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1.
Gastroenterol Rep (Oxf) ; 11: goac081, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36686571

RESUMO

Background: In colonoscopy screening for colorectal cancer, human vision limitations may lead to higher miss rate of lesions; artificial intelligence (AI) assistance has been demonstrated to improve polyp detection. However, there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during colonoscopy. In this study, we aimed to compare the effectiveness of assistance from AI and human observer during colonoscopy. Methods: A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in China. Eligible patients were randomized to either computer-aided detection (CADe)-assisted group or observer-assisted group. The primary outcome was adenoma per colonoscopy (APC). Secondary outcomes included polyp per colonoscopy (PPC), adenoma detection rate (ADR), and polyp detection rate (PDR). We compared continuous variables and categorical variables by using R studio (version 3.4.4). Results: A total of 1,261 (636 in the CADe-assisted group and 625 in the observer-assisted group) eligible patients were analysed. APC (0.42 vs 0.35, P = 0.034), PPC (1.13 vs 0.81, P < 0.001), PDR (47.5% vs 37.4%, P < 0.001), ADR (25.8% vs 24.0%, P = 0.464), the number of detected sessile polyps (683 vs 464, P < 0.001), and sessile adenomas (244 vs 182, P = 0.005) were significantly higher in the CADe-assisted group than in the observer-assisted group. False detections of the CADe system were lower than those of the human observer (122 vs 191, P < 0.001). Conclusions: Compared with the human observer, the CADe system may improve the clinical outcome of colonoscopy and reduce disturbance to routine practice (Chictr.org.cn No.: ChiCTR1900025235).

2.
Environ Res ; 221: 115308, 2023 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-36646199

RESUMO

The heteroatoms and transition metal co-doped carbon-based catalysts are an important way to improve the catalytic activity of oxygen reduction reaction (ORR). Herein, we reported a facile method to obtain iron, nitrogen, and sulfur co-doped cellulose paper carbon fibers as catalysts (Fe-N-S/CFs) for ORR in microbial fuel cells (MFCs) with the adsorption recovery of Congo red molecules from dye wastewater. The thermal treatment promoted the etching of carbon surface by ferric ions, resulting in increased surface roughness for forming the defective carbon structure. The rich active species and defective carbon formed on the etched surface to enhance the electroactive surface area and effective sites. Fe-N-S/CFs catalysts achieved high half-wave potential due to the synergy effect between chemical components and defect structures. The assembled single-chamber air cathode MFC gained a high maximum power density of 1773 ± 40 mW m-2 versus Pt/C MFC of 1325 ± 94 mW m-2. This work provides a strategy for recovering dye molecules from wastewater to prepare non-precious metal catalysts for enhancing ORR activity.

3.
J Colloid Interface Sci ; 636: 627-636, 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36680953

RESUMO

The development of electronic information technology has placed higher demands on microwave absorption materials (MAMs), especially the exploration of novel MAMs to broaden their application. At present, little attention has been given the wave absorption properties of transition metal borides (TMBs). In this work, a simple and economical method is developed to prepare Ni3B/Ni heterostructure nanosheets and their possible applications for microwave absorption (MA) and supercapacitor are evaluated. It is worth noting that Ni3B/Ni nanosheets exhibit excellent MA properties due to the aggregated nanosheet-like morphology of Ni3B/Ni with enhancing interfacial polarization, as well as the synergistic effect of dielectric and magnetic losses. It is observed in experiments that the minimum reflection loss value of Ni3B/Ni is -41.60 dB at 16.8 GHz. Moreover, the maximum effective absorption bandwidth can reach 3.28 GHz. Furthermore, Ni3B/Ni has good energy storage characteristics and is able to provide a specific capacity of 1150.6F g-1 at a current density of 1 A g-1. Meanwhile, it has the ability to maintain an initial capacity of 74.4 % after 1000 cycles at a current density of 10 A g-1. Therefore, this study provides an idea to explore TMBs as high-performance MA and supercapacitor materials.

