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1.
Artigo em Inglês | MEDLINE | ID: mdl-38959901

RESUMO

While the recent prediction and observation of magnetic skyrmions bears inspiring promise for next-generation spintronic devices, how to detect and track their position becomes an important issue. In this work, we investigate the spin transport in a two-dimensional magnetic nanoribbon with the Hall-bar geometry in the presence of Rashba spin-orbit coupling and magnetic skyrmions. We employ the Kwant tight-binding code to compute the Hall conductance and local spin-polarized current density. We consider two versions of the model: One with single skyrmion and one with two separate skyrmions. It is found that the size and position of the skyrmions strongly modulate the Hall conductance near the Hall-bar position. The geometry of the Hall bar also has a strong influence on the Hall conductance of the system. With the decreasing of the width of Hall leads, the peak of Hall conductance becomes sharper. We also show the spatial distribution of the spin-polarized current density around a skyrmion located at different positions. We extend this study toward two separate skyrmions, where the Hall conductance also reveals a sizable dependence on the position of the skyrmions and their distance. Our numerical analysis offers the possibility of electrically detecting the skyrmion position, which could have potential applications in ultrahigh-density storage design.

2.
Sci Rep ; 14(1): 15294, 2024 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-38961120

RESUMO

Reliability mapping of 5G low orbit constellation network slice is an important means to ensure link network communication. The problem of state space explosion is a typical problem. The deep reinforcement learning method is introduced. Under the 5G low orbit constellation integrated network architecture based on software definition network (SDN) and network function virtualization (NFV), the resource requirements and resource constraints of the virtual network function (VNF) are comprehensively considered to build the 5G low orbit constellation network slice reliability mapping model, and the reliability mapping model parameters are trained and learned by using deep reinforcement learning, solve the problem of state space explosion in the reliability mapping process of 5G low orbit constellation network slices. In addition, node backup and link backup strategies based on importance are adopted to solve the problem that VNF/link reliability is difficult to meet in the reliability mapping process of 5G low orbit constellation network slice. The experimental results show that this method improves the network throughput, packet loss rate and intra slice traffic of 5G low orbit constellation, and can completely repair network faults within 0.3 s; For different number of 5G low orbit constellation network slicing requests, the reliability of this method remains above 98%; For SFC with different lengths, the average network delay of this method is less than 0.15 s.

3.
Mol Biol (Mosk) ; 58(1): 43-53, 2024.
Artigo em Russo | MEDLINE | ID: mdl-38943579

RESUMO

Spore-forming bacteria have a unique resistance to negative environmental conditions, including aggressive space factors, and are an excellent model for studying adaptation mechanisms and survival strategies at the molecular level. The study analyzed the genome of Bacillus velezensis, which remained viable after a 2-year exposure in outer space on the outer surface of the ISS as part of the Test space experiment. A comparative analysis of the draft genomes of the exhibit strain and the ground control did not reveal significant changes; the average nucleotide identity was 99.98%, which indicates the ability of microorganisms to maintain genome stability in space conditions, due to both increased stress resistance of bacterial spores and efficient operation of the system of repair of accumulated changes. The study of a single nucleotide polymorphism in the genome of B. velezensis revealed nine point substitutions, three of which are in intergenic regions, six in protein-coding genes, three of them are missense mutations, two nucleotide deletions leading to a shift in the reading frame, and one synonymous substitution. The profiles of the housekeeping genes were determined during MLST typing and it was found that the allelic profiles obtained for B. velezensis T15.2 and 924 strains do not correspond to any of the previously described sequence types. The presented results indicate the ability of B. velezensis bacteria to maintain the viability of spores and the integrity of the genome for a long time under extreme conditions of outer space, which is important for the problem of planetary protection, as well as the potential possibility of performing biotechnological processes based on B. velezensis during space exploration.


Assuntos
Bacillus , Genoma Bacteriano , Instabilidade Genômica , Bacillus/genética , Bacillus/metabolismo , Polimorfismo de Nucleotídeo Único , Esporos Bacterianos/genética , Tipagem de Sequências Multilocus
4.
Nano Lett ; 24(25): 7706-7715, 2024 Jun 26.
Artigo em Inglês | MEDLINE | ID: mdl-38869369

