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1.
Interdiscip Neurosurg ; 27: 101416, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34729362

RESUMO

Background: Globally, there is a shooting pandemic that affected many healthcare systems. Healthcare facilities had to set up strategies to avoid exhaustion while facing a catastrophic health problem. Vaccines or perfect therapies were not available over a long pandemic time and also no certified immunity against that disease is guaranteed. Therefore, it is probable that healthcare systems will face it for an exceptionally long period. That already had a grave effect on the strategy of daily practice of different specialties' services at healthcare centers. Methods: We tried simply to share a countryside hospital's expertise in managing neurosurgical cases amid a dreadful health crisis. Healthcare workers' safety and patient safety were typical priorities for neurosurgical service at Damietta Specialized Hospital. We expose the lines of management, triaging cases, the methods of handling confirmed and suspected neurosurgical patients, and strategies for discharging and following up patients. We identified hospital admission and discharge records starting from February 2020 till February 2021 to track the neurosurgical case burden, the state of service offered and the rate of infection among healthcare workers who participated in surgeries. Results: At the peak time of the COVID­19 pandemic in Egypt starting from February 2020 till February 2021, we have admitted about 500 neurosurgical patients. About 400 (80%) of them did surgeries according to the triaging protocol of the hospital. About 150 (30%) of those who did surgeries were urgent and the rest were borderline or semi­urgent. About 20 (4%) were tested COVID-19 positive and six of them died due to acute respiratory distress syndrome. Only two mortality cases were reported due to post-operative complications and not related to SARS­CoV­2 infection. The rest of the cases (97.6%) were discharged for follow­up without complications. No neurosurgeons but three anesthesia staff were infected with SARS­CoV­2. A successful undisturbed neurosurgical care was available for patients during COVID-19 time. Conclusions: Following the suggested strategies, a rural area-serving hospital managed to provide uninterrupted neurosurgical care amid COVID-19 pandemic in Egypt. Rural areas in developing countries are in need of strategies to deal with pandemics in the future without dismantling the normal health system, especially for life­saving cases in a critical specialty as neurosurgery.

2.
J Colloid Interface Sci ; 607(Pt 2): 1153-1162, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34571302

RESUMO

Transition metal oxalates have attracted wide attention due to the characteristics of the conversion reaction as anode materials in lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs), However, there are huge volume expansion and sluggish circulation dynamics during the reversible Li+ and Na+ insertion/extraction process, which would lead to unsatisfactory reversible capacity and stability. In order to solve these problems, a rod-like structure Ni0.5Co0.5C2O4·2H2O is in-situ formed on the reduced graphene oxide layer (Ni0.5Co0.5C2O4·2H2O/rGO) in a glycol-water mixture medium via an interface induced engineering strategy. Benefitting from the synergistic cooperation of nano-diameter rod-like structure and high conductive rGO networks, the experimental results show that the prepared Ni0.5Co0.5C2O4·2H2O/rGO electrode has predominant rate performance and ultra-long cycle stability. For the LIBs, it not only exhibits an ultrahigh reversible capacity (1179.9 mA h g-1 at 0.5 A g-1 after 300 cycles), but also presents outstanding rate and cycling performance (646.5 mA h g-1 at 5 A g-1 after 1200 cycles). Besides, the Ni0.5Co0.5C2O4·2H2O/rGO electrode displays remarkable sodium storage capacity of 221.6 mA h g-1 after 100 cycles at 0.5 A g-1. Further, the extraordinary electrochemical capability of Ni0.5Co0.5C2O4·2H2O/rGO active material is also reflected in two full-cells, assembled using commercial LiCoO2 as cathode for LIBs and commercial Na3V2(PO4)3 as cathode for SIBs, both of which can show wonderful specific capacity and cycling stability. It is found in in-situ Raman experiments that the reversible changes of oxalate peaks are monitored in a charge/discharge process, which is scientific evidence for the transform reaction mechanism of metal oxalates in LIBs. These findings not only provide important ideas for studying the charge/discharge storage mechanism but also give scientific basis for the design of high-performance electrode materials.

