Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 19 de 19
Filtrar
Mais filtros








Base de dados
Intervalo de ano de publicação
1.
Sci Total Environ ; 730: 139182, 2020 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-32402978

RESUMO

The objectives of this research were to assess the physical properties of six different growing substrate mixtures destined for roof gardens and determine the influence of these substrates on the morphology, physiology, growth and flower quality of pansy (Viola × wittrockiana), Madagascar periwinkle (Catharanthus roseus), and Pavia lily (Longiflorum×Asiatic lilies (Lilium) 'Pavia'). Six green roof growing substrate mixtures (by volume) were used [T1: coarse tuff+fine tuff+cocopeat (5:1:4), T2:coarse tuff+medium tuff+fine tuff+cocopeat (5:5:2:8), T3: medium tuff+fine tuff+cocopeat (5:1:4), T4:medium tuff+fine tuff + peat moss (5:1:4), T5: perlite+medium tuff+fine tuff+cocopeat (5:5:2:8), and T6: lightweight expandable clay aggregates+fine tuff+cocopeat (5:1:4)]. The T6 (LECA-cocopeat) had the lowest weight at field capacity and good aeration and WHC to sustain optimal plant growth. Medium tuff-peat moss (T4) produced the highest pansy flowers number per plants. However, peat moss (T4) has been identified by environmentalists as an unsustainable media. LECA-cocopeat (T6) had a higher number of lily flowers and leaf area than T1-T4. The cost of the LECA substrate ($US 215 m-3, T6) is extremely higher than that of volcanic tuff ($US 36 m-3, T1-T4), and perlite ($US 100 m-3, T5). Overall, T6 can be an ideal option in terms of physical properties of growing substrate and flower quality but it might not be the best option for green roofs when cost is the primary concern. In addition, certain growing substrates could be used to satisfy specific growing requirements without sacrificing performance. For example, the combination of medium tuff and peat moss (T4) produced the highest pansy flower numbers per plant but required a longer period to flower (95 days). So, this growing substrate could be used where plentiful blooms are desired and the time to bloom is not a concern.


Assuntos
Desenvolvimento Vegetal , Plantas , Flores , Região do Mediterrâneo , Folhas de Planta
2.
Int J Surg Case Rep ; 67: 54-61, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32007865

RESUMO

INTRODUCTION: Lipomatous tumors of the adrenal glands are a diverse group of tumors characterized by the composition of adipose tissue. This group of tumors include myelolipomas, angiomyolipomas (AML), lipomas, and teratomas. They are usually benign, non-functioning tumors, and they account for 5% of all primary adrenal tumors. This study aimed to elucidate the management of the initial size of the adrenal mass and symptoms of presentation. We provide a succinct literature review regarding angiomyolipomas tumors of the adrenal glands. PRESENTATION OF CASES: Here, we report 5 cases of lipomatous tumors of the adrenal glands. All 5 tumors were non-functioning. Four of them were myelolipoma, and one was AML. Two cases of myelolipoma presented with flank pain, while the rest of the 3 cases presented with hypochondrium pain. Three cases of myelolipoma were managed with laparoscopic adrenalectomy, one case of myelolipoma was converted from laparoscopic to open adrenalectomy because of abdominal adhesions, and the last case was AML and was managed with open adrenalectomy. All patients had an uneventful recovery with regular follow-up. DISCUSSION: Myelolipoma, the most common lipomatous tumor of the adrenal gland, consists of a mixture of bone morrow element and adipose tissue. AML consists of a mixture of a thick-walled blood vessel, smooth muscle, and adipose tissue. They mimic many different benign and malignant tumors on radiography, and the histopathological examination is still needed to confirm the diagnosis. There is still controversy in the management of these tumors. Usually, the management is individualized on each case. Reporting of these tumors are increasing due the wide-spread use of modern imaging modalities. CONCLUSION: Adrenal lipomatous tumors are uncommon but with the increase use of imaging modalities their detection has increased. Further studies are needed to establish guidelines in the management of these tumors, especially that they can mimic malignant conditions.

