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2.
Artigo em Inglês | MEDLINE | ID: mdl-36117326

RESUMO

The MrgD receptor agonist, alamandine (ALA) and Mas receptor agonist, AVE0991 have recently been identified as protective components of the renin-angiotensin system. We evaluated the effects of ALA and AVE0991 on cardiovascular function and remodeling in angiotensin (Ang) II-induced hypertension in rats. Sprague Dawley rats were subject to 4-week subcutaneous infusions of Ang II (80 ng/kg/min) or saline after which they were treated with ALA (50 µg/kg), AVE0991 (576 µg/kg), or ALA+AVE0991 during the last 2 weeks. Systolic blood pressure (SBP) and heart rate (HR) values were recorded with tail-cuff plethysmography at 1, 15, and 29 days post-treatment. After euthanization, the heart and thoracic aorta were removed for further analysis and vascular responses. SBP significantly increased in the Ang II group when compared to the control group. Furthermore, Ang II also caused an increase in cardiac and aortic cyclophilin-A (CYP-A), monocyte chemoattractant protein-1 (MCP-1), and cardiomyocyte degeneration but produced a decrease in vascular relaxation. HR, matrix metalloproteinase-2 and -9, NADPH oxidase-4, and lysyl oxidase levels were comparable among groups. ALA, AVE0991, and the drug combination produced antihypertensive effects and alleviated vascular responses. The inflammatory and oxidative stress related to cardiac MCP-1 and CYP-A levels decreased in the Ang II+ALA+AVE0991 group. Vascular but not cardiac angiotensin-converting enzyme-2 levels decreased with Ang II administration but were similar to the Ang II+ALA+AVE0991 group. Our experimental data showed the combination of ALA and AVE0991 was found beneficial in Ang II-induced hypertension in rats by reducing SBP, oxidative stress, inflammation, and improving vascular responses.

3.
Arq. Ciênc. Vet. Zool. UNIPAR (Online) ; 25(2): e8154, jul-dez. 2022.
Artigo em Português | LILACS, VETINDEX | ID: biblio-1399602

RESUMO

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)


The real vulture is a compact bird of extraordinary color (in adult plumage). Its bare head, as the scientific name suggests, has caricatures and fleshy red papillae applied around the beak, and an iris of the eye is white with a red orbital ring. In captivity, stress is a widely observed condition, which can lead to self-mutilation, which can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in the case of automation in Sarcoramphus papa, kept in captivity and with an importance of the appropriate manual for this species in captivity. He was seen at a University Veterinary Hospital, a king vulture showed a contaminated wound, with bone exposure on the right. After treatment or animal was sent to a conservation reserve to be conditioned and return to its natural habitat.(AU)


buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza desnuda, tiene carúnculas y papilas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede llevar a la automutilación, posiblemente evolucionando en lesiones graves de la piel y los músculos. El objetivo del presente informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenido en cautividad, y la importancia del manejo adecuado para esta especie en cautividad. Un buitre real que presentaba una lesión contaminada con exposición ósea en el ala derecha fue tratado en un Hospital Universitario Veterinario. Tras el tratamiento, el animal fue enviado a una reserva de conservación para que pudiera ser acondicionado para volver a su hábitat natural.(AU)


Assuntos
Animais , Automutilação , Comportamento Animal , Aves Predatórias/fisiologia , Estresse Fisiológico/fisiologia
4.
J Pharmacol Sci ; 149(4): 175-178, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35717070

RESUMO

Since information is still limited whether atrial IK,ACh may become a potential therapeutic target to terminate persistent atrial fibrillation (AF), we assessed it by using the persistent AF canine model with representative IK,ACh inhibitor AVE0118 and class I drugs. AVE0118 (6 mg/kg, n = 7), disopyramide (3 mg/kg, n = 7) and cibenzoline (3 mg/kg, n = 6) terminated the AF in 3/7, 1/7 and 2/6 animals, respectively, whereas aprindine (3 mg/kg, n = 6) did not suppress it. These findings suggest that IK,ACh inhibition in addition to open-state INa suppression with slow dissociation kinetics can synergistically exert potent antiarrhythmic action against persistent AF.