3.
Amino Acids ; 2021 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-34741684

RESUMO

Dietary supplementation with 0.4 or 0.8% L-arginine (Arg) to gilts between days 14 and 25 of gestation enhances embryonic survival and vascular development in placentae; however, the underlying mechanisms are largely unknown. This study tested the hypothesis that Arg supplementation stimulated placental expression of mRNAs and proteins that enhance angiogenesis, including endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), placental growth factor (PGF), GTP cyclohydrolase-I (GTP-CH1), ornithine decarboxylase (ODC1), and vascular endothelial growth factor receptors 1 and 2 (VEGFR1 and VEGFR2). Beginning on the day of breeding, gilts were fed daily 2 kg of a corn-soybean meal-based diet supplemented with 0.0 (control), 0.4, or 0.8% Arg. On day 25 of gestation, gilts were hysterectomized to obtain uteri and conceptuses for histochemical and biochemical analyses. eNOS and VEGFR1 proteins were localized to endothelial cells of maternal uterine blood vessels and to the uterine luminal epithelium, respectively. Compared with the control, dietary supplementation with 0.4 or 0.8% Arg increased (P < 0.05) the amounts of nitrite plus nitrate (NOx; oxidation products of NO) and polyamines in allantoic and amniotic fluids, concentrations of NOx, tetrahydrobiopterin (BH4, an essential cofactor for all NOS isoforms) and polyamines in placentae, as well as placental protein abundances of GTP-CH1 (the key enzyme for BH4 production) and ODC1 (the key enzyme for polyamine synthesis). Placental  mRNA levels for GTP-CH1, eNOS, PGF, VEGF, and VEGFR2 increased in response to both 0.4% and 0.8% Arg supplementation. Collectively, these results indicate that dietary Arg supplementation to gilts between days 14 and 25 of pregnancy promotes placental angiogenesis by increasing the expression of mRNAs and proteins for angiogenic factors as well as NO and polyamine syntheses.

4.
IDCases ; 26: e01310, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34729358

RESUMO

Fungal endocarditis is a rare condition, specifically in immunocompetent patients. Aspergillus species are the etiology in less than 30% of the cases. Moreover, Aspergillus flavus endocarditis is extremely rare and reported in only 7% of the total Aspergillus endocarditis cases. The most common predisposing factors are immunocompromised state, prosthetic valve, and previous cardiac surgery. In most cases, the diagnosis is delayed and occasionally missed. Prompt medical management combined with early surgical intervention is recommended once the diagnosis is established since the mortality rate is nearly 100% without surgical intervention. We report a rare and fatal case of native aortic valve endocarditis in a 49 years old diabetic patient who presented with fever and abdominal pain, complicated by multiple septic embolizations (splenic infarction, cerebral emboli, and limbs ischemia), and in which A. flavus was confirmed post mortem.

5.
Indian J Crit Care Med ; 25(8): 890-895, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34733030

RESUMO

The respiratory care (RC) discipline in Yemen emerged 15 years ago. Although there have been significant advancements in the domain, no documented history is available regarding its development and progress over the years. This paper highlights the history and development of the RC field in Yemen and highlights the major events that took place during these times that shaped the development of the RC discipline. A detailed, comprehensive review and assessment were conducted through direct communication, personal interviews, and the review of existing documents in the hospital's archives, academic institutes, Ministry of Public Health and Population, and other relevant resources. The gathered data were evaluated for relevance and grouped on a thematic basis. So far, this is the first paper on the comprehensive history and development of the RC discipline in Yemen. How to cite this article: Hamilah SN, Ahmari MAI, Alsabri MA, Alrubaiee GG. Respiratory Care Profession in Yemen: Past, Present, and Future. Indian J Crit Care Med 2021;25(8):890-895.