4.
Materials (Basel) ; 16(2)2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36676410

RESUMO

Nickel-aluminum bronze (NAB) is widely used to fabricate flow-handling components because of its good cavitation corrosion (CE) resistance and superior casting property. The existence of different phases, e.g., the α phase, ß phase and κ phase, can cause significant selective phase corrosion on NAB. However, under the action of CE with different times, the influence of these phases on the corrosion behavior of NAB, including selective phase corrosion and uniform corrosion, needs to be further studied, which can contribute to a deep understanding of the CE mechanism of NAB in corrosive media. In this work, the corrosion behavior of NAB in 3.5 wt.% NaCl solution after different CE times was evaluated by electrochemical noise (EN), combined with scanning Kelvin probe force microscopy (SKPFM) and morphology analysis. The results showed that the corrosion behavior of NAB was closely associated with the variation in its complex microstructure after different CE times. Selective phase corrosion played a crucial role in the surface damage before 0.5 h of CE. With the prolongation of CE time, the stripping of κ phases decreased the degree of selective phase corrosion of NAB. As a result, both selective phase corrosion and uniform corrosion presented equal performances after 1 h of CE. However, after CE for 2-5 h, uniform corrosion had a dominant impact on the surface damage of NAB. Eventually, the corrosion mechanism of NAB after different CE times was clarified based on the relevant experimental results.

5.
Artigo em Inglês | MEDLINE | ID: mdl-36689155

RESUMO

Intervertebral disc degeneration (IDD) is characterised by nucleus pulposus (NP) loss and extracellular matrix (ECM) degeneration. Circular RNAs (circRNAs) have been reported to be dysregulated during IDD progression. Recently, reports showed that hsa_circ_0040039 was increased in degenerated lumbar disc samples. The aim of this study was to explore the specific role and underlying mechanisms of hsa_circ_0040039 in IDD. The expression of hsa_circ_0040039 was investigated in NP tissues of IDD patients. IL-1ß was used to treat NP cells to construct an IDD in vitro model. Overexpression and loss-of-function assays and bioinformatic analysis were performed to evaluate the role and potential mechanism of hsa_circ_0040039 during IDD progression. Hsa_circ_0040039 expression was increased about 2 folds in NP tissues compared with normal tissues and IL-1ß-stimulated NP cells also presented hsa_circ_0040039 upregulation, and its overexpression promoted cell proliferation and ECM degeneration. The depletion of hsa_circ_0040039 had the opposite effects. Based on bioinformatics prediction, Luciferase assay, PCR and Western blot, our study verified that hsa_circ_0040039 directly bond to miR-146b-3p, then mediated its targeted MMP2 and PCNA. Moreover, the overexpression of miR-146b-3p and the silence of MMP2 or PCNA, partially abolished the effect of hsa_circ_0040039 on IL-1ß-stimulated NPs. Hsa_circ_0040039 may participate in IDD development by mediating the repair and regeneration of NPs through upregulation MMP2 and PCNA mediated by miR-146b-3p.

6.
Br Poult Sci ; 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36628626

RESUMO

1. Although PRL-PRLR signalling plays important roles in regulating avian reproduction, there is a paucity of information regarding the functional significance of PRLR in goose ovarian follicle development.2. The full-length 2,496 bp coding sequence of PRLR was obtained from Sichuan White goose (Anser cygnoides) for the first time and was seen to encode a polypeptide conatining 831 amino acids. Goose PRLR shares similar sequence characteristics and conserved functional domains to other avian species and was phylogenetically clustered into the avian clade.3. The qPCR results suggested that the mRNA levels of PRLR significantly increased in primary follicles during weeks 3 to 4 of age and were higher in secondary- than in primordial follicles at week 5 post-hatching, which suggested that the PRLR-mediated signalling could be involved in regulation of early folliculogenesis.4. The PRLR mRNA was expressed at the highest levels in the prehierarchical 8-10 mm granulosa layers throughout goose ovarian follicle development, indicating a role for PRLR in the process of follicle selection.5. PRLR mRNA was differentially expressed in the three cohorts of in vitro cultured granulosa cells harvested from different sized goose ovarian follicles, which suggested that PRLR was involved in regulating granulosa cell functions depending on the stage of follicle development. These data provide novel insights into the role of PRLR during goose ovarian follicle development, although the underlying mechanisms await further investigations.