3.
Gene ; 733: 144267, 2020 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-31809838

RESUMO

Genetic variations in the dopamine D4 receptor (DRD4) gene and the serotonin transporter (SLC6A4) gene are involved in the aetiology of substance abuse disorder (SUD). The main aim of this study is to evaluate the genetic association of DRD4 (48 bp-VNTR) and SLC6A4 (rs25531 and 5-HTTLPR VNTR) gene polymorphisms with SUD susceptibility among the Jordanian Arab population. This study included 500 SUD patients and 500 healthy matched controls. The VNTR Genetic polymorphisms of DRD4 and SLC6A4 genes were genotyped using conventional polymerase chain reaction (PCR). While, the rs25531 SNP was genotyped using PCR-restriction fragment length polymorphism (PCR-RFLP) technique. The genetic association was analysed using different statistical analyses including chi-square, Fisher exact test and one way ANOVA test. The DRD4 exon III VNTR polymorphism was associated with SUD significantly in case of alleles 4, 7 and genotype 7/7 (P = 0.004, 0.0005 and 0.01, respectively). While, there was no genetic association between the 5-HTTLPR (LL, LS, SS), rs25331 (AA, AG, GG) and tri-allelic (SASA, LASG, LASA, LALG, LALA) genotypes (P = 0.26, 0.71 and 0.52, respectively) and SUD. Moreover, using multinomial regression analysis, the homozygous 7/7 and 2/2 VNTR genotypes of DRD4 gene were nominally significantly associated with a lower risk of addiction (OR = 0.285 with P = 0.003 and OR = 0.447 with P = 0.031, respectively) after adjusting for other covariates. Our findings showed that 4 and 7 repeats and the genotype 7/7 of DRD4 exon III VNTRs polymorphism are involved in the aetiology of SUD among Jordanian population in compared to the 5-HTTLPR polymorphisms.


Assuntos
Receptores de Dopamina D4/genética , Proteínas da Membrana Plasmática de Transporte de Serotonina/genética , Transtornos Relacionados ao Uso de Substâncias/genética , Adulto , Alelos , Árabes/genética , Estudos de Casos e Controles , Éxons/genética , Frequência do Gene/genética , Genótipo , Homozigoto , Humanos , Jordânia/epidemiologia , Masculino , Repetições Minissatélites/genética , Polimorfismo Genético/genética , Regiões Promotoras Genéticas/genética , Receptores de Dopamina D4/metabolismo , Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo
4.
Front Microbiol ; 10: 1639, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31396175

RESUMO

Plant growth promoting rhizobacteria (PGPR) are beneficial microorganisms that can be utilized to improve plant responses against biotic and abiotic stresses. In this study, 74 halotolerant bacterial isolates were isolated from rhizosphere and endorhizosphere of durum wheat (Triticum turgidum subsp. durum) plants cultivated in saline environments in the Ghor region near the east of the Dead Sea. 16S rDNA partial sequences and phylogenetic analysis of 62 isolates showed clear clustering of the isolates into three phyla: Firmicutes (61.3%), Proteobacteria (29.0%), and Actinobacteria (9.7%). At the genus level, the majority of them were grouped within the Bacillus, Oceanobacillus, and Halomonas genera. The isolates, which possessed plant growth promoting traits including nitrogen fixation, ACC deaminase activity, auxin production, inorganic phosphate solubilization and siderophore production, were selected. The effect of the inoculation of selected PGPR strains on growth of salt sensitive and salt tolerant durum wheat genotypes under high salt stress conditions was evaluated. Six halotolerant PGPR strains were able to improve survival in inoculated plants under high salinity stress conditions as reflected in higher germination percentages and seedling root growth when compared with non-inoculated plants. Furthermore, three halotolerant PGPR strains were able to improve durum wheat tolerance to water deficit stress. In addition, antagonistic effect in four halotolerant PGPR strains against an aggressive pathogenic isolate of Fusarium culmorum that causes crown rot disease was observed in a dual culture assay. In conclusion, the halotolerant PGPR strains described in this study might have great potential to improve durum wheat productivity under different stress conditions.