6.
Front Neurol ; 12: 707420, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34733227

RESUMO

Background: Stroke is a medical condition that leads to major disability and mortality worldwide. Some evidence suggests that weather and seasonal variations could have an impact on stroke incidence and outcome. However, the current evidence is inconclusive. Therefore, this study examines the seasonal variations and meteorological influences on stroke incidence and outcome in the largest city in Saudi Arabia. Methods: From February 2016 to July 2019, we retrospectively reviewed data from all patients with acute ischemic (AIS) or hemorrhagic stroke (HS) admitted to the stroke unit in a tertiary academic center in Saudi Arabia. The corresponding daily meteorological data were obtained for the same period. We considered the months from November to March as the cold season and April to October as the hot season. Results: The final cohort included 1,271 stroke patients; 60.89% (n = 774) cases occurred in the hot season, while 39.1% (n = 497) in the cold season. Males accounted for 69.6% (n = 884) of the cases. The proportion of ischemic stroke was 83.2% [hot season 83.9% (n = 649) vs. cold season 82.3% (n = 409)]. We found no statistically significant difference between seasons (hot or cold) in stroke incidence, severity [National Institutes of Health Stroke Scale (NIHSS)], hospital course (pneumonia, thromboembolism, intensive care stay, or length of stay), or outcome [modified Rankin scale (mRS) on discharge and death]. Conclusions: In Riyadh, Saudi Arabia, our study found no impact of weather or seasonal variations on stroke incidence, hospital course, or outcomes. However, our findings warrant further research in different country regions.

7.
ACS Omega ; 6(43): 28923-28935, 2021 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-34746584

RESUMO

With the aim of upgrading the power conversion efficiency of organic solar cells (OSCs), four novel non-fullerene, A1-A2-D-A2-A1-type small molecules were designed that are derivatives of a recently synthesized molecule SBDT-BDD reported for its efficient properties in all-small-molecule OSCs (ASM-OSCs). Optoelectronic properties of the designed molecules were theoretically computed with a selected CAM-B3LYP functional accompanied by the 6-31G(d,p) basis set of density functional theory (DFT), and excited-state calculations were performed through the time-dependent self-consistent field. The parameters of all analyzed molecules describing the charge distribution (frontier molecular orbitals, density of states, molecular electrostatic potential), absorption properties (UV-vis absorption spectra), exciton dynamics (transition density matrix), electron-hole mobilities (reorganization energies), and exciton binding energies were computed and compared. All the designed molecules were found to be superior regarding the aforesaid properties to the reference molecule. Among all molecules, SBDT1 has the smallest band gap (3.88 eV) and the highest absorption maxima with broad absorption in the visible region. SBDT3 has the lowest binding energy (1.51 eV in chloroform solvent) ensuring easier and faster dissociation of excitons to produce free charge-carriers and has the highest open-circuit voltage (2.46 eV) with PC61BM as the acceptor. SBDT1 possesses the highest hole mobility because it has the lowest value of λ+ (0.0148 eV), and SBDT4 exhibits the highest electron mobility because it has the lowest value of λ- (0.0146 eV). All the designed molecules are good candidates for ASM-OSCs owing to their superior and optimized properties.

8.
Artigo em Inglês | MEDLINE | ID: mdl-34757702

RESUMO

OBJECTIVES: To assess the incidence of testicular adrenal rest tumors (TARTs) among male children with congenital adrenal hyperplasia (CAH) in tertiary care centers. METHODS: All male children aged 1-14 years diagnosed with CAH due to 21-hydroxylase deficiency (21 HOD), 11ß-hydroxylase deficiency, and 3ß-hydroxysteroid dehydrogenase deficiency, confirmed by biochemical and/or genetic testing, underwent scrotal ultrasound examination to identify TARTs. After receiving the diagnosed patients' data, patients' electronic medical records were accessed to collect demographic data and scrotal ultrasound results, along with growth parameters and specific biochemical test results within 2 months of the ultrasound. RESULTS: TARTs were observed in 5 (10.9%) of 46 male children with CAH. Four patients with positive findings had 21 HOD classical CAH with salt loss and one had 21 HOD simple virilizing classical CAH. All patients had poor compliance and stage 2 bilateral TARTs. Three TART-positive patients (60.0%) had high ACTH levels, 5 patients (100%) had elevated 17-OHP levels, and 5 patients (100%) had advanced bone age. The youngest patient with positive findings was 4 years old. CONCLUSIONS: The prevalence of TARTs increases with age and can be present in young males with classical CAH with 21 HOD. It is associated with elevated 17-hydroxyprogesterone (17-OHP) and advanced bone age SDS. TARTs are less likely to be associated with nonclassical CAH with 21 HOD or other less common CAHs due to 11ß-hydroxylase deficiencies and 3ß-hydroxysteroid dehydrogenase deficiencies in children. Our study recommends early and routine screening of TARTs in children with CAH.

