GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response.

The looming stimulus-evoked flight response to approaching predators is a defensive behavior in most animals. However, how looming stimuli are detected in the retina and transmitted to the brain remains unclear. Here, we report that a group of GABAergic retinal ganglion cells (RGCs) projecting to the superior colliculus (SC) transmit looming signals from the retina to the brain, mediating the looming-evoked flight behavior by releasing GABA. GAD2-Cre and vGAT-Cre transgenic mice were used in combination with Cre-activated anterograde or retrograde tracer viruses to map the inputs to specific GABAergic RGC circuits. Optogenetic technology was used to assess the function of SC-projecting GABAergic RGCs (scpgRGCs) in the SC. FDIO-DTA (Flp-dependent Double-Floxed Inverted Open reading frame-Diphtheria toxin) combined with the FLP (Florfenicol, Lincomycin & Prednisolone) approach was used to ablate or silence scpgRGCs. In the mouse retina, GABAergic RGCs project to different brain areas, including the SC. ScpgRGCs are monosynaptically connected to parvalbumin-positive SC neurons known to be required for the looming-evoked flight response. Optogenetic activation of scpgRGCs triggers GABA-mediated inhibition in SC neurons. Ablation or silencing of scpgRGCs compromises looming-evoked flight responses without affecting image-forming functions. Our study reveals that scpgRGCs control the looming-evoked flight response by regulating SC neurons via GABA, providing novel insight into the regulation of innate defensive behaviors.

Investigating looming tactile takeover requests with various levels of urgency in automated vehicles.

Designing an effective takeover request (TOR) in conditionally automated vehicles is crucial to ensure driving safety when the system reaches its limit. In our study, we aimed to investigate the effects of looming tactile TORs (whose urgency is dynamically mapped to the situation's criticality as the vehicle approaches the upcoming obstacle) on takeover performance and subjective experience compared with conventional non-looming TORs (several tactile pulses with consistent inter-pulse intervals). In addition, the impact of the TOR urgency level (with urgency levels matched or unmatched to the situation's criticality) was considered. A total of 30 participants were recruited for this study. They were first asked to map the urgency of tactile signals to the criticality of takeover situations with various times to collision according to the recorded video clips. The looming TORs were constructed based on these mapping results. Then, a simulated driving experiment, employing a within-subject design, was conducted to explore the effects of the tactile TOR type (looming vs. non-looming) and urgency level (less urgency vs. matched urgency vs. greater urgency) on takeover performance and drivers' subjective experience. The results showed that the looming TOR can lead to a shorter takeover time and less maximum lateral acceleration compared with the non-looming TOR. Drivers also rated the looming TOR as more useful. Therefore, the looming TOR has great application potential for enhancing driving safety in automated vehicles. In addition, we found that as the TOR's level of urgency increased, the takeover time decreased. However, the TOR with an urgency level matched to the situation's criticality received higher usefulness and satisfaction ratings, suggesting that there was an important trade-off between the advantage of high-urgency TORs in speeding up driver responses and its cost of a poor experience. The findings of our study shed some light on the design and implementation of the takeover warning system for related practitioners.

Emotion-gaze interaction affects time-to-collision estimates, but not preferred interpersonal distance towards looming faces.

Estimating the time until impending collision (time-to-collision, TTC) of approaching or looming individuals and maintaining a comfortable distance from others (interpersonal distance, IPD) are commonly required in daily life and contribute to survival and social goals. Despite accumulating evidence that facial expressions and gaze direction interactively influence face processing, it remains unclear how these facial features affect the spatiotemporal processing of looming faces. We examined whether facial expressions (fearful vs. neutral) and gaze direction (direct vs. averted) interact on the judgments of TTC and IPD for looming faces, based on the shared signal hypothesis that fear signals the existence of threats in the environment when coupled with averted gaze. Experiment 1 demonstrated that TTC estimates were reduced for fearful faces compared to neutral ones only when the concomitant gaze was averted. In Experiment 2, the emotion-gaze interaction was not observed in the IPD regulation, which is arguably sensitive to affective responses to faces. The results suggest that fearful-averted faces modulate the cognitive extrapolation process of looming motion by communicating environmental threats rather than by altering subjective fear or perceived emotional intensity of faces. The TTC-specific effect may reflect an enhanced defensive response to unseen threats implied by looming fearful-averted faces. Our findings provide insight into how the visual system processes facial features to ensure bodily safety and comfortable interpersonal communication in dynamic environments.

