Microwave Vertebrae Strength Probe Development: Robust and Fast Phase Unwrapping Technique.

We have developed a new transmission-based, open-ended coaxial probe for assessing vertebrae strength during spinal fusion surgery. The approach exploits the fact that the probes are within the far field of each other implying that the phase varies linearly with respect to propagation distance. Determining the absolute phase is critical for recovering the associated tissue dielectric properties from which bone strength will be determined. Unfortunately, unwanted multi-path signals corrupt the signals at the lower end of the operating frequency range from which our conventional unwrapping strategy depends. Our new approach requires only three measurements within the prime frequency range and can be determined robustly with a minimum of computations. This will be vital to developing a commercial device since the signal levels will be extremely low power requiring longer than usual data acquisition times, which will be mitigated by measuring the data at only a few frequencies. Fast and efficient operation will be critical for clinical success.

Intravenous lidocaine infusion therapy and intraoperative neurophysiological monitoring in adolescents undergoing idiopathic scoliosis correction: A retrospective study.

BACKGROUND: Posterior spinal instrumentation and fusion is an established surgical procedure for the correction of adolescent idiopathic scoliosis. Intraoperative neurophysiological monitoring is standard practice for this procedure. Anesthetic agents can have different, but significant, effects on neurophysiological monitoring outcomes. AIM: To determine if intravenous lidocaine infusion therapy has an impact on the intraoperative neurophysiological monitoring during posterior spinal instrumentation and fusion for adolescent idiopathic scoliosis. METHODS: Following ethical approval, we conducted a retrospective review of charts and the archived intraoperative neurophysiological data of adolescents undergoing posterior spinal instrumentation and fusion for adolescent idiopathic scoliosis. Intraoperative neurophysiological monitoring data included the amplitude of motor evoked potentials and the amplitude and latency of somatosensory evoked potentials. A cohort who received intraoperative lidocaine infusion were compared to those who did not. RESULTS: Eighty-one patients were included in this analysis, who had surgery between February 4, 2016 and April 22, 2021: 39 had intraoperative intravenous lidocaine infusion and 42 did not. Based on hourly snapshot data, there was no evidence that lidocaine infusion had a detrimental effect on the measured change from baseline for MEP amplitudes in either lower (mean difference 41.9; 95% confidence interval -304.5 to 388.3; p = .182) or upper limbs (MD -279.0; 95% CI -562.5 to 4.4; p = .054). There was also no evidence of any effect on the measured change from baseline for SSEP amplitudes in either lower (MD 16.4; 95% CI -17.7 to 50.5; p = .345) or upper limbs (MD -2.4; 95% CI -14.5 to 9.8; p = .701). Finally, there was no evidence of a difference in time to first reportable neurophysiological event (hazard ratio 1.13; 95% CI 0.61 to 2.09; p = .680). CONCLUSIONS: Data from these two cohorts provide preliminary evidence that intravenous lidocaine infusion has no negative impact on intraoperative neurophysiological monitoring during PSIF for adolescent idiopathic scoliosis.

Advancements in hydrogel-based embolic agents: Categorized by therapeutic mechanisms.

BACKGROUND: Transcatheter arterial embolization (TAE) is a crucial technique in interventional radiology. Hydrogel-based embolic agents show promise due to their phase transition and drug-loading capabilities. However, existing categorizations of these agents are confusing. AIMS: This review tackles the challenge of categorizing hydrogel-based embolic agents based on their therapeutic mechanisms, including transportation, accumulation, interaction, and elimination. It also addresses current challenges and controversies in the field while highlighting future directions for hydrogel-based embolicagents. MATERIALS AND METHODS: We conducted a systematic review of papers published in PUBMED from 2004 to 2024, focusing primarily on preclinical trials. RESULTS: Various kinds of hydrogel embolic agents were introduced according to their therapeutic mechanisms. DISCUSSION: Most hydrogel embolic agents were specifically designed for effective accumulation and interaction. Recent advancement highlight the potential of multifunctional hydrogel embolic agents. CONCLUSION: This new categorizations provided valuable insights into hydrogel embolic agents, potentially guiding material scientists and interventional radiologists in the development of novel hydrogel embolic agents in transarterial embolization.

Imprints of massive black-hole binaries on neighbouring decihertz gravitational-wave sources.