9.
Saudi Pharm J ; 29(11): 1272-1277, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34819789

RESUMO

Background: Meropenem is commonly used in the ICU to treat gram-negative infections. Due to various pathophysiological changes, critically ill patients are at higher risk of having subtherapeutic concentrations and hence have a higher risk of treatment failure-especially in regions where gram-negative drug resistance is increasing, such as Saudi Arabia. No studies have evaluated the pharmacokinetics of meropenem in critically ill patients in Saudi Arabia. Our primary objective is to assess the percentage of patients achieving the therapeutic target for meropenem. Methods: This prospective observational study was conducted in the ICUs of King Khalid University Hospital. Patient were included if >18 years-of-age and received meropenem for a clinically suspected or proven bacterial infection. The primary outcome was to assess the percentage of patients who achieved the pharmacokinetic/pharmacodynamic (PKPD) therapeutic target of a free trough concentration four times the MIC. The secondary outcome was to estimate the pharmacokinetics of meropenem. Pharmacokinetic analysis was performed using Monolix Suite 2020R1 (Lixoft, France). Results: Trough concentrations were highly variable and ranged from <0.5 µg/mL to 39 µg/mL, with a mean ± SD trough concentration of 8.5 ± 8 µg/mL. Only 46% of patients achieved the therapeutic target. The only significant predictor of failing to achieve the PKPD target was augmented renal clearance. Conclusion: In conclusion, more than half of our patients did not achieve the PKPD target. Thus, there is a need for better dosing strategies of meropenem in critically ill patients in Saudi Arabia such as extended and continuous infusion.

10.
Front Public Health ; 9: 745149, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34820350

RESUMO

Aims: This study aimed to (1) assess the non-pharmaceutical intervention (NPI) measures that were used by the Jordanian population against COVID-19, and (2) determine the sociodemographic and behavioral predictors of contracting COVID-19 with a focus on the utilization of personal precautionary measures. Methods: A descriptive questionnaire-based cross-sectional survey was used in this study. A structured web-based questionnaire was disseminated to the Jordanian community through social media platforms. Participants were asked a series of questions about socio-demographic characteristics, in addition to the knowledge, attitudes, and commitment toward using various personal precautionary measures (e.g., face mask, hand washing, social distancing) against the COVID-19. Data were analyzed using descriptive statistics, cross-tabulation, and binary logistic regression through SPSS®. Results: Responses from 7,746 participants were included in our final analyses. Descriptive statistics showed that most participants (82.6%) believed that face mask protects against COVID-19. Around 69.5% of the participants were completely committed to wearing a face mask, while 65% of the participants were completely committed to hand washing. The results of the regression analysis revealed that female gender (AOR = 1.2; 95% CI: 1.07-1.35; p = 0.002), having a family member infected with COVID-19 (AOR = 8.5; 95% Cl: 7.51-9.70; p = 0.001), having a health-related work or study (AOR = 1.2; 95% Cl: 1.09-1.38; p = 0.001), believing that face masks do not protect against COVID-19 (AOR = 1.3; 95% Cl: 1.12-1.47; p = 0.001), and partial commitment to handwashing (AOR = 1.2; 95% Cl: 1.11-1.75; p = 0.006) were all associated with an increased odds of contracting COVID-19 among the participants. Conclusion: Overall, commitment to non-pharmaceutical intervention (NPI) measures, such as wearing a face mask, hand washing, and physical distancing, was not optimal among Jordanians. This might explain the dramatic increase in the infectivity rate of the COVID-19 virus in the past few months in the country. More sustainable efforts regarding health promotion and strict policies are required to prevent a third wave of hitting the country and to prevent similar infectious threats in the future.

