Spatiotemporal responses to emotional conflict and its psychiatric correlates in adolescents with epilepsy using magnetoencephalography.

People with epilepsy often suffer from comorbid psychiatric disorders, which negatively affects their quality of life. Emotion regulation is an important cognitive process that is impaired in individuals with psychiatric disorders, such as depression. Adults with epilepsy also show difficulties in emotion regulation, particularly during later-stage, higher-order cognitive processing. Yet, the spatiotemporal and frequency correlates of these functional brain deficits in epilepsy remain unknown, as do the nature of these deficits in adolescent epilepsy. Here, we aim to elucidate the spatiotemporal profile of emotional conflict processing in adolescents with epilepsy, relative to controls, using magnetoencephalography (MEG) and relate these findings to anxiety and depression symptom severity assessed with self-report scales. We hypothesized to see blunted brain activity during emotional conflict in adolescents with epilepsy, relative to controls, in the posterior parietal, prefrontal and cingulate cortices due to their role in explicit and implicit regulation around participant response (500-1000 ms). We analyzed MEG recordings from 53 adolescents (28 epilepsy [14focal,14generalized], 25 controls) during an emotional conflict task. We showed that while controls exhibited behavioral interference to emotional conflict, adolescents with epilepsy failed to exhibit this normative response time pattern. Adolescents with epilepsy showed blunted brain responses to emotional conflict in brain regions related to error evaluation and learning around the average response time (500-700 ms), and in regions involved in decision making during post-response monitoring (800-1000 ms). Interestingly, behavioral patterns and psychiatric symptom severity varied between epilepsy subgroups, wherein those with focal epilepsy showed preserved response time interference. Thus, brain responses were regressed with depression and anxiety levels for each epilepsy subgroup separately. Analyses revealed that under activation in error evaluation regions (500-600 ms) predicted anxiety and depression in focal epilepsy, while regions related to learning (600-700 ms) predicted anxiety in generalized epilepsy, suggesting differential mechanisms of dysfunction in these subgroups. Despite similar rates of anxiety and depression across the groups, adolescents with epilepsy still exhibited deficits in emotional conflict processing in brain and behavioral responses. This suggests that these deficits may exist independently from psychopathology and may stem from underlying dysfunctions that predispose these individuals to develop both disorders. Findings such as these may provide potential targets for future research and therapies.

Effects of contextualized emotional conflict control on domain-general conflict control: fMRI evidence of neural network reconfiguration.

Domain-general conflict control refers to the cognitive process in which individuals suppress task-irrelevant information and extract task-relevant information. It supports both effective implementation of cognitive conflict control and emotional conflict control. The present study employed functional magnetic resonance imaging and adopted an emotional valence conflict task and the arrow version of the flanker task to induce contextualized emotional conflicts and cognitive conflicts, respectively. The results from the conjunction analysis showed that the multitasking-related activity in the pre-supplementary motor area, bilateral dorsal premotor cortices, the left posterior intraparietal sulcus (IPS), the left anterior IPS and the right inferior occipital gyrus represents common subprocesses for emotional and cognitive conflict control, either in parallel or in close succession. These brain regions were used as nodes in the domain-general conflict control network. The results from the analyses on the brain network connectivity patterns revealed that emotional conflict control reconfigures the domain-general conflict control network in a connective way as evidenced by different communication and stronger connectivity among the domain-general conflict control network. Together, these findings offer the first empirical-based elaboration on the brain network underpinning emotional conflict control and how it reconfigures the domain-general conflict control network in interactive ways.

Temporal characteristics of emotional conflict processing: the modulation role of attachment styles.