7.
Carbohydr Polym ; 302: 120430, 2023 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-36604091

RESUMO

Plant proteins have high nutritional value, a wide range of sources and low cost. However, it is easily affected by the environmental factors of processing and lead the problem of poor functionality. These problems of plant proteins can be improved by the polysaccharides induced Maillard reaction. The interaction between proteins and polysaccharides through Maillard reaction can change the structure of proteins as well as improve the functional properties and biological activity. The products of Maillard reaction, such as reductone intermediates, heterocyclic compounds and melanoidins have certain antioxidant, antibacterial and other biological activities. However, heterocyclic amines, acrylamide, and products generated in the advanced stage of the Maillard reaction also have a negative impact, which may increase cytotoxicity and be associated with chronic diseases. Therefore, it is necessary to effectively control the process of Maillard reaction. This review focuses on the modification of plant proteins by polysaccharide-induced Maillard reaction and the effects of Maillard reaction on protein structure, functional properties and biological activity. It also points out how to accurately reflect the changes of protein structure in Maillard reaction. In addition, it also points out the application ways of plant protein-polysaccharide complexes in the food industry, for example, emulsifiers, delivery carriers of functional substances, and natural antioxidants due to their improved solubility, emulsifying, gelling and antioxidant properties. This review provides theoretical support for controlling Maillard reaction based on protein structure.


Assuntos
Reação de Maillard , Proteínas de Plantas , Proteínas de Plantas/química , Antioxidantes/farmacologia , Antioxidantes/química , Polissacarídeos/química , Indústria Alimentícia
8.
Nat Microbiol ; 8(1): 162-173, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36604510

RESUMO

The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcriptomes of 31 different tick species in the Ixodidae and Argasidae families from across mainland China, and identified 724 RNA viruses with distinctive virome compositions among genera. A total of 1,801 assembled and complete or nearly complete viral genomes revealed an extensive diversity of genome architectures of tick-associated viruses, highlighting ticks as a reservoir of RNA viruses. We examined the phylogenies of different virus families to investigate virome evolution and found that the most diverse tick-associated viruses are positive-strand RNA virus families that demonstrate more ancient divergence than other arboviruses. Tick-specific viruses are often associated with only a few tick species, whereas virus clades that can infect vertebrates are found in a wider range of tick species. We hypothesize that tick viruses can exhibit both 'specialist' and 'generalist' evolutionary trends. We hope that our virome dataset will enable much-needed research on vertebrate-pathogenic tick-associated viruses.


Assuntos
Vírus de RNA , Carrapatos , Vírus , Animais , Vírus de RNA/genética , Genoma Viral/genética , RNA
9.
Food Chem (Oxf) ; 6: 100156, 2023 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-36588602

RESUMO

Flammulina filiformis (F. filiformis) is one of the four major edible types of fungus in the world and has been cultivated in China since 800 CE (Anno Domini). Some of the most essential criteria for evaluating the quality of F. filiformis are the types and contents of volatile components present. A focused study on screened the terpene synthase genes involved in the aroma of offspring and compared key terpenoids between parents and offspring, which is helpful for the development and application of F. filiformis. Firstly, the volatile aroma components of parent and offspring F. filiformis were extracted using two pretreatment procedures, and then were semi-quantified by an internal standard. Forty-eight, fifty-eight, and forty-eight volatile compounds were identified in parents and offspring of three different strains, and 15, 22, and 12 aroma compounds (OAVs ≥ 1) were further screened out via calculating their odor activity values (OAVs). Terpenoids, in particular linalool and eucalyptol, which contribute more to the aroma, result in the unique green and grassy aroma of the offspring. At last, the F. filiformis genome was resequenced and the coordinates of genes related to terpenoid synthase were determined. The results showed that Scaffolds, including scaffold3.t874 and scaffold9.t157 were connected to terpenoid synthesis of offspring (No. 61523). The variant genes g269 and g61 were related to terpenoid synthase sequences. This study provides a theoretical foundation for the cultivation of more diverse and unique varieties of F. filiformis.