11.
Cureus ; 13(11): e19834, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34824952

RESUMO

Background and study aims Currently, there are no studies conducted in the Kingdom of Saudi Arabia (KSA) that have assessed the relationship between ulcerative colitis (UC) flare-ups and smoking. The present study aims to assess the risk of UC flare-ups and evaluate the relationship between UC flare-ups and smoking in adult patients following up at King Abdulaziz University Hospital in Jeddah, KSA. Patients and methods This was a retrospective study involving patients with confirmed UC between January 2015 and December 2020. Various information was examined, including demographic, clinical, endoscopic, radiologic, and laboratory data. Descriptive statistics were used for summarizing findings and a logistic regression analysis was applied to test for possible associations. Results Eighty-nine patients with UC were included in the study. Almost half (48.3%) had recurrent UC flare-ups during follow-up. A non-significant relationship was found between recurrent UC flares and all types of smoking habits (cigarette smoking, P = 0.15; shisha smoking, P = 0.88; and vape smoking, P = 0.09). Participants who were underweight (P = 0.041), had family history of UC (P = 0.013), depression (P = 0.033), fecal incontinence (P = 0.003), iron deficiency anemia (P = 0.009), or a malignancy (P = 0.039) had a significantly higher probability of experiencing recurrent flares. Binary logistic regressions revealed that family history of UC (OR = 5.3, P = 0.007) and fecal incontinence (OR = 4.7, P = 0.006) were associated significantly with recurrent flares. Conclusion There was no clear association between smoking and recurrent UC flares identified in this cohort. Of the variables considered, UC patients with fecal incontinence or family history of UC were at the highest risk of developing recurrent flares.

12.
Int J Surg Case Rep ; 89: 106521, 2021 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-34775321

RESUMO

INTRODUCTION AND IMPORTANCE: Locoregional flaps, particularly the pedicled lateral forehead flap, are not usually used in reconstructing oral floor defects following oncologic resection. Rather, microscopic free flaps have evolved to be the standard of care in head and neck reconstruction. However, the pedicled lateral forehead flap could be valuable in floor of the mouth reconstruction in the absence of resources or other options. CASE PRESENTATION: A-56 years old lady with multiple comorbidities who underwent near total glossectomy, bilateral supraomohyoid neck dissection, and right lateral mandibulotomy due to a locally advanced lingual squamous carcinoma. The last resort was the pedicled lateral forehead flap after many unsuccessful reconstructive attempts utilizing the free anterolateral flap, free radial forearm flap, and pedicled pectoralis major flap. CLINICAL DISCUSSION: Decreased donor site morbidity and reliable anatomy are among many of the advantages that made free flaps favorable over locoregional pedicled flaps, especially in oral cavity defects coverage. Of the latter, the pedicled forehead flap, rich in vascularity and neighboring the oropharyngeal defects, could be used with different techniques and modifications. Close monitoring and patient condition optimization is required. CONCLUSION: Choosing a particular reconstructive option should be done considering the available resources and expertise and the patient's condition. The pedicled forehead flap remains valuable when other options are inappropriate or have failed.

13.
Int J Chron Obstruct Pulmon Dis ; 16: 3065-3082, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795479

RESUMO

Background: Bronchodilator responsiveness (BDR) is commonly used in the diagnosis of lung disease. Although small airways dysfunction is a feature of asthma and COPD, physiological tests of small airways are not included in guidelines for BDR testing. This systematic review assessed the current evidence of BDR using small airways function in asthma and COPD. Methods: The systematic review used standard methodology with the protocol prospectively registered on PROSPERO (CRD42020164140). Electronic medical databases (EMBASE and Medline) were searched using related keywords. Abstracts and full texts were screened independently by two reviewers. Studies that reported the change of physiological small airways function and FEV1 were included in the review. The revised Cochrane risk of bias tool for RCT and NIH quality assessment tool for cohort and cross-sectional studies were used to evaluate the studies. Results: A total of 934 articles were identified, with 12 meeting the inclusion criteria. Ten studies included asthma patients, 1 study included COPD patients and 1 study included both asthma and COPD. A total of 1104 participants were included, of whom 941 were asthmatic, 64 had COPD and 109 were healthy controls. Studies were heterogeneous in design including the device, dose and time intervals for BDR assessment. A small airway BDR was seen for most tests in asthma and COPD, including oscillometry (R5-20, reactance (X5), area of reactance (AX) and resonant frequency (Fres)) and Maximal Mid Expiratory Flow. Conclusion: There is a measurable BDR in the small airways. However, with no consensus on how to assess BDR, studies were heterogeneous. Further research is needed to inform how BDR should be assessed, its clinical impact and place in routine clinical practice.