Theoretical account of attachment proposed that individual differences in adult attachment styles play a key role in adjusting balance between affective evaluation and cognitive control. Yet, little is known about the temporal characteristics of emotional conflict processing modulated by attachment styles. Accordingly, the present study used event-related potentials (ERP) and multivariate pattern analysis (MVPA) combined with an emotional face-word Stroop task to investigate the temporal dynamics of attachment-related cognitive-affective patterns in emotional conflict processing. The ERP results demonstrated multiple-process of emotional conflict modulated by attachment styles. In early sensory processing, positive faces captured avoidant attachment individuals' attention as reflected in greater P1, while the same situation led to greater N170 in secure and anxious individuals. Crucially, impairment in conflict-monitoring function was found in anxious individuals as reflected by the absence of interference effect on N450, leading to impaired ability of inhibitory control as indicated by decreased slow potential. In contrast, avoidant individuals showed greater slow potential for inhibiting emotional interference. Furthermore, MVPA revealed that the corresponding time window for conflict monitoring was found for emotional distractors decoding rather than congruency decoding in the anxious attachment group. Convergent results from ERPs and MVPA indicated that the deficits in emotional conflict monitoring and resolution among anxious individuals might be due to the excessive approach to emotional distractors, as they habitually use emotional evaluation rather than cognitive control. In summary, the present study provides electrophysiological evidence that attachment styles modulated emotional conflict processing, which highlights the contribution of attachment to social information processing.

fMRI reveals overlapping and non-overlapping neural bases of domain-general and emotional conflict control.

The present study uses functional magnetic resonance image (fMRI) to examine the overlapping and specific neural correlates of contextualized emotional conflict control and domain-general conflict control. During a performance on emotional and domain-general conflict tasks, conjunction analyses showed that neural areas distributed in the frontoparietal network were engaged in both processes, supporting the notion that similar neural mechanisms are implemented in these two types of control. Importantly, disjunction analyses revealed a broader neural recruitment of emotional conflict control compared to domain-general conflict control as shown by the possible lateralization of the lateral prefrontal cortex (lPFC), such that emotional conflict control significantly involved the left lPFC while domain-general conflict control seemly involved the right lPFC. Results of generalized psychophysiological interaction (gPPI) analyses further demonstrated that emotional conflict control, compared to domain-general conflict control, elicited broader synergistic activities in individuals' brain networks. Together, these findings offer novel and compelling neural evidence that furthers our understanding of the complex relationship between domain-general and emotional conflict control.

The neural correlates of emotional conflict monitoring as an early manifestation of affective and cognitive declines in persons with Type 2 diabetes.

Patients with Type 2 diabetes are known to be more susceptible to experience dementia and depression/anxiety. The neural circuits of emotional conflict monitoring, as indicated by a Stroop task, might become altered in terms of cognitive and affective impairments in diabetes. This study investigated alterations in the emotional conflict monitoring and associations of corresponding brain activities with metabolic parameters in persons with Type 2 diabetes. Participants with normal cognitive and affective functioning, including 40 persons with Type 2 diabetes and 30 non-diabetes control subjects, underwent a functional MRI paradigm with the face-word emotional Stroop task and detailed cognitive and affective assessments, including the Montreal Cognitive Assessment and Beck Anxiety Inventory. Compared with the controls, people with diabetes exhibited stronger emotional interference, as indicated by differential reaction times between congruent and incongruent trials (Δcon). Δcon was correlated with Montreal Cognitive Assessment test scores and fasting glucose levels. People with diabetes demonstrated altered brain activation and functional connectivity in the neural network for emotional conflict monitoring. The neural network for emotional conflict monitoring mediated the association of pancreatic function with anxiety scores as well as the relationship between Δcon and Montreal Cognitive Assessment scores. Results suggested that alterations in the neural network underlying emotional conflict monitoring might present before clinically measurable cognitive and affective decrements were apparent, thereby bridging the gap between dementia and anxiety/depression in persons with diabetes.

Proactive and reactive cognitive control for emotional conflict in individuals with high schizotypy: An ERP study.

OBJECTIVE: The present study aimed to examine how individuals with high schizotypy, a high risk group of schizophrenia patients, resolve emotional conflict in proactive and reactive control and the underlying neural mechanisms. METHODS: Thirty-two individuals with high schizotypy and 30 matched individuals with low schizotypy completed an emotional face-word Stroop task with electroencephalographic data recorded. The proportion of incongruent trials was manipulated in the task to induce proactive control (mostly incongruent trials context, MI context) or reactive control (mostly congruent trials context, MC context). Two event-related potential (ERP) components (N170 and N2) were examined, which represent face processing and cognitive control processes, respectively. RESULTS: In the MC context, significantly decreased N2 and N170 amplitudes were found in high schizotypy individuals compared with low schizotypy individuals, suggesting abnormal neural activity of reactive control in high schizotypy individuals. No significant differences were found between the two groups in the MI context. CONCLUSIONS: These results provide initial evidence for dissociation of neural activity of proactive and reactive control on emotional conflict in individuals with high schizotypy. SIGNIFICANCE: The current findings provide important insight into the emotional conflict resolution in the schizophrenia spectrum.

The importance of informal support and a listening ear: A narrative analysis of emotional conflict and support needs of siblings of children with a psychiatric disorder.

This study investigates the self-reported impact of children's psychiatric disorders on their siblings and assesses what forms of support such children most value. We used a qualitative research design with open interviews to stimulate children between 8 and 15 years old to talk about their experiences living with a brother or sister with a psychiatric disorder. Their stories were analysed within a hermeneutic phenomenological framework in order to identify narrative themes and interpret the meaning of shared experiences. From our analysis, nine shared narrative themes emerge. Overall, siblings report feeling conflicted about adapting their lives to their brother's or sister's disorder and signal a need for personalized attention from parents. They also indicate that being involved in the care for their brother or sister helps them to better understand their behaviour. Finally, siblings reveal that, in their experience, formal, protocolized forms of support foreground family problems and stress. Thus, we recommend to involve children in the care process; to acknowledge their personal needs and conflicts; and to be mindful of the style of support: help offered in an informal or playful way, instead of formal and protocolized, could be a more effective way of meeting siblings' needs.

The role of arousal and motivation in emotional conflict resolution: Implications for spinal cord injury.

Under many conditions, emotional information is processed with priority and it may lead to cognitive conflict when it competes with task-relevant information. Accordingly, being able to ignore emotional information relies on cognitive control. The present perspective offers an integrative account of the mechanism that may underlie emotional conflict resolution in tasks involving response activation. We point to the contribution of emotional arousal and primed approach or avoidance motivation in accounting for emotional conflict resolution. We discuss the role of arousal in individuals with impairments in visceral pathways to the brain due to spinal cord lesions, as it may offer important insights into the "typical" mechanisms of emotional conflict control. We argue that a better understanding of emotional conflict control could be critical for adaptive and flexible behavior and has potential implications for the selection of appropriate therapeutic interventions.

Attention bias modification through transcranial direct current stimulation (tDCS): A review.

Attention bias is a tendency to preferably detect, orient and select emotionally valued stimuli, as compared to neutral stimuli, and plays a crucial role in the psychopathology of various psychiatric disorders. Transcranial direct current stimulation (tDCS) has been applied for the alteration of attention bias in health and disease with different parameters and conditions, but the contribution of these factors to the magnitude and directionality of effects has not previously been comprehensively reviewed. In this review, we aimed to systematically explore the effects of tDCS on attention bias in different tasks, tDCS conditions, and health states. Data were collected in accordance with the PRISMA approach. A literature search identified 22 original experiments that explored the effects of tDCS on attention bias. Determinants of tDCS effects on attention bias were cortical target areas, the specific task under study, stimulation parameters, and the presence of psychopathology. Relevant cortical areas for modification of attention bias via tDCS were the dorsolateral prefrontal cortex (dlPFC) and ventromedial prefrontal cortex (vmPFC). The observed heterogeneity of the impact of tDCS on the modulation of attention bias can be explained by the area of stimulation, valence of stimuli, task characteristics, and the intensity of stimulation.

The role of the dorsolateral and ventromedial prefrontal cortex in emotion regulation in females with major depressive disorder (MDD): A tDCS study.

BACKGROUND: Individuals with major depressive disorder (MDD) have deficits in emotion regulation, which plays a putative role in psychopathology. The ventromedial prefrontal cortex (vmPFC) and dorsolateral prefrontal cortex (dlPFC) are assumed to be involved in respective processes. In the present study, we aimed to explore the effect of stimulation over the dlPFC and vmPFC on emotion regulation in female with MDD. MATERIAL AND METHODS: Twenty women with MDD performed the Emotional Stroop, Emotional Go/No-Go, and Emotional 1-Back tasks during transcranial direct current stimulation (tDCS) in three separate sessions with the following electrode montages: anodal dlPFC (F3)/cathodal vmPFC (Fp2), anodal vmPFC (Fp2)/cathodal dlPFC (F3), and sham stimulation. RESULTS: Independent of the valence of the respective stimuli, accuracy and speed of interference control, accuracy of pre-potent inhibition, and accuracy, but not speed, of working memory performance improved during anodal left dlPFC/cathodal right vmPFC stimulation. Independent of stimulation conditions, interference control was reduced for sad faces, as compared to happy and neutral faces, and working memory performance was faster for happy than for neutral and sad faces. For the impact of stimulation on specific emotional qualities, anodal left dlPFC/cathodal right vmPFC, compared to sham stimulation, led to improved interference control of sad and neutral faces in the emotional Stroop task, as shown by faster reaction times. Furthermore, in that task accuracy with respect to neutral and happy face conditions was higher during both real stimulation conditions, as compared to sham stimulation. CONCLUSION: The dlPFC is involved in emotion regulation in MDD. Emotional valence is moreover relevant for the effect of stimulation over this area on interference control in MDD.

Affective Dysregulation in Children Is Associated With Difficulties in Response Control in Emotional Ambiguous Situations.

BACKGROUND: Affective dysregulation (AD), or synonymously "irritability," is a transdiagnostic construct that serves as a diagnostic criterion in various childhood mental disorders. It is characterized by severe or persistent outbursts of anger and aggression. Emotional self-regulation is highly dependent on the ability to process relevant and ignore conflicting emotional information. Understanding neurophysiological mechanisms underlying impairment in AD may provide a starting point for research on pharmacological treatment options and evaluation of psychotherapeutic intervention. METHODS: A total of 120 children 8 to 12 years of age (63 with AD and 57 typically developing) were examined using an emotional Stroop task. Signal-decomposed electroencephalographic recordings providing information about the affected sensory-perceptual, response selection, or motor information processing stage were combined with source localization. RESULTS: Behavioral performance revealed dysfunctional cognitive-emotional conflict monitoring in children with AD, suggesting difficulties in differentiating between conflicting and nonconflicting cognitive-emotional information. This was confirmed by the electroencephalographic data showing that they cannot intensify response selection processes during conflicting cognitive-emotional situations. Typically developing children were able to do so and activated a functional-neuroanatomical network comprising the left inferior parietal cortex (Brodmann area 40), right middle frontal (Brodmann area 10), and right inferior/orbitofrontal (Brodmann area 47) regions. Purely sensory-perceptual selection and motor execution processes were not modulated in AD, as evidenced by Bayesian analyses. CONCLUSIONS: Behavioral and electroencephalogram data suggest that children with AD cannot adequately modulate controlled response selection processes given emotionally ambiguous information. Which neurotransmitter systems underlie these deficits and how they can be improved are important questions for future research.

Incongruence effects in cross-modal emotional processing in autistic traits: An fMRI study.

In everyday life, emotional information is often conveyed by both the face and the voice. Consequently, information presented by one source can alter the way in which information from the other source is perceived, leading to emotional incongruence. Here, we used functional magnetic resonance imaging (fMRI) to examine neutral correlates of two different types of emotional incongruence in audiovisual processing, namely incongruence of emotion-valence and incongruence of emotion-presence. Participants were in two groups, one group with a low Autism Quotient score (LAQ) and one with a high score (HAQ). Each participant experienced emotional (happy, fearful) or neutral faces or voices while concurrently being exposed to emotional (happy, fearful) or neutral voices or faces. They were instructed to attend to either the visual or auditory track. The incongruence effect of emotion-valence was characterized by activation in a wide range of brain regions in both hemispheres involving the inferior frontal gyrus, cuneus, superior temporal gyrus, and middle frontal gyrus. The incongruence effect of emotion-presence was characterized by activation in a set of temporal and occipital regions in both hemispheres, including the middle occipital gyrus, middle temporal gyrus and inferior temporal gyrus. In addition, the present study identified greater recruitment of the right inferior parietal lobule in perceiving audio-visual emotional expressions in HAQ individuals, as compared to the LAQ individuals. Depending on face or voice-to-be attended, different patterns of emotional incongruence were found between the two groups. Specifically, the HAQ group tend to show more incidental processing to visual information whilst the LAQ group tend to show more incidental processing to auditory information during the crossmodal emotional incongruence decoding. These differences might be attributed to different attentional demands and different processing strategies between the two groups.

Neurocognitive Effects of Preceding Facial Expressions on Perception of Subsequent Emotions.

In everyday life, individuals successively and simultaneously encounter multiple stimuli that are emotionally incongruent. Emotional incongruence elicited by preceding stimuli may alter emotional experience with ongoing stimuli. However, the underlying neural mechanisms of the modulatory influence of preceding emotional stimuli on subsequent emotional processing remain unclear. In this study, we examined self-reported and neural responses to negative and neutral pictures whose emotional valence was incongruent with that of preceding images of facial expressions. Twenty-five healthy participants performed an emotional intensity rating task inside a brain scanner. Pictures of negative and neutral scenes appeared, each of which was preceded by a pleasant, neutral, or unpleasant facial expression to elicit a degree of emotional incongruence. Behavioral results showed that emotional incongruence based on preceding facial expressions did not influence ratings of subsequent pictures' emotional intensity. On the other hand, neuroimaging results revealed greater activation of the right dorsomedial prefrontal cortex (dmPFC) in response to pictures that were more emotionally incongruent with preceding facial expressions. The dmPFC had stronger functional connectivity with the right ventrolateral prefrontal cortex (vlPFC) during the presentation of negative pictures that followed pleasant facial expressions compared to those that followed unpleasant facial expressions. Interestingly, increased functional connectivity of the dmPFC was associated with the reduced modulatory influence of emotional incongruence on the experienced intensity of negative emotions. These results indicate that functional connectivity of the dmPFC contributes to the resolution of emotional incongruence, reducing the emotion modulation effect of preceding information on subsequent emotional processes.

Semi-supervised random forest regression model based on co-training and grouping with information entropy for evaluation of depression symptoms severity.

Semi-supervised learning has always been a hot topic in machine learning. It uses a large number of unlabeled data to improve the performance of the model. This paper combines the co-training strategy and random forest to propose a novel semi-supervised regression algorithm: semi-supervised random forest regression model based on co-training and grouping with information entropy (E-CoGRF), and applies it to the evaluation of depression symptoms severity. The algorithm inherits the ensemble characteristics of random forest, and combines well with co-training. In order to balance the accuracy and diversity of co-training random forests, the algorithm proposes a grouping strategy to decision trees. Moreover, the information entropy is used to measure the confidence, which avoids unnecessary repeated training and improves the efficiency of the model. In the practical application of evaluation of depression symptoms severity, we collect cognitive behavioral data of emotional conflict based on the depressive affective disorder. And on this basis, feature construction and normalization preprocessing are carried out. Finally, the test is conducted on 35 labeled and 80 unlabeled depression patients. The result shows that the proposed algorithm obtains MAE (Mean Absolute Error) = 3.63 and RMSE (Root Mean Squared Error) = 4.50, which is better than other semi-supervised regression algorithms. The proposed method effectively solves the modeling difficulties caused by insufficient labeled samples, and has important reference value for the diagnosis of depression symptoms severity.

The Inhibitory Effect of Emotional Conflict Control on Memory Retrieval.

Evidence is mounting that emotional conflict is mainly resolved by the rostral anterior cingulate inhibiting the processing of emotional distractors. However, this theory has not been verified from the perspective of memory retrieval. This experiment aimed to explore the offline effect of emotional conflict processing on memory retrieval. We adopted a modified encoding-retrieval paradigm to explore this issue. Participants' electroencephalography (EEG) signal were also collected. A face-word Stroop task was used to create the congruency factor. In addition, an old/new judgment task was used to evaluate the recognition performance. During the retrieval phase, the response time of the incongruent condition was longer and the recognition accuracy was lower compared with congruent and neutral conditions in the behavioral data. For event-related potentials (ERP), we detected two well-established old/new effects related to memory retrieval under both neutral and emotional conditions: the frontal negativity (FN400) related to familiarity-driven recognition and the late posterior negativity (LPN) related to reconstructive processing or evaluation of retrieval outcomes. More importantly, the old/new effects were missing for incongruent condition during the early stage of FN400 (300-400 ms). Besides, for LPN (700-900 ms), the old/new effects of the incongruent condition are greater than the congruent condition. The results prove that the encoding phase's emotional congruency factor has a regulatory effect on the retrieval phase's early familiarity processing and evaluation of retrieval outcomes. Our data confirm the inhibitory effect of emotional conflict control on memory retrieval and support the emotional conflict control mechanism found in previous studies.

The influence of social power on neural responses to emotional conflict.

BACKGROUND: Major power theories assume that social power can play an important role in an individual's goal-related behaviors. However, the specific psychological mechanisms through which this occurs remain unclear. Some studies suggested that having power enhanced individuals' goal-related behaviors, by contrast, other studies suggested that low-power individuals were associated with a greater performance in goal-directed tasks. We were particularly interested in how social power changes individuals' goal-related behaviors during an emotional face-word Stroop task. METHOD: Social power was primed by asking participants to recall a past situation in which they were in a position of power (high-power individuals), or a situation in which they were lacking power (low-power individuals). Afterward, participants were asked to complete an emotional face-word Stroop task. In the task, words representing specific emotions were written in a prominent red color across a face, and these words and facial expressions were either congruent or incongruent. The participant's task was to judge the emotion of the face while ignoring the red emotional words. RESULTS: Our behavioral data showed that these individuals displayed faster reaction time and better accuracy in congruent conditions, slower reaction time for fearful faces and worse accuracy for happy faces in both incongruent and congruent conditions. The event-related potential analyses showed that, compared with low-power individuals, high-power individuals showed greater P1 amplitudes when faced with emotional stimuli (both incongruent and congruent conditions), indicating that power affects individuals' attention in the early sensory processing of emotional stimuli. For the N170 component, low-power individuals showed more negative amplitudes when facing emotional stimuli, indicated that low-power individuals paid more attention to the construct information of emotional stimuli. For the N450 component, compared with congruent conditions, incongruent conditions elicited more negative amplitudes for both high- and low-power individuals. More importantly, fearful faces provoked enhanced P1 amplitudes in incongruent conditions than in congruent conditions only for low-power individuals, while, happy faces elicited larger P1 amplitudes in congruent conditions than in incongruent conditions only for high-power individuals. The findings suggested that during the initial stage of stimuli processing low-power individuals are more sensitive to negative stimuli than high-power individuals. CONCLUSION: These findings provided electrophysiological evidence that the differences in the emotional conflict process between high- and low-power individuals mainly lies in the early processing stages of emotional information. Furthermore, evidence from P1 and N170 showed that there was also a redistribution of attentional resources in low-power individuals.

Functional connectivity between the ventral anterior cingulate and amygdala during implicit emotional conflict regulation and daily-life emotion dysregulation.

Emotional conflict adaptation involving ventral anterior cingulate cortex (ACC) suppression of the amygdala is thought to be important in emotion regulation, with evidence of impaired implicit emotion regulation in emotional distress disorders. However, it is unclear how this impairment is associated with daily-life emotion dysregulation in emotional distress disorders. In the current study, female participants with an emotional distress disorder (N = 27) were scanned with MRI while completing an implicit emotion conflict regulation task that involved identifying the facial expression of an image while ignoring an overlaid congruent or incongruent affect label. Participants then completed two weeks of ambulatory assessment of daily-life emotion dysregulation. Consistent with previous research on comorbid emotional distress disorders (Etkin and Schatzberg, 2011), there was no behavioral effect of emotional conflict adaptation (p = .701) but a significant effect of congruent adaptation (p = .006), suggesting impairment is specific to implicit emotional conflict regulation. Additionally, there was no neural evidence of emotional conflict adaptation in the ventral ACC and amygdala (ps > .766). Further, in our primary psychophysiological interactions analyses, we examined ventral ACC-amygdala functional connectivity. As hypothesized, increased ventral ACC-amygdala functional connectivity for emotional conflict adaptation was associated with increased daily-life affective instability (p = .022), but not mean daily-life negative affect (p = .372). Overall, results provide behavioral and neural evidence of impaired implicit emotional conflict adaptation in individuals with emotional distress disorders and suggests that this impairment is related to daily-life affective instability in these disorders.

Facial and Vocal Expressions During Clinical Interviews Suggest an Emotional Modulation Paradox in Borderline Personality Disorder: An Explorative Study.

