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1.
Dermatol Clin ; 40(2): 127-136, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35366967

RESUMO

Improved understanding of the genetic basis of vascular anomalies has uncovered a growing need for targeted medical therapies. This is especially important for lesions not amenable to surgical interventions or interventional radiologic techniques. Recent studies and case reports have documented the effective use of tailored medical therapies in several distinct types of vascular anomalies. Sirolimus, mitogen-activated protein kinase inhibitors, and phosphoinositide 3-kinase inhibitors have emerged as potential therapies. Although this remains a growing field with significant knowledge gaps, a more optimistic outlook for patients with previously devastating impact on function and quality of life seems now within reach.


Assuntos
Fosfatidilinositol 3-Quinases , Malformações Vasculares , Genótipo , Humanos , Qualidade de Vida , Sirolimo , Malformações Vasculares/tratamento farmacológico , Malformações Vasculares/genética
2.
Pediatr Dermatol ; 39(2): 255-259, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35178750

RESUMO

For infantile hemangiomas (IH) requiring treatment, including those in high-risk locations or in the setting of ulceration, oral propranolol is first-line therapy. Here, we present three cases of infantile hemangioma with worsening ulceration following initiation or escalation of oral propranolol at standard doses.


Assuntos
Hemangioma Capilar , Hemangioma , Neoplasias Cutâneas , Administração Oral , Antagonistas Adrenérgicos beta/efeitos adversos , Hemangioma/tratamento farmacológico , Hemangioma Capilar/tratamento farmacológico , Humanos , Lactente , Propranolol/efeitos adversos , Neoplasias Cutâneas/tratamento farmacológico , Resultado do Tratamento
3.
Pediatr Dermatol ; 39(2): 316-319, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35014097

RESUMO

Capillary malformation-arteriovenous malformation (CM-AVM) syndrome is an autosomal dominant condition characterized by multifocal, noncontiguous pink patches on the skin that often have a surrounding pale halo. In some cases, an association with a fast flow, arteriovenous malformation (AVM) can be identified. Here, we describe a case report of a 16-year-old woman with CM-AVM syndrome and significant cardiac compromise successfully treated with trametinib, a mitogen-activated protein kinase (MEK) inhibitor.


Assuntos
Malformações Arteriovenosas , Mancha Vinho do Porto , Adolescente , Malformações Arteriovenosas/complicações , Malformações Arteriovenosas/tratamento farmacológico , Capilares/anormalidades , Feminino , Humanos , Mancha Vinho do Porto/complicações , Mancha Vinho do Porto/tratamento farmacológico , Piridonas , Pirimidinonas , Proteína p120 Ativadora de GTPase
4.
Pediatr Dermatol ; 38(5): 1222-1225, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34515364

RESUMO

Reactive infectious mucocutaneous eruption (RIME) was proposed as new terminology to encompass postinfectious mucocutaneous eruptions. The term includes all postinfectious mucocutaneous eruptions such as the widely reported Mycoplasma pneumoniae-induced rash and mucositis (MIRM). Very few reports in the literature regarding recurrent RIME are found. We present two adolescent cases of recurrent RIME that involve SARS-CoV-2 and influenza A where the latter is a newly reported infectious trigger; in both patients, the initial episode was likely triggered by Mycoplasma pneumoniae (MP) infection.


Assuntos
COVID-19 , Exantema , Influenza Humana , Pneumonia por Mycoplasma , Adolescente , Humanos , Mycoplasma pneumoniae , Pneumonia por Mycoplasma/complicações , Pneumonia por Mycoplasma/diagnóstico , SARS-CoV-2
6.
Arch Dermatol Res ; 313(2): 71-77, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32270323