RESUMO

Field-free switching (FFS) and spin-orbit torque (SOT)-based neuromorphic characteristics were realized in a W/Pt/Co/NiO/Pt heterostructure with a perpendicular exchange bias (HEB) for brain-inspired neuromorphic computing (NC). Experimental results using NiO-based SOT devices guided the development of fully spin-based artificial synapses and sigmoidal neurons for implementation in a three-layer artificial neural network. This system achieved impressive accuracies of 91-96% when applied to the Modified National Institute of Standards and Technology (MNIST) image data set and 78.85-81.25% when applied to Fashion MNIST images, due presumably to the emergence of robust NiO antiferromagnetic (AFM) ordering. The emergence of AFM ordering favored the FFS with an enhanced HEB, which suppressed the memristivity and reduced the recognition accuracy. This indicates a trade-off between the requirements for solid-state memory and those required for brain-inspired NC devices. Nonetheless, our findings revealed opportunities by which the two technologies could be aligned via controllable exchange coupling.

5.
Nano Lett ; 2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38842923

RESUMO

Epitaxial heterostructures with topological insulators enable novel quantum phases and practical device applications. Their topological electronic states are sensitive to the microscopic parameters, including structural inversion asymmetry (SIA), which is an inherent feature of many real heterostructures. Controlling SIA is challenging, because it requires the ability to tune the displacement field across the topological film. Here, using nanopatterned gates, we demonstrate a tunable displacement field in a heterostructure of the two-dimensional topological insulator cadmium arsenide. Transport studies in magnetic fields reveal an extreme sensitivity of the band inversion to SIA. We show that a relatively small displacement field (∼50 mV/nm) converts the crossing of the two zeroth Landau levels in magnetic field to an avoided crossing, signaling a change to trivial band order. This work demonstrates a universal methodology for tuning electronic states in topological thin films.

6.
Heliyon ; 10(11): e32358, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38912490

RESUMO

In this work, a bibliometric study was carried out to perform a scientific and technological analysis of exchange-spring magnets, an alternative permanent magnet synthesized by reducing or eliminating the use of critical raw materials, such as rare earths. The bibliometric analysis utilized the Scopus database, Orbit-Intellixir, VOSviewer, Orbit-Intelligence and Loglet Lab 4 software for maturity analysis, keyword network representations, charts and graphs for scientific articles and/or patents. A special analysis was performed on nanocomposite and thin-films systems based on Nd-Fe-B, SmCo5 and Mn-Al-C alloys, either mixed or layered with a soft magnetic phase, where relevant information on their magnetic parameters was compilated in tables, highlighting the nanostructured systems that have been exhibited the best permanent magnet properties. The bibliometric analysis revealed that the primary production of scientific articles is concentrated in industrialized countries, and they are predominantly published in journals dedicated to magnetism. A patents analysis showed that Nissan motors is by far the main applicant, with most of its patents is focused on technological domains related to electrical machinery, apparatus, energy and metallurgy. On the other hand, the S-curve of maturity for scientific articles indicated that the study of exchange-spring magnets is entering a mature state. In contrast, patent production, following a bi-logistic model, is in a saturation stage for the second S-curve. Maturity analyses, employing S-curve, bi-logistic and multi-logistic models, were performed on nanocomposites and thin films based on Nd-Fe-B, SmCo5 and Mn-Al-C alloys, respectively. We found that the investigation in Nd-Fe-B-based alloys is close to enter to a scientific saturation stage, while an average growth stage is observed for the SmCo5 and Mn-Al-C-based alloys. This suggests that research on alternative magnets, capable of fulfilling technological applications where a Nd-Fe-B magnets are commonly used, is a topic of significant interest.

7.
Artigo em Inglês | MEDLINE | ID: mdl-38913866

RESUMO

OBJECTIVES: The aim of this study was to identify cone-beam computed tomography (CBCT) protocols that offer an optimal balance between effective dose and 3D model for orthognathic virtual surgery planning, using CT as a reference, and to assess whether such protocols can be defined based on technical image quality metrics. METHODS: Eleven CBCT (VISO G7, Planmeca Oy, Helsinki, Finland) scan protocols were selected out of 32 candidate protocols, based on effective dose and technical image quality measurements. Next, an anthropomorphic RANDO SK150 phantom was scanned using these 11 CBCT protocols and 2 CT scanners for bone quantity assessments. The resulting DICOM files were converted into STL models that were used for bone volume and area measurements in the predefined orbital region to assess the validity of each CBCT protocol for VSP. RESULTS: The highest CBCT bone volume and area of the STL models were obtained using normal dose protocol (F2) and ULD protocol (J13) which resulted in 48% and 96% of the mean STL bone volume and 48% and 95% of the bone area measured on CT scanners, respectively. CONCLUSIONS: The optimal normal dose CBCT protocol" F2" offered optimal bone area and volume balance for STL. The optimal CBCT protocol can be defined exhibited similar using CNR and MTF values that were similar with of those of the reference CT scanners'. CBCT scanner with selected protocols can offer a viable alternative to CT scanners for acquiring STL models for VSP at a lower effective dose.