5.
J Orthod Sci ; 7: 23, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30547019

RESUMO

OBJECTIVE: To evaluate the effect of different surface treatments and bonding modalities on the shear bond strength (SBS) between metallic orthodontic brackets and zirconia crowns. MATERIALS AND METHODS: Sixty zirconia specimens were computer-aided design/computer-aided manufacturing milled, sintered, glazed, and embedded in acrylic resin. The specimens were divided into three groups according to the surface treatment applied: C: no surface treatment (control), S: sandblasted with 50 µm Al2O3, and D: Sof-Lex disc roughening. Each group was further subdivided into two subgroups according to the resin cement used: P: Clearfil Ceramic Primer + Panavia F2.0 (Kuraray) and R: RelyX U200 (3M/ESPE). Metallic orthodontic brackets were bonded to the labial surface of the specimens. All specimens underwent thermocycling. SBS test was applied using a universal test machine at a cross head speed of 1 mm/min. Data were analyzed using Mann-Whitney test (α = 0.05). RESULTS: Subgroup SP showed the highest SBS (20.8 ± 4.8 MPa), followed by subgroups SR (16.7 ± 4.6 MPa), DP (12.3 ± 2.8 MPa), and DR (11.6 ± 3 MPa). However, all specimens in the control group underwent debonding during thermocycling. The different surface treatment groups showed highly significant differences (P < 0.05), whereas the resin cement subgroups showed no significant differences (P > 0.05). CONCLUSION: SBS between glazed zirconia crowns and metallic brackets strongly depended on the surface treatment applied. Sandblasting achieved the highest SBS. Roughening with Sof-Lex disc proved to be a reliable surface treatment modality for glazed zirconia. Bonding to untreated glazed zirconia surfaces led to bond failure. Both resin cements yielded strong SBS results.

6.
Int J Mol Sci ; 15(11): 19499-515, 2014 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-25350113

RESUMO

Increasing cuticular wax accumulation in plants has been associated with improving drought tolerance in plants. In this study, a cDNA clone encoding the SlSHN1 transcription factor, the closest ortholog to WIN/SHN1 gene in Arabidopsis, was isolated from tomato plant. Expression analysis of SlSHN1 indicated that it is induced in response to drought conditions. The over-expression of SlSHN1 in tomato under the control of the constitutive CaMV 35S promoter produced plants that showed mild growth retardation phenotype with shiny and dark green leaves. Scanning electron microscopy showed that the over-expression of SlSHN1 in tomato resulted in higher cuticular wax deposition on leaf epidermial tissue when compared to non-transformed plants. Expression analysis in transgenic lines over-expressing SlSHN1 indicated that several wax-related synthesis genes were induced. Transgenic tomato plants over-expressing SlSHN1 showed higher drought tolerance when compared with wild type plants; this was reflected in delayed wilting of transgenic lines, improved water status and reduced water loss rate when compared with wild type plants. In conclusion, the SlSHN1 gene can modulate wax accumulation and could be utilized to enhance drought tolerance in tomato plant.


Assuntos
Adaptação Fisiológica/genética , Secas , Expressão Gênica , Genes de Plantas , Lycopersicon esculentum/genética , Lycopersicon esculentum/metabolismo , Ceras/metabolismo , Sequência de Aminoácidos , Regulação da Expressão Gênica de Plantas , Dados de Sequência Molecular , Fenótipo , Filogenia , Folhas de Planta/metabolismo , Folhas de Planta/ultraestrutura , Plantas Geneticamente Modificadas , Alinhamento de Sequência
7.
Antimicrob Agents Chemother ; 58(7): 4238-41, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24820083

RESUMO

In vitro activity of the aminoglycoside 6'-N-acetyltransferase type Ib [AAC(6')-Ib] was inhibited by ZnCl2 with a 50% inhibitory concentration (IC50) of 15 µM. Growth of Acinetobacter baumannii or Escherichia coli harboring aac(6')-Ib in cultures containing 8 µg/ml amikacin was significantly inhibited by the addition of 2 µM Zn(2+) in complex with the ionophore pyrithione (ZnPT).


Assuntos
Acetiltransferases/antagonistas & inibidores , Acinetobacter baumannii/enzimologia , Amicacina/farmacologia , Cloretos/farmacologia , Escherichia coli/enzimologia , Compostos de Zinco/farmacologia , Antibacterianos/farmacologia , Farmacorresistência Bacteriana/efeitos dos fármacos , Ionóforos/farmacologia , Testes de Sensibilidade Microbiana , Piridinas/farmacologia , Tionas/farmacologia
8.
Genet Mol Res ; 12(4): 5283-8, 2013 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-24301789

RESUMO

Farmers in northern parts of Pakistan face severe shortage of green forage for their livestock during the harsh winter season. Winter wheat has the potential to be used as a dual-purpose crop for forage plus grain production in these areas. Ten elite winter wheat lines from Oklahoma State University were evaluated at Hazara Research Station Abbottabad under unclipped and clipped treatment level during 2005-06. The material was planted in a randomized complete block design with three replications, with a row length of four meters and a row to row space of 25 cm. Data were recorded on green forage yield, plant height, spike length, spikelets/spike, days to maturity, spike weight, biological weight, and grain yield. Analysis of variance indicated significant differences among genotypes for all traits except spike length. Similarly all traits except spikelets/spike exhibited significant differences between unclipped and clipped treatment levels. Genotype x clipping interaction was non-significant for all traits except grain yield. Overall, winter wheat lines OK98G508W and OK00611W performed better for important traits such as early maturity, biological yield and grain yield, although over-environment testing is needed before recommendations can be made to the farmers.