RESUMO

Excess amounts of skin surface oil can lead to adverse psychological consequences. Grease-spot photometry-based techniques measure sebum production rate. However, besides being tedious, these measurements are influenced by contact area, applied pressure, and time of application. Image analysis of polarized images has the potential to provide objective, quantitative information of skin oiliness. This study was designed to set up an imaging device for capturing and enhancing the changes in skin surface oiliness and to clinically and quantitatively, (via image analysis), evaluate varying levels of skin surface oiliness. Mineral oil was used to simulate skin surface oil. 40.5 µL of the mineral oil was applied within a two inch square area of interest on facial skin in twelve steps, from 1 to 40.5 µL, at 40% increments. The results indicate a strong correlation between the quantitative skin surface oiliness measurements and the clinical assessments. This sensitive technique has the potential to be utilized in future studies to evaluate product efficacies in reducing skin oiliness.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Óleos/análise , Fotografação/métodos , Pele/diagnóstico por imagem , Acne Vulgar/diagnóstico , Acne Vulgar/etiologia , Acne Vulgar/prevenção & controle , Face , Estudos de Viabilidade , Voluntários Saudáveis , Humanos , Óleos/metabolismo , Sebo/química , Sebo/metabolismo , Pele/química , Pele/metabolismo , Higiene da Pele/métodos , Resultado do Tratamento
7.
Arch Dermatol Res ; 312(10): 725-730, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32253506

RESUMO

Postinflammatory hyperpigmentation (PIH) occurs following cutaneous injury and is common following resolution of acne especially in patients with skin of color. The objective of this study was to further validate a trichloroacetic acid (TCA)-induced PIH model and compare it to acne-induced PIH using topical bakuchiol, a botanical extract that has been shown to have antimicrobial, anti-inflammatory, antioxidant, and antiacne properties. A prospective, non-randomized clinical trial was conducted on subjects with skin phototypes IV-VI with a history of acne-induced PIH. Subjects applied bakuchiol or vehicle cream twice daily to 2 acne-induced and 2 TCA-induced PIH lesions for 28 days with a third lesion serving as a control in each group. Degree of improvement was defined as the change in the Investigator Global Assessment (IGA) score over 28 days of treatment. Twenty subjects (6 males, 14 females) completed the study. For TCA-induced PIH sites, there was a statistically significant (p < 0.05) degree of improvement with bakuchiol treatment (- 0.50 ± 0.18) compared to vehicle (0.05 ± 0.15) and control (- 0.06 ± 0.17). For acne-induced PIH, there was a greater degree of improvement for bakuchiol (- 1.06 ± 0.23) when compared to vehicle (- 0.56 ± 0.16) and control (- 0.69 ± 0.18); however, statistical significance was not reached (p > 0.05). TCA-induced PIH sites were uniform in size and pigment intensity thereby allowing better comparison among sites. This emphasizes the relevance of using this model for PIH which may help reduce the barriers in clinical trials and help improve access to treatments for patients who suffer from PIH. The results suggest that topical bakuchiol may decrease the severity of PIH.


Assuntos
Acne Vulgar/complicações , Hiperpigmentação/tratamento farmacológico , Inflamação/complicações , Fenóis/administração & dosagem , Ácido Tricloroacético/imunologia , Acne Vulgar/imunologia , Adolescente , Feminino , Seguimentos , Humanos , Hiperpigmentação/diagnóstico , Hiperpigmentação/imunologia , Inflamação/induzido quimicamente , Inflamação/imunologia , Masculino , Estudos Prospectivos , Índice de Gravidade de Doença , Pele/efeitos dos fármacos , Pele/imunologia , Creme para a Pele/administração & dosagem , Pigmentação da Pele/efeitos dos fármacos , Pigmentação da Pele/imunologia , Resultado do Tratamento , Ácido Tricloroacético/administração & dosagem , Adulto Jovem
8.
J Am Acad Dermatol ; 83(2): 554-562, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32289386

RESUMO

Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting intertriginous skin areas, and it is characterized by recurrent painful episodes of inflammatory drainage. Although the pathophysiology of HS is not fully understood, recent research points to an imbalance of cytokines as a contributing factor to the associated symptoms of purulent drainage and sinus tract formation. HS lesions are often characterized by a superimposed pathogenic/commensal bacterial infection that can improve with targeted antibiotic therapy. New medical treatments have emerged in recent years, many of which specifically work against a variety of proinflammatory mediators associated with HS. These newer, specified treatment options, in conjunction with surgery and lasers, are thought to provide positive outcomes and an overall improvement in quality of life in patients with HS.