10.
BMC Med Res Methodol ; 23(1): 5, 2023 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-36611147

RESUMO

BACKGROUND: In the development of prediction models for a clinical event, it is common to use the static prediction modeling (SPM), a regression model that relates baseline predictors to the time to event. In many situations, the data used in training and validation are from longitudinal studies, where predictor variables are time-varying and measured at clinical visits. But these data are not used in SPM. The landmark analysis (LA), previously proposed for dynamic prediction with longitudinal data, has interpretational difficulty when the baseline is not a risk-changing clinical milestone, as is often the case in observational studies of chronic disease without intervention. METHODS: This paper studies the generalized landmark analysis (GLA), a statistical framework to develop prediction models for longitudinal data. The GLA includes the LA as a special case, and generalizes it to situations where the baseline is not a risk-changing clinical milestone with a more useful interpretation. Unlike the LA, the landmark variable does not have to be time since baseline in the GLA, but can be any time-varying prognostic variable. The GLA can also be viewed as a longitudinal generalization of localized prediction, which has been studied in the context of low-dimensional cross-sectional data. We studied the GLA using data from the Chronic Renal Insufficiency Cohort (CRIC) Study and the Wisconsin Allograft Replacement Database (WisARD) and compared the prediction performance of SPM and GLA. RESULTS: In various validation populations from longitudinal data, the GLA generally had similarly or better predictive performance than SPM, with notable improvement being seen when the validation population deviated from the baseline population. The GLA also demonstrated similar or better predictive performance than LA, due to its more general model specification. CONCLUSIONS: GLA is a generalization of the LA such that the landmark variable does not have to be the time since baseline. It has better interpretation when the baseline is not a risk-changing clinical milestone. The GLA is more adaptive to the validation population than SPM and is more flexible than LA, which may help produce more accurate prediction.


Assuntos
Estudos Transversais , Humanos , Prognóstico , Estudos Longitudinais , Fatores de Risco
11.
BMC Surg ; 23(1): 1, 2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36600246

RESUMO

OBJECTIVE: To investigate the effect of laparoscopic purse-string sutures in adult complicated appendicitis treatment. METHODS: The data of 568 adult cases of complicated appendicitis treated by laparoscopic appendectomy at the Hefei Second People's Hospital, Anhui Province, China, from September 2018 to September 2021 were analysed retrospectively. The patients were divided into two groups: 295 cases in the laparoscopic purse-string suture treatment group (observation group) and 273 cases in the simple Hem-o-lok® clamp treatment group (control group). The baseline data collected included age, gender, preoperative body temperature, leukocyte count and percentage of neutrophils and the surgery time. The postoperative data collected included antibiotic treatment duration, drainage tube placement time and the incidence of complications. RESULTS: There were no significant differences in the baseline data of the two groups, including age, gender, preoperative body temperature, leukocyte count and neutrophil percentage (all P > 0.05). Compared with the control group, the postoperative hospital length of stay, duration of antibiotic treatment, the recovery time of peripheral white blood cell and neutrophil counts and the incidence of postoperative complications in the observation group were significantly decreased (P < 0.05). CONCLUSION: Purse-string sutures can effectively reduce the incidence of postoperative complications after a laparoscopic appendectomy for adult acute complicated appendicitis. There was faster postoperative recovery when patients' appendiceal stumps were treated with laparoscopic purse-string sutures.


Assuntos
Apendicite , Laparoscopia , Humanos , Adulto , Apendicite/cirurgia , Técnicas de Sutura/efeitos adversos , Estudos Retrospectivos , Apendicectomia/efeitos adversos , Complicações Pós-Operatórias/etiologia , Laparoscopia/efeitos adversos , Suturas/efeitos adversos , Tempo de Internação
12.
J Am Chem Soc ; 2023 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-36689781

RESUMO

Molecular one-dimensional topological insulators (1D TIs), which conduct through energetically low-lying topological edge states, can be extremely highly conducting and exhibit a reversed conductance decay, affording them great potential as building blocks for nanoelectronic devices. However, these properties can only be observed at the short length limit. To extend the length at which these anomalous effects can be observed, we design topological oligo[n]emeraldine wires using short 1D TIs as building blocks. As the wire length increases, the number of topological states increases, enabling an increased electronic transmission along the wire; specifically, we show that we can drive over a microampere current through a single ∼5 nm molecular wire, appreciably more than what has been observed in other long wires reported to date. Calculations and experiments show that the longest oligo[7]emeraldine with doped topological states has over 106 enhancements in the transmission compared to its pristine form. The discovery of these highly conductive, long organic wires helps overcome a fundamental hurdle to implementing molecules in complex, nanoscale circuitry: their structures become too insulating at lengths that are useful in designing nanoscale circuits.