8.
Nano Lett ; 24(26): 7927-7933, 2024 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-38885648

RESUMO

In nanoscale structures with rotational symmetry, such as quantum rings, the orbital motion of electrons combined with a spin-orbit interaction can produce a very strong and anisotropic Zeeman effect. Since symmetry is sensitive to electric fields, ring-like geometries provide an opportunity to manipulate magnetic properties over an exceptionally wide range. In this work, we show that it is possible to form rotationally symmetric confinement potentials inside a semiconductor quantum dot, resulting in electron orbitals with large orbital angular momentum and strong spin-orbit interactions. We find complete suppression of Zeeman spin splitting for magnetic fields applied in the quantum dot plane, similar to the expected behavior of an ideal quantum ring. Spin splitting reappears as orbital interactions are activated with symmetry-breaking electric fields. For two valence electrons, representing a common basis for spin-qubits, we find that modulating the rotational symmetry may offer new prospects for realizing tunable protection and interaction of spin-orbital states.

9.
J Phys Condens Matter ; 36(40)2024 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-38941989

RESUMO

By incorporating inert KCl into the Na2IrO3+ 2CuCl → Cu2IrO3+ 2NaCl topochemical reaction, we significantly reduced the synthesis temperature of Cu2IrO3from the 350 °C reported in previous studies to 170 °C. This adjustment decreased the Cu/Ir antisite disorder concentration in Cu2IrO3from ∼19% to ∼5%. Furthermore, magnetic susceptibility measurements of the present Cu2IrO3sample revealed a weak ferromagnetic-like anomaly with hysteresis at a magnetic transition temperature of ∼70 K. Our research indicates that the spin-disordered ground state reported in chemically disordered Cu2IrO3is an extrinsic phenomenon, rather than an intrinsic one, underscoring the pivotal role of synthetic chemistry in understanding the application of Kitaev model to realistic materials.

10.
Chemphyschem ; : e202400457, 2024 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-38828488

RESUMO

The title compound has two polymorphic crystal structures having strikingly different absorption and luminescence spectra that result from different packing motifs in the crystal lattice. The polymorph with brick wall-like packing of molecules is white and shows very weak violet fluorescence whereas the second polymorph, where molecules are arranged in columnar stacks, is bright yellow and displays intense green fluorescence with maximum at 487 nm (20530 cm-1). In the white polymorph, where the distance between neighboring chromophores is increased, absorption and fluorescence spectra are similar to those of monomer in solution, and intersystem crossing to triplet manifold is the dominant pathway of relaxation. In the yellow polymorph, molecules within the columnar stacks are rotated which mitigates the steric hindrance and leads to closer π-stacking of the pyrene cores. That increases the ππ overlap and strengthens intermolecular interactions decreasing energy of the excited states. This affects emission spectra and photophysical processes - fluorescence yield grows whereas triplet formation yield decreases when S1 is lowered below higher triplet states and conditions for effective vibronic spin-orbit coupling are not favorable. The effect is not observed for other similar pyrene derivatives, testifying the uniqueness of the phenomenon.

11.
J Fr Ophtalmol ; 47(7): 104215, 2024 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-38843609

RESUMO

Perivascular epithelioid cell tumors (PEComas) are a family of benign neoplasms characterized by smooth muscle and melanocytic differentiation. Orbital cases are rare. A 9-year-old male presented with a slowly growing orbital mass. Magnetic resonance imaging (MRI) revealed a well-defined orbital mass without intracranial extension. The microscopic appearance of the complete resection specimen showed large nests of epithelioid cells with wide cytoplasm containing melanin pigment and round to oval nuclei with mild cytonuclear atypia and low mitotic activity. Immunohistochemistry was positive for HMB45 and negative for melanA, smooth muscle actin, desmin and S-100 protein. Pangenomic RNA-sequencing identified an in-frame NONO-TFE3 rearrangement, and clustering data showed that the tumor's gene expression profile was grouped with other previously studied PEComas. A diagnosis of orbital pigmented PEComa with uncertain malignant potential associated with a NONO-TFE3 rearrangement was made. There was no recurrence after 1 year of follow-up.

