História da construção de saberes em enfermagem traumato-ortopédica / History of knowledge construction in trauma and orthopedic nursing care / Historia de la construcción del conocimiento en enfermería traumatológica ortopédica

Objetivo: analisar o desenvolvimento da enfermagem traumato-ortopédica a partir da primeira turma de residentes de um hospital especializado. Método: o estudo seguiu a metodologia histórica com abordagem qualitativa. As fontes foram documentos escritos e orais. Resultados: trabalhar em uma instituição especializada foi o ponto de partida para a busca por especialização de enfermeiras atuantes no cuidado traumato-ortopédico, que perceberam o saber/poder adquirido no trabalho assistencial, além da intenção de qualificar a assistência e elevar o hospital a instituto. Estratégias empregadas reúnem a busca por parcerias com instituições universitárias e associativas, além da criação de uma associação própria. Considerações finais: a enfermagem traumato-ortopédica ampliou seu espaço científico ao criar um curso de especialização com uma unidade acadêmica. Foi possível delimitar o poder acadêmico e institucional da enfermagem na instituição de saúde pela formação de enfermeiras especialistas constituindo um grupo de reconhecido pelo saber científico.

Objective: to analyze the development of trauma and orthopedic nursing care from the very first class of residents of a specialized hospital. Method: historical methodology study with a qualitative approach. The sources consisted of written and oral documents. Results: working in a specialized institution was the starting point for nurses who were seeking specialization in the field of trauma and orthopedic care as they noticed the power-knowledge acquired through care work, plus they were willing to improve assistance and take the hospital up to an institute level. Strategies used include the search for partnerships with universities and associative-type institutions, in addition to creating their own association. Final considerations: trauma and orthopedic nursing care expanded its scientific space by creating a specialization course together with an academic unit. It was possible to define the academic and institutional power of the nursing staff in the health institution by considering the training process of its nurse specialists, who consisted of a group recognized for their scientific knowledge.

Objetivo: analizar el desarrollo de la enfermería traumatológica ortopédica a partir del primer grupo de residentes de un hospital especializado. Método: estudio con metodología histórica con un enfoque cualitativo. Las fuentes fueron documentos escritos y orales. Resultados: el trabajo en una institución especializada fue el punto de partida para la búsqueda de la especialización de las enfermeras que trabajaban en la atención traumatológica ortopédica, quienes notaron el saber/poder adquirido en el trabajo asistencial, además de la intención de cualificar la atención y elevar el hospital al nivel de instituto. Las estrategias empleadas incluyen la búsqueda de alianzas con instituciones universitarias y asociaciones, y la creación de una asociación propia. Consideraciones finales: la enfermería traumatológica ortopédica amplió su espacio científico mediante la creación de un curso de especialización con una unidad académica. Se logró delimitar el poder académico e institucional de la enfermería en la institución de salud a través de la formación de enfermeros especialistas, que es un grupo reconocido por el conocimiento científico.

Sexual selection and life history interact to influence the evolution of paternal care.

Parental care is essential to offspring survival in many species. Understanding why males of some species provide care, whereas others do not, has received substantial attention. Previous research has found that sexual selection can favor paternal care, yet we still do not fully understand why sexual selection favors male care in some species but not others. It is also unclear when paternal care versus other preferred male trait(s) will be favored by sexual selection. We hypothesize that sexual selection can interact with basic life history to influence the conditions under which paternal care and/or another preferred male trait will be favored by sexual selection. We used a mathematical approach in which males alone provide parental care and exhibit a non-care trait that is preferred in mate choice. Using this approach, we demonstrate that life-history characteristics (stage-specific mortality, fertilization success, gamete numbers) can interact with sexual selection to influence the evolution of paternal care and/or a preferred non-care trait. In particular, whether (1) adult mortality, egg mortality, and fertilization success are high versus low and (2) a tradeoff exists between paternal care and a non-care preferred trait will influence whether selection most strongly favors additional paternal care or a non-care preferred trait. In general, we would expect strong selection for more male care when it is preferred in mate choice. In some cases, mate preferences for paternal care can inhibit selection for a preferred non-care trait. Mate preferences for paternal care can also broaden the life-history conditions under which we would expect the elaboration of male care to occur.

