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1.
IEEE Trans Biomed Eng ; 64(4): 928-934, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-27337706

RESUMO

OBJECTIVE: Recently, we reported the development of a stent-mounted electrode array (Stentrode) capable of chronically recording neural signals from within a blood vessel with high fidelity. Preliminary data suggested incorporation of the Stentrode into the blood vessel wall was associated with improved recording sensitivity. We now investigate neointimal incorporation of the Stentrode, implanted in a cohort of sheep for up to 190 days. METHODS: Micro-CT, obtained from the Imaging and Medical Beamline at the Australian Synchrotron, and histomorphometic techniques developed specifically for evaluation of cerebral vasculature implanted with a stent-electrode array were compared as measures to assess device incorporation and vessel patency. RESULTS: Both micro-CT analysis and histomorphometry, revealed a strong correlation between implant duration and the number of incorporated stent struts. <10% (26/268) of stent struts were covered in neointima in sheep implanted for <2 weeks, increasing to >78% (191/243) between 2 and 4 weeks. Average strut-to-lumen thickness from animals implanted >12 weeks was comparable across both modalities, 339 ±15 µm measured using micro-CT and 331 ±19 µm ( n = 292) measured histologically. There was a strong correlation between lumen areas measured using the two modalities ( ), with no observation of vessel occlusion observed from any of the 12 animals implanted for up to 190 days. CONCLUSION: Micro-CT and the histomorphometric techniques we developed are comparable and can both be used to identify incorporation of a Stentrode implanted in cerebral vessels. SIGNIFICANCE: This study demonstrates preliminary safety of a stent-electrode array implanted in cerebral vasculature, which may facilitate technological advances in minimally invasive brain-computer interfaces.


Assuntos
Artérias Cerebrais/citologia , Artérias Cerebrais/diagnóstico por imagem , Técnicas de Diagnóstico Neurológico/instrumentação , Eletrodos Implantados , Stents , Animais , Prótese Vascular , Artérias Cerebrais/cirurgia , Procedimentos Endovasculares/instrumentação , Procedimentos Endovasculares/métodos , Desenho de Equipamento , Análise de Falha de Equipamento , Feminino , Implantação de Prótese , Ovinos , Tomografia Computadorizada por Raios X/métodos
2.
Nat Biotechnol ; 34(3): 320-7, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26854476

RESUMO

High-fidelity intracranial electrode arrays for recording and stimulating brain activity have facilitated major advances in the treatment of neurological conditions over the past decade. Traditional arrays require direct implantation into the brain via open craniotomy, which can lead to inflammatory tissue responses, necessitating development of minimally invasive approaches that avoid brain trauma. Here we demonstrate the feasibility of chronically recording brain activity from within a vein using a passive stent-electrode recording array (stentrode). We achieved implantation into a superficial cortical vein overlying the motor cortex via catheter angiography and demonstrate neural recordings in freely moving sheep for up to 190 d. Spectral content and bandwidth of vascular electrocorticography were comparable to those of recordings from epidural surface arrays. Venous internal lumen patency was maintained for the duration of implantation. Stentrodes may have wide ranging applications as a neural interface for treatment of a range of neurological conditions.


Assuntos
Procedimentos Endovasculares , Córtex Motor/fisiologia , Neurônios/fisiologia , Stents , Animais , Catéteres , Angiografia Cerebral/métodos , Eletrodos , Humanos , Ovinos
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