Assuntos
Fibrilação Atrial , Potenciais de Ação , Animais , Antiarrítmicos/farmacologia , Antiarrítmicos/uso terapêutico , Fibrilação Atrial/tratamento farmacológico , Compostos de Bifenilo , Cães , Átrios do Coração
5.
Int J Disaster Risk Reduct ; 75: 102951, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35463866

RESUMO

Currently, many institutions and academics are working to establish strategies of economic recovery with the aim of mitigating the short- and long-term impacts of the COVID-19 crisis. The main aim of this study is to analyze how this crisis has impacted Spanish SMEs, considering their operating, financial, and investment activities. We also analyze the initiatives or public policies that SME managers consider necessary in order to face the effects of COVID-19. To do this, an empirical study has been carried out based on information from 612 Spanish SMEs, estimating a PLS research model and multigroup analysis that considers the activity sector as a moderating variable. The results are useful to companies and different economic and social agents, providing information to facilitate decision-making to overcome pandemic crisis mainly in the economic and strategic spheres.

6.
Acta sci. vet. (Online) ; 50(suppl.1): Pub. 753, 15 fev. 2022. ilus
Artigo em Português | VETINDEX | ID: vti-765212

RESUMO

Background: Botulism is a disease caused by the ingestion of neurotoxin produced by Clostridium botulinum, characterizedby flaccid paralysis, which can lead to high mortality. They have seven types of neurotoxins (A, B, C, D, E, F, and G) and,in birds, most cases are attributed to type C. They are considered sources of botulinum toxins where the decomposition oforganic matter occurs, like stagnant water and rotting food. The main feature of the disease in birds is ascending symmetricflaccid paralysis. The present study aims to describe an outbreak of type C botulism in backyard poultry in the state ofSanta Catarina, Southern Brazil.Case: A visit was made to the property with 160 backyard poultry with a history of high mortality in the municipality ofAgrolândia, Santa Catarina. Clinical signs were characterized by paralysis of the pelvic limbs, neck and pendular wings,which progressed to death within 48 h. There was a mortality rate of 37.5% (60/160) between March and May 2019. Thesebirds were kept in an overcrowded environment, with different species (chickens, ducks, teals, and turkeys) fed irregularly.The water supplied was provided from kitchen exhaust, accumulating in puddles on the floor that contained organic matterresidues such as animal feces, food waste and bone fragments. The disposal of the carcasses of birds that died was in thesame enclosure, buried superficially, facilitating the access of other birds to dig them up and consume them. Necropsywas performed on 2 chickens and one duck, no macroscopic or histopathological lesions were observed. Blood, liver, andgastrointestinal content samples were sent for research and identification of botulinum toxin through the serum neutralization test in mice. The presence of type C botulinum toxin was confirmed in the liver chicken of one sampled animals.Discussion: The identification of type C botulism toxin enabled the characterization of the outbreak, which is...(AU)


Assuntos
Animais , Botulismo/epidemiologia , Botulismo/veterinária , Clostridium botulinum tipo C/isolamento & purificação , Neurotoxinas , Galinhas/microbiologia , Brasil , Surtos de Doenças/veterinária
7.
Iheringia, Sér. zool ; 112: e2022009, 2022. mapa, graf, ilus
Artigo em Inglês | VETINDEX | ID: biblio-1370037

RESUMO

Six species of the Family Threskiornithidae are found in the Pantanal. Despite being abundant and conspicuous birds, information on aspects of their breeding biology in this wetland remains scarce. The aim of this study was to examine breeding aspects (nest support plants and breeding season) of the two species of the genus Theristicus Wagler, 1832 that are found in the Brazilian wetland. Field work occurred in 2008, and a search for records (photographs) with evidences of breeding activities was done in the WikiAves and eBird databases in March 2020. A total of 49 records were obtained between 2007 and 2019 in four municipalities, mostly in Poconé. Records (n = 37) involving breeding Plumbeous Ibis, Theristicus caerulescens (Vieillot,1817), were obtained between March and November, and incubation has been documented mainly between May and September. Records (n = 12) of the Buff-necked Ibis, Theristicus caudatus (Boddaert, 1783), occurred between April and December, and nests with an incubating adult or nestlings were mainly found between September and December. Breeding activities of T. caudatus were delayed in relation to those of T. caerulescens. Nests of both species were platforms built with large amounts of branches. Most nests of T. caudatus were built in palms, while nests of T. caerulescens were found mainly in non-palm trees. Both species nested in tree species that are commonly found in areas where they forage.