Assuntos
Agricultura , Estações do Ano , Triticum/fisiologia , Grão Comestível
9.
Bioorg Med Chem Lett ; 23(20): 5694-8, 2013 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-24011645

RESUMO

AAC(6')-Ib is an important aminoglycoside resistance enzyme to target with enzymatic inhibitors. An in silico screening approach was used to identify potential inhibitors from the ChemBridge library. Several compounds were identified, of which two of them, 4-[(2-{[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl}phenoxy)methyl]benzoic acid and 2-{5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl}benzoic acid, showed micromolar activity in inhibiting acetylation of kanamycin A. These compounds are predicted to bind the aminoglycoside binding site of AAC(6')-Ib and exhibited competitive inhibition against kanamycin A.


Assuntos
Acetiltransferases/antagonistas & inibidores , Inibidores Enzimáticos/química , Bibliotecas de Moléculas Pequenas/química , Acetiltransferases/metabolismo , Sítios de Ligação , Inibidores Enzimáticos/metabolismo , Canamicina/química , Canamicina/metabolismo , Cinética , Simulação de Acoplamento Molecular , Ligação Proteica , Estrutura Terciária de Proteína , Bibliotecas de Moléculas Pequenas/metabolismo
10.
Saudi Med J ; 25(3): 373-5, 2004 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-15048181

RESUMO

We report here a rare concurrence of medullary and papillary carcinomas of the thyroid in a 39-year-old Saudi male. He presented with a solitary nodule of the right thyroid lobe and underwent total thyroidectomy based on the cytological diagnosis of papillary carcinoma. Subsequent detailed histopathologic examination of the thyroid revealed 2 different types of malignancies in the 2 lobes papillary cancer in the right and medullary cancer in the left lobe. A single small lymph node showed metastatic replacement by both cancers. The extreme rarity and the interesting pathological features of such combinations are discussed.


Assuntos
Carcinoma Medular/patologia , Carcinoma Papilar/patologia , Linfonodos/patologia , Neoplasias da Glândula Tireoide/patologia , Nódulo da Glândula Tireoide/patologia , Adulto , Humanos , Metástase Linfática , Masculino , Nódulo da Glândula Tireoide/cirurgia , Tireoidectomia
11.
Ann Saudi Med ; 15(3): 276-7, 1995 May.
Artigo em Inglês | MEDLINE | ID: mdl-17590580
12.
Clin Nutr ; 10(6): 342-7, 1991 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16839942

RESUMO

Several methods have been propsed to assess nutritional status of patients in relation to post-operative complications including instant nutritional assessment (INA) and prognostic nutritional index (PNI). Weight loss (WL) has also been related to post-operative morbidity. A prospective study was conducted to evaluate the prognostic ability of INA, PNI and WL in 300 patients affected by major and semi-major surgeries. Post-operative sepsis occurred in 28 (9.3%) patients. Of the 300 patients studied, 91 (30.2%) had WL 10%; 12 patients were septic. Of the 28 septic patients indentified, 24 (85.7%) were within the high-risk group as identified by PNI characterisation. When both serum albumin and total lymphocyte count were abnormal, sepsis rate was 100%. All methods had a Youden index greater than one. Therefore, WL should be the first parameter assessed, and if WL is > 10%, then INA can be used to assess the patient further.

13.
Ann Saudi Med ; 11(4): 381-4, 1991 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-17590752

RESUMO

Twenty-six (26) transsphincteric anal fistulate with secondary high extension and sixteen (16) suprasphincteric anal fistulate with secondary high extensions have been treated successfully over a period of 3 years. The operative technique depends on exploration of the intersphincteric plane with removal of the primary source of the infection, together with excision of the primary tract, and drainage of he secondary high extensions. The patients have been followed for 2 years without recurrence. Continence for flatus and liquid feces was 92.1% and 96.15%, respectively, in the transsphincteric and 75% and 93.75%, respectively, in the suprasphincteric group but the continence for solid feces was 100% in both. Thus, the so-called excision technique for treatment of high fistula is safe and results are excellent.

