Assuntos
Dietilexilftalato/metabolismo , Ácidos Ftálicos/metabolismo , Animais , Bile/metabolismo , Biotransformação , Dieta , Cães , Masculino , Ratos , Suínos , Distribuição TecidualAssuntos
Ácidos Ftálicos/metabolismo , Animais , Cães , Fezes/análise , Meia-Vida , Masculino , Ácidos Ftálicos/urina , Ratos , Especificidade da Espécie , Suínos , Distribuição TecidualAssuntos
Hexaclorocicloexano/farmacologia , Microssomos Hepáticos/enzimologia , Fenobarbital/farmacologia , Animais , Cães , Indução Enzimática/efeitos dos fármacos , Feminino , Masculino , Microssomos Hepáticos/efeitos dos fármacos , Oxigenases de Função Mista/metabolismo , Fenobarbital/sangue , Especificidade da Espécie , Suínos , Fatores de TempoRESUMO
Miniature swine were fed brominated sesame oil at dietary levels of 0, 5, 25, 50 or 500 mg/kg of body weight for 17 weeks and brominated soybean oil at levels of 0, 5, 50 or 500 mg/kg of body weight for 28 weeks. Growth rate and food intake were decreased only at the high dose level in the brominated sesame oil study. In both studies, signs of lethargy and ataxia occurred in pigs fed the highest dose, and were probably due to a dose-related increase in serum bromine concentrations. Marked elevations in lactic dehydrogenase (LDH), serum glutamic-oxalacetic transaminase (SGOT) and serum glutamicpyruvic transaminase (SGPT) values were seen at the highest dose level with both substances and these enzyme activities were increased at the 50 mg/kg dose level in the brominated sesame oil study. Histopathologic lesions were confined to animals given the highest dose level of either oil. Marked fatty degeneration of the hepatic plate cells and renal tubular epithelial cells were seen in both studies. In the brominated sesame oil study, neutral fat was moderately increased in the myocardium of the pigs fed 500 mg/kg. However, marked diffuse accumulation of LDH, marked diffuse fatty degeneration and focal degeneration, and/or necrosis of individual or small groups of cardiac muscle fibers were seen in the group fed brominated soybean oil at 500 mg/kg. A moderate to marked testicular atrophy was also observed in this group. A dose-related accumulation of total and hexane-soluble bromine was observed in all tissues examined in both studies; the highest concentrations occurred in adipose tissue of the pigs given the highest dose level. Kidneys, livers, hearts and thyroids of these groups also contained large amounts of bromine. In pigs given the 50 mg/kg dose level, total and hexane-soluble bromine concentrations were higher in the brominated sesame oil study than in the longer brominated soybean oil study and may be responsible for the elevations in LDH, SGPT and SGOT activities in this group.