Seis espécies da Família Threskiornithidae são encontradas no Pantanal. Embora sejam aves abundantes e conspícuas, informações sobre sua biologia reprodutiva nesta planície ainda são escassos. O objetivo deste estudo foi examinar aspectos da reprodução (uso de plantas para nidificação e época de reprodução) das duas espécies do gênero Theristicus Wagler, 1832 que ocorrem no Pantanal brasileiro. Observações de campo ocorreram em 2008, e uma busca por registros (fotografias) com evidências de atividades reprodutivas foi feita nas bases de dados de WikiAves e eBird em março de 2020. Um total de 49 registros foram obtidos entre 2007 e 2019 em quatro municípios, principalmente em Poconé. Registros (n = 37) de curicaca-real, Theristicus caerulescens (Vieillot, 1817), foram obtidos entre março e novembro, e a incubação foi documentada principalmente entre maio e setembro. Registros (n = 12) de curicaca, Theristicus caudatus (Boddaert, 1783), ocorreram entre abril e dezembro, e ninhos com um adulto incubando ou com filhotes pequenos foram encontrados principalmente entre setembro e dezembro. Assim, as atividades reprodutivas de T. caudatus ocorreram atrasadas em relação àquelas de T. caerulescens. Os ninhos das duas espécies eram plataformas feitas com grande quantidade de galhos. A maioria dos ninhos de T. caudatus foram construídos em palmeiras, enquanto que aqueles de T. caerulescens foram feitos em árvores que não eram palmeiras. As duas espécies nidificaram em espécies de árvores que são comuns em áreas próximas aos ambientes onde costumam se alimentar.


Assuntos
Animais , Reprodução , Aves , Comportamento de Nidação
8.
J Inflamm Res ; 14: 7007-7019, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34955647

RESUMO

OBJECTIVE: Emerging evidence suggests that brain angiotensin-(1-7) (Ang-(1-7)) deficiency contributes to the pathogenesis of Alzheimer's disease (AD). Meanwhile, our previous studies revealed that restoration of brain Ang-(1-7) levels provided neuroprotection by inhibition of inflammatory responses during AD progress. However, the potential molecular mechanisms by which Ang-(1-7) modulates neuroinflammation remain unclear. MATERIALS AND METHODS: APP/PS1 mice were injected intraperitoneally with AVE0991 (a nonpeptide analogue of Ang-(1-7)) once a day for 30 consecutive days. Cognitive functions, neuronal and synaptic integrity, and inflammation-related markers were assessed. Since astrocytes played a crucial role in AD-related neuroinflammation whilst long noncoding RNAs (lncRNAs) were reported to participate in modulating inflammatory responses, astrocytes of APP/PS1 mice were isolated for high-throughput lncRNA sequencing to identify the most differentially expressed lncRNA following AVE0991 treatment. Afterward, the downstream pathways of this lncRNA in the anti-inflammatory action of AVE0991 were investigated using primary astrocytes. RESULTS: AVE0991 rescued spatial cognitive impairments and alleviated neuronal and synaptic damage in APP/PS1 mice. The levels of Aß1-42 in the brain of APP/PS1 mice were not affected by AVE0991. By employing high-throughput lncRNA sequencing, our in vitro study demonstrated for the first time that AVE0991 suppressed astrocytic NLRP3 inflammasome-mediated neuroinflammation via a lncRNA SNHG14-dependent manner. SNHG14 acted as a sponge of miR-223-3p while NLRP3 represented a direct target of miR-223-3p in astrocytes. In addition, miR-223-3p participated in the AVE0991-induced suppression of astrocytic NLRP3 inflammasome. CONCLUSION: Our results suggest that Ang-(1-7) analogue AVE0991 inhibits astrocyte-mediated neuroinflammation via SNHG14/miR-223-3p/NLRP3 pathway and offers neuroprotection in APP/PS1 mice. These findings reveal the underlying mechanisms by which Ang-(1-7) inhibits neuroinflammation under AD condition and uncover the potential of its nonpeptide analogue AVE0991 in AD treatment.