14.
Ann Saudi Med ; 11(1): 73-9, 1991 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17588060

RESUMO

Hemorrhoid is a common anal problem in our country that is currently treated by many different methods. Three modalities were assessed in a randomized prospective trial in which 848 patients with a second-degree hemorrhoid were treated by rubber band ligation (470 patients), injection sclerotherapy (280 patients), or cryosurgery (98 patients). The effectiveness of each method was assessed clinically at 3, 6, 9, and 12 months after initial treatment, and determined by improvement in presenting symptoms. All patients complained of rectal bleeding and prolapse of the hemorrhoid on defecation, but only 69% had anal pain and 14% suffered from pruritus ani. Rubber band ligation was found to be superior to the other methods, and displayed statistical significance when compared to injection sclerotherapy and cryosurgery.

15.
Clin Sci (Lond) ; 79(2): 139-47, 1990 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-1975227

RESUMO

1. The effect of dexamethasone (30 micrograms day-1 100 g-1 body weight) on the regulation of glutamine metabolism was studied in skeletal muscles of rats after 9 days of treatment. 2. Dexamethasone resulted in negative nitrogen balance, and produced increases in the plasma concentrations of alanine (23.4%) and insulin (158%) but a decrease in the plasma concentration of glutamine (28.7%). 3. Dexamethasone treatment increased the rate of glutamine production in muscle, skin and adipose tissue preparations, with muscle production accounting for over 90% of total glutamine produced by the hindlimb. 4. Blood flow and arteriovenous concentration difference measurements across the hindlimb showed an increase in the net exchange rates of glutamine (25.3%) and alanine (90.5%) in dexamethasone-treated rats compared with corresponding controls. 5. Dexamethasone treatment produced significant decreases in the concentrations of skeletal muscle glutamine (51.8%) and 2-oxoglutarate (50.8%). The concentrations of alanine (16.2%), pyruvate (45.9%), ammonia (43.3%) and inosine 5'-phosphate (141.8%) were increased. 6. The maximal activity of glutamine synthetase was increased (21-34%), but there was no change in that of glutaminase, in muscles of dexamethasone-treated rats. 7. It is concluded that glucocorticoid administration enhances the rates of release of both glutamine and alanine from skeletal muscle of rats (both in vitro and in vivo). This may be due to changes in efflux and/or increased intracellular formation of glutamine and alanine.


Assuntos
Dexametasona/farmacologia , Glutamina/metabolismo , Músculos/metabolismo , Alanina/metabolismo , Aminoácidos/análise , Animais , Técnicas de Cultura , Glutamato-Amônia Ligase/metabolismo , Glutaminase/metabolismo , Membro Posterior , Masculino , Músculos/efeitos dos fármacos , Ratos , Ratos Endogâmicos
16.
J Lab Clin Med ; 115(6): 660-8, 1990 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-2366030

RESUMO

The intestinal metabolism of glucose and glutamine was studied in rats made septic by cecal ligation and puncture technique. Sepsis resulted in negative nitrogen balance and produced increases in the concentrations of blood pyruvate, lactate, alanine, and glutamine, and decreases in those of 3-hydroxybutyrate and acetoacetate. Both plasma insulin and glucagon concentrations were increased by 2.2- and 3.2-fold in septic rats, respectively. Portal-drained visceral blood flow increased in septic rats, and was accompanied by a decrease in the rates of utilization of glutamine and production of lactate, glutamate, and ammonia compared with those rates in sham-operated animals. Enterocytes isolated from septic rats showed decreased rates of glucose and glutamine utilization compared with cells isolated from corresponding controls. The maximal activities of hexokinase, 6-phosphofructokinase, pyruvate kinase, and glutaminase were decreased in intestinal mucosal scrapings of septic rats. It is concluded that a moderate form of sepsis decreases the rates of glucose and glutamine utilization (both in vivo and in vitro) by the epithelial cells of the small intestine. This may be caused by changes in the maximal activities of key enzymes in the pathways of glucose and glutamine metabolism in these cells as a metabolic adaptation to spare glucose and glutamine for use by other tissues.