Assuntos
Asma , Doença Pulmonar Obstrutiva Crônica , Adulto , Asma/diagnóstico , Asma/tratamento farmacológico , Broncodilatadores/efeitos adversos , Estudos Transversais , Volume Expiratório Forçado , Humanos , Doença Pulmonar Obstrutiva Crônica/diagnóstico , Doença Pulmonar Obstrutiva Crônica/tratamento farmacológico , Espirometria
14.
Int J Periodontics Restorative Dent ; 41(6): e243-e253, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34818391

RESUMO

This study evaluated long-term clinical and patient satisfaction outcomes following a modified lip repositioning technique that utilized periosteal sutures in a twin population. Twin sisters diagnosed with maxillary lip hypermobility were randomly assigned to either the control group (original LipStaT technique) or test group (addition of periosteal sutures). The participants (n = 12; 6 per group) were evaluated at intervals for up to 3 years postoperative. Clinical measurements, digital images, and patient satisfaction surveys were collected. Descriptive statistics were used to assess outcome variables: average lip width at rest (ALW), vertical lip translation (VLT), and average gingival display (AGD). Student t test, one-way analysis of variance, and Spearman rank correlation tests were used to compare mean values of variables at five time points for both groups. The level of significance was α = .05. In the control group, mean VLT and AGD values showed statistically significant decreases from baseline (14.8 mm and 7.0 mm, respectively) to 2 years (5.7 mm and 2.4 mm, respectively), but a slight increase was seen at 3 years (7.5 mm and 5.0 mm, respectively; P < .0001). In the test group, mean VLT and AGD values showed statistically significant decreases from baseline (14.8 mm and 6.9 mm, respectively) to 3 years (5.5 mm and 3.5 mm, respectively; P < .0001). A higher participant satisfaction score at 3-year follow-up was observed in the test group. The modified lip repositioning technique in a population of twins resulted in more stable outcomes that lasted up to 3 years postoperatively.

15.
Kathmandu Univ Med J (KUMJ) ; 19(74): 248-252, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34819445

RESUMO

Background Thrombocytopenia is a common haematological abnormality noted in clinical practice, however, it can be missed in cases where specific investigations are not asked for. Acute Febrile Illness with thrombocytopenia is a diagnostic and therapeutic challenge, as thrombocytopenia has an inverse relation to mortality and morbidity in various febrile illnesses. Vector-borne and zoonotic diseases (like malaria, dengue, scrub typhus, and leptospirosis), infections and sepsis are some of the common causes of fever with thrombocytopenia. Objective To identify the causes of fever with thrombocytopenia, assess the clinical complications associated with febrile thrombocytopenia, and overall study the clinical profile of thrombocytopenia in a tertiary care hospital Method Medical records of all adult patients, admitted to a tertiary level hospital, with fever and thrombocytopenia (platelet count < 1,00,000 /mm3 ) were assessed (from October 2009 to March 2011). Detailed case history, general physical examination findings, routine and specific examinations were recorded according to a pre-decided format. Data were analysed using SPSS 16.0 Result Acute febrile illness with thrombocytopenia was most commonly seen in Dengue patients. Headache and arthralgia were more commonly encountered in scrub typhus. Platelet transfusions were necessitated in a large number of patients, especially in scrub typhus. Malaria patients had the highest mortality rate. Conclusion Acute Febrile Illnesses (AFI) are of varied origins, and proper diagnosis is imperative. The degree of thrombocytopenia in infections has a prognostic value. It can also help in differential diagnosis and clear identification of aetiology of acute febrile illnesses. Timely identification and management of thrombocytopenia in acute febrile illness can positively impact the overall patient outcome.