The most massive black holes in our Universe form binaries at the centre of merging galaxies. The recent evidence for a gravitational-wave (GW) background from pulsar timing may constitute the first observation that these supermassive black-hole binaries (SMBHBs) merge. Yet, the most massive SMBHBs are out of reach of interferometric GW detectors and are exceedingly difficult to resolve individually with pulsar timing. These limitations call for unexplored strategies to detect individual SMBHBs in the uncharted frequency band ≲10-5 Hz to establish their abundance and decipher the coevolution with their host galaxies. Here we show that SMBHBs imprint detectable long-term modulations on GWs from stellar-mass binaries residing in the same galaxy at a distance d ≲ 1 kpc. We determine that proposed decihertz GW interferometers sensitive to numerous stellar-mass binaries could uncover modulations from ~O(10-1-104) SMBHBs with masses ~O(107-108) M⊙out to redshift z ≈ 3.5. This offers a unique opportunity to map the population of SMBHBs through cosmic time, which might remain inaccessible otherwise.

Practical guidelines and challenges in the isolation and characterization of microplastics/microfibers by Raman microscopy.

We address some challenges usually encountered in the analysis of microplastics (MPs) and microfibers (MFs) using Raman microscopy. Those issues are examined considering that the researchers that carry out the collection and analysis of MP contamination may not have necessarily specialized expertise in Raman microscopy or polymer chemistry. Topics such as effective particle isolation or the use of adequate substrates are approached on the base of the impact they have on the spectroscopic characterization. Issues as the control of background signal, the influence of sample digestion, and the presence of internal interferences such as pigments, dyes, and fillers, are discussed. Spectral features of the polymer families found as MP/MF contaminants are presented based upon polymer structure, properties, and applications. The use of open-source libraries to complement chemical identification is also discussed. Overall, this work aims to enhance the practice and understanding of Raman microscopy for researchers engaged in characterizing MP/MF contaminants.

Elective Lumbar Spine Surgery Leads to the Development of Chronic Pancreatitis and Pancreatic Pseudocyst: A Case Report and Literature Review.

The occurrence of pancreatitis shortly after elective lumbar spine surgery in an adult is rare. We report a case of a 63-year-old female who developed, for the first time, acute pancreatitis within three days of elective lumbar (L) spine surgery that was performed for degenerative disk disease without significant deformity (i.e., no scoliosis or spondylolisthesis). The surgery was conducted using a lateral transpsoas approach and included interbody fusions at L3-L4 and L4-L5 levels and posterior instrumentation with pedicle screws and rods. Ten years prior, she had a cholecystectomy, and she was not diabetic or obese. She began experiencing significant nausea and malaise two days after that lumbar spine surgery, requiring hospitalization on the third postoperative day. Her pancreatitis became chronic, and a large pancreatic pseudocyst developed and persisted despite using an external drainage catheter for 52 days. At 126 days after the spinal surgery, an open Roux-en-Y pancreatic cystojejunostomy was performed to internally drain the cyst, which had enlarged to 19 cm. Significant pre-surgical risk factors for this first-time case of pancreatitis were not identified. The spine surgeon denied iatrogenic causes such as instrument plunging or complications associated with the use of a "lateral access retraction system," and surgical blood loss was only 50 ml during the elective lumbar spine surgery. However, during the lumbar spine surgery, hypotension occurred for 20 minutes (mean arterial pressure: 63-73 mmHg), which was associated with transient acute kidney injury. This might have contributed to the development of her pancreatitis because the pancreas is more sensitive to ischemia than the kidney. During the initial week after the onset of pancreatitis, her symptoms were mainly believed to be due to an acute postoperative infection. However, there was no growth in cultures from aspirations of the pleural effusion, retroperitoneal effusion, and deeper incision area. Despite extensive workup, the cause of the patient's pancreatitis was not determined. We report this case not only because of its rarity but also to help surgeons and other healthcare providers in the workup and management of similar situations.

Non-Surgical Treatment of Moderate Periodontal Intrabony Defects With Adjunctive Cross-Linked Hyaluronic Acid: A Single-Blinded Randomized Controlled Clinical Trial.