9.
Dokl Biol Sci ; 501(1): 171-176, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34962601

RESUMO

The remains of the white-toothed shrew Crocidura kornfeldi Kormos, 1934 (one skull fragment with almost complete dentition, the fragmental rostral part of a skull with the left upper incisor, a maxillary fragment, five mandibular fragments and an isolated upper incisor) from the Lower Pleistocene deposits of the Taurida cave in the central Crimea (Belogorsk district, Zuya village) are described. This earliest European species of the genus Crocidura was quite common in the Early Pleistocene of Central Europe and the Mediterranean; for the first time, it is described from Crimea and the entire Eastern Europe.


Assuntos
Fósseis , Musaranhos , Animais , Europa (Continente) , Maxila/anatomia & histologia , Crânio
10.
Nat Prod Res ; : 1-5, 2021 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-34623207

RESUMO

A new ß-class milbemycin, 13α-hydroxy milbemycin ß6 (1), was isolated from the fermentation broth of a mutant of genetically engineered strain Streptomyces avermitilis AVE-H39. Its structure and absolute configuration were elucidated by extensive spectroscopic methods and confirmed by single crystal X-ray diffraction.

11.
Mayo Clin Proc Innov Qual Outcomes ; 5(5): 928-945, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34585086

RESUMO

OBJECTIVE: To investigate structural relationships of latent constructs such as occupational wellbeing, resilience, work meaningfulness, and psychological empowerment with affective and cognitive clinical empathy among a community of physicians and advanced practice providers. METHODS: We conducted a cross-sectional observational study. We gathered data by an anonymous self-administered multidimensional questionnaire disseminated electronically between March and May 2016. Participants were physicians and advanced practice providers belonging to the Health Texas Provider Network, a group private practice affiliated with the Baylor Scott and White Health system. We excluded allied health care staff (eg, nurses) and trainees (eg, residents, medical students). We pursued a 3-step strategy: (1) confirmatory factor analysis of a theory-driven measurement model, (2) a modified structural equation model from which pathways with nonsignificant path coefficients were deleted, and (3) multigroup analyses of the modified model. RESULTS: Cognitive empathy was the strongest predictor of affective empathy. We observed modest positive associations of resilience with cognitive and affective empathy and of well-being and meaning with affective but not with cognitive empathy. Resilience, meaning, and psychological empowerment were surprisingly negatively associated with well-being, suggesting diminished self-care among practitioners. Effects of psychological empowerment on empathy and well-being were mediated by resilience and meaning. CONCLUSION: Cognitive empathy directly influenced affective empathy; well-being and meaningfulness exerted direct positive effects on affective but not on cognitive empathy, whereas resilience had direct positive associations with both empathy dimensions. Resilience and meaning manifested direct, negative associations with well-being, revealing clinicians' disproportionate focus on patient care at the expense of self-care.

12.
Tese em Português | VETTESES | ID: vtt-222090

RESUMO

A Rhynchotus rufescens é uma ave pequena e robusta, com uma musculatura bem desenvolvida, apresenta fácil adaptação e manutenção em cativeiro, sua criação vem se popularizando, considerando o destaque na produção alimentícia. Estudos sobre a osteologia craniana dos Tinamídeos ainda são escassos, o presente estudo almeja contribuir no conhecimento da osteologia craniana, descrevendo a morfologia e morfometria craniana utilizando-se paquímetro digital e tomografia computadorizada, visando estabeler dados específicos desta espécie e comparar ao descrito em outras aves e especimes da familia dos Tinamídeos. Utilizou-se 30 espécimes, adultos, ambos os sexos, as quais foram submetidas à mensuração da cabeça, exame de imagem, dissecação para mensurações de acidentes ósseos e descrição morfológica das estruturas cranianas. Os principais caracteres que diferenciam a Rhynchotus rufescens dos outros membros da família são: ausência de ossículos supra-orbitais, forame do ducto nasolacrimal no local da incisura do ducto nasolacrimal, ausência da fissura etmoidal, presença de um processo na lâmina do paraesfenóide, a presença de uma região globular dos exoccipitais, presença do processo caudal do palatino, processo orbital do quadrado desenvolvido, não apresentam os sulcos laterais na porção sínfise da mandíbula, se observa um resquício da fenestra caudal da mandíbula. Destaca-se a verificação de possíveis alterações dentro da mesma espécie, como encontrado no fontículo interorbital e processo pós-orbital.