12.
Artigo em Inglês | MEDLINE | ID: mdl-38876957

RESUMO

The orbital cavity is a subject of interest for various specialists, and achieving optimal outcomes requires comprehensive, multidisciplinary management. This study aims to report 10 years of experience in the preoperative, surgical, and postoperative care of patients with orbital lesions, examining their clinical, radiological, and anatomopathological features and outcomes. A retrospective review of 125 patients who underwent surgical treatment for intraorbital masses between January 2012 and December 2021 was performed. Outcome measures included postoperative diplopia, exophthalmos, decimal visual acuity, eyeball position, ocular motility, operative time, complications, and aesthetic results. A total of 107 patients were included. All cases were discussed with a neuroradiologist to determine the best therapeutic approach based on preoperative imaging. Preoperative diplopia was linked to extraconal (p = 0.03) and anterior (p = 0.001) lesions, and exophthalmos and visual acuity deterioration were associated with intraconal (p = 0.02; p = 0.03) and retrobulbar (p = 0.001; p = 0.02) lesions. Complications (11.2%) included diplopia, worsened visual acuity, postoperative blepharoptosis, and postoperative ectropion. Of the patients, 80.4% reported an "excellent" aesthetic outcome. This study underscores the importance of a multidisciplinary approach based on a thorough analysis of preoperative imaging. Periorbital approaches tailored to the lesion's three-dimensional location enables safe access to most intraorbital lesions, resulting in minimal complications and good aesthetic results.

13.
BMC Ophthalmol ; 24(1): 257, 2024 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-38877497

RESUMO

BACKGROUND: Echinococcosis, commonly known as hydatid disease, is a zoonotic infection resulting from the tapeworm Echinococcus granulosus. The occurrence of hydatid cysts in the orbital region is uncommon, representing less than 1% of all reported hydatid cases. This report details a unique case of an intramuscular hydatid cyst in the orbital region that led to compressive optic neuropathy. CASE PRESENTATION: A 22-year-old male from Kabul, Afghanistan presented with a five-month history of progressive proptosis in his left eye, associated with a gradual decrease in vision over the past three weeks. The left eye exhibited upward globe dystopia, ocular motility limitation, mild conjunctival injection, and chemosis. Diagnosis was achieved through imaging and histopathological examination. Treatment involves surgical removal of the cyst and prolonged albendazole therapy. The postoperative course showed significant improvement in the patient's condition and restoration of his vision. CONCLUSIONS: Despite its rarity, this case underscores the importance of awareness and knowledge of hydatid disease among physicians, especially those working in endemic areas. It emphasizes the importance of including hydatid disease in the differential diagnosis of orbital masses, particularly in endemic regions.


Assuntos
Equinococose , Infecções Oculares Parasitárias , Doenças do Nervo Óptico , Doenças Orbitárias , Humanos , Masculino , Equinococose/diagnóstico , Equinococose/complicações , Adulto Jovem , Doenças do Nervo Óptico/diagnóstico , Doenças do Nervo Óptico/parasitologia , Doenças do Nervo Óptico/cirurgia , Infecções Oculares Parasitárias/diagnóstico , Infecções Oculares Parasitárias/parasitologia , Infecções Oculares Parasitárias/cirurgia , Doenças Orbitárias/parasitologia , Doenças Orbitárias/diagnóstico , Imageamento por Ressonância Magnética , Albendazol/uso terapêutico , Tomografia Computadorizada por Raios X
14.
Molecules ; 29(11)2024 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-38893497

RESUMO

Developing materials with dynamic room-temperature phosphorescence (RTP) properties is crucial for expanding the applications of organic light-emitting materials. In this study, we designed and synthesized two novel RTP molecules by combining functional units, incorporating the folded unit thianthrene into the classic luminescent cores thioxanthone or anthraquinone to construct TASO and TA2O. In this combination, the TA unit contributes to the enhancement of spin-orbit coupling (SOC), while the luminescent core governs the triplet energy level. After the strategic manipulation of SOC using the thianthrene unit, the target molecules exhibited a remarkable enhancement in RTP performance. This strategy led to the successful development of TASO and TA2O molecules with outstanding dynamic RTP properties when exposed to continuous ultraviolet irradiation, a result that can be ascribed to their efficient RTP, improved absorption ability, and oxygen-sensitive RTP properties. Leveraging the oxygen-mediated ultraviolet-radiation-induced RTP enhancement in TASO-doped polymer films, we developed a novel time-resolved detection technique for identifying phase separation in polymers with varying oxygen permeability. This research offers a promising approach for constructing materials with dynamic RTP properties.