AIM: To evaluate the clinical outcomes of moderate intrabony defects treated with minimally invasive non-surgical technique (MINST) with or without adjunctive delivery of cross-linked hyaluronic acid (xHyA) gel. MATERIALS AND METHODS: Forty-two patients with 42 interdental intrabony defects were randomly assigned to test (MINST + xHyA) or control procedures (MINST alone). Probing depth (PD), clinical attachment level (CAL), gingival recession (GR) and bleeding on probing (BOP) at the treated sites were assessed at baseline and at 3 and 6 months. Full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) were recorded at baseline and after 6 months. Radiographic evaluation was performed at baseline and after 6 months, assessing the defect fill (DF) and radiographic defect angle (RDA). The primary outcome variable was PD change. RESULTS: Thirty-eight patients completed the trial without any adverse events. At 6 months, a statistically significant improvement (p < 0.05) was measured in all clinical parameters except GR (p > 0.05). However, no statistically significant differences were found between the experimental and control procedures (p > 0.05). Statistically significant differences between the test and control sites were observed at 3 months for PD and CAL changes (p < 0.05). The DF change was statistically significant when comparing experimental and control procedures at 6 months (p < 0.05). Both procedures failed to show statistically significant differences in terms of RDA changes at 6 months (p > 0.05). CONCLUSION: Within their limitations, the present results indicate that (a) treatment of intrabony defects with MINST, with or without application of xHyA gel, resulted in statistically significant improvements in the investigated clinical parameters at 3 and 6 months after therapy, and (b) although the adjunctive use of xHyA gel to MINST improved the clinical outcomes compared with MINST alone up to 3 months, statistically significant differences were not observed at 6 months. The study protocol was registered in ClinicalTrial.gov (NCT05188898).

Patient-specific instrumentation improved clinical outcome and implant survival but is not superior compared to conventional total knee arthroplasty: Ten years follow-up of a multicenter double-blind randomized controlled trial.

PURPOSE: Patient-specific instrumentation (PSI) is a commonly used technique designed to improve mechanical alignment in total knee arthroplasty (TKA) and was therefore believed to lead to better clinical outcome and implant survival rates compared with conventional instruments (CIs). To date, long-term results comparing these two techniques are not available. METHODS: This study is a 10-year follow-up of a previous double-blind multicenter randomized controlled trial where PSI was compared with CI. Patients with osteoarthritis of the knee who were candidates for TKA were included. Exclusion criteria were metal near the knee-, ankle- or hip joint, patients with contra-indications for a magnetic resonance imaging (MRI) scan and patients who had previous knee surgery (except arthroscopic meniscectomy). Clinical outcomes were assessed using patient-reported outcome measures (PROMs), and the analysis was performed with a general linear mixed model for repeated measurements. Kaplan-Meier curves were used to compare revision rates. X-rays were obtained and examined by two individual reviewers for any signs of loosening of the components. RESULTS: At a mean follow-up of 10.1 (SD 0.1) years, 129 patients (loss to follow-up 23%) were analysed in this trial. No statistically significant difference between the two groups were found for any of the PROMs and revision rates were comparable, six in the PSI group and three in the CI group (p = 0.29). Two X-rays in the PSI group showed a radiolucent line of the femoral component. CONCLUSION: At 10-year follow-up, PSI does not lead to better clinical outcome or survival of the prosthesis compared with CI.

A Practical Guide to 3D Printing for Chemistry and Biology Laboratories.

Three-dimensional (3D) printing promises a revolution in laboratory creativity by enabling rapid prototyping, broader availability of scientific apparatuses, and transformative scientific workflows. We believe all chemistry and biology laboratories should equip themselves with one or more 3D printers and a critical mass of scientists trained to operate them. This overview surveys the techniques, intricacies, and pitfalls associated with 3D printing of functional parts, including measurements, computer-aided design, slicing, limitations of 3D printing, troubleshooting, tips for tricky filaments, and 3D printer maintenance. A flow cells are essential tools in chemistry and biology laboratories, we discuss techniques relevant to the construction of watertight 3D-printed parts. Finally, we articulate a set of principles required for reporting 3D-printed innovations to improve the field's reproducibility and encourage iterative improvements by other scientists. Ideally, authors, peer reviewers, and editors will adopt these principles. We hope these protocols inspire a new generation of publications applying 3D printing in chemistry and biology-especially highly reproducible inventions with the requisite detail and associated documentation. Such reports will facilitate broad adoption and creative iteration of the most innovative designs, thus accelerating discovery in chemistry and biology. © 2024 The Author(s). Current Protocols published by Wiley Periodicals LLC.

Impact of periodontal phenotype on the outcome of subgingival instrumentation in Stage II and III, Grade A and B periodontitis.