Revisiting the ecology and evolution of burying beetle behavior (Staphylinidae: Silphinae).

Investigating fundamental processes in biology requires the ability to ground broad questions in species-specific natural history. This is particularly true in the study of behavior because an organism's experience of the environment will influence the expression of behavior and the opportunity for selection. Here, we provide a review of the natural history and behavior of burying beetles of the genus Nicrophorus to provide the groundwork for comparative work that showcases their remarkable behavioral and ecological diversity. Burying beetles have long fascinated scientists because of their well-developed parenting behavior, exhibiting extended post-hatching care of offspring that varies extensively within and across taxa. Despite the burgeoning success of burying beetles as a model system for the study of behavioral evolution, there has not been a review of their behavior, ecology, and evolution in over 25 years. To address this gap, we leverage a developing community of researchers who have contributed to a detailed knowledge of burying beetles to highlight the utility of Nicrophorus for investigating the causes and consequences of social and behavioral evolution.

From Mysore to Cambridge and back: The education of a groundnut breeder.

Studies that show how empire influenced the development of plant genetics add to the established history of genetics and 20th-century agricultural science. One approach to broadening this history is to consider the contributions of students studying abroad and their greater careers back home. Research agendas differed between and within institutions, much as they do today. This article explores the postgraduate education of an Indian groundnut breeder. It highlights the structural challenges faced by researchers at agricultural departments who sought promotion through education and examines the consequences for plant breeding and for farmers. Summary: Through the biography of V.K. Badami, this article contributes to debates about genetics and plant breeding in the history of science. Badami, an accomplished breeder in the Mysore Department of Agriculture, took a leave to study genetics at the University of Cambridge. His professors nearly failed him, yet Badami's groundnut breeding experiments proved influential for Indian farmers as well as advances in crop science. This history adds to the thesis that academic genetics varied in support of professional plant breeding by comparing institutional expections between Mysore and Cambridge.The argument is developed by reading Badami's student records along with his groundnut breeding experiments in South India.The study connects the disciplinary history of genetics to plant breeding for the British empire.Badami's experience at Cambridge is indicative of the power relationship between academic genetics and imperial plant breeding in the early 20th century. In this case, his commitments as an Indian agricultural officer conflicted with the discipline's devotion to quantitative analysis.

Tibetan lake sediment records reveal historical emission and long-range atmospheric transport of chlorinated paraffins.

The Tibetan Plateau, a recognized global sink for Persistent Organic Pollutants (POPs), lies adjacent to two major emitting regions, inland China and India. This unique geographical setting makes it a pivotal site for examining the presence and compositional evolution of POPs following their long-range atmospheric transport (LRAT). This study focuses on the current predominant POPs, chlorinated paraffins (CPs). We comprehensively screened 675 homologues of the very short- (vSCCPs), short- (SCCPs), medium- (MCCPs), and long-chain CPs (LCCPs) in six dated sediment cores across the extensive Tibetan area. The findings unveiled pronounced temporal disparities in CP concentrations and compositions between Tibet's southern and eastern sectors, reflecting divergent usage and emission chronicles of inland China and India. Notably, a market shift in China from regulated SCCPs to the in-use MCCPs and LCCPs was observed in the 21st century, contrasting with India's unregulated production of SCCPs. The Organization for Economic Cooperation and Development (OECD) Screening Tool, developed to assess the overall persistence (POV) and long-range transport potential (LRTP) of organic chemicals, elucidated the erosion of CP source signatures induced by fractionation, a process that intensifies with transport distance from the source regions. This study enhances our understanding of the emission inventories and LRAT behavior of these transitional regulatory contaminants, highlighting the Tibetan Plateau's crucial role as an environmental sentinel in global pollution dynamics.

The power of Hispanic nurses in advancing health equity: The career of Henrietta Villaescusa.