The Rhynchotus rufescens is a small and robust bird, with a well-developed musculature, with easy adaptation and maintenance in captivity, its breeding has become popular, with emphasis in food production. Studies on cranial osteology of Tinamids are still scarce, the present study aims to contribute to the knowledge of cranial osteology, describing cranial morphology and morphometry using digital pachymeter and computed tomography, aiming to establish specific data for this species and compare to that described in other birds and specimens from the family of Tinamids. We used 30 specimens, adults, both genders, which were submitted to head measurement, image examination, dissection for measurements of bone accidents and morphological description of cranial structures. The main characters that differentiate Rhynchotus rufescens from other family members are: absence of supraorbital ossicles, nasolacrimal duct foramen at the nasolacrimal duct notch site, absence of ethmoidal fissure, presence of a process in the parasphenoid lamina, presence from a globular region of the exoccipitals, presence of the caudal process of the palatine, orbital process of the developed square, they do not present the lateral grooves in the symphysis portion of the mandible, there is a remnant of the mandible's caudal fenestra. Noteworthy is the verification of possible alterations within the same species, as found in the interorbital fonticulum and post-orbital process.

13.
Conserv Biol ; 35(6): 1821-1832, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34166530

RESUMO

The reintroduction of a species that is extinct in the wild demands caution because reintroduction locations may be associated with threats, such as hunting, poor-quality habitat, and climate change. This is the case for Cyanopsitta spixii (Spix's Macaw), which has been extinct in the wild since 2000. The few living individuals were created in captivity and will be used in a reintroduction project within the species' original distribution area, the Caatinga domain (Brazil). Because the occurrence records for this bird are old and inaccurate, we investigated the current and future environmental suitability of the 14 plant species used by C. spixii as resource. These plants are key elements for the long-term reestablishment of the species in the wild, so the use of models helps in the assessment of the effects of climate change on the availability of these resources for the species and informs selection of the best places for reintroduction. We based our models of environmental suitability on 19 bioclimatic variables and nine physical soil and topography variables. Climate projections were created for the present and for the year 2070 with an optimistic (SSP2-4.5) and a pessimistic (SSP5-8.5) climate scenario. Both future climate scenarios lead to a reduction in area of environmental suitability that overlapped for all the plant species: 33% reduction for SSP2-4.5 and 63% reduction for SSP5-8.5. If our projections materialize, climate change could thus affect the distribution of key resources, and the maintenance of C. spixii would depend on restoration of degraded areas, especially riparian forests, and the preservation of already existing natural areas. The Caatinga domain is very threatened by habitat loss and, for the success of this reintroduction project, the parties involved must act to protect the species and the resources it uses.


Evaluación de los Sitios de Reintroducción de Especies con base en la Futura Idoneidad Climática para los Recursos Alimenticios Resumen La reintroducción de una especie que se encuentra extinta en vida libre exige precaución pues las localidades de reintroducción pueden estar asociadas con amenazas como la cacería, hábitats de mala calidad y el cambio climático. Éste es el caso para Cyanopsitta spixii (Guacamaya de Spix), que ha estado extinta en vida libre desde el 2000. Los pocos individuos vivos nacieron en cautiverio y se usarán para un proyecto de reintroducción dentro del área original de distribución de la especie: el dominio Caatinga (Brasil). Ya que los registros de la presencia de esta ave son viejos e imprecisos, investigamos la idoneidad ambiental actual y a futuro de 14 especies de plantas que C. spixii usa como recurso. Estas plantas son elementos importantes para el restablecimiento a largo plazo de las especies en vida silvestre, así que el uso de modelos asiste en la evaluación de los efectos del cambio climático sobre la disponibilidad de recursos para la especie e informa la selección de los mejores lugares para la reintroducción. Basamos nuestros modelos de la idoneidad ambiental en 19 variables bioclimáticas y 9 variables físicas del suelo y la topografía. Las proyecciones climáticas fueron creadas para el presente y para el año 2070 con un escenario climático optimista (SSP2-4.5) y uno pesimista (SSP5-8.5) Ambos escenarios climáticos futuros llevan a una reducción en el área de idoneidad ambiental sobrepuesta para todas las especies de plantas: 33% de reducción para SSP2-4.5 y 63% de reducción para SSP5-8.5. Si nuestras proyecciones se materializan, el cambio climático podría entonces afectar la distribución de los recursos importantes, por lo que la conservación de C. spixii dependería de la restauración de las áreas degradadas, especialmente los bosques riparios y la preservación de las áreas naturales existentes. El dominio Caatinga se encuentra muy amenazado por la pérdida del hábitat y, para el éxito de este proyecto de reintroducción, las partes involucradas deben actuar para proteger a la especie y los recursos que utiliza.