13.
Phys Med Biol ; 2023 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-36646060

RESUMO

OBJECTIVE: X-ray fluorescence computed tomography (XFCT) is a promising noninvasive technique for in-vivo imaging of high-Z elements (e.g., gadolinium (Gd) or gold (Au)). In this study we upgraded our experimental XFCT system using a flat panel photon counting detector with redesigned pinhole collimation in order to achieve 3D XFCT images during one scan. APPROACH: Aiming at the characteristics of pinhole-collimated cone-beam XFCT imaging, a new scatter correction algorithm was proposed to estimate the normalized spectrum of scatter background based on K-N formula and realize correction by a weighted least squares method. Then, images were quantitatively reconstructed by a maximum likelihood iterative algorithm with the attenuation correction. MAIN RESULTS: The potential on full-field in-vivo XFCT imaging of this new system was investigated. An imaging experiment of a PMMA phantom with the diameter of 35mm was carried out for quantitative evaluation of the system performance. Results show that 2mg/ml Gd solutions can be successfully reconstructed with a 45-minute cone-beam XFCT scan. In-vivo XFCT imaging experiments of mice with injection of Gd nanoparticles (GdNPs) were also performed and demonstrated in this paper. A mouse was injected through the tail vein with 20mg/mL NaGdF4 solution and then anesthetized with isoflurane during the cone-beam XFCT scan. SIGNIFICANCE: The distribution of the GdNPs inside the mouse can be well reconstructed so that the deposition of NPs in vivo can be clearly observed, which indicates the feasibility of the proposed system for full-field XFCT of small animals and further potential in relevant in-vivo research.

14.
Adv Sci (Weinh) ; : e2206729, 2023 Jan 16.
Artigo em Inglês | MEDLINE | ID: mdl-36646508

RESUMO

The application of photoelectrochemical (PEC) water splitting is limited by the sluggish surface oxygen evolution reaction (OER) kinetics. OER kinetics can be effectively improved through cocatalyst engineering. However, the tardy transfer process and serious recombination of carriers are the key factors restricting the cocatalyst development. Taking BiVO4 as an example, a Co-modified heme film rich in large conjugated ring structures is introduced onto the photoanode surface using a solvothermal method. This film functions as an efficient cocatalyst. It considerably reduces the surface overpotential, promotes the transfer of photogenerated holes, and boosts the kinetics of OER by specifically affecting the formation of OOH*. Simultaneously, the formed CoOV bonds induce strong interaction at the photoanode/cocatalyst interfaces, reducing the recombination of photogenerated carriers. Consequently, the onset potential of the optimized photoanode decreases from 0.45 to 0.07 V and the photocurrent density at 1.23 V versus reversible hydrogen electrode boosts to 5.3 mA cm-2 . This work demonstrates a facile strategy for designing cocatalysts to obtain rapid hole transfer capability and reduced carrier recombination for improved PEC performance.