There is increased national attention to the impact nurses can and should have in advancing health equity. Nurses of color have made important contributions in nursing and other sectors to this end, but their efforts remain invisible. To amplify the contribution of Latino nurses in advancing health equity, we use oral histories and supplemental records to examine the career of Henrietta Villaescusa, RN, FAAN to illuminate her impact across government, health, and nursing sectors in advocating for the health of Latino communities. She was skilled in community activism, political savvy, and developing and leading intersectoral networks to address and identify Hispanic health issues and strategies to address them. Her career serves as an exemplar to the importance of including and supporting diverse nurses in leading health equity efforts.

Life history strategies predict responses of lacustrine fish communities to eutrophication.

The demographic traits of an organism are key components of its fitness and life history theory aims at identifying the environmental drivers underlying the evolution of life history strategies. For fishes, the equilibrium species, those investing into larval survival (large eggs, parental care) rather than into absolute fecundity, are hypothesized to have evolved in stable and predictable environments with high biotic pressure. Human induced nutrient enrichment in many lakes around the world makes them increasingly subjected to perturbations such as anoxia and toxic algal blooms. We hypothesized that eutrophication results in lakes becoming more unstable, unpredictable and less resource-limited, in turn less favorable to equilibrium species. Another hypothesis states that lacustrine environment stability increases with ecosystem size. This study presents the first attempt to compare the two hypotheses in a group of 26 lakes. We found that the population abundance of equilibrium species was negatively related to increasing eutrophication. Long-lived and highly fecund periodic species responded more positively to eutrophication than short lived opportunistic species, with no parental care. This result could be demonstrated by seasonality in primary productivity which favors periodic species, disconnection from the river which prevents good colonist (i.e., opportunistic) species to (re)-establish after perturbation events, and predation by periodic species on opportunistic species. In contrast, we found no support for the ecosystem size hypothesis. Overall, we showed that human driven eutrophication affected species according to their life history strategies, reinforcing the usefulness of life history theory as a framework for assessing fish community response to a large array of human perturbations. More generally, our study emphasizes the importance of species traits to assess, explain, and predict community responses to human and natural perturbations.

Importance of health history analysis in Parkinson's disease.

The objective of this research article is to investigate the impact of various health history factors on the risk of developing Parkinson's disease (PD). From the medical history we can identify PD Symptoms and this also help to detect the progression of PD symptoms. By conducting statistical analyses, the study seeks to identify independent risk and protective factors for Parkinson's disease (PD), considering variations in impact across genders and BMI categories. Introduction: In the diagnosis of PD the analysis of previous health history is very rare in practice while the main diagnosis have been done through the different motor and non-motor symptoms taking in consideration besides the cardinal symptoms of PD for identification and determination the stages of PD. Here we have analyzed the impact of 56 different diseases, symptoms, and surgeries which a subject may have experienced in their life before PD, considered as a health history. Methods: The behavioral impact for each types of health history have been analyzed statistically with 31,265 subjects including PD, and Control. In this analysis we have calculated the variation of impact for both the Male, and Female, as well as subjects BMI. Results: 98.12 % PD patients, where 97.63 % Male PD, and 98.71 % Female PD were found with at least one health history record. Coronary heart disease odds ratio (OR) 2.15 (1.85-2.51), Colon Cancer OR 2.11 (1.45-3.05), Cranial brain surgery OR 6.21 (5.11-7.56) have the higher risks to PD. Having the history of Asthma OR 0.66 (0.6-0.72), Anemia OR 0.56 (0.51-0.63), Cirrhosis in Liver OR 0.7 (0.57-0.86), Cosmetic surgery OR 0.7 (0.64-0.77), and Gastritis OR 0.78 (0.71-0.87) have been found to be protective to PD. The risk of developing PD varies between male, and female including subjects BMI for each individual health history types. The diseases which reduce the oxygen saturation in blood like, anemia, asthma, and thalassemia act as protective to PD. Conclusions: In this study we have analyzed fifty six diseases which include surgeries as a health history of PD patients. Study suggests that a thorough health history could greatly aid in understanding the onset and progression of Parkinson's disease (PD).

Scientific plurality and amyotrophic lateral sclerosis (ALS): A philosophical and historical perspective on Charcot's texts.

The history of amyotrophic lateral sclerosis (ALS)-also known as Charcot's disease, Lou Gehrig's disease, and motor neuron disease (MND)-freezes the texts of the scientist and physician Jean-Martin Charcot in a hagiographic narrative describing a brilliant discovery, based on the anatomo-clinical method. This narrative is often used by biologists and physicians as a reference point. This article shows that the use of the hagiographic register faces limitations. In particular, it obscures points of interest from Charcot's texts on ALS, such as the epistemological and ontological implications of scientific plurality in medicine. Although Charcot recognized the importance of scientific plurality in medicine, he prioritized the approaches and conferred the most important epistemic authority on clinical and pathological observations. In his view, animal modeling remains secondary to the understanding of disease. The concept of ALS and its diagnostic operability are the result of symptoms and lesions. By studying the past, we can highlight the specific features of the present. Today, although the ALS concept retains its diagnostic and clinical relevance, it is increasingly called into question in etiological and mechanistic research. Despite these differences, Charcot's reflections are a reminder of the importance of theoretical thinking on scientific plurality, all the more so today in the context of ALS research, in which combining different approaches is increasingly valued to understand the phenotypic and genetic heterogeneity of ALS.

[Brief history and application prospect of robotic spine surgery].

Spinal robotics has rounded out twenty years in clinical, is mainly used for pedicle screw placement at present, can significantly increase the accuracy of screw placement and reduce radiation exposure to the patient and the surgeon. In the future, haptic feedback, automatic collision avoidance, and other technologies will further expand its application to complete precise operations such as decompression and correction, providing safety guarantee for the implementation of complex spinal surgery.

Alternative access in transcatheter aortic valve replacement-an updated focused review.

Aortic Stenosis (AS) is a common condition with an estimated pooled prevalence of all AS in the elderly population at around 12.4%, with that of severe AS estimated to be around 3.4%. In the past, surgical aortic valve replacement was the primary treatment option for severe AS for decades. However, with the compelling evidence on the safety and efficacy of transcatheter aortic valve replacement (TAVR), it has become the gold standard treatment option for many patients with symptomatic severe AS. Transfemoral access has been the preferred method for transcatheter heart valve delivery. However, the prevalent use of TAVR on a diverse patient profile with different risk factors, such as peripheral artery disease, precluded the possibility of a transfemoral approach despite the improvement of valves and delivery systems technology. Therefore, alternative TAVR approaches have gained increasing utility in cases where transfemoral access is unfavorable. We review the journey, evolution, and techniques for different approaches of percutaneous TAVR, including transfemoral, transcarotid, transsubclavian/transaxillary, and transcaval approaches, in addition to the traditional "surgical" transaortic and transapical accesses. Consolidating these data highlights each approach's practicality and limitations, providing additional grounding for case-by-case utilization and future clinical research.

A tale of clubs, pitches and men. How association football took root in the Lake Geneva region (1860s-1910s).

'Tomorrow, Thursday, at 3pm, a football match will take place on the Plaine de Plainpalais, between 11 English from Lausanne and Geneva'. This brief notice, published in January 1869 in Le Journal de Genève, may be one of the earliest mentions in the area's press of a new ball game - football. Although the chronology of association football's 'cultural transfer' to Switzerland and the conditions that facilitated the game's introduction to the country are well-documented, the game's adoption by the local population remains under-researched. Based on extensive empirical research combining original archive materials and articles from contemporary generalist and sports newspapers, the present study explored the factors that led young men in Geneva and Lausanne to embrace a foreign game. It also examined two less-well studied aspects of the game's early history in Europe: the difficulty of finding places to play football in urban areas and the profiles of football's first leaders. The results extend previous research on the creation of the first football clubs (association or rugby) outside Great Britain and on the history of associations in Switzerland.

Sex-specific life-history trait expression in hybrids of a cave- and surface-dwelling fish (Poecilia mexicana, Poeciliidae).