A computationally efficient and robust looming perception model based on dynamic neural field.

There are primarily two classes of bio-inspired looming perception visual systems. The first class employs hierarchical neural networks inspired by well-acknowledged anatomical pathways responsible for looming perception, and the second maps nonlinear relationships between physical stimulus attributes and neuronal activity. However, even with multi-layered structures, the former class is sometimes fragile in looming selectivity, i.e., the ability to well discriminate between approaching and other categories of movements. While the latter class leaves qualms regarding how to encode visual movements to indicate physical attributes like angular velocity/size. Beyond those, we propose a novel looming perception model based on dynamic neural field (DNF). The DNF is a brain-inspired framework that incorporates both lateral excitation and inhibition within the field through instant feedback, it could be an easily-built model to fulfill the looming sensitivity observed in biological visual systems. To achieve our target of looming perception with computational efficiency, we introduce a single-field DNF with adaptive lateral interactions and dynamic activation threshold. The former mechanism creates antagonism to translating motion, and the latter suppresses excitation during receding. Accordingly, the proposed model exhibits the strongest response to moving objects signaling approaching over other types of external stimuli. The effectiveness of the proposed model is supported by relevant mathematical analysis and ablation study. The computational efficiency and robustness of the model are verified through systematic experiments including on-line collision-detection tasks in micro-mobile robots, at success rate of 93% compared with state-of-the-art methods. The results demonstrate its superiority over the model-based methods concerning looming perception.

Cortical responses to looming sources are explained away by the auditory periphery.

A wealth of behavioral evidence indicate that sounds with increasing intensity (i.e. appear to be looming towards the listener) are processed with increased attentional and physiological resources compared to receding sounds. However, the neurophysiological mechanism responsible for such cognitive amplification remains elusive. Here, we show that the large differences seen between cortical responses to looming and receding sounds are in fact almost entirely explained away by nonlinear encoding at the level of the auditory periphery. We collected electroencephalography (EEG) data during an oddball paradigm to elicit mismatch negativity (MMN) and others Event Related Potentials (EPRs), in response to deviant stimuli with both dynamic (looming and receding) and constant level (flat) differences to the standard in the same participants. We then combined a computational model of the auditory periphery with generative EEG methods (temporal response functions, TRFs) to model the single-participant ERPs responses to flat deviants, and used them to predict the effect of the same mechanism on looming and receding stimuli. The flat model explained 45% variance of the looming response, and 33% of the receding response. This provide striking evidence that difference wave responses to looming and receding sounds result from the same cortical mechanism that generate responses to constant-level deviants: all such differences are the sole consequence of their particular physical morphology getting amplified and integrated by peripheral auditory mechanisms. Thus, not all effects seen cortically proceed from top-down modulations by high-level decision variables, but can rather be performed early and efficiently by feed-forward peripheral mechanisms that evolved precisely to sparing subsequent networks with the necessity to implement such mechanisms.

Effects of looming audio on transcranial magnetic stimulation-induced phosphene perception.

Looming sounds are known to influence visual function in the brain, even as early as the primary visual cortex. However, despite evidence that looming sounds have a larger impact on cortical excitability than stationary sounds, the influence of varying looming strengths on visual ability remains unclear. Here, we aim to understand how these signals influence low-level visual function. Fourteen healthy undergraduate students participated. They were blindfolded and received transcranial magnetic stimulation (TMS) to the primary visual cortex following auditory stimulation with different strength looming sounds. Participants reported whether they perceived a phosphene, or an illusory visual percept, following TMS stimulation. We hypothesized that rates of phosphene activity would increase with increasing levels of looming strength. A linear mixed-effect model showed that phosphene activity was significantly higher at higher strength of looming (F(1, 69) = 5.33, p = .024) and at higher TMS pulse strength (F(1, 18) = 4.71, p = .043). However, there was also a significant interaction between looming strength and pulse strength (F(1, 69) = 4.33, p = .041). At lower levels of TMS strength, phosphene rate increased with looming strength, while at higher levels of TMS strength the effect was reversed. These results suggest a complex relationship between looming strength and cortical activity, potentially reflecting the mixed contribution of total auditory energy and the rate of changes. This work will enhance our ability to predict audiovisual interactions and may help improve auditory warning systems designed to capture visual attention.