Assuntos
Infecções Bacterianas/metabolismo , Glucose/metabolismo , Glutamina/metabolismo , Intestino Delgado/metabolismo , Peritonite/metabolismo , Animais , Artérias , Infecções Bacterianas/microbiologia , Peso Corporal , Células Cultivadas , Ciclo do Ácido Cítrico , Glicólise , Mucosa Intestinal/metabolismo , Intestino Delgado/irrigação sanguínea , Masculino , Peritonite/microbiologia , Ratos , Ratos Endogâmicos , Fluxo Sanguíneo Regional , Veias
17.
Burns ; 16(1): 36-40, 1990 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-2322393

RESUMO

A prospective study was conducted on paediatric thermal injury patients admitted to the Burns Unit at King Fahd Hospital, Jeddah, Saudi Arabia over a 2-year period (December 1985 to December 1987). A total of 197 patients (out of 319) were paediatric, aged up to 18 years. Infants and toddlers accounted for 59.4 per cent and adolescents for 14.2 per cent. Scalding and flame injuries accounted for 98 per cent with most injuries occurring at home (97.5 per cent) and the overall paediatric mortality rate was 4.4 per cent.


Assuntos
Queimaduras/epidemiologia , Acidentes Domésticos , Adolescente , Fatores Etários , Superfície Corporal , Queimaduras/etiologia , Queimaduras/mortalidade , Queimaduras/terapia , Queimaduras Químicas/epidemiologia , Queimaduras por Corrente Elétrica/epidemiologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Estudos Prospectivos , Arábia Saudita/epidemiologia , Estações do Ano , Sepse/mortalidade , Fatores Sexuais , Transplante de Pele
18.
J Lab Clin Med ; 114(5): 579-86, 1989 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-2681481

RESUMO

The regulation of hepatic gluconeogenesis was studied in rats made septic by cecal-ligation and puncture technique. Blood glucose was not significantly different in septic rats, but lactate, pyruvate, and alanine were markedly increased. Conversely, blood ketone body concentrations were markedly decreased in septic rats. Both plasma insulin and glucagon were markedly elevated in septic rats. The maximal activities of glucose 6-phosphatase, fructose 1,6-biphosphatase, pyruvate carboxylase, and phosphenolpyruvate carboxykinase were decreased in livers obtained from septic rats suggesting a diminished hepatic gluconeogenesis. Hepatic concentrations of lactate, pyruvate, and other gluconeogenic intermediates were markedly increased in septic rats, whereas those of fructose 2,6-bisphosphate and acetyl-CoA were decreased. The rate of gluconeogenesis from added lactate, pyruvate, alanine, and glutamine was decreased in isolated incubated hepatocytes from septic rats. It is concluded that the diminished capacity of hepatic gluconeogenesis of septic rats could be the result of changes in the maximal activities or regulation of key nonequilibrium gluconeogenic enzymes or both but do not exclude other factors (e.g., toxins).


Assuntos
Infecções Bacterianas/metabolismo , Gluconeogênese , Fígado/metabolismo , Alanina/sangue , Animais , Glicemia/análise , Temperatura Corporal , Peso Corporal , Ácidos Graxos não Esterificados/sangue , Glucagon/sangue , Hemodinâmica , Insulina/sangue , Corpos Cetônicos/sangue , Lactatos/sangue , Fígado/enzimologia , Masculino , Tamanho do Órgão , Piruvatos/sangue , Ácido Pirúvico , Ratos , Ratos Endogâmicos
19.
Burns ; 15(5): 295-8, 1989 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-2590402

RESUMO

Three hundred and nineteen patients with different types of burns were studied at King Fahd Hospital, Jeddah, Saudi Arabia over a 2-year period (December, 1985 to December, 1987). Scalding was the most common cause (56.4 per cent) of burn injuries compared with 41.4 per cent of patients who sustained flame injury; 84.6 per cent of the thermal injuries occurred at home, with children (less than or equal to 18 years of age) being affected most frequently (61.8 per cent). The overall mortality was 9.4 per cent.


Assuntos
Unidades de Queimados/estatística & dados numéricos , Queimaduras/epidemiologia , Países em Desenvolvimento , Unidades de Terapia Intensiva/estatística & dados numéricos , Adolescente , Adulto , Queimaduras/etiologia , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Incidência , Lactente , Masculino , Pessoa de Meia-Idade , Arábia Saudita/epidemiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA