Exposure to the herbicide 2,4-dichlorophenoxyacetic acid and prostate cancer among U.S. adult men.

PURPOSE: Prostate cancer is the second most diagnosed male malignancy in the U.S. 2,4-Dichlorophenoxyacetic acid (2,4-D) is a commonly used herbicide and potential carcinogen. The researchers evaluated the association between prostate cancer and 2,4-D. METHODS: Data was leveraged from the National Health and Nutrition Examination Survey (NHANES), a population-based, cross-sectional study of men and women in the U.S. Our cohort of interest was men aged 50 years and over. Urinary 2,4-D served as the measure of exposure. Our primary outcome was history of prostate cancer based on an individual's reply of "yes" to either ever having been diagnosed with prostate cancer and/or having received treatment for prostate cancer. Chi-square, one-way analysis of variance (ANOVA), and multivariable, weighted logistic regression were used to analyze the relationship between 2,4-D and prostate cancer. RESULTS: We identified 1,788 eligible men, representing an estimated 691,709 men after survey weighting. The median 2,4-D level was 0.28 µg/L (IQR: 0.26-0.53), and the geometric mean was 0.38 µg/L. Increasing exposure of 2,4-D was associated with prostate cancer (OR 1.72, 95% CI [1.2,2.4]). Individuals in the highest quartile of 2,4-D exposure had a higher odds of a prostate cancer diagnosis compared to the lowest quartile (OR = 3.46 95% CI [1.11,10.72]). Age stratification revealed statistically significant associations between 2,4-D and prostate cancer in men age 70 + who were in the highest quartile of exposure (OR = 3.79 95% CI [1.51,9.52]). CONCLUSIONS: These findings implicate 2,4-D exposure in the risk of prostate cancer. Future studies are warranted to corroborate these findings and elucidate potential mechanisms underlying these associations.

Environmental health risk assessment and acute effects of sulfur dioxide (SO2) inhalation exposure on traditional sulfur miners at Ijen Crater Volcano, Indonesia.

The Ijen Crater volcano is one of the geological wonders recognized by UNESCO. Inside it is a blue lake with a high acidity level, and a blue fire phenomenon has formed due to the very high concentration of sulfur. This crater is also one of Indonesia's largest sources of sulfur and is used by locals as a traditional sulfur mine. This study aims to measure SO2 concentrations and assess the health risks of SO2 exposure in traditional sulfur mine workers. The SO2 measurements were taken using impingers at six sample points along the mine workers' path. In addition, anthropometric data, work activity patterns, and health complaints during work were collected through direct interviews with 30 respondents selected based on inclusion criteria. Short-Term Health Impact Method was carried out based on a comparison of threshold level values and acute effects obtained from interviews regarding health complaints. The Hazard Question Index (HQ Index) of SO2 exposure was calculated using the health risk assessment method. The SO2 concentrations between 3.14 and 18.24 mg/m3. All sample points were above the quality standard threshold set by the EPA of 1.97 mg/m3. The most common health complaints workers experienced were eye irritation and coughing while working, followed by headache, shortness of breath, and skin irritation. The HQ index of SO2 exposure in workers was 1.02 for real-time exposure and 2.15 for long-term exposure. An HQ index ≥ 1 indicates a potential health risk for workers. Therefore, it is important to control workers' SO2 exposure.

Applying Latent Variable Models to Estimate Cumulative Exposure Burden to Chemical Mixtures and Identify Latent Exposure Subgroups: A Critical Review and Future Directions.

Environmental mixtures, which reflect joint exposure to multiple environmental agents, are a major focus of environmental health and risk assessment research. Advancements in latent variable modeling and psychometrics can be used to address contemporary questions in environmental mixtures research. In particular, latent variable models can quantify an individual's cumulative exposure burden to mixtures and identify hidden subpopulations with distinct exposure patterns. Here, we first provide a review of measurement approaches from the psychometrics field, including structural equation modeling and latent class/profile analysis, and discuss their prior environmental epidemiologic applications. Then, we discuss additional, underutilized opportunities to leverage the strengths of psychometric approaches. This includes using item response theory to create a common scale for comparing exposure burden scores across studies; facilitating data harmonization through the use of anchors. We also discuss studying fairness or appropriateness of measurement models to quantify exposure burden across diverse populations, through the use of mixture item response theory and through evaluation of measurement invariance and differential item functioning. Multi-dimensional models to quantify correlated exposure burden sub-scores, and methods to adjust for imprecision of chemical exposure data, are also discussed. We show that there is great potential to address pressing environmental epidemiology and exposure science questions using latent variable methods.

Examining select sociodemographic characteristics of sub-county geographies for public health surveillance.

BACKGROUND: Mapping health outcomes related to environmental health hazards at the county level can lead to a simplification of risks experienced by populations in that county. The Centers for Disease Control and Prevention's National Environmental Public Health Tracking Program has developed sub-county geographies that aggregate census tracts to allow for stable, minimally suppressed data to be displayed. This helps to highlight more local variation in environmental health outcomes and risk data. However, we wanted to understand whether the aggregation method used was aggregating sociodemographically similar or dissimilar areas with one another. This analysis attempts to explore whether the distributions of select people who may be at increased risk for exposure to environmental health hazards as identified by the Tracking Program are preserved in these sub-county geographies with the census tracts used as the foundation to create them. METHODS: Mean values of three sociodemographic characteristics (persons aged 65 years and older, people from racial and ethnic minority groups, and population below the poverty level) for each sub-county geography in five states were calculated and placed into five break groups. Differences in break groups were determined and compared for each sub-county geography and census tract. RESULTS: The sociodemographic characteristics among the census tracts and two aggregated sub-county geographies were similar. In some instances, census tracts with a low population or a highly skewed population (e.g., very high percentage of population aged 65 years and older) were aggregated with dissimilar census tracts out of necessity to meet the requirements set by the Tracking Program's aggregation methodology. This pattern was detected in 2.41-6.59% of census tracts within the study area, depending on the sociodemographic variable and aggregation level. CONCLUSIONS: The Tracking Program's sub-county aggregation methodology aggregates census tracts with similar characteristics. The two new sub-county geographies can serve as a potential option for health officials and policymakers to develop targeted interventions using finer resolution health outcome and environmental hazard data compared to coarser resolution county-level data.

Utopia of Safe Air: How Soviet Research Challenged Western Air Quality Norms, 1950s-1960s.

During the mid-twentieth century, the Soviet Union developed ambitious hygiene standards for clean air that were grounded in extremely sensitive methods of physiological research. As Western experts sought to develop universal standards for environmental regulation, Soviet hygiene research posed a challenge. This article examines the discussions surrounding the Soviet approach at international conferences on air pollution and industrial hygiene during the mid-twentieth century. The article shows that although the Soviet approach was rejected especially by United States experts, many of its qualities resonated with the ongoing discussions about environmental health in the US. The sensitive and holistic methods of the Soviets were compelling in the effort to reveal the most subtle effects environments had on human health. This article shows how the rejection of Soviet standards stemmed not from different scientific methods but from the differences in the overall ideals of environmental regulation. I argue that Soviet hygiene can be seen as an extreme version of technocratic expertise, and its failure highlights the limits of scientific expertise in managing environmental pollution.

Comparative analysis of the bioaccumulation of bisphenol A in the blood serum and follicular fluid of women living in two areas with different environmental impacts.