Evaluating the fitness of hybrids can provide important insights into genetic differences between species or diverging populations. We focused on surface- and cave-ecotypes of the widespread Atlantic molly Poecilia mexicana and raised F1 hybrids of reciprocal crosses to sexual maturity in a common-garden experiment. Hybrids were reared in a fully factorial 2 × 2 design consisting of lighting (light vs. darkness) and resource availability (high vs. low food). We quantified survival, ability to realize their full reproductive potential (i.e., completed maturation for males and 3 consecutive births for females) and essential life-history traits. Compared to the performance of pure cave and surface fish from a previous experiment, F1s had the highest death rate and the lowest proportion of fish that reached their full reproductive potential. We also uncovered an intriguing pattern of sex-specific phenotype expression, because male hybrids expressed cave molly life histories, while female hybrids expressed surface molly life histories. Our results provide evidence for strong selection against hybrids in the cave molly system, but also suggest a complex pattern of sex-specific (opposing) dominance, with certain surface molly genes being dominant in female hybrids and certain cave molly genes being dominant in male hybrids.

A Comparative Study of Access Analysis Service Utilization on Japanese Medical Institutions' Websites with GDPR-Compliant Cases.

The browsing history of a medical institution's website can potentially reveal or identify information about the health condition of the website visitor through browser cookies and fingerprints. In Japan, although the Personal Information Protection Law was revised in April 2022, the use of access analysis services to collect browsing history on medical institution websites has not been investigated. Therefore, this study investigates the actual usage of access analysis services on Japanese medical institution websites and compares it with the current situation in France, which follows the General Data Protection Regulation. The results revealed that the larger the size of the hospital, the higher the percentage of adoption of access analytics services in Japan. However, the implementation of a system for obtaining consent for the use of access analysis in Japan was found to be poor compared to that of French medical institutions. While access analysis tools are used in the websites of several medical institutions in Japan, the implementation of the process of obtaining consent to acquire browsing history is poor.

Generative AI Analysis of Topics from IMIA Historical Narratives in Medical Informatics.

This describes a project that analyzes and compares the research topics in medical and health informatics emphasized by authors of autobiographical narratives contained in the online IMIA History eBook published in 2021, as the field advanced over the past half century in its international and interdisciplinary dimensions from its early days until the present.

Clinical significance of germline breast cancer susceptibility gene (gBRCA) testing and olaparib as maintenance therapy for patients with pancreatic cancer.

BACKGROUND: Germline breast cancer susceptibility gene (gBRCA) mutation in patients with pancreatic cancer (PC) is not common in clinical practice. Therefore, factors that efficiently show gBRCA mutations and the real-world outcomes of olaparib maintenance therapy have not been fully established. In the present study, we clarified the indicators for the effective detection of gBRCA mutation and the efficacy and safety of olaparib as maintenance therapy. METHODS: We retrospectively analyzed 84 patients with PC who underwent gBRCA testing (BRACAnalysis, Myriad Genetics, Salt Lake City, UT, USA) at our institute between January 2021 and March 2022. For each patient, clinical data were extracted from medical records. RESULTS: The median patient age was 64 y (29-85 y), and 41 patients (48.8%) were male. The gBRCA mutations were identified in 10 (11.9%) patients; two patients had BRCA1 mutation and eight had BRCA2 mutation. All patients with gBRCA mutation had a family history of any cancer, and eight of them had a family history of Hereditary Breast and Ovarian Cancer syndrome (HBOC)-related cancer. The gBRCA mutation rate was higher for patients with PC with a family history of HBOC-related cancer compared to that in patients with PC having a family history of other cancers and no family history of cancer (22.9% vs. 4.1%; P = 0.014). In our study, eight out of 10 patients with gBRCA-positive PC received olaparib after platinum-based chemotherapy. The best responses to platinum-based chemotherapy included a complete response in one patient (12.5%) and a partial response in seven patients (87.5%). The median duration of treatment with platinum-based chemotherapy plus olaparib was 17.5 months (8-87 months), and the duration of treatment with olaparib maintenance therapy was 11 months (1-30 months). During olaparib maintenance therapy, three patients showed no disease progression. One of these three patients underwent conversion surgery after receiving olaparib for 12 months. CONCLUSIONS: The gBRCA testing should be considered proactively, especially in patients with PC with a family history of HBOC-related cancer.

Reward history cues focal attention in whisker somatosensory cortex.