16.
Sci Rep ; 11(1): 22747, 2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34815462

RESUMO

The food industry produces large quantities of waste, which is available in bulk at zero cost. This study aimed to investigate a new method to maximize the protein intake from pea peels and its further utilization as a value-added food ingredient to produce healthy snack crackers and dry soup. Dehydrated green curd of pea peel (DGCPp) with high protein content (35%) was prepared and incorporated into snack cracker and instant soup powder. Wheat flour was substituted with DGCPp to prepare crackers at three substitution levels (5, 10, and 15%) compared to the cracker control sample (100% wheat flour). Increasing the level of this substitution improved the nutritional value of crackers, with highest protein content was in DGCPp crackers (15%). Crackers also had higher contents of mineral and essential amino acids. The physicochemical and sensorial properties of soup samples were significantly influenced by the addition of DGCPp. Higher rehydration value and mineral content (Ca, Mg, Fe, and Zn) were observed in DGCPp soup samples compared to the control sample. Soup samples of all proportions were more acceptable by all the panelists compared with the control sample. With these findings, it can be concluded that DGCPp can be utilized in a variety of food products (such as crackers and soups) with higher nutritive values.

17.
Saudi Dent J ; 33(7): 495-502, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34803292

RESUMO

Objectives: Assessment of the effect of aging and bonding on the reparability of different temporary crown and bridge materials using a flowable resin composite. Methods: The materials used included two bis-acryl and two polymethylmethacrylate materials. The materials were aged either dry, in distilled water, or in a 75% ethanol/water solution. Each group was divided into three subgroups (n = 6) according to the bonding method: application of a universal adhesive, application of a universal primer followed by a universal adhesive, or no bonding. Materials were repaired with a light-cure flowable resin composite; then, they were subjected to thermocycling and tested by shear bond strength. The data were analysed using three-way ANOVA, one-way ANOVA, and Tukey post hoc tests (α = 0.05). Results: The shear bond strength was significantly higher for bis-acryl compared to polymethylmethacrylate materials (p < 0.001). In terms of aging conditions, shear bond strength was in the order of 75% ethanol/water solution < dry < water. The application of bonding agents significantly increased the shear bond strength of polymethylmethacrylate-based materials (p < 0.001). The difference between water and dry storage was insignificant (p = 0.558); however, storage in a 75% ethanol/water solution showed significantly lower values compared to both dry and water storage in most of experimental groups (p < 0.001). Polymethylmethacrylate-based materials mainly demonstrated adhesive failure, while bis-acryl materials predominantly showed cohesive failure. Conclusion: The bond strength of a light-cure flowable resin composite is significantly higher with bis-acryl compared to that with polymethylmethacrylate-based substrates. Aging in water does not have a significant effect; however, the 75% ethanol/water solution tends to negatively affect repairability. The application of different bonding agents positively affects the repair strength, especially for polymethylmethacrylate-based substrates.

18.
Saudi Dent J ; 33(7): 761-768, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34803331

RESUMO

Objective: To compare the translucency and masking of zirconia-reinforced lithium silicate with lithium disilicate glass-ceramic and hybrid composite. Materials and methods: One hundred and twenty disc-shaped specimens were fabricated using Enamic, Celtra Duo, IPS E.max CAD, and Suprinity. Twelve groups were prepared according to material type and thickness (0.5, 1.0, and 1.5 mm). The specimens were tested over five substrates: composite resin-A3.5 shade (A3.5 control group), zirconia-A1 shade (ZR), nickel-chromium alloy (NC), black (B), and white (W). A spectrophotometer operating at wavelengths from 360 to 750 nm and a view-area size of 9.53 mm was used for color measurement. Results: Mean color difference values (ΔΕ) were found to be lowest in Suprinity and highest in IPS E.max. CAD. Color difference values were significantly related to substrate shade. The A3.5 substrate revealed the significantly lowest ΔΕ values of all the substrates (P = 0.05). Regarding the translucency parameters for ceramics of different thicknesses, a significant difference was observed among all groups except in Suprinity. Conclusions: Different ceramic types with different thicknesses and substrate strongly affect translucency and masking. Clinical significance: Fabricating durable aesthetic restorations that also meets patients' expectations is among the most significant challenges in dentistry. With high demand for more natural restorations, ceramics based on computer-aided design (CAD) and computer-aided manufacture (CAM) became popular and exhibited excellent results. However, various factors such as abutment shade, luting cement color, and ceramic type, thickness, and translucency may affect the prosthesis shade. The objective of this study was to evaluate the effects of these factors on the final shades of CAD/CAM-based ceramic restorations.