Introduction: Bisphenol A (BPA) is a common contaminant widely used in many industrial sectors. Because of its wide use and dispersion, it can be accumulated in living human bodies through both oral assumption and nondietary routes. BPA exhibits hormone-like properties, falling under the class of endocrine disruptors; therefore, it can alter relevant physiological functions. In particular, in women, it can affect folliculogenesis and therefore reproduction, contributing not only to infertility, but also to endometriosis and premature puberty. Methods: We conducted a multicenter study on 91 women undergoing a first in vitro fertilization (IVF) treatment in the Campania region (Southern Italy). We investigated the presence and concentration of BPA in serum and follicular fluids to assess the effects of airborne BPA contamination. The analysis was conducted on 32 women living in a low environmental impact (LEI) area, from the Sele Valley River and Cilento region, and 59 women living in a high environmental impact (HEI) area, the so-called "Land of Fires", a highly contaminated territory widely exposed to illegal waste practices. Results: A higher average BPA content in both blood serum and follicular fluid was revealed in the HEI group when compared with the LEI group. In addition, we revealed higher average BPA content in blood serum than in folliclular fluid in the HEI area, with opposite average content in the two fluids in the LEI zone. In addition, our results also showed a lack of correlation between BPA content in follicular and serum fluids both in the overall population and in the HEI and LEI groups, with peculiar trends in different subsets of women. Conclusion: From our results, we revealed a heterogeneity in the distribution of BPA content between serum and follicular fluid. Further studies are needed to unravel the bioaccumulation mechanisms of BPA in highly polluted and nonpolluted areas.

Climate change and human health in Alpine environments: an interdisciplinary impact chain approach understanding today's risks to address tomorrow's challenges.

The European Alps, home to a blend of permanent residents and millions of annual tourists, are found to be particularly sensitive to climate change. This article employs the impact chain concept to explore the interplay between climate change and health in Alpine areas, offering an interdisciplinary assessment of current and future health consequences and potential adaptation strategies.Rising temperatures, shifting precipitation patterns and increasing extreme weather events have profound implications for the Alpine regions. Temperatures have risen significantly over the past century, with projections indicating further increases and more frequent heatwaves. These trends increase the risk of heat-related health issues especially for vulnerable groups, including the elderly, frail individuals, children and recreationists. Furthermore, changing precipitation patterns, glacier retreat and permafrost melting adversely impact slope stability increasing the risk of gravity-driven natural hazards like landslides, avalanches and rockfalls. This poses direct threats, elevates the risk of multi-casualty incidents and strains search and rescue teams.The environmental changes also impact Alpine flora and fauna, altering the distribution and transmission of vector-borne diseases. Such events directly impact healthcare administration and management programmes, which are already challenged by surges in tourism and ensuring access to care.In conclusion, Alpine regions must proactively address these climate change-related health risks through an interdisciplinary approach, considering both preventive and responsive adaptation strategies, which we describe in this article.

Microplastics and nanoplastics in cardiovascular disease-a narrative review with worrying links.

With the widespread use of plastic products and the increase in waste, microplastics and nanoplastics (MNPs) have become an important issue in global environmental pollution. In recent years, an increasing number of studies have shown that MNPs may have negative impacts on human health. This review aimed to explore the association between MNPs and cardiovascular disease and provide an outlook for future research. Research has shown that there may be a link between MNPs exposure and cardiovascular disease. Laboratory studies have shown that animals exposed to MNPs often exhibit abnormalities in the cardiovascular system, such as increased blood pressure, vascular inflammation, and myocardial damage. Epidemiological surveys have also revealed that people exposed to MNPs are more likely to suffer from cardiovascular diseases, such as hypertension and myocardial infarction. Although the specific impact mechanism is not fully understood, there are several possible pathways of action, including the effects of toxic substances on MNPs and interference with the endocrine system. In summary, MNPs exposure may have a negative impact on cardiovascular health, but further research is needed to confirm its specific mechanism and extent of impact to guide relevant public health and environmental policies.

Cross-environmental cycling of antimicrobial resistance in agricultural areas fertilized with poultry litter: A one health approach.

