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INTRODUCTION: This study evaluated socioeconomic inequality in morbid obesity (body mass index, BMI ≥40 kg/m2) through an analysis of population health survey data in the United States (US) and England (UK). METHODS: We analysed data for the National Health and Nutrition Examination Survey and the Health Survey for England for 2011 to 2014. Age-adjusted odds ratios (AOR) were used to evaluate income- and education-inequality. RESULTS: There were 26,898 eligible UK and 10,628 US participants. Morbid obesity was more frequent in women than men, and higher in the US than the UK (men: US, 4.8%; UK, 1.7%; women US, 9.6%; UK, 3.7%). In the UK, morbid obesity showed graded income-inequality in both genders (AOR, for lowest income quintile: men, 1.83, 95% confidence interval 1.16 to 2.88; women, 2.18, 1.55 to 3.07), as well as education-inequality (AOR for no school qualifications, men 2.57, 1.64 to 4.02; women, 2.18, 1.55 to 3.07). In the US, morbid obesity showed a consistent gradient only for income in women (AOR for lowest income quintile 1.97, 1.19 to 3.25). When compared with all other US groups, having college education (AOR, men, 0.56, 0.29 to 1.08; women, 0.36, 0.22 to 0.60) or household income ≥$75 000 (AOR, men 0.52, 0.27 to 0.98; women, 0.51, 0.33 to 0.80) appeared to protect against morbid obesity. CONCLUSIONS: Morbid obesity is associated with lower socioeconomic status in men and women in the UK. In the US, morbid obesity was twice as prevalent, but less strongly associated with socioeconomic status, suggesting that morbid obesity may now have spread to all but the highest socioeconomic groups.
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To date, the only published reports of bone mineral density (BMD) in MPS IV involve patients with MPS IVA; no reports exist describing BMD for MPS IVB. In this prospective study of BMD in three patients with MPS IVB, BMD was acquired by dual-energy X-ray absorptiometry (DXA) at whole body (WB), lumbar spine (LS), and lateral distal femur (LDF). Functional abilities, ambulatory status, medical history, and height z-score were evaluated. Three patients with MPS IVB (two females), aged 17.7, 31.4 and 31.7 years, were evaluated. Every patient was ambulatory and one sustained two fractures caused by trauma. Whole body and hip DXA scans were technically invalid in every patient due to the presence of prosthetic hip hardware. Lumbar spine was valid in only 1 patient due skeletal abnormalities, and was normal (Z-score of - 0.8). The LDF was valid in every patient and was low at all three regions of interest: average LDF z-scores were - 3.1 (range, - 2.9 to - 3.6), - 2.3 (range, - 2.0 to - 2.5), and - 2.1 (range, - 2.0 to - 2.3) for region 1-region 3, respectively. Patients with MPS IVB have low BMD of the lower extremities even with full-time ambulation. Routine body sites to measure by DXA were problematic; hip and WB were invalid due to artifact, and LS had limited utility. The LDF was the only body site consistently available on all patients. Patients did not experience low-energy fractures despite low BMD.