An ethologically relevant paradigm to assess defensive response to looming visual contrast stimuli.

In the animal kingdom, threat information is perceived mainly through vision. The subcortical visual pathway plays a critical role in the rapid processing of visual information-induced fear, and triggers a response. Looming-evoked behavior in rodents, mimicking response to aerial predators, allowed identify the neural circuitry underlying instinctive defensive behaviors; however, the influence of disk/background contrast on the looming-induced behavioral response has not been examined, either in rats or mice. We studied the influence of the dark disk/gray background contrast in the type of rat and mouse defensive behavior in the looming arena, and we showed that rat and mouse response as a function of disk/background contrast adjusted to a sigmoid-like relationship. Both sex and age biased the contrast-dependent response, which was dampened in rats submitted to retinal unilateral or bilateral ischemia. Moreover, using genetically manipulated mice, we showed that the three type of photoresponsive retinal cells (i.e., cones, rods, and intrinsically photoresponsive retinal ganglion cells (ipRGCs)), participate in the contrast-dependent response, following this hierarchy: cones > > rods > > > ipRGCs. The cone and rod involvement was confirmed using a mouse model of unilateral non-exudative age-related macular degeneration, which only damages canonical photoreceptors and significantly decreased the contrast sensitivity in the looming arena.

SLoN: a spiking looming perception network exploiting neural encoding and processing in ON/OFF channels.

Looming perception, the ability to sense approaching objects, is crucial for the survival of humans and animals. After hundreds of millions of years of evolutionary development, biological entities have evolved efficient and robust looming perception visual systems. However, current artificial vision systems fall short of such capabilities. In this study, we propose a novel spiking neural network for looming perception that mimics biological vision to communicate motion information through action potentials or spikes, providing a more realistic approach than previous artificial neural networks based on sum-then-activate operations. The proposed spiking looming perception network (SLoN) comprises three core components. Neural encoding, known as phase coding, transforms video signals into spike trains, introducing the concept of phase delay to depict the spatial-temporal competition between phasic excitatory and inhibitory signals shaping looming selectivity. To align with biological substrates where visual signals are bifurcated into parallel ON/OFF channels encoding brightness increments and decrements separately to achieve specific selectivity to ON/OFF-contrast stimuli, we implement eccentric down-sampling at the entrance of ON/OFF channels, mimicking the foveal region of the mammalian receptive field with higher acuity to motion, computationally modeled with a leaky integrate-and-fire (LIF) neuronal network. The SLoN model is deliberately tested under various visual collision scenarios, ranging from synthetic to real-world stimuli. A notable achievement is that the SLoN selectively spikes for looming features concealed in visual streams against other categories of movements, including translating, receding, grating, and near misses, demonstrating robust selectivity in line with biological principles. Additionally, the efficacy of the ON/OFF channels, the phase coding with delay, and the eccentric visual processing are further investigated to demonstrate their effectiveness in looming perception. The cornerstone of this study rests upon showcasing a new paradigm for looming perception that is more biologically plausible in light of biological motion perception.

Mosquitoes escape looming threats by actively flying with the bow wave induced by the attacker.