Poultry litter, commonly used as an organic fertilizer, can contain antimicrobial residues, resistant bacteria, and/or antimicrobial resistance genes. After application to soil, these contaminants can reach crops and be transported to aquatic systems through leaching and runoff. Once in water bodies, they can return to soil and crops through irrigation, establishing a cycle that promotes the selection, spread and persistence of antimicrobial resistance. To investigate the hypothesis of a cyclical event, samples of poultry litter, cultivable soil fertilized with this organic residue, rhizosphere soil from Sechium edule (chayote), water, and sediments from irrigation ponds were collected across two agricultural and poultry-producing areas during the dry and rainy seasons. Clinically significant bacteria, especially bacteria belonging to the Enterobacteriaceae family, were isolated. Fifty-three strains exhibited one or more antimicrobial resistance genes, as detected by PCR amplification, including those conferring resistance to sulfonamides (sul1 and sul2), fluoroquinolones (qnrB, qnrA, and qnrS), and ß-lactams (blaGES, blaTEM, blaSHV, blaCTX-M-1/2,blaCTX-M-8, and blaCTX-M-14). Genes encoding integrases related to class-1 and 2 integrons (intI1 and intI2) were also observed. A rare occurrence of the blaGES gene was observed in Stenotrophomonas sp. and Brevundimonas sp. Strains of Escherichia sp. were multidrug resistant. Sequencing of the 16S rRNA encoding gene indicated unique operational taxonomic units (OTUs) originating from poultry litter and found in the soil, rhizosphere, water, and sediment, highlighting the dissemination of this material across agricultural substrates. These findings strongly suggest the spread of antimicrobial-resistant bacteria in agricultural environments, posing potential risks to both human and animal health.

Measuring Nurses' Knowledge and Awareness of Climate Change and Climate-Associated Diseases: Systematic Review of Existing Instruments.

BACKGROUND: As early as 1995, the Institute of Medicine suggested that nurses were inadequately prepared for and educated about climate change and its health consequences. The aim of this systematic review is to identify the most reliable, robust, and valid instruments for measuring nurses' knowledge and awareness of climate change and climate-associated diseases. METHODS: Included studies were appraised using the Mixed-Methods Appraisal Tool and the Appraisal tool for Cross-Sectional Studies. The psychometrics and clinimetrics of the instruments were evaluated using the COSMIN Risk of Bias checklist and the COSMIN methodology for assessing content validity. RESULTS: Medline, PubMed, Embase, CINAHL Ebesco, Cochrane Library Wiley, Web of Science Core Collection, Trip Database, JBI OVID SP, GreenFILE EBSCO, Google Scholar, ProQuest Dissertations and Theses Global, and DART-EU were consulted. The 14 studies retained identified eight different instruments evaluating attitudes, perceptions, environmental awareness, environmental sensitivity, environmental attitudes, behaviours, motivation, concern, optimism, and experience. This review is reported according to the PRISMA guidelines. CONCLUSIONS: The New Ecological Paradigm Scale (NEPS) and the Climate, Health, and Nursing Tool (CHANT) are the most reliable, robust, and valid instruments for measuring nurses' knowledge and awareness of climate change and climate-associated diseases.

Estimating the potential health effects of cleaner air in the initial stages of the COVID-19 pandemic: a study in Malmö, Sweden.

BACKGROUND: During the initial phase of the COVID-19 pandemic, reductions in air pollution were globally observed owing to decreased human activities, underscoring the potential for cleaner air through shifts in human behaviour. OBJECTIVES: The objective of the present study was to hypothetically estimate the resulting population health impacts in Malmö, Sweden, if these improvements in air quality were to become permanent. METHODS: We utilized air pollution data from two measurement campaigns conducted in the spring of 2019 and the spring of 2020 for our Health Impact Assessment, applying standard methods. This assessment involved making assumptions about baseline population risk and using established concentration-response functions. RESULTS: In the spring of 2020, the NO2 concentrations exhibited an average decrease of 6.6 µg/m3 (42%) decrease and PM2.5 concentrations a 1.9 µg/m3 (22%) decrease, compared to the spring of 2019. If sustained, such improvements could lead to an estimated 1-3% decrease in premature deaths, a 2% decrease in preeclampsia cases, a 6% decrease in low birthweight children, a 4% decrease in bronchitis cases among children, a 2% decrease in asthma cases, a 0.2% decrease in hospital admissions for respiratory diagnoses, and an estimated 11% decrease in dementia cases annually. CONCLUSION: The findings illustrate the potential for enhanced health in Malmö due to improved air quality. Efforts to combat air pollution and implement long-term strategies, such as those targeting urban mobility and commuting patterns, are essential for the health and well-being of both local and global populations.

Main findings: Air quality improvements, akin to those seen during the early COVID-19 phase, could prevent 1­3% of premature deaths, benefiting population health.Added knowledge: The study emphasizes human activities' impact on local air pollution, and the potential for health protection through pollution reduction.Global health impact for policy and action: Such findings stress the urgency for enduring solutions to combat air pollution.

Quantifying the impact of COVID-19 restrictions on air pollution in Ahvaz: a comparative dual-approach assessment of observed against baseline and forecasted criteria air pollutants.

In response to the COVID-19 pandemic, the Iranian government swiftly implemented immediate and decisive measures to control the spread of the infection. This study aims to demonstrate the impact of restriction measure on air pollution, also to highlight the potential variability in results that can arias from different methodological approach. A comprehensive dual-approach assessment was conducted to evaluate the effect of the lockdown measures on criteria air pollutants. Firstly, a traditional approach compared air quality during the pandemic period with baseline conditions from 2013 to 2019. Secondly, observed air pollution values during different periods with varying restrictions in 2020 were compared with expected values. This comprehensive analysis allows for a robust comparison and quantification of the impact of different lockdown measures in Ahvaz. The study revealed significant changes in air pollutant concentrations in Ahvaz during 2020, with variations observed across different pollutants. Notable reductions were observed in O3 levels, particularly in November (-54.44% compared to the baseline) and December (-63.58% compared to expected values). Decreases in CO levels were observed in multiple months, while substantial reductions in PM10 and PM2.5 were observed during various periods. Inconsistencies in the magnitudes and directions of changes were found when comparing baseline and forecasted values. The overall stringency index showed an inverse association with changes in O3, NO2, and CO, with international travel controls and restrictions on internal movement having significant impacts. This study provides valuable insights into the impact of COVID-19 lockdown measures on air pollution in Ahvaz, Iran, using a comprehensive dual-approach assessment. The findings highlight the effectiveness of these measures in reducing specific criteria air pollutants and emphasize the importance of implementing appropriate strategies for air quality management during similar public health emergencies.

The cost of obesity and related NCDs in Brazil: An analysis of hospital admissions, disability retirement benefits, and statutory sick pay.

OBJECTIVES: This study analyses the prevalence of overweight/obesity in Brazil, and its costs regarding hospital admissions (HA), disability retirement benefits (DRB), and statutory sick pay (SSP) associated with obesity-related non-communicable diseases (NCDs). STUDY DESIGN: Time-series study. METHODS: This study analyses data from the VIGITEL system (2010-2019) to calculate the body-mass index (BMI) of adult residents in Brazil's state capitals. Data on HA, DRB, and SSP were obtained from Brazil's SIH/SUS and AEPS Infologo systems. Pearson's correlation and linear regression models were applied. The study selected 23 diseases of the International Classification of Disease (ICDs) belonging to chapters C; E; I; and K. Cost values in BRL were deflated using IPCA. RESULTS: The results showed a significant increase in overweight and obesity rates in Brazil, with BMI rising by 0.09 kg/m2 annually. Regression analysis revealed that each 1-point increase in the average BMI of the population is associated with an increase of 81,772 (BRL 237.51 million/year) new HA per year, 5541 (BRL 18.8 million/year) new DRB granted per year, and 42,360 (BRL 131 million/year) new SSP per year. Also, every 1 % increase in the share of the Brazilian population with obesity is associated with an increase of 16,973 (BRL 48.8 million/year) new HA per year, 1202 (BRL 3.97 million/year) new DRB granted per year, and 8686 (BRL 26.8 million/year) new SSP per year. Regressions for deflated values showed lower significance, suggesting a strong impact of inflation on health costs in Brazil. CONCLUSIONS: Obesity prevalence in Brazil implies high direct and indirect costs for the Brazilian government, especially considering circulatory system diseases.