Background: The influence of periodontal phenotype (PP) has been documented in the outcomes of various surgical periodontal interventions such as crown lengthening, mucogingival surgery, implant restoration, and open flap debridement. Previous studies with smaller sample sizes have assessed the role of PP on the outcome of nonsurgical periodontal therapy with inconsistent results. Aim: The aim of the current interventional study is to estimate the influence of PP on the outcome of subgingival instrumentation in Stage II and III, Grade A and B periodontitis. Materials and Methods: Fifty-two patients (n = 27 thick PP and n = 25 thin PP) underwent subgingival instrumentation using ultrasonic scalers and curettes under local anesthesia in a single sitting, and periodontal parameters were recorded at baseline, 2, 4, and 6 months. The McNemar and Chi-square tests were applied for categorical data, whereas the Wilcoxon signed-rank test and Mann-Whitney U-test were applied for continuous data in intra- and intergroup comparisons, respectively. Results: Significantly better improvements in deeper pockets (>5 mm) with thick PP were observed. Loss of attachment was found in thin, bleeding on probing (BOP)-negative sites with an initial probing depth of ≤3 mm. However, BOP-positive sites belonging to both groups exhibited higher improvements in terms of clinical parameters. Conclusion: Probing depth, PP, and periodontal inflammation recorded in terms of BOP influence the gain in clinical attachment following subgingival instrumentation.

Urchin-like Co3O4 microspheres-boosted catalytic oxidation: Environmentally-friendly CO2 vapor generation for total organic carbon detection by microplasma optical emission spectrometry.

Total organic carbon (TOC) is a crucial indicator of organic pollutants, widely used in environmental water quality monitoring and risk assessment. Conventional TOC detection methods often require high temperatures, complex equipment, and inefficient oxidation processes, limiting their field application due to time consumption, intricate operations, and limited sensitivity. Therefore, we developed a novel approach for TOC measurement using catalytic oxidation vapor generation coupled with miniaturized point discharge optical emission spectrometry (µPD-OES). This method employs urchin-like Co3O4 microspheres to convert organic pollutants to carbon dioxide during persulfate catalytic oxidation, followed by collection and quantification via carbon atomic emission line (λ = 193.0 nm). Standard or sample solutions were acidified with phosphoric acid and purged with Ar before quantification. Under optimal conditions, the proposed method achieved a detection limit of 0.01 mg L-1, offering precision (RSD, n = 11) better than 3.7 %. The feasibility of the system was tested using a certified reference material (GBW(E)082053) and environmental water samples, achieving satisfactory recoveries (98-102 %). This method provides high oxidation efficiency, sensitivity, and accuracy, while also reducing the demand for expensive and bulky instruments and minimizing energy consumption, making it suitable for rapid, sensitive field analysis of TOC.

STABILITY OF MEDIALLY AND LATERALLY MALPOSITIONED SCREWS: A BIOMECHANICAL STUDY ON CADAVERS.

BACKGROUND CONTEXT: Pedicle screw instrumentation is widely used in spine surgery. Axial screw misplacement is a common complication. In addition to the recognized neurovascular risks associated with screw misplacement, the biomechanical stability of misplaced screws remains a subject of debate. PURPOSE: The present study investigates whether screw misplacement in the lumbar spine reduces mechanical screw hold. STUDY DESIGN/SETTING: Cadaveric biomechanical study METHODS: Pedicle screw (mis)placement was planned for 12 fresh frozen cadaveric spines between the T12 and the L5 levels. The screws were then implanted into the vertebrae with the help of 3D-printed template guides. Pre- and post-instrumentation computed tomography (CT) scans were acquired for instrumentation planning and quantification of the misplacement. The instrumented vertebrae were potted into CT transparent boxes using Polymethyl methacrylate and mounted on a standardized biomechanical setup for pull-out (PO) testing with uniaxial tensile load. RESULTS: The bone density of all the specimens as per HU was comparable. The predicted pull-out force (POF) for screws medially misplaced by 2mm, 4mm, and 6mm was respectively 985 N (SD 474), 968 N (SD 476) and 822 N (SD 478). For screws laterally misplaced by 2mm, 4mm, and 6mm the POF was respectively 605 N (SD 473), 411 N (SD 475), and 334 N (SD 477). Screws that did not perforate the pedicle (control) resisted pull-out forces of 837 N (SD 471). CONCLUSIONS: Medial misplacement is associated with increased axial screw hold against static loads compared to correctly placed screws and laterally placed screws. CLINICAL SIGNIFICANCE: In clinical settings, the reinsertion of medially misplaced screws should primarily aim to prevent neurological complications while the reinsertion of lateral misplaced screws should aim to prevent screw loosening.

Nonlinear optical encoding enabled by recurrent linear scattering.