15.
Cancer Imaging ; 23(1): 6, 2023 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-36647150

RESUMO

BACKGROUND: Deep-learning-based computer-aided diagnosis (DL-CAD) systems using MRI for prostate cancer (PCa) detection have demonstrated good performance. Nevertheless, DL-CAD systems are vulnerable to high heterogeneities in DWI, which can interfere with DL-CAD assessments and impair performance. This study aims to compare PCa detection of DL-CAD between zoomed-field-of-view echo-planar DWI (z-DWI) and full-field-of-view DWI (f-DWI) and find the risk factors affecting DL-CAD diagnostic efficiency. METHODS: This retrospective study enrolled 354 consecutive participants who underwent MRI including T2WI, f-DWI, and z-DWI because of clinically suspected PCa. A DL-CAD was used to compare the performance of f-DWI and z-DWI both on a patient level and lesion level. We used the area under the curve (AUC) of receiver operating characteristics analysis and alternative free-response receiver operating characteristics analysis to compare the performances of DL-CAD using f- DWI and z-DWI. The risk factors affecting the DL-CAD were analyzed using logistic regression analyses. P values less than 0.05 were considered statistically significant. RESULTS: DL-CAD with z-DWI had a significantly better overall accuracy than that with f-DWI both on patient level and lesion level (AUCpatient: 0.89 vs. 0.86; AUClesion: 0.86 vs. 0.76; P < .001). The contrast-to-noise ratio (CNR) of lesions in DWI was an independent risk factor of false positives (odds ratio [OR] = 1.12; P < .001). Rectal susceptibility artifacts, lesion diameter, and apparent diffusion coefficients (ADC) were independent risk factors of both false positives (ORrectal susceptibility artifact = 5.46; ORdiameter, = 1.12; ORADC = 0.998; all P < .001) and false negatives (ORrectal susceptibility artifact = 3.31; ORdiameter = 0.82; ORADC = 1.007; all P ≤ .03) of DL-CAD. CONCLUSIONS: Z-DWI has potential to improve the detection performance of a prostate MRI based DL-CAD. TRIAL REGISTRATION: ChiCTR, NO. ChiCTR2100041834 . Registered 7 January 2021.


Assuntos
Aprendizado Profundo , Neoplasias da Próstata , Masculino , Humanos , Estudos Retrospectivos , Reprodutibilidade dos Testes , Neoplasias da Próstata/diagnóstico por imagem , Neoplasias da Próstata/patologia , Imageamento por Ressonância Magnética/métodos , Imagem de Difusão por Ressonância Magnética/métodos
16.
Adv Sci (Weinh) ; : e2205907, 2023 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-36658721

RESUMO

Oxide-based photoelectrodes commonly generate deep trap states associated with various intrinsic defects such as vacancies, antisites, and dislocations, limiting their photoelectrochemical properties. Herein, it is reported that rhombohedral GaFeO3 (GFO) thin-film photoanodes exhibit defect-inactive features, which manifest themselves by negligible trap-states-associated charge recombination losses during photoelectrochemical water splitting. Unlike conventional defect-tolerant semiconductors, the origin of the defect-inactivity in GFO is the strongly preferred antisite formation, suppressing the generation of other defects that act as deep traps. In addition, defect-inactive GFO films possess really appropriate oxygen vacancy concentration for the oxygen evolution reaction (OER). As a result, the as-prepared GFO films achieve the surface charge transfer efficiency (ηsurface ) of 95.1% for photoelectrochemical water splitting at 1.23 V versus RHE without any further modification, which is the highest ηsurface reported of any pristine inorganic photoanodes. The onset potential toward the OER remarkably coincides with the flat band potential of 0.43 V versus RHE. This work not only demonstrates a new benchmark for the surface charge transfer yields of pristine metal oxides for solar water splitting but also enriches the arguments for defect tolerance and highlights the importance of rational tuning of oxygen vacancies.

17.
Nano Lett ; 23(2): 567-572, 2023 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-36602221

RESUMO

Understanding how molecular geometry affects the electronic properties of single-molecule junctions experimentally has been challenging. Typically, metal-molecule-metal junctions are measured using a break-junction method where electrode separation is mechanically evolving during measurement. Here, to probe the impact of the junction geometry on conductance, we apply a sinusoidal modulation to the molecular junction electrode position. Simultaneously, we probe the nonlinearity of the current-voltage characteristics of each junction through a modulation in the applied bias at a different frequency. In turn, we show that junctions formed with molecules that have different molecule-electrode interfaces exhibit statistically distinguishable Fourier-transformed conductances. In particular, we find a marked bias dependence for the modulation of junctions where transmission is mediated thorough the van der Waals (vdW) interaction. We attribute our findings to voltage-modulated vdW interactions at the single-molecule level.