To detect and escape looming threats, night-flying insects must rely on other senses than vision alone. Nocturnal mosquitoes can evade looming objects in the dark, but how they achieve this is still unknown. Here, we show how night-active female malaria mosquitoes escape from rapidly looming objects that simulate defensive actions of blood-hosts. First, we quantified the escape performance of flying mosquitoes from an event-triggered mechanical swatter, showing that mosquitoes use swatter-induced airflow to increase their escape success. Secondly, we used high-speed videography and deep-learning-based tracking to analyze escape flights in detail, showing that mosquitoes use banked turns to evade the threat. By combining escape kinematics data with numerical simulations of attacker-induced airflow and a mechanistic movement model, we unraveled how mosquitoes control these banked evasive maneuvers: they actively steer away from the danger, and then passively travel with the bow wave produced by the attacker. Our results demonstrate that night-flying mosquitoes can detect looming objects when visual cues are minimal, suggesting that they use attacker-induced airflow both to detect the danger and as a fluid medium to move with away from the threat. This shows that escape strategies of flying insects are more complex than previous visually induced escape flight studies suggest. As most insects are of similar or smaller sizes than mosquitoes, comparable escape strategies are expected among millions of flying insect species. The here-observed escape maneuvers are distinct from those of mosquitoes escaping from odor-baited traps, thus providing new insights for the development of novel trapping techniques for integrative vector management.

The association between looming cognitive style and posttraumatic stress symptoms: The case of older Holocaust survivors.

The looming cognitive style (LCS) refers to a tendency to produce mental illustrations and images of adverse events and potentially threatening situations with perceived accumulating threat and danger. LCS is a well-known cognitive vulnerability for anxiety, nevertheless few studies examined the relationship between LCS and posttraumatic reactions. Among the existing studies, a higher LCS was reported in Holocaust survivors relative to matched comparisons, and directly associated with posttraumatic stress symptoms (PTSS) in older Holocaust survivors. The current study aimed to expand the understanding of the relationship between LCS with PTSS in general, and among older Holocaust survivors in particular. Moreover, whether the number of Holocaust experiences encountered by Holocaust survivors moderated this relationship. The sample consisted of 153 older Holocaust survivors (Mage = 82.42, SD = 5.75). Participants were interviewed regarding their background characteristics, PTSS, LCS, and number of Holocaust experiences. Participants reporting higher LCS showed higher PTSS. There was an interaction between LCS and number of Holocaust experiences for predicting PTSS, suggesting that LCS was associated with higher PTSS to a stronger degree among Holocaust survivors who experienced a smaller number of Holocaust experiences. The findings indicate that Holocaust trauma may have influenced the LCS of Holocaust survivors throughout their lives and into old age. The results provide insight for mental health practitioners treating older Holocaust survivors in focusing on reducing schematic processing biases for threat information and anxiety to enhance better mental health for those suffering from posttraumatic stress symptoms.

Effect of a looming visual cue on situation awareness and perceived urgency in response to a takeover request.

This study aimed to investigate the effect of a looming visual cue on situation awareness and perceived urgency in response to a takeover request (TOR), and to explore the underlying mechanisms of this effect through three experiments. In Experiment 1, the optimal size and speed of a red disk were determined, which were effective in capturing looming motion and conveying the urgency of the situation. The results indicated that both looming speed and size ratio had significant effects on situation awareness and perceived urgency. In Experiment 2, the effects of looming stimuli were compared with dimming stimuli, and the results showed that the looming visual cue was more effective in promoting perceived urgency and situation awareness. The results also indicated that the looming visual cue attracted more visual attention than the dimming visual cue, in line with previous studies. Experiment 3 utilized a driving simulator to test the effectiveness of the looming visual cue in promoting fast and appropriate responses to TORs in complex driving scenarios. The results showed that the looming visual cue was more effective in promoting perceived urgency and enhancing situation awareness, especially in highly complex driving situations. Overall, the findings suggest that the looming visual cue is a powerful tool for promoting fast and appropriate responses to TORs and enhancing situation awareness, particularly in complex driving scenarios. These results have important implications for designing effective TOR systems and improving driver safety on the road.

Looming Angry Faces: Preliminary Evidence of Differential Electrophysiological Dynamics for Filtered Stimuli via Low and High Spatial Frequencies.