Assuntos
Fármacos Dermatológicos/uso terapêutico , Procedimentos Cirúrgicos Dermatológicos/métodos , Hidradenite Supurativa/terapia , Terapia a Laser/métodos , Qualidade de Vida , Terapia Combinada/métodos , Hidradenite Supurativa/complicações , Hidradenite Supurativa/diagnóstico , Humanos , Índice de Gravidade de Doença , Resultado do Tratamento
9.
Open Forum Infect Dis ; 7(2): ofaa030, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32099844

RESUMO

BACKGROUND: Shigella causes an estimated 500 000 enteric illnesses in the United States annually, but the association with socioeconomic factors is unclear. METHODS: We examined possible epidemiologic associations between shigellosis and poverty using 2004-2014 Foodborne Diseases Active Surveillance Network (FoodNet) data. Shigella cases (n = 21 246) were geocoded, linked to Census tract data from the American Community Survey, and categorized into 4 poverty and 4 crowding strata. For each stratum, we calculated incidence by sex, age, race/ethnicity, and FoodNet site. Using negative binomial regression, we estimated incidence rate ratios (IRRs) comparing the highest to lowest stratum. RESULTS: Annual FoodNet Shigella incidence per 100 000 population was higher among children <5 years old (19.0), blacks (7.2), and Hispanics (5.6) and was associated with Census tract poverty (incidence rate ratio [IRR], 3.6; 95% confidence interval [CI], 3.5-3.8) and household crowding (IRR, 1.8; 95% CI, 1.7-1.9). The association with poverty was strongest among children and persisted regardless of sex, race/ethnicity, or geographic location. After controlling for demographic variables, the association between shigellosis and poverty remained significant (IRR, 2.3; 95% CI, 2.0-2.6). CONCLUSIONS: In the United States, Shigella infections are epidemiologically associated with poverty, and increased incidence rates are observed among young children, blacks, and Hispanics.

10.
J Am Acad Dermatol ; 82(4): 869-877, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31542406

RESUMO

BACKGROUND: Beach vacations are high-risk settings for overexposure to ultraviolet radiation. OBJECTIVE: To compare the sunburn protective efficacy of SPF 50+ and SPF 100+ sunscreens under actual use at the beach. METHODS: A prospective, randomized, double-blind, single-center, split-body/face study of 55 healthy individuals. Each participant applied both sunscreens to randomized sides of the face/body for up to 5 consecutive days. Blinded clinical evaluation of erythema by a single grader and objective instrumental assessments, colorimetry, and diffuse reflectance spectroscopy were performed the morning after each sun exposure. RESULTS: After 5 days, 31 (56%) participants had more sunburn on the SPF 50+ side compared to 4 (7%) on the SPF 100+ side. Overall, mean erythema intensity showed statistically significantly less erythema on the SPF 100+ side compared with the SPF 50+ side. The first observation of sunburn exclusively on the SPF 50+ side occurred after 1 day of sun exposure, whereas that for SPF 100+ occurred after 3 days of sun exposure. LIMITATIONS: Only initial sunscreen application was monitored, only 1 participant with skin phototype I was recruited, and participants were recruited from a local beach area. CONCLUSION: SPF 100+ was significantly more effective in protecting against ultraviolet radiation-induced erythema and sunburn than SPF 50+ in actual use in a beach vacation setting.


Assuntos
Fator de Proteção Solar , Queimadura Solar/prevenção & controle , Protetores Solares/administração & dosagem , Adolescente , Adulto , Colorimetria , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Análise Espectral , Protetores Solares/uso terapêutico , Adulto Jovem
11.
J Drugs Dermatol ; 18(12): 1198-1203, 2019 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-31859468

RESUMO

BACKGROUND: Visible light (VL) has multiple effects on the skin that currently available sunscreens do not protect against. Polypodium leucotomos extract (PLE) has properties that may offer protection against VL. OBJECTIVES: To determine the effectiveness of PLE in preventing VL-induced effects. METHODS: Twenty-two subjects with Fitzpatrick skin phototype IV-VI were enrolled. On day 0, subjects were irradiated with VL. Clinical Investigator's Global Assessment (IGA) scoring and spectroscopic evaluations were performed immediately, 24 hours, and 7 days after irradiation. Subjects then received a 28-day supply of PLE (480 mg daily). Irradiation and evaluation were repeated. Three 4-mm punch biopsies were obtained for immunohistochemistry analysis: one from normal unirradiated skin and the other two twenty-four hours after irradiation, pre- and post-PLE, from sites irradiated with highest dose of VL. RESULTS: All subjects had immediate pigment darkening, persistent pigment darkening, and delayed tanning both pre- and post-PLE. For the highest VL dose (480 J/cm²) spectroscopic assessments demonstrated a statistically significant decrease in persistent pigment darkening and delayed tanning post-PLE. In addition, there was a significant decrease in cyclooxygenase-2, and a trend towards decreases in the markers for cellular damage post-PLE. While there was a trend towards lower IGA scores post-PLE, statistical significance was not reached possibly due to lack of sensitivity of the visual IGA scoring system in detecting small changes. CONCLUSIONS: Spectroscopic data and immunohistochemistry indicate an effect of PLE on visible light induced effects. As such, PLE may be used as an adjuvant to traditional means of photoprotection to protect against the effects of VL. Clinical trial registration number: NCT02904798. J Drugs Dermatol. 2019;18(12):1198-1203.


