the most commonly performed procedures in palliative oncological surgery were marginal resection, debulking, and amputation. In contrast to human medicine, palliative limb-sparing surgery, stent placement, and embolization were rarely used in veterinary settings, mainly because of a general lack of expertise among veterinarians, elevated costs, and recourse to euthanasia. Taken together, the survey results highlight the need for appropriate guidelines in the field of oncological surgery. To establish general guidelines and direct veterinarians towards the most appropriate judgement, understanding how and what veterinary surgeons manage palliative oncological surgery and how they perceive the main ethical, social, medical, and financial concerns are essential. Such guidelines will lead to better care for ailing animals and will facilitate the path to healing for owners.