15.
Sensors (Basel) ; 24(11)2024 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-38894201

RESUMO

Information-Centric Networking (ICN) is the emerging next-generation internet paradigm. The Low Earth Orbit (LEO) satellite mega-constellation based on ICN can achieve seamless global coverage and provide excellent support for Internet of Things (IoT) services. Additionally, in-network caching, typically characteristic of ICN, plays a paramount role in network performance. Therefore, the in-network caching policy is one of the hotspot problems. Especially, compared to caching traditional internet content, in-networking caching IoT content is more challenging, since the IoT content lifetime is small and transient. In this paper, firstly, the framework of the LEO satellite mega-constellation Information-Centric Networking for IoT (LEO-SMC-ICN-IoT) is proposed. Then, introducing the concept of "viscosity", the proposed Caching Algorithm based on the Random Forest (CARF) policy of satellite nodes combines both content popularity prediction and satellite nodes location prediction, for achieving good cache matching between the satellite nodes and content. And using the matching rule, the Random Forest (RF) algorithm is adopted to predict the matching relationship among satellite nodes and content for guiding the deployment of caches. Especially, the content is cached in advance at the future satellite to maintain communication with the current ground segment at the time of satellite switchover. Additionally, the policy considers both the IoT content lifetime and the freshness. Finally, a simulation platform with LEO satellite mega-constellation based on ICN is developed in Network Simulator 3 (NS-3). The simulation results show that the proposed caching policy compared with the Leave Copy Everywhere (LCE), the opportunistic (OPP), the Leave Copy down (LCD), and the probabilistic algorithm which caches each content with probability 0.5 (prob 0.5) yield a significant performance improvement, such as the average number of hops, i.e., delay, cache hit rate, and throughput.

16.
Sensors (Basel) ; 24(11)2024 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-38894488

RESUMO

Aiming to address the chicken-and-egg problem in star identification and the intrinsic parameter determination processes of on-orbit star sensors, this study proposes an on-orbit self-calibration method for star sensors that does not depend on star identification. First, the self-calibration equations of a star sensor are derived based on the invariance of the interstar angle of a star pair between image frames, without any requirements for the true value of the interstar angle of the star pair. Then, a constant constraint of the optical path from the star spot to the center of the star sensor optical system is defined to reduce the biased estimation in self-calibration. Finally, a scaled nonlinear least square method is developed to solve the self-calibration equations, thus accelerating iteration convergence. Our simulation and analysis results show that the bias of the focal length estimation in on-orbit self-calibration with a constraint is two orders of magnitude smaller than that in on-orbit self-calibration without a constraint. In addition, it is shown that convergence can be achieved in 10 iterations when the scaled nonlinear least square method is used to solve the self-calibration equations. The calibrated intrinsic parameters obtained by the proposed method can be directly used in traditional star map identification methods.

17.
ACS Appl Mater Interfaces ; 16(24): 31438-31446, 2024 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-38843313

RESUMO

Spin-orbit torque (SOT) has emerged as an effective means of manipulating magnetization. However, the current energy efficiency of SOT operation is inefficient due to low damping-like SOT efficiency per unit current bias. In this work, we dope conventional rare earth oxides, GdOy, into highly conductive platinum by magnetron sputtering to form a new group of spin Hall materials. A large damping-like spin-orbit torque (DL-SOT) efficiency of about 0.35 ± 0.013 is obtained in Pt0.70(GdOy)0.30 measured by the spin-torque ferromagnetic resonance (ST-FMR) technique, which is about five times that of pure Pt under the same conditions. The substantial enhancement of the spin Hall effect is revealed by theoretical analysis to be attributed to the strong side jump induced by the rare earth oxide GdOy impurities. Moreover, this large DL-SOT efficiency contributes to a low critical switching current density (8.0 × 106 A·cm-2 in the Pt0.70(GdOy)0.30 layer) in current-induced magnetization switching measurements. This systematic study on SOT switching properties suggests that Pt1-x(GdOy)x is an attractive spin current source with large DL-SOT efficiency for future SOT applications and provides another idea to regulate the spin Hall angle.

