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5.
Bull Anesth Hist ; 21(4): 12-4, 2003 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17494237

RESUMO

The German firm E. Merck released in 1928, an injectable mixture of scopolamine, oxycodone, and ephedrine under the name SEE. This drug, renamed Scophedal in 1942 caused deep and prolonged analgesia, sedation, euphoria and amnesia without significant respiratory or circulatory depression. Used extensively by the German and Central European surgeons in the 1930s, Scophedal enjoyed immense popularity with the Wehrmacht's medical officers treating frontline mass casualties during World War II. The use of Scophedal declined after 1945, and its production was discontinued in 1987. Despite the clinical enthusiasm it raised, SEE was never critically investigated. This drug may deserve a rigorous re-evaluation.


Assuntos
Analgésicos Opioides/história , Anestesia/história , Simpatomiméticos/história , Adjuvantes Anestésicos/história , Combinação de Medicamentos , Efedrina/história , História do Século XIX , História do Século XX , Humanos , Oxicodona/história , Escopolamina/história , II Guerra Mundial
8.
Anaesthesia ; 46(1): 49-51, 1991 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-1996757

RESUMO

Curare was used in the 19th century in England by a wide variety of scientists, physicians and veterinarians. Their experiments indicated many of the properties of the drug, but its clinical usage remained very limited and was reserved for cases of tetanus, hydrophobia and strychnine poisoning. Griffith and Johnson are usually credited with the introduction of curare into clinical anaesthesia in 1942, but a Dr F.P. de Caux working at the North Middlesex Hospital, London, in 1928 utilised curare in a series of seven patients. His work was not widely publicized and this contribution to anaesthetic history has been overlooked by subsequent authors.


Assuntos
Adjuvantes Anestésicos/história , Anestesia por Inalação/história , Curare/história , História do Século XX , Londres , Nova Zelândia
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