19.
Cureus ; 13(10): e18787, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34804653

RESUMO

Research problem Advances in technology have ensured its inevitable integration in our life. Children, being at a vulnerable age period of development, are spending more time on electronic devices. Some studies reported negative effects on sleep, physical health such as obesity and vision problems, and behavioral changes such as aggressive behavior with exposure to violent media content. Research significance We will study the effect of using electronic devices on communication skills in children in Saudi Arabia. Our findings can be used to raise awareness on this matter. Research objectives The aim of our study is to examine the association between screen time and social communication skills among children of four years to six years of age in Saudi Arabia. Research methodology A cross-sectional study was conducted to investigate the relationship between social skills development and screen time by using a validated Arabic version of the Social Communication Questionnaire (SCQ). The sample in this study consists of 308 children from four to six years of age. Research results The results showed that the hours spent using the electronic device were significantly associated with having an SCQ score ≥ 15 (P < 0.05). A high SCQ score was prevalent in 19.7% (n = 31) of children who spent >3 hours using an electronic device compared to 10.2% (n = 5) and 7.84% (n = 8) of children who spent an hour or <2 hours using electronic devices, respectively. Conclusion Our study highlighted a significant association between the daily hours spent on devices and having an SCQ score above 15, which suggests a deficit in social skill development and having autism spectrum disorder-like symptoms.

20.
Cureus ; 13(10): e18791, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34804657

RESUMO

Background Diabetic foot care is vital as it is preventable complication but dangerous even a small trauma can end with serious consequences. Diabetes may cause nerve damage that affects feet sensation. Diabetes may also reduce blood flow to the feet, making it harder to heal an injury or resist infection. Because of these problems, patients may lose notice of early foot abnormalities. Diabetic patients' awareness regarding how to care for their feet plays a significant role in preventing these complications. Methods A correlation cross-sectional study was conducted targeting all diabetic patients aging 20 years or more. Online questionnaire was used for data collection. Questionnaire was uploaded online using social media platforms by the researchers and their relatives and friends. The questionnaire included patient personal data, patients' knowledge regarding diabetic foot, attitude and practice regarding the risk of diabetic foot among diabetic patients. Results A total of 1,000 diabetic patients fulfilling the inclusion criteria completed the study questionnaire. Exact of 77.5% of the patients know that Diabetics can get gangrene in the foot, 74.9% know diabetics can develop ulcers in the foot, 66.7% reported that Diabetes can reduce blood flow to the feet of diabetic patients, 66.6% agreed that diabetic patients can suffer from a lack of sensation in the feet. Exact of 84.5% of the study participants agreed that Diabetics should check for any wounds on their feet daily, 78.7% agreed that Diabetics should visit a doctor when there is any infection or wound in the feet, 76.6% think that diabetic patients should wear specialized shoes to avoid diabetic foot according to the doctor's instructions. A total of 822 (82.2%) of the study patients wash their feet daily, and 295 (29.5%) usually wear cotton socks regularly and 39.6% sometimes wear the stock. Only 192 (19.2%) regularly walk barefoot and 41.7% sometimes do. Conclusion In conclusion, the current study results showed that nearly two out of each three diabetic patients were knowledgeable for diabetic foot and its care. High knowledge was associated with young age, high education and having family member with diabetes mellitus (DM). Also, patients had a good attitude towards diabetic foot care and the effect of diabetes on foot health with to some level accepted practice except for some issues.

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