18.
Nanotechnology ; 35(36)2024 Jun 21.
Artigo em Inglês | MEDLINE | ID: mdl-38861984

RESUMO

Electric field control of spin-orbit torque (SOT) exhibits promising potential in advanced spintronic devices through interfacial modulation. In this work, we investigate the influence of electric field and interfacial oxidation on SOT efficiency in annealed Ta/CoFeB/HfOxheterostructures. By varying annealing temperatures, the damping-like SOT efficiency reaches its peak at the annealing temperature of 320 °C, with an 80% field-free magnetization switching ratio induced by SOT having been demonstrated. This enhancement is ascribed to the annealing-induced modulation of oxygen ion migration at the CoFeB/HfOxinterface. By applying voltages across the Ta/CoFeB/HfOxheterostructures, which drives the O2‒migration across the interface, a reversible, bipolar, and non-volatile modulation of SOT efficiency was observed. The collective influence of annealing temperature and electric field effects on SOT carried out in this work provides an effective approach into facilitating the optimization and control of SOT in spintronic devices.

19.
BMJ Open Ophthalmol ; 9(1)2024 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-38886120

RESUMO

BACKGROUND: Graves' ophthalmopathy is a complex autoimmune disorder that can significantly affect quality of life (QoL), vision and physical appearance. Recently, a deeper understanding of the underlying pathogenesis has led to the development of novel treatment options. AIMS: The purpose of this review is to explore the current literature on conventional and novel treatment modalities and to evaluate which interventions provide the most favourable psychological and clinical outcomes in patients with moderate to severe, active Grave's ophthalmopathy. For example, QoL is an important psychosocial outcome of disease management. However, available literature demonstrates that not all clinically effective treatment options improve patients' QoL. METHODS: A systematic literature review was conducted to assess the clinical and psychosocial outcomes of different therapies for Graves' ophthalmopathy. An extensive database search of Ovid Medline, Ovid Embase and Cochrane Central Register of Controlled Trials was conducted. Studies generated were reviewed and the relevant selected data were retrieved and analysed. RESULTS: Results showed intravenous steroids, rituximab (RTX), tocilizumab and teprotumumab were all significantly effective in improving Clinical Activity Scores. Orbital radiotherapy showed a slight improvement in proptosis and diplopia. All interventions were safe with few serious adverse events being reported across all studies. All treatment modalities demonstrated beneficial improvements in both components of the Graves' Ophthalmopathy-QoL (QoL) questionnaire, apart from orbital radiotherapy which only demonstrated improvements in the visual functioning subscale. Teprotumumab was identified to be the most effective intervention for improving both clinical and psychosocial outcomes. However, further research needs to be conducted to evaluate its side effect profile and cost-effectiveness. Nonetheless, with time it has the potential to be a first-line treatment option in the management of active moderate to severe Graves' ophthalmopathy.


Assuntos
Oftalmopatia de Graves , Qualidade de Vida , Humanos , Oftalmopatia de Graves/terapia , Oftalmopatia de Graves/psicologia , Anticorpos Monoclonais Humanizados/uso terapêutico , Rituximab/uso terapêutico , Fatores Imunológicos/uso terapêutico , Glucocorticoides/uso terapêutico
20.
Clin Case Rep ; 12(6): e9018, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38827937

RESUMO

Key Clinical Message: Timely diagnosis, multidisciplinary surgical intervention, and appropriate imaging are crucial in managing transorbital-penetrating intracranial injuries (TOPIs), minimizing morbidity, and optimizing patient outcomes. Abstract: Transorbital-penetrating intracranial injuries (TOPIs) are rare occurrences with potential for severe neurological complications and high mortality rates. Prompt diagnosis and management are essential to mitigate adverse outcomes. Understanding injury patterns and employing appropriate imaging modalities are crucial for effective surgical planning and patient care. We present a case of a 22-year-old male mechanic who sustained a TOPI involving bilateral frontal lobes with evisceration of the right eye following a workplace accident with a metal cutter. Upon arrival at the emergency department, the patient exhibited vision loss in the right eye, proptosis, and a dilated pupil. Imaging studies revealed the trajectory of a metal arrow through the right orbital roof, necessitating surgical intervention. A multidisciplinary team performed bifrontal craniectomy with duroplasty to remove the foreign body and address associated injuries. Postoperatively, the patient received broad-spectrum antibiotics and anticonvulsants, leading to full recovery and discharge on postoperative day 10. TOPIs present unique challenges due to their rarity and potential for devastating consequences. Our case highlights the importance of timely diagnosis, meticulous surgical planning, and multidisciplinary collaboration in achieving favorable outcomes. Radiological imaging plays a crucial role in guiding treatment decisions and optimizing patient care. This report underscores the significance of early surgical intervention, antimicrobial therapy, and prophylactic measures in reducing morbidity and mortality associated with TOPIs.

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