Looming motion interacts with threatening emotional cues in the initial stages of visual processing. However, the underlying neural networks are unclear. The current study investigated if the interactive effect of threat elicited by angry and looming faces is favoured by rapid, magnocellular neural pathways and if exogenous or endogenous attention influences such processing. Here, EEG/ERP techniques were used to explore the early ERP responses to moving emotional faces filtered for high spatial frequencies (HSF) and low spatial frequencies (LSF). Experiment 1 applied a passive-viewing paradigm, presenting filtered angry and neutral faces in static, approaching, or receding motions on a depth-cued background. In the second experiment, broadband faces (BSF) were included, and endogenous attention was directed to the expression of faces. Our main results showed that regardless of attentional control, P1 was enhanced by BSF angry faces, but neither HSF nor LSF faces drove the effect of facial expressions. Such findings indicate that looming motion and threatening expressions are integrated rapidly at the P1 level but that this processing relies neither on LSF nor on HSF information in isolation. The N170 was enhanced for BSF angry faces regardless of attention but was enhanced for LSF angry faces during passive viewing. These results suggest the involvement of a neural pathway reliant on LSF information at the N170 level. Taken together with previous reports from the literature, this may indicate the involvement of multiple parallel neural pathways during early visual processing of approaching emotional faces.

Face your fears: direct and indirect measurement of responses to looming threats.

This study investigated the emotional and behavioural effects of looming threats using both recalled (self-reported valence) and real-time response measurements (facial expressions). The looming bias refers to the tendency to underestimate the time of arrival of rapidly approaching (looming) stimuli, providing additional time for defensive reactions. While previous research has shown negative emotional responses to looming threats based on self-reports after stimulus exposure, facial expressions offer valuable insights into emotional experiences and non-verbal behaviour during stimulus exposure. A face reading experiment examined responses to threats in motion, considering stimulus direction (looming versus receding motion) and threat strength (more versus less threatening stimuli). We also explored the added value of facial expression recognition compared to self-reported valence. Results indicated that looming threats elicit more negative facial expressions than receding threats, supporting previous findings on the looming bias. Further, more (vs. less) threatening stimuli evoked more negative facial expressions, but only when the threats were looming rather than receding. Interestingly, facial expressions of valence and self-reported valence showed opposing results, suggesting the importance of incorporating facial expression recognition to understand defensive responses to looming threats more comprehensively.

A Non-canonical Excitatory PV RGC-PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response.

Parvalbumin-positive retinal ganglion cells (PV+ RGCs) are an essential subset of RGCs found in various species. However, their role in transmitting visual information remains unclear. Here, we characterized PV+ RGCs in the retina and explored the functions of the PV+ RGC-mediated visual pathway. By applying multiple viral tracing strategies, we investigated the downstream of PV+ RGCs across the whole brain. Interestingly, we found that the PV+ RGCs provided direct monosynaptic input to PV+ excitatory neurons in the superficial layers of the superior colliculus (SC). Ablation or suppression of SC-projecting PV+ RGCs abolished or severely impaired the flight response to looming visual stimuli in mice without affecting visual acuity. Furthermore, using transcriptome expression profiling of individual cells and immunofluorescence colocalization for RGCs, we found that PV+ RGCs are predominant glutamatergic neurons. Thus, our findings indicate the critical role of PV+ RGCs in an innate defensive response and suggest a non-canonical subcortical visual pathway from excitatory PV+ RGCs to PV+ SC neurons that regulates looming visual stimuli. These results provide a potential target for intervening and treating diseases related to this circuit, such as schizophrenia and autism.

Interception of vertically approaching objects: temporal recruitment of the internal model of gravity and contribution of optical information.