Optical information processing and computing can potentially offer enhanced performance, scalability and energy efficiency. However, achieving nonlinearity-a critical component of computation-remains challenging in the optical domain. Here we introduce a design that leverages a multiple-scattering cavity to passively induce optical nonlinear random mapping with a continuous-wave laser at a low power. Each scattering event effectively mixes information from different areas of a spatial light modulator, resulting in a highly nonlinear mapping between the input data and output pattern. We demonstrate that our design retains vital information even when the readout dimensionality is reduced, thereby enabling optical data compression. This capability allows our optical platforms to offer efficient optical information processing solutions across applications. We demonstrate our design's efficacy across tasks, including classification, image reconstruction, keypoint detection and object detection, all of which are achieved through optical data compression combined with a digital decoder. In particular, high performance at extreme compression ratios is observed in real-time pedestrian detection. Our findings open pathways for novel algorithms and unconventional architectural designs for optical computing.

Comparative Evaluation of Effectiveness of Rotary and Hand File Systems in Terms of Quality of Obturation and Instrumentation Time among Primary Teeth: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Aim: This systematic review and meta-analysis aimed to answer the following focused question: Are rotary file systems more effective than hand file systems in terms of the quality of obturation and instrumentation time among primary teeth? Study eligibility criteria participants and interventions: The inclusion criteria comprised studies that compared the effect on quality of obturation and instrumentation time among primary teeth after using rotary and hand file systems for biomechanical preparation of the root canals. Materials and methods: This review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The searched databases included Medline (via PubMed), EBSCO, and Google Scholar. Articles published from January 2000 to December 2021, but only in English, were included. Results: The search resulted in 8,003 published studies. After the removal of duplicate studies and full-text analysis, 9 studies were selected for systematic review, and 8 were selected for meta-analysis. Overall, the results demonstrated the promising effects of rotary file systems in reducing instrumentation time and improving obturation quality compared to hand files. Conclusion: Within the limitations of this review, it can be asserted that rotary file systems are superior to hand files in primary teeth for pulpectomy procedures. Clinical significance: Rotary files, a more recent technique, are more efficient than traditional hand files in lowering the time required for instrumentation. Additionally, they provide superior obturation quality in primary molars, making them particularly beneficial for pediatric patients. How to cite this article: Gala UP, Kalaskar R, Vinay V, et al. Comparative Evaluation of Effectiveness of Rotary and Hand File Systems in Terms of Quality of Obturation and Instrumentation Time among Primary Teeth: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Int J Clin Pediatr Dent 2024;17(8):962-969.

[The instrument technician, responsible for the smooth running of the procedure and safety in the operating field]. / L'instrumentiste, garant du bon déroulement de l'intervention et de la sécurité sur le champ opératoire.

As a specialized nurse working as part of an operating room team, the ORN is at the heart of patient care: when the patient is admitted to the operating room, during the operation and postoperatively, in the recovery room. He or she plays a variety of roles within the team, and more specifically, works alongside the surgeon as an instrumentalist, one of the three roles of an operating room nurse.

Repeated γ irradiation and thermal annealing via built-in thermo-electric coolers of Si avalanche photodiodes.

When operating in space, on-board Silicon Geiger-Mode Avalanche Photodiodes (GM-APDs) are exposed to radiation damage that result in an increase in dark count rates. Thermal annealing has been found to mitigate the damage, although prior studies have largely focused on annealing following a single session of proton irradiation. This work reports that thermal annealing can be performed simply with the built-in thermo-electric coolers of the GM-APDs. Annealing was also done in 10 min intervals for a clearer view of the recovery curve. Mitigation of damage from repeated γ radiation was observed from the: (1) halving of the increase in dark count rates on average and (2) outperformance of room temperature annealing ( 25 ∘ C) by 33 % . Additionally, we show that heavy doses of γ radiation (21 krad) have a probability of causing Random Telegraph Signals in GM-APDs that can be suppressed by lowering the operating temperature.

Atacama Large Aperture Submillimeter Telescope (AtLAST) science: Our Galaxy.