Assuntos
Conservação dos Recursos Naturais , Mudança Climática , Ecossistema , Florestas , Humanos
14.
Arq. ciênc. vet. zool. UNIPAR ; 24: e2402, jan.-jun. 2021. ilus
Artigo em Português | VETINDEX | ID: vti-31916

RESUMO

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)


The king vulture (Sarcoramphus papa) is a large bird with extraordinary color, bold head, presenting red and orange fleshy papules and papillae around its beak, with white iris and a red orbital ring. In captivity, stress is a condition that is widely observed, which can lead to self-mutilation. Such mutilation, in turn, can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in a case of self-mutilation in Sarcoramphus papa, kept in captivity, and the importance of proper management for this species in captivity. The king vulture presenting a contaminated wound with bone exposure on the right wing was treated at a University Veterinary Hospital. After treatment, the bird was sent to a conservation reserve to be conditioned to return to its natural habitat.(AU)


El buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza descubierta, tiene carúnculas y papilas carnosas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede conducir a la automutilación, pudiendo progresar lesiones graves en la piel y músculos. El propósito de este informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenida en cautiverio, y la importancia del manejo adecuado de esta especie en cautiverio. Se atendió en un Hospital Veterinario Universitario, un buitre real presentando una herida contaminada, con exposición ósea en el ala derecha. Luego después del tratamiento, se envió el animal a una reserva de conservación para que fuera condicionado a volver a su hábitat natural.(AU)


Assuntos
Animais , Automutilação , Ferimentos e Lesões , Aves/lesões , Bem-Estar do Animal
15.
Arq. Ciênc. Vet. Zool. UNIPAR (Online) ; 24(1, cont.): e2402, jan-jun. 2021. ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-1222351

RESUMO

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)


The king vulture (Sarcoramphus papa) is a large bird with extraordinary color, bold head, presenting red and orange fleshy papules and papillae around its beak, with white iris and a red orbital ring. In captivity, stress is a condition that is widely observed, which can lead to self-mutilation. Such mutilation, in turn, can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in a case of self-mutilation in Sarcoramphus papa, kept in captivity, and the importance of proper management for this species in captivity. The king vulture presenting a contaminated wound with bone exposure on the right wing was treated at a University Veterinary Hospital. After treatment, the bird was sent to a conservation reserve to be conditioned to return to its natural habitat.(AU)


El buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza descubierta, tiene carúnculas y papilas carnosas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede conducir a la automutilación, pudiendo progresar lesiones graves en la piel y músculos. El propósito de este informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenida en cautiverio, y la importancia del manejo adecuado de esta especie en cautiverio. Se atendió en un Hospital Veterinario Universitario, un buitre real presentando una herida contaminada, con exposición ósea en el ala derecha. Luego después del tratamiento, se envió el animal a una reserva de conservación para que fuera condicionado a volver a su hábitat natural.(AU)


Assuntos
Animais , Automutilação , Ferimentos e Lesões , Aves/lesões , Bem-Estar do Animal
16.
Arq. ciênc. vet. zool. UNIPAR ; 24: e2402, jan.-jun. 2021. ilus
Artigo em Português | VETINDEX | ID: vti-765243

RESUMO

O abutre real (Sarcoramphus papa) é um pássaro compacto de cor extraordinária, cabeça nua, possui carúnculas e papilas carnudas vermelhas e alaranjadas em torno do bico, a íris é branca com um anel orbital vermelho. Em cativeiro, o estresse é uma condição bastante observada, o que pode levar a automutilação, podendo evoluir para lesões graves na pele e músculos. O objetivo do presente relato é descrever os procedimentos adotados em um caso de automutilação em Sarcoramphus papa, mantido em cativeiro, e a importância do manejo adequado para essa espécie em cativeiro. Foi atendido em um Hospital Veterinário Universitário, um urubu-rei apresentando ferimento contaminado, com exposição óssea na asa direita. Após tratamento o animal foi encaminhado para uma reserva conservacionista para que fosse condicionada a voltar para seu habitat natural.(AU)