Assuntos
Hiperpigmentação/prevenção & controle , Extratos Vegetais/farmacologia , Polypodium/química , Pigmentação da Pele/efeitos dos fármacos , Administração Oral , Ciclo-Oxigenase 2/metabolismo , Feminino , Humanos , Luz , Masculino , Extratos Vegetais/administração & dosagem , Pigmentação da Pele/efeitos da radiação
12.
Photodermatol Photoimmunol Photomed ; 35(6): 393-399, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31152612

RESUMO

Solar radiation is a major contributor to the development of skin cancer. Recent studies have shown that visible light (VL), a major portion of solar spectrum, induces biologic effects on the skin. Ultraviolet filters in currently available broad-spectrum sunscreens do not offer protection against VL. This study was designed to identify the spectral characteristics of the skin responses induced by VL, which can be utilized for time efficient in vivo VL testing. Thirty-one subjects were irradiated with a light source emitting visible light with less than 0.5% long wavelength UVA1 (VL + UVA1, 370-700 nm), and 41 subjects were irradiated with pure visible light (pure VL, 400-700 nm). Assessments including clinical photography, investigator's global assessment of pigmentation and erythema, and diffuse reflectance spectroscopy (DRS) performed immediately and seven days after irradiation. Clinical and spectroscopic data showed that VL + UVA1 spectral output induced significantly darker and persistent skin responses as compared to those induced by pure VL. Spectroscopic signatures of skin responses induced by both radiation sources were identified. The signatures were found to be specific to the radiation source and time of collection. A method to evaluate VL protection factor, using quantitative information from the spectral signatures obtained, was proposed.


Assuntos
Eritema/etiologia , Luz/efeitos adversos , Processamento de Sinais Assistido por Computador , Pigmentação da Pele/efeitos da radiação , Área Sob a Curva , Feminino , Humanos , Masculino , Conceitos Matemáticos , Fotografação , Pele/efeitos da radiação , Protetores Solares , Raios Ultravioleta/efeitos adversos
13.
Photodermatol Photoimmunol Photomed ; 35(5): 318-321, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31004553

RESUMO

BACKGROUND: Vitiligo is a disorder of dyspigmentation that can impact quality of life. While narrow-band ultraviolet B (NBUVB) is an effective treatment for vitiligo, a subset of patients are unable to respond to phototherapy as they cannot photoadapt. However, nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to increase the minimal erythema dose. PURPOSE: To determine whether ibuprofen allows non-photoadapters to respond to therapeutic doses of NBUVB and maintain photoadaptation. METHOD: Four patients unable to tolerate NBUVB or excimer past a dose of 1000 mJ/cm2 were enrolled in the study and given ibuprofen 400 mg prior to phototherapy, which was performed 2-3 times a week. Patients were followed up to 72 treatments to demonstrate photoadaptation and maintenance of response to phototherapy. Patients were clinically monitored by serial photographs approximately every 12 treatments. Response to phototherapy was monitored by tracking the dose of NBUVB received at each session. Maintenance of response was monitored for six treatments after discontinuing the ibuprofen. Percent change in pigmentation was also recorded. RESULTS: Three out of four subjects enrolled in the study were able to increase their doses of phototherapy to a therapeutic range, and subjects continued to photoadapt for six treatments after discontinuing ibuprofen. Two subjects achieved repigmentation during their course of phototherapy. CONCLUSION: Ibuprofen may be a safe alternative to corticosteroids for select patients with vitiligo that are unable to photoadapt. It appears that the ability to photoadapt continues once ibuprofen is discontinued, negating the need for chronic use. Enabling photoadaptation allows patients to achieve therapeutic doses of NBUVB phototherapy, leading to repigmentation and improved outcomes. TRIAL REGISTRATION: The trial was registered through Henry Ford Hospital IRB-No. 9744.