Long-term inhalation exposure: A model for phthalate accumulation in the respiratory tract.

BACKGROUND: Inhalation is a major pathway for phthalates (PAEs), an endocrine disruptor, to enter the human body. The actual internal exposure amount that participates in metabolism cannot be estimated by calculating total inhalation intake. OBJECTIVE: To estimate the accumulation in each region of the respiratory tract after long-term exposure to PAEs in different populations. METHODS: A mass transfer model was developed to simulate the long-term accumulation of PAEs in respiratory tract through inhalation. The model considered (1) mass transfer of PAEs in three phases across seven regions, (2) the effect of temperature differences on the mass transfer process. Based on this model, we simulated adult exposure to PAEs in a laboratory, identified key model parameters, and further simulated various scenarios for children, adults, and elders. RESULTS: PAEs are not completely cleared from the respiratory tract after 16 hours, following 8 hours of daily exposure. Under regular laboratory environment, accumulation after 30 days is 3.8 times higher than that after the first day. The distribution of PAEs between the gas and mucus phases has a greater impact on the results than between the gas and particle phases. Children are at the highest risk to Diethyl phthalate (DEP) exposure compared with adults and elders. Nearly 80 % of DEP is exhaled, with 14 % accumulating in the alveolar region after an hour. CONCLUSION: This model links indoor air PAEs to human internal exposure, showing that most PAEs are exhaled, while the remainder accumulates in the respiratory tract and may participate in human metabolism.

The use of digital health services to combat E-waste health hazards: A review on the impact and awareness in Southwest Nigeria.

The rapid advancement of technology has led to a significant increase in electronic waste (e-waste), posing serious health and environmental risks, particularly in developing regions like Southwest Nigeria. This review explores the utilization of digital health services to combat the health hazards associated with e-waste exposure. Digital health technologies, including mobile health applications, telemedicine, and electronic health records, play a critical role in raising awareness about e-waste toxicity, monitoring health impacts, and providing remote healthcare services to at-risk populations. This article discusses the effectiveness of these technologies in promoting safer e-waste handling practices and mitigating health risks, highlighting their potential in supporting public health interventions in underserved areas. The study underscores the need for strategic investments and policy support to enhance the adoption of digital health solutions in managing e-waste hazards by analyzing current challenges and opportunities, ultimately contributing to better health outcomes and environmental sustainability.

Projected impact of climate change on human health in low- and middle-income countries: a systematic review.

Low- and middle-income countries (LMICs) contribute relatively little to global carbon emissions but are recognised to be among the most vulnerable parts of the world to health-related consequences of climate change. To help inform resilient health systems and health policy strategies, we sought to systematically analyse published projections of the impact of rising global temperatures and other weather-related events on human health in LMICs. A systematic search involving multiple databases was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify studies with modelled projections of the future impact of climate change on human health. Qualitative studies, reviews and meta-analyses were excluded. The search yielded more than 2500 articles, of which 70 studies involving 37 countries met criteria for inclusion. China, Brazil and India were the most studied countries while the sub-Saharan African region was represented in only 9% of studies. Forty specific health outcomes were grouped into eight categories. Non-disease-specific temperature-related mortality was the most studied health outcome, followed by neglected tropical infections (predominantly dengue), malaria and cardiovascular diseases. Nearly all health outcomes studied were projected to increase in burden and/or experience a geographic shift in prevalence over the next century due to climate change. Progressively severe climate change scenarios were associated with worse health outcomes. Knowledge gaps identified in this analysis included insufficient studies of various high burden diseases, asymmetric distribution of studies across LMICs and limited use of some climate parameters as independent variables. Findings from this review could be the basis for future research to help inform climate mitigation and adaptation programmes aimed at safeguarding population health in LMICs.