The king vulture (Sarcoramphus papa) is a large bird with extraordinary color, bold head, presenting red and orange fleshy papules and papillae around its beak, with white iris and a red orbital ring. In captivity, stress is a condition that is widely observed, which can lead to self-mutilation. Such mutilation, in turn, can progress to severe skin and muscle injuries. The purpose of this report is to describe the procedures adopted in a case of self-mutilation in Sarcoramphus papa, kept in captivity, and the importance of proper management for this species in captivity. The king vulture presenting a contaminated wound with bone exposure on the right wing was treated at a University Veterinary Hospital. After treatment, the bird was sent to a conservation reserve to be conditioned to return to its natural habitat.(AU)


El buitre real (Sarcoramphus papa) es un ave compacta de extraordinario color, cabeza descubierta, tiene carúnculas y papilas carnosas rojas y anaranjadas alrededor del pico, el iris es blanco con un anillo orbital rojo. En cautiverio, el estrés es una condición ampliamente observada, que puede conducir a la automutilación, pudiendo progresar lesiones graves en la piel y músculos. El propósito de este informe es describir los procedimientos adoptados en un caso de automutilación en Sarcoramphus papa, mantenida en cautiverio, y la importancia del manejo adecuado de esta especie en cautiverio. Se atendió en un Hospital Veterinario Universitario, un buitre real presentando una herida contaminada, con exposición ósea en el ala derecha. Luego después del tratamiento, se envió el animal a una reserva de conservación para que fuera condicionado a volver a su hábitat natural.(AU)


Assuntos
Animais , Automutilação , Ferimentos e Lesões , Aves/lesões , Bem-Estar do Animal
17.
Tese em Português | VETTESES | ID: vtt-222091

RESUMO

A descrição de valores de referência em testes diagnósticos oftalmológicos para o Ramphastos toco, ave silvestre cada vez mais inserida no ambiente urbano e no atendimento veterinário especializado, faz-se necessária. No estudo, foi realizado a avaliação lacrimal por teste de Schirmer (TLS- I) e ponta de papel endodôntica padronizada (PPEP) e pressão intraocular com tonômetros de aplanação e rebote (Tonovet e Tonovet plus) em 15 Tucanos toco adultos e saudáveis ao exame clínico e oftalmológico, apenas com contenção física. Os resultados obtidos foram: TLS- I 7,77 ± 3,66 mm/min e PPEP 17,17 ± 2,97 mm/min; pressão intraocular com Tonopen 13,73 ± 3,58 mmHg; Tonovet 18,23 ± 1,78 mmHg; Tonovet Plus (cão): 22,52 ± 2,13 mmHg; Tonovet Plus (gato): 15,69 ± 1,50 mmHg. A tonometria de rebote é um método de fácil execução e acurado para utilização nos tucanos com valores maiores que a tonometria de aplanação. Para todos os testes, não houve diferença significativa considerando lateralidade dos olhos. A utilização de PPEP foi efetiva na mensuração da produção lacrimal com baixa variabilidade e desconforto. Na literatura consultada não há registro de valores de pressão com tonometria de rebote ou quantificação lacrimal com pontas de papel endodôntica em Tucano-toco, tornando estes resultados fundamentais para diagnóstico e tratamento de doenças oculares na espécie.


It is necessary to describe reference values in ophthalmic diagnostic tests for Ramphastos toco, a wild bird increasingly inserted in the urban environment and in specialized veterinary care. In this study, the tear evaluation was performed with Schirmer test (STT-I) and standardized endodontic absorbent paper point tear test (PPTT), and intraocular pressure with applanation tonometer (Tonopen) and rebound tonometers (Tonovet and Tonovet plus) in 15 adult, physically restrained Toco-toucans, healthy on clinical and ophthalmological examination. The results obtained were: STT-I 7.77 ± 3.66 mm / min and PPTT 17.17 ± 2.97 mm / min; intraocular pressure with Tonopen, 13.73± 3.58 mmHg; Tonovet, 18.23 ± 1.78 mmHg; Tonovet Plus (dog), 22.52 ± 2.13 mmHg; Tonovet Plus (cat), 15.69 ± 1.50 mmHg. Rebound tonometry is an easy and accurate method for use in Toco toucans, with higher values than applanation tonometry. There was no significant difference among the tests, regarding the laterality of the eyes. The use of PPTT was effective in measuring tear production with low variability and discomfort. There was no record of intraocular pressure values with rebound tonometry, or tear quantification with standardized endodontic absorbent paper point tear test for the Toco-toucan in the consulted literature, making these results fundamental for the diagnosis and treatment of ocular diseases in the species.