Introduction: Recent views posit that precise control of the interceptive timing can be achieved by combining on-line processing of visual information with predictions based on prior experience. Indeed, for interception of free-falling objects under gravity's effects, experimental evidence shows that time-to-contact predictions can be derived from an internal gravity representation in the vestibular cortex. However, whether the internal gravity model is fully engaged at the target motion outset or reinforced by visual motion processing at later stages of motion is not yet clear. Moreover, there is no conclusive evidence about the relative contribution of internalized gravity and optical information in determining the time-to-contact estimates. Methods: We sought to gain insight on this issue by asking 32 participants to intercept free falling objects approaching directly from above in virtual reality. Object motion had durations comprised between 800 and 1100 ms and it could be either congruent with gravity (1 g accelerated motion) or not (constant velocity or -1 g decelerated motion). We analyzed accuracy and precision of the interceptive responses, and fitted them to Bayesian regression models, which included predictors related to the recruitment of a priori gravity information at different times during the target motion, as well as based on available optical information. Results: Consistent with the use of internalized gravity information, interception accuracy and precision were significantly higher with 1 g motion. Moreover, Bayesian regression indicated that interceptive responses were predicted very closely by assuming engagement of the gravity prior 450 ms after the motion onset, and that adding a predictor related to on-line processing of optical information improved only slightly the model predictive power. Discussion: Thus, engagement of a priori gravity information depended critically on the processing of the first 450 ms of visual motion information, exerting a predominant influence on the interceptive timing, compared to continuously available optical information. Finally, these results may support a parallel processing scheme for the control of interceptive timing.

Full field-of-view virtual reality goggles for mice.

Visual virtual reality (VR) systems for head-fixed mice offer advantages over real-world studies for investigating the neural circuitry underlying behavior. However, current VR approaches do not fully cover the visual field of view of mice, do not stereoscopically illuminate the binocular zone, and leave the lab frame visible. To overcome these limitations, we developed iMRSIV (Miniature Rodent Stereo Illumination VR)-VR goggles for mice. Our system is compact, separately illuminates each eye for stereo vision, and provides each eye with an ∼180° field of view, thus excluding the lab frame while accommodating saccades. Mice using iMRSIV while navigating engaged in virtual behaviors more quickly than in a current monitor-based system and displayed freezing and fleeing reactions to overhead looming stimulation. Using iMRSIV with two-photon functional imaging, we found large populations of hippocampal place cells during virtual navigation, global remapping during environment changes, and unique responses of place cell ensembles to overhead looming stimulation.

Convergent escape behaviour from distinct visual processing of impending collision in fish and grasshoppers.

In animal species ranging from invertebrate to mammals, visually guided escape behaviours have been studied using looming stimuli, the two-dimensional expanding projection on a screen of an object approaching on a collision course at constant speed. The peak firing rate or membrane potential of neurons responding to looming stimuli often tracks a fixed threshold angular size of the approaching stimulus that contributes to the triggering of escape behaviours. To study whether this result holds more generally, we designed stimuli that simulate acceleration or deceleration over the course of object approach on a collision course. Under these conditions, we found that the angular threshold conveyed by collision detecting neurons in grasshoppers was sensitive to acceleration whereas the triggering of escape behaviours was less so. In contrast, neurons in goldfish identified through the characteristic features of the escape behaviours they trigger, showed little sensitivity to acceleration. This closely mirrored a broader lack of sensitivity to acceleration of the goldfish escape behaviour. Thus, although the sensory coding of simulated colliding stimuli with non-zero acceleration probably differs in grasshoppers and goldfish, the triggering of escape behaviours converges towards similar characteristics. Approaching stimuli with non-zero acceleration may help refine our understanding of neural computations underlying escape behaviours in a broad range of animal species. KEY POINTS: A companion manuscript showed that two mathematical models of collision-detecting neurons in grasshoppers and goldfish make distinct predictions for the timing of their responses to simulated objects approaching on a collision course with non-zero acceleration. Testing these experimental predictions showed that grasshopper neurons are sensitive to acceleration while goldfish neurons are not, in agreement with the distinct models proposed previously in these species using constant velocity approaches. Grasshopper and goldfish escape behaviours occurred after the stimulus reached a fixed angular size insensitive to acceleration, suggesting further downstream processing in grasshopper motor circuits to match what was observed in goldfish. Thus, in spite of different sensory processing in the two species, escape behaviours converge towards similar solutions. The use of object acceleration during approach on a collision course may help better understand the neural computations implemented for collision avoidance in a broad range of species.

Applying the Accumulator model to predict driver's reaction time based on looming in approaching and braking conditions.