Videotape recordings obtained during an initial and conventional psychiatric interview were used to assess possible emotional differences in facial expressions and acoustic parameters of the voice between Borderline Personality Disorder (BPD) female patients and matched controls. The incidence of seven basic emotion expressions, emotional valence, heart rate, and vocal frequency (f0), and intensity (dB) of the discourse adjectives and interjections were determined through the application of computational software to the visual (FaceReader) and sound (PRAAT) tracks of the videotape recordings. The extensive data obtained were analyzed by three statistical strategies: linear multilevel modeling, correlation matrices, and exploratory network analysis. In comparison with healthy controls, BPD patients express a third less sadness and show a higher number of positive correlations (14 vs. 8) and a cluster of related nodes among the prosodic parameters and the facial expressions of anger, disgust, and contempt. In contrast, control subjects showed negative or null correlations between such facial expressions and prosodic parameters. It seems feasible that BPD patients restrain the facial expression of specific emotions in an attempt to achieve social acceptance. Moreover, the confluence of prosodic and facial expressions of negative emotions reflects a sympathetic activation which is opposed to the social engagement system. Such BPD imbalance reflects an emotional alteration and a dysfunctional behavioral strategy that may constitute a useful biobehavioral indicator of the severity and clinical course of the disorder. This face/voice/heart rate emotional expression assessment (EMEX) may be used in the search for reliable biobehavioral correlates of other psychopathological conditions.

Fluid intelligence and neural mechanisms of emotional conflict adaptation.

Emotional conflict adaptation is an important process of cognitive control in human behavioral regulation. The face-word Stroop task and the emotional Simon task were employed to explore the correlation between fluid intelligence and neural processes of emotional conflict adaptation using event-related potential (ERP) techniques. Thirty-two intellectually average children (mean age of 10.72 years) and thirty-four intellectually gifted children (mean age of 10.86 years) participated in the present study. The behavioral results indicated that both intellectually gifted and average children showed reliable emotional conflict adaptation effects (CAEs) on reaction times (RTs) and error rates. However, the two IQ groups differed in the magnitude of error rates during emotional conflict adaptation. The electrophysiological results further revealed that the IQ differences in emotional conflict adaptation were mainly associated with emotional conflict detection processes as demonstrated by the frontal N2-CAE values. The two IQ groups did not differ in early P3 or late P3 responses during emotional conflict resolution processes. The gifted and average children showed different patterns during cognitive control processes when facing emotional Simon conflicts and emotional Stroop conflicts. The current study emphasizes the importance of frontal function during cognitive control of emotional information from the perspective of individual differences.

Escitalopram ameliorates differences in neural activity between healthy comparison and major depressive disorder groups on an fMRI Emotional conflict task: A CAN-BIND-1 study.

BACKGROUND: Identifying objective biomarkers can assist in predicting remission/non-remission to treatment, improving remission rates, and reducing illness burden in major depressive disorder (MDD). METHODS: Sixteen MDD 8-week remitters (MDD-8), twelve 16-week remitters (MDD-16), 14 non-remitters (MDD-NR) and 30 healthy comparison participants (HC) completed a functional magnetic resonance imaging emotional conflict task at baseline, prior to treatment with escitalopram, and 8 weeks after treatment initiation. Patients were followed 16 weeks to assess remitter status. RESULTS: All groups demonstrated emotional Stroop in reaction time (RT) at baseline and Week 8. There were no baseline differences between HC and MDD-8, MDD-16, or MDD-NR in RT or accuracy. By Week 8, MDD-8 demonstrated poorer accuracy compared to HC. Compared to HC, the baseline blood-oxygen level dependent (BOLD) signal was decreased in MDD-8 in brain-stem and thalamus; in MDD-16 in lateral occipital cortex, middle temporal gyrus, and cuneal cortex; in MDD-NR in lingual and occipital fusiform gyri, thalamus, putamen, caudate, cingulate gyrus, insula, cuneal cortex, and middle temporal gyrus. By Week 8, there were no BOLD activity differences between MDD groups and HC. LIMITATIONS: The Emotional Conflict Task lacks a neutral (non-emotional) condition, restricting interpretation of how mood may influence perception of non-emotionally valenced stimuli. CONCLUSIONS: The Emotional Conflict Task is not an objective biomarker for remission trajectory in patients with MDD receiving escitalopram treatment. Escitalopram may have influenced emotion recognition in MDD groups in terms of augmented accuracy and BOLD signal in response to an Emotional Conflict Task, following 8 weeks of escitalopram treatment.