Disaster management training for environmental health: A narrative literature review.

The growing frequency and severity of disasters worldwide have highlighted the need for environmental health practitioners to be equipped with specialised training to respond effectively to evolving public health contexts. Disasters can have long-lasting impacts on the environment and environmental health services, necessitating prompt and effective responses. However, the current environmental health workforce faces challenges in acquiring the necessary competencies to address environmental health threats during disasters. This narrative review synthesises existing literature on disaster management education for environmental health professionals, exploring current training, advancements and emerging trends. The review follows Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines and includes a total of 45 records that met inclusion criteria (compromising 15 peer-reviewed articles and 30 training records) published between 2002 and 2023. Findings highlight the expansion of environmental health degree programmes to include disaster management, better preparing newly qualified practitioners. However, a knowledge gap remains for previously qualified practitioners. High-income countries prioritising capacity building for environmental health practitioners in disaster management are better equipped to respond to and mitigate disasters. Contribution: The review suggests that with proper basic training for disaster responders, more lives can be saved during and after disasters. It highlights the insufficiency of current training programmes and emphasises the need for advanced role-specific training for environmental health practitioners. The review emphasises the need for advanced role-specific training, community assessment skills and focused disaster response strategies to enhance environmental health practitioners' ability to respond to disasters and improve public health resilience. Enhanced training, capacity building and collaboration are necessary to improve the competencies, skills and knowledge of environmental health practitioners in disaster risk management and public health emergencies.

An insight into impact of nanomaterials toxicity on human health.

In recent years, advances in nanotechnology have significantly influenced electronics manufacturing, industrial processes, and medical research. Various industries have seen a surge in the use of nanomaterials. However, several researchers have raised the alarm about the toxicological nature of nanomaterials, which appear to be quite different from their crude forms. This altered nature can be attributed to their unique physicochemical profile. They can adversely affect human health and the environment. Nanomaterials that have been released into the environment tend to accumulate over time and can cause a significant impact on the ecosystem and organisms with adverse health effects. Increased use of nanoparticles has led to increased human exposure in their daily lives, making them more vulnerable to nanoparticle toxicity. Because of their small size, nanomaterials can readily cross biological membranes and enter cells, tissues, and organs. Therefore, the effect of nanomaterials on the human environment is of particular concern. The toxicological effects of nanomaterials and their mechanisms of action are being researched worldwide. Technological advances also support monitoring new nanomaterials marketed for industrial and household purposes. It is a challenging area because of the exceptional physicochemical properties of nanomaterials. This updated review focuses on the diverse toxicological perspective of nanomaterials. We have discussed the use of different types of nanoparticles and their physiochemical properties responsible for toxicity, routes of exposure, bio-distribution, and mechanism of toxicity. The review also includes various in vivo and in vitro methods of assessing the toxicity of nanomaterials. Finally, this review will provide a detailed insight into nano material-induced toxicological response, which can be beneficial in designing safe and effective nanoparticles.

Commentary: A road map for future data-driven urban planning and environmental health research.

Recent advances in data science and urban environmental health research utilise large-scale databases (100s-1000s of cities) to explore the complex interplay of urban characteristics such as city form and size, climate, mobility, exposure, and environmental health impacts. Cities are still hotspots of air pollution and noise, suffer urban heat island effects and lack of green space, which leads to disease and mortality burdens preventable with better knowledge. Better understanding through harmonising and analysing data in large numbers of cities is essential to identifying the most effective means of disease prevention and understanding context dependencies important for policy.