Assuntos
Anti-Inflamatórios não Esteroides/administração & dosagem , Eritema/prevenção & controle , Ibuprofeno/administração & dosagem , Terapia Ultravioleta/efeitos adversos , Vitiligo/terapia , Idoso , Eritema/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Projetos Piloto
14.
Exp Dermatol ; 28(1): 94-103, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30484907

RESUMO

The 2nd Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 03-05 November 2017 in Detroit, Michigan, USA. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF Inc.) founded in the USA, and the Canadian Hidradenitis Suppurativa Foundation (CHSF). This was the second annual meeting of the SHSA with experts from different disciplines arriving from North America, Europe and Australia, in a joint aim to discuss most recent innovations, practical challenges and potential solutions to issues related in the management and care of Hidradenitis Suppurativa patients. The last session involved clinicians, patients and their families in an effort to educate them more about the disease.


Assuntos
Anti-Infecciosos/uso terapêutico , Procedimentos Cirúrgicos Dermatológicos , Hidradenite Supurativa/etiologia , Hidradenite Supurativa/terapia , Anti-Inflamatórios/uso terapêutico , Pesquisa Biomédica , Comorbidade , Hidradenite Supurativa/diagnóstico por imagem , Hidradenite Supurativa/epidemiologia , Humanos , Incidência , Qualidade de Vida , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Ultrassonografia
15.
Int J Dermatol ; 57(9): 1088-1093, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29774531

RESUMO

BACKGROUND: A paucity of knowledge exists regarding the use of ertapenem in hidradenitis suppurativa. Our retrospective chart review and telephone interview aims to investigate the utility of intravenous ertapenem in severe, refractory hidradenitis suppurativa. METHODS: This retrospective chart review and telephone interview included patients with severe, refractory hidradenitis suppurativa treated with intravenous ertapenem between March 2013 and December 2016. Data were obtained from medical charts. During the telephone interview, patients were asked questions relating to satisfaction, quality of life changes, and disease state changes with ertapenem therapy. RESULTS: A total of 36 patients including 22 females and 14 males with Hurley stage II or III hidradenitis suppurativa were included. Thirty-five patients (97.2%), demonstrated improvements in hidradenitis suppurativa with ertapenem treatment. In total, 28 patients participated in our telephone interview. Twenty patients (71.4%) were very satisfied (n = 12) or satisfied (n = 8). Quality of life improved in 85.7% of patients (n = 24). CONCLUSION: Following ertapenem therapy, patients reported improvements in quality of life. This treatment appears promising as an adjunct to biologics or as a bridge to surgery in the treatment of severe, refractory hidradenitis suppurativa.


Assuntos
Antibacterianos/uso terapêutico , Ertapenem/uso terapêutico , Hidradenite Supurativa/tratamento farmacológico , Satisfação do Paciente , Qualidade de Vida , Administração Intravenosa , Adulto , Antibacterianos/administração & dosagem , Quimioterapia Combinada , Ertapenem/administração & dosagem , Feminino , Humanos , Masculino , Recidiva , Retratamento , Estudos Retrospectivos , Índice de Gravidade de Doença
16.
Pediatr Dermatol ; 35(3): 370-373, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29575194

RESUMO

BACKGROUND: Although recent hidradenitis suppurativa studies have shown that early-onset disease is associated with a positive family history and more widespread disease, research in pediatric hidradenitis suppurativa is limited. METHODS: Thirty-three children diagnosed with hidradenitis suppurativa during an 18-month period were included in this institutional review board-approved, retrospective chart review. Information on demographic characteristic, family history, and timing of onset (prepubescent vs postpubescent) was extracted. The Fisher exact test, Cochran-Armitage exact trend test, and chi-square test were used to examine the association between prepubescent or postpubescent onset of hidradenitis suppurativa and sex, disease severity, and family history. RESULTS: A significantly higher percentage of patients with postpubescent onset were female (85.7%) than male (14.3%), whereas those with prepubescent onset were more likely to be male (58.3%) than female (41.7%; P = .02). Associations between disease onset and positive family history of hidradenitis suppurativa (P = .47) or higher Hurley stage of disease (P = .15) were not statistically significant. CONCLUSION: Boys are more likely to have prepubescent onset of hidradenitis suppurativa and girls to have postpubescent onset. This shift in sex distribution is unexplained, but we hypothesize that, whereas the role of ovarian hormones in the pathogenesis of HS may underlie much of adult-onset disease, it is less important in prepubescent disease.