INTRODUCTION: The prediction of when the driver will react to a change in the lead vehicle motion is critical for assessing rear-end crash risk using car-following models. Past studies have assumed constant reaction time and driver's continuous reaction. However, these assumptions are not valid as the driver's reaction time can vary in different car-following situations and the driver does not continuously react to the lead vehicle motion. Thus, this study predicted the driver's reaction time using the Wiedemann car-following model and the Accumulator model. The Accumulator model assumes the driver's start of reaction based on the accumulation of looming and thereby reflects the driver's intermittent reaction. METHOD: Fifty drivers' behavior was observed using a driving simulator in two scenarios: (1) approach and follow a moving lead vehicle and (2) approach a stopped lead vehicle. The Accumulator model predicted the reaction times based on different looming variables (angular velocity and tau-inverse), lead vehicle type (car and truck), and lead vehicle brake lights (on or off). RESULTS: The Accumulator model showed lower prediction errors of the reaction time than the Wiedemann model, which assumes reaction based on the fixed looming threshold. The Accumulator model predicted the reaction times more accurately when it was calibrated with the angular velocity due to width and height of lead vehicles. Moreover, the Accumulator model with tau-inverse produced the smallest prediction error of reaction times among different Accumulator models and the Wiedemann model when lead vehicle brake lights were on. CONCLUSIONS: This study demonstrates that the Accumulator model is a promising method of predicting the driver's reaction time in car-following situations, which affects rear-end crash risk. PRACTICAL APPLICATIONS: The Accumulator model can be incorporated into a car-following model for the prediction of reaction times and can estimate the rear-end collision risk of vehicles more accurately.

IRIS: Integrated Retinal Functionality in Image Sensors.

Neuromorphic image sensors draw inspiration from the biological retina to implement visual computations in electronic hardware. Gain control in phototransduction and temporal differentiation at the first retinal synapse inspired the first generation of neuromorphic sensors, but processing in downstream retinal circuits, much of which has been discovered in the past decade, has not been implemented in image sensor technology. We present a technology-circuit co-design solution that implements two motion computations-object motion sensitivity and looming detection-at the retina's output that could have wide applications for vision-based decision-making in dynamic environments. Our simulations on Globalfoundries 22 nm technology node show that the proposed retina-inspired circuits can be fabricated on image sensing platforms in existing semiconductor foundries by taking advantage of the recent advances in semiconductor chip stacking technology. Integrated Retinal Functionality in Image Sensors (IRIS) technology could drive advances in machine vision applications that demand energy-efficient and low-bandwidth real-time decision-making.

Ten-m4 plays a unique role in the establishment of binocular visual circuits.

The patterning of binocular vision requires distinct molecular pathways for inputs arising from each side of the nervous system. Recent studies have demonstrated important roles for members of the Ten-m/Odz/teneurin family in the development of ipsilateral retinal projections. Here, we further highlight the significance of this gene family in visual development by identifying a role for Ten-m4 during the formation of the ipsilateral projection in the mouse. Ten-m4 was found to be expressed in the retina, dorsal lateral geniculate nucleus (dLGN), superior colliculus (SC), and primary visual cortex (V1) during development. Anterograde and retrograde tracing experiments in Ten-m4 knockout (KO) mice revealed a specific increase in ipsilateral retinal ganglion cells projecting to dLGN and SC. This increase was most prominent in regions corresponding to temporal retina. Consistent with this, EphB1 expression in the retina around the time of decussation was enhanced in this temporal region for KO mice, suggesting that the increased size of the ipsilateral population arises due to an increased number of retinal ganglion cells remaining ipsilaterally at the optic chiasm due to EphB1-mediated repulsion. The ectopic ipsilaterally targeted retinal ganglion cell projection observed in Ten-m4 KOs was associated with changes in response to ethologically relevant visual stimuli. Together, these data demonstrate a requirement for Ten-m4 in the establishment of ipsilateral projections from the retina, which likely acts in combination with other Ten-m members (Ten-m2 and Ten-m3) to promote the formation of functional binocular circuits.