18.
Medicine (Baltimore) ; 102(1): e32543, 2023 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-36607877

RESUMO

BACKGROUND: There are more and more clinical studies on the efficacy of warm acupuncture in treating sciatica, but the systematic review of the efficacy of warm acupuncture is still lacking. The objective of this study was to evaluate the efficacy and safety of warm acupuncture combined with conventional Western medicine in the treatment of sciatica. METHODS: The review was registered in the PROSPERO database (CRD42022379486) and was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The following databases will be used to search the existing literature (from inception to January 2023): Web of Science, Embase, Cochrane Library, PubMed, Cumulative Index to Nursing and Allied Health Literature, Wanfang, Allied and Complementary Medicine Database, China Knowledge Network, and SPORT-Discus. Included studies are considered eligible if they met the population, intervention, comparator, outcomes, and study design criteria as follows: Population: patients with newly diagnosed sciatica; Intervention: warm acupuncture combined with conventional Western medicine; Comparator: Western medicine alone; Outcomes: total response rate, pain score and pain threshold, adverse events and recurrence rate. Study design: randomized controlled trials or non-randomized cohort studies. Review Manager (RevMan) V.5.3 will be used to perform statistical analyses and to generate forest plots. RESULTS: The review will add to the existing literature by showing compelling evidence and improved guidance in clinic settings.


Assuntos
Terapia por Acupuntura , Ciática , Humanos , Ciática/terapia , Ciática/etiologia , Resultado do Tratamento , Revisões Sistemáticas como Assunto , Metanálise como Assunto , Terapia por Acupuntura/efeitos adversos , Terapia por Acupuntura/métodos , Projetos de Pesquisa
19.
Environ Pollut ; 320: 121034, 2023 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-36623790

RESUMO

Sichuan Province is rich in crop straw, yet little is known about its spatial distribution pattern, potential in replacing chemical fertilizer and mitigating nutrient loss. Based on the statistical data and literature review, the spatial distribution and potential of nutrient resources in crop straw for replacing chemical fertilizers was evaluated in this study. The nutrient loss with both crop incorporation and chemical fertilizer application were examined using a nutrient release coefficient method and compared. Results showed that Chengdu Plain, Northeast and South Sichuan produced more than 95% of the total straw nutrient resources during the period of 2016-2020. The potential of crop straw to substitute potassium (K), nitrogen (N) and phosphorus (P) fertilizer were K2O 33.08-285.95 kg hm-2, N 9.52-82.32 kg hm-2 and P2O5 4.91-28.71 kg hm-2, respectively. If chemical fertilizer was substituted by all the available straw nutrient resources, N and P loss can be decreased by 55.12% and 65.84% in average in Sichuan Province. 343.93 t of N loss and 20.05 t of P loss can be reduced in plain areas, 122.88 t of N loss and 46.29 t of P loss can be reduced in mountainous and hilly areas, and 5.65 t of t N loss and 3.54 t of P loss can be reduced in plateau areas. It can be concluded that there were rich crop straw nutrient resources in Sichuan Province with obvious spatial variability, solid consideration should be put on to the proper use of crop straw nutrient resources, with the aim of chemical fertilizer reduction, nutrient loss reduction and sustainable development.

20.
Nat Med ; 29(1): 158-169, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36624313

RESUMO

Richter syndrome (RS) arising from chronic lymphocytic leukemia (CLL) exemplifies an aggressive malignancy that develops from an indolent neoplasm. To decipher the genetics underlying this transformation, we computationally deconvoluted admixtures of CLL and RS cells from 52 patients with RS, evaluating paired CLL-RS whole-exome sequencing data. We discovered RS-specific somatic driver mutations (including IRF2BP2, SRSF1, B2M, DNMT3A and CCND3), recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which were confirmed in 45 independent RS cases and in an external set of RS whole genomes. Through unsupervised clustering, clonally related RS was largely distinct from diffuse large B cell lymphoma. We distinguished pathways that were dysregulated in RS versus CLL, and detected clonal evolution of transformation at single-cell resolution, identifying intermediate cell states. Our study defines distinct molecular subtypes of RS and highlights cell-free DNA analysis as a potential tool for early diagnosis and monitoring.

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