Assuntos
Hidradenite Supurativa/epidemiologia , Adolescente , Criança , Feminino , Hidradenite Supurativa/diagnóstico , Humanos , Masculino , Estudos Retrospectivos , Distribuição por Sexo
17.
J Am Acad Dermatol ; 77(6): 1038-1046, 2017 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-28917381

RESUMO

BACKGROUND: Psoriasis and hidradenitis suppurativa (HS) exhibit distinct clinical features, but no studies have directly compared the health-related quality of life (HRQoL) in patients with moderate-to-severe manifestations of these conditions. OBJECTIVE: To determine which disease is associated with more severe HRQoL impairment. METHODS: Weighted averages of each of the following baseline HRQoL measures were determined and compared between HS and psoriasis populations from 5 clinical trials: Visual Analog Scale (VAS) for pain, Total Work Productivity Impairment, Dermatology Life Quality Index; EuroQOL 5D VAS, and Short Form-36 Health Survey. RESULTS: Compared with patients with psoriasis, patients with HS reported higher scores for VAS-pain (54.3 vs 36.1 [P < .0001]), Dermatology Life Quality Index (15.3 vs 11.3 [P < .0001]), EuroQOL 5D VAS (58.8 vs 50.8 [P < .0002]), and Total Work Productivity Impairment (35.4 vs 18.2). Patients with HS had lower Short Form-36 Health Survey scores than did patients with psoriasis (physical, 39.6 vs 49.0; mental, 41.5 vs 47.5 [both P < .0001]). LIMITATIONS: This analysis was performed using published summary data rather than patient-level data, and weighted pooled averages were compared. CONCLUSIONS: Patients with HS have a higher HRQoL burden than patients with psoriasis. This study clearly documents the needs of patients with HS and the potential impact of medical, scientific, and societal consensus for the development of more effective HS treatments.


Assuntos
Hidradenite Supurativa , Psoríase , Qualidade de Vida , Adulto , Efeitos Psicossociais da Doença , Feminino , Hidradenite Supurativa/diagnóstico , Humanos , Masculino , Psoríase/diagnóstico , Índice de Gravidade de Doença
18.
F1000Res ; 6: 1272, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28794864

RESUMO

Hidradenitis suppurativa (HS) is a devastating disease involving abscesses, sinus tracts, and inflammation classically affecting the axilla, groin, and/or anogenital region. Although the disease pathogenesis is not fully understood, recent advances suggest that HS pathology runs much deeper than the cutaneous manifestations. It is now believed that HS is a systemic inflammatory disease that gives rise to the characteristic cutaneous manifestations. This disease is problematic for both patients and physicians to manage because of a variety of diagnostic and management difficulties. This article seeks to provide updates on the current understanding of HS to increase awareness and improve management.

19.
Semin Cutan Med Surg ; 36(2): 67-74, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28538747

RESUMO

Hidradenitis suppurativa (HS) is a chronic skin disease that is difficult to manage and often refractory to medical management. Light and laser therapies have been utilized in the field of dermatology to treat a variety of skin conditions, but more recently were studied in the management of HS. Usually performed as outpatient procedures with a low risk of complications, they offer several advantages to traditional cold knife surgical procedures. We reviewed the various light- and laser-based treatments studied in HS and compared their efficacy. Outcome measures were not standardized, which made comparison difficult. Studies performed were few in number and often limited by small patient samples. Larger, randomized controlled trials that compare these treatment modalities to medical and surgical management are needed. Despite their limitations, light- and laser-based therapies are promising treatment options for patients with refractory HS.


Assuntos
Hidradenite Supurativa/terapia , Terapia a Laser , Fototerapia , Humanos , Estudos Retrospectivos , Resultado do Tratamento
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