18.
Front Aging Neurosci ; 13: 624387, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33658918

RESUMO

Delayed neurocognitive recovery (dNCR) after surgery is a common postoperative complication in older adult patients. Our previous studies have demonstrated that cognitive impairment after surgery involves an increase in the brain renin-angiotensin system (RAS) activity, including overactivation of the angiotensin 2/angiotensin receptor-1 (Ang II/AT1) axis, which provokes the disruption of the hippocampal blood-brain barrier (BBB). Nevertheless, the potential role of the counter-regulatory RAS axis, the Ang-(1-7)/Mas pathway, in dNCR remains unknown. Using an aged rat model of dNCR, we dynamically investigated the activity of both axes of the RAS following laparotomy. AVE 0991, a nonpeptide analog of Ang-(1-7), was administered intranasally immediately after laparotomy. We found that the elevation of Ang II, induced by surgery was accompanied by a decrease of Ang-(1-7) in the hippocampus, but not in the circulation. Surgery also significantly downregulated hippocampal Mas receptor expression at 24 h postsurgery. Mas activation with intranasal AVE 0991 treatment significantly improved hippocampus-dependent learning and memory deficits induced by surgery. Furthermore, it attenuated hippocampal neuroinflammation, as shown by the decreased level of the microglial activation marker cluster of differentiation 11b (CD11b) and the decreased production of several inflammatory molecules. Along with these beneficial effects, the AVE 0991 treatment also alleviated the imbalance between matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-3 (TIMP-3), modulated the expression of occludin, and alleviated the IgG extravasation, thereby restoring the integrity of the BBB. In conclusion, these data indicate that activation of Mas by AVE 0991 attenuates dNCR after surgery by reducing neuroinflammation and restoring BBB integrity. Our findings suggest that the Ang-(1-7)/Mas pathway may be a novel therapeutic target for treating dNCR after surgery in older adult patients.

19.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 203-206, Jan.-Feb. 2021. ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1153036

RESUMO

Teratoma is a rare neoplasia with differentiation in two or three germ cell lines. Intracranial teratoma in birds has rarely been reported, especially affecting the brain. This is the first report of a brain teratoma in a mallard with neurological clinical signs. The neoplasm was characterized as a mature brain teratoma, extending from the cerebellum to the brainstem, and with one nodule in the cortex.(AU)


O teratoma é uma neoplasia rara, com diferenciação em duas ou três linhagens de células germinativas. Teratomas intracranianos, em aves, são raramente relatados, principalmente, com localização cerebral. Este é o primeiro relato de teratoma cerebral em um pato-real com sinais clínicos neurológicos. A neoplasia foi caracterizada como um teratoma cerebral maduro, estendendo do cerebelo ao tronco encefálico e com um nódulo no córtex.(AU)


Assuntos
Animais , Teratoma/veterinária , Neoplasias Encefálicas/veterinária , Patos , Animais Selvagens
20.
Ann Lab Med ; 41(2): 221-224, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33063684

RESUMO

Stool examination is the gold standard for the detection of intestinal parasites. We assessed the performance of a newly developed AVE-562 analyzer (AVE Science & Technology Co., Hunan, China) for the vision-based detection of eggs of Clonorchis sinensis-the most common intestinal parasite in Korea-in stool samples. In total, 30 stool samples with a high or low egg count or without eggs (as negative control samples) (N=10 each) were prepared and analyzed. The performance of the AVE-562 analyzer was compared with that of the formalin-ether concentration (FEC) method. The overall correct identification rate of the AVE-562 analyzer based on FEC results was 66.6%. The sensitivity, specificity, positive predictive value, and negative predictive value of the AVE-562 analyzer for detecting C. sinensis eggs were 36.4%, 100.0%, 100.0%, and 73.1%, respectively. The average time required to run five tests simultaneously was 27 min using the AVE-562 analyzer and 58 min using the FEC method. Although the AVE-562 analyzer enables rapid and convenient stool examination, its sensitivity needs to be improved, particularly considering the prevalence of low-burden C. sinensis infection in Korea.


Assuntos
Clonorquíase , Clonorchis sinensis , Animais , Fezes , Humanos , República da Coreia
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