As we learn more about the multi-scale interstellar medium (ISM) of our Galaxy, we develop a greater understanding for the complex relationships between the large-scale diffuse gas and dust in Giant Molecular Clouds (GMCs), how it moves, how it is affected by the nearby massive stars, and which portions of those GMCs eventually collapse into star forming regions. The complex interactions of those gas, dust and stellar populations form what has come to be known as the ecology of our Galaxy. Because we are deeply embedded in the plane of our Galaxy, it takes up a significant fraction of the sky, with complex dust lanes scattered throughout the optically recognizable bands of the Milky Way. These bands become bright at (sub-)millimetre wavelengths, where we can study dust thermal emission and the chemical and kinematic signatures of the gas. To properly study such large-scale environments, requires deep, large area surveys that are not possible with current facilities. Moreover, where stars form, so too do planetary systems, growing from the dust and gas in circumstellar discs, to planets and planetesimal belts. Understanding the evolution of these belts requires deep imaging capable of studying belts around young stellar objects to Kuiper belt analogues around the nearest stars. Here we present a plan for observing the Galactic Plane and circumstellar environments to quantify the physical structure, the magnetic fields, the dynamics, chemistry, star formation, and planetary system evolution of the galaxy in which we live with AtLAST; a concept for a new, 50m single-dish sub-mm telescope with a large field of view which is the only type of facility that will allow us to observe our Galaxy deeply and widely enough to make a leap forward in our understanding of our local ecology.

There are many individual components contributing to the overall evolution of our Galaxy, the Milky Way. Through understanding the physics and chemistry of the Galaxy around us, we better understand our origins, our environment, and where we're going. Here we outline a number of observational surveys of our Galaxy that would produce a step change in our understanding of the evolution of the Galaxy around us, both as a template for others, and as the only way of understanding our place in the larger Universe. We present surveys of the Galactic Plane focusing on the dust and magnetic fields, chemistry, and dynamics of the gas. We then suggest surveys of local stars and star forming regions to uncover the origins of stars, planets and how those planetary systems evolve over the course of their lives, helping to put our Sun and Solar System in context. These types of observations require simultaneously sensitive, long wavelength (between 0.3 and 3 millimetre) observations as well as a large coverage of the sky, and cannot be done with current observatories operating at these wavelengths. Future leaps in understanding these systems will require a new telescope; a large telescope at a good observing location with a large field of view. This telescope, the Atacama Large Sub-mm Telescope (AtLAST; http://atlast-telescope.org/) is being developed, and here we are presenting the science cases for this new telescope from the point of view of our Galaxy. Together, these studies will revolutionise our understanding of the history and evolution of our Galaxy and bring us yet another step closer to understanding our place in, and the evolution of, our Universe.

Development of a scale to measure selection, optimization, compensation (SOC) strategy in late middle-aged women: a methodological study.

PURPOSE: Selection-optimization-compensation (SOC) models have been proposed and applied to various populations to examine successful aging from a multidimensional perspective. This study aimed to develop a scale to measure SOC strategy among late middle-aged women (aged 50 to 64 years) and to test its validity and reliability. METHODS: Preliminary items were developed through a literature review and interviews. Overall, 32 preliminary items were confirmed via two rounds of expert content validity analysis and a pilot survey. Data were collected from 299 late middle-aged women and analyzed using IBM SPSS/PC+ version 27.0. Construct validity, criterion validity, and reliability tests were conducted. RESULTS: The SOC strategy scale, reflecting the characteristics of late middle-aged women and developed through exploratory factor analysis, comprised 19 items across four factors: goal-oriented selection, compensation for loss, outcome optimization, and ability-based optimization. The scale explained 66.9% of the variance in total factors, with a Cronbach's α of .95. Statistically significant correlations with the reference scale (r=.30, p<.001) were observed. CONCLUSION: The developed scale demonstrated high validity and reliability, thus representing a viable instrument for measuring SOC strategy among late middle-aged women. Using this scale to assess the use of SOC approaches in these women can improve our understanding of the aging process and help establish supportive programs for their aging journeys.

Validity and Reliability of the Sickle Cell Self-Efficacy Scale in an Online, Anonymous Sample of Adults Living With Sickle Cell Disease.

Background and Purpose: The aim of the study was to examine the psychometric properties of the Sickle Cell Self-efficacy Scale (SCSES) in an anonymous, online cohort of adults with sickle cell disease (SCD). Methods: The SCSES was completed by 60 adults with SCD. An exploratory factor analysis was conducted. Convergent validity and discriminant validity were assessed using bivariate correlations between the SCSES and other study variables, and internal consistency reliability was evaluated through examining an alpha coefficient. Results: A unidimensional factor structure explained 49.6% of the variance in self-efficacy. The SCSES demonstrated convergent validity and discriminant validity with the select battery of measured concepts and sufficient internal consistency reliability (Cronbach's alpha = .87). Conclusions: The SCSES remains a valid and reliable measure of SCD self-efficacy among adults when used in anonymous, online research.