Prior reward is a potent cue for attentional capture, but the underlying neurobiology is largely unknown. In a novel whisker touch detection task, we show that mice flexibly shift attention between specific whiskers on a trial-by-trial timescale, guided by the recent history of stimulus-reward association. 2-photon calcium imaging and spike recordings revealed a robust neurobiological correlate of attention in somatosensory cortex (S1), boosting sensory responses to the attended whisker in L2/3 and L5, but not L4. Attentional boosting in L2/3 pyramidal cells was topographically precise and whisker-specific, and shifted receptive fields towards the attended whisker. L2/3 VIP interneurons were broadly activated by whisker stimuli, motion and arousal but did not carry a whisker-specific attentional signal, and thus did not mediate focal tactile attention. Thus, the history of stimuli and rewards in the recent past can dynamically engage local modulation in cortical sensory maps to guide flexible shifts in ongoing behavior.

An International Retrospective Early Natural History Study of LAMA2-Related Dystrophies.

Background: LAMA2-related dystrophies (LAMA2-RDs) represent one of the most common forms of congenital muscular dystrophy and have historically been classified into two subtypes: complete or partial deficiency of laminin-211 (merosin). Patients with LAMA2-RD with the typical congenital phenotype manifest severe muscle weakness, delayed motor milestones, joint contractures, failure to thrive, and progressive respiratory insufficiency. Objective: While a comprehensive prospective natural history study has been performed in LAMA2-RD patients over 5 years of age, the early natural history of patients with LAMA2-RD 5 years and younger has not been comprehensively characterized. Methods: We extracted retrospective data for patients with LAMA2-RD ages birth through 5 years via the Congenital Muscle Disease International Registry (CMDIR). We analyzed the data using a phenotypic classification based on maximal motor milestones to divide patients into two phenotypic groups: "Sit" for those patients who attained that ability to remain seated and "Walk" for those patients who attained the ability to walk independently by 3.5 years of age. Results: Sixty patients with LAMA2-RD from 10 countries fulfilled the inclusion criteria. Twenty-four patients had initiated non-invasive ventilation by age 5 years. Hospitalizations during the first years of life were often related to respiratory insufficiency. Feeding/nutritional difficulties and orthopedic issues were commonly reported. Significant elevations of creatine kinase (CK) observed during the neonatal period declined rapidly within the first few months of life. Conclusions: This is the largest international retrospective early natural history study of LAMA2-RD to date, contributing essential data for understanding early clinical findings in LAMA2-RD which, along with the data being collected in international, prospective early natural history studies, will help to establish clinical trial readiness. Our proposed nomenclature of LAMA2-RD1 for patients who attain the ability to sit (remain seated) and LAMA2-RD2 for patients who attain the ability to walk independently is aimed at further improving LAMA2-RD classification.

Tabit Ibn Qurrah's contributions to toxicology.

Mankind has been familiar with poisons since ancient times. On the other hand, there is a wealth of knowledge in the medical books including medieval works of Middle Eastern polymaths such as Avicenna, "al-Razi," and "Tabit Ibn Qurrah." This study presented and analyzed the knowledge of medical toxicology in one of the mainstay works of "Tabit Ibn Qurrah" entitled "al-Dahirah Fy Ꜥilm al-Tibb" also known as The Treasury of Medicine after the translation of the book from Arabic to English carefully and faithfully. Also, related toxicological literature was applied wherever required using English, Arabic, and Persian databases including Scopus, PubMed, Web of Science, WorldCat, Magiran, IranDoc, Scientific Information Database, Noor Mags, Noorlib, and Al Manhal. Our research revealed that chapter 25 of the mentioned book specifically focused on toxicology. This chapter was divided into sections on different aspects of toxicology from the categorization of poisons to compound mixtures causing poisonings to introducing blade poisons to signs and symptoms of poisonings, preventive approaches, and therapeutic agents. Specific antidotes and general therapies were introduced that included medicinal plants, cupping therapy, and bandages, just to name a few. Also, there were some monographs on the common poisonous agents and their treatments. The toxicological data of the book was comparable with modern toxicology. Our study highlighted the contributions of "Tabit Ibn Qurrah" to medical toxicology by authoring The Treasury of Medicine. Further research is recommended to elucidate the full aspects of the history of toxicology including the contributions of the past scholars.