RESUMO
Differential diagnosis of the underlying cause of new-onset total body paralysis can be challenging and unsatisfying. In akinetic mutism, a rare side effect of tacrolimus, patients become apathetic, mute, and lose voluntary muscle movement. Epidural subarachnoid migration can present with similar symptoms. Delayed emergence/paralysis after anesthesia can include the common culprits of residual operative medications, stroke, as well as tacrolimus-induced akinetic mutism and thoracic epidural migration. We present a case of new-onset total body paralysis, presenting on postoperative day 1 following a double-lung transplant in a patient started on tacrolimus with a thoracic epidural catheter in place.
Assuntos
Afasia Acinética , Anestesia Epidural , Humanos , Tacrolimo/efeitos adversos , Afasia Acinética/induzido quimicamente , Afasia Acinética/diagnóstico , Anestesia Epidural/efeitos adversos , Paralisia , Catéteres/efeitos adversosRESUMO
Very few data are available on the long-term changes in the cognitive abilities of patients with loss of psychic self-activation syndrome (LPSAS). Here, we present a 25-year follow-up study on a case of LPSAS resulting from bilateral pallidal lesions caused by carbon monoxide intoxication. Typical signs of LPSAS were observed, showing no changes in severity, but Ganser syndrome (GS) gradually developed and worsened during the follow-up period. GS is generally assumed to be a psychogenic syndrome, but an organic etiology has been suspected by the authors of several case reports. Here, atypical features of GS plead against the independence of GS and LPSAS. DaTSCAN and brain 18FDG-PET were performed. Since left hippocampal hypometabolism has been previously described in patients with functional amnesia, it is possible that long periods of mental inactivity may have psychological consequences, but the atypical features of GS also suggest that an organic mechanism may be involved.
Assuntos
Afasia Acinética , Intoxicação por Monóxido de Carbono/complicações , Transtornos Autoinduzidos , Adulto , Afasia Acinética/induzido quimicamente , Afasia Acinética/diagnóstico , Afasia Acinética/fisiopatologia , Encéfalo/metabolismo , Encéfalo/patologia , Encéfalo/fisiopatologia , Transtornos Autoinduzidos/induzido quimicamente , Transtornos Autoinduzidos/diagnóstico , Transtornos Autoinduzidos/etiologia , Feminino , Seguimentos , HumanosRESUMO
The toxicity of xenobiotics can result inrare disorders of consciousness, such as akinetic mutism and somnambulism as well as syndromes mimicking consciousness disturbances, such as locked-in syndrome and psychogenic coma. Akinetic mutism is a condition characterized by a lack of spontaneous movements and little or no vocalization. Somnambulism include performing of complex motor activity in an automatic manner during deep sleep, without any awareness of its execution. The locked-in syndrome is a state with quadriplegia coexisting with cranial nerves palsies and mutism, but with fully preserved consciousness. Psychogenic coma is a condition in which the patient has preserved level of consciousness and awareness, but does not communicate with theenvironment and does not exhibit the external manifestations of consciousness. This paper presents the etiology, clinical characteristics, as well as diagnostic and therapeutic issues for the above syndromes.
Assuntos
Afasia Acinética/induzido quimicamente , Coma/induzido quimicamente , Quadriplegia/induzido quimicamente , Sonambulismo/induzido quimicamente , Xenobióticos/intoxicação , Afasia Acinética/diagnóstico , Afasia Acinética/terapia , Coma/diagnóstico , Coma/terapia , Diagnóstico Diferencial , Humanos , Quadriplegia/diagnóstico , Quadriplegia/terapia , Sonambulismo/diagnóstico , Sonambulismo/terapiaRESUMO
The incidence of neurotoxicity from calcineurin inhibitors varies by the organ transplanted. Akinetic mutism is characterized by the inability to perform voluntary movements and express language, without alterations in mental status. This process has been reported in neurotoxicity due to high serum levels of calcineurin inhibitors, but in rare cases, it presents as a form of tacrolimus toxicity after renal transplantation, despite normal serum levels. We report a clinical case of a renal transplant patient in whom reversible acute encephalopathy and akinetic mutism developed. Brain lesions appeared on magnetic resonance imaging, and the condition resolved after the drug was withdrawn.
Assuntos
Afasia Acinética/induzido quimicamente , Encéfalo/efeitos dos fármacos , Inibidores de Calcineurina , Imunossupressores/efeitos adversos , Transplante de Rim/imunologia , Síndromes Neurotóxicas/etiologia , Tacrolimo/efeitos adversos , Afasia Acinética/sangue , Afasia Acinética/diagnóstico , Afasia Acinética/patologia , Biomarcadores/sangue , Encéfalo/metabolismo , Encéfalo/patologia , Substituição de Medicamentos , Everolimo , Feminino , Humanos , Imunossupressores/sangue , Imunossupressores/farmacocinética , Transplante de Rim/efeitos adversos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Exame Neurológico , Síndromes Neurotóxicas/sangue , Síndromes Neurotóxicas/diagnóstico , Síndromes Neurotóxicas/patologia , Sirolimo/administração & dosagem , Sirolimo/análogos & derivados , Tacrolimo/sangue , Tacrolimo/farmacocinética , Resultado do TratamentoRESUMO
A 49-year-old woman developed a catatonic mute state a few weeks after methadone overdose. Clinical, radiological and histological findings were consistent with toxic spongiform leukoencephalopathy, which adds a potentially deadly side-effect to a generally considered safe substitution for heroin.
Assuntos
Afasia Acinética/induzido quimicamente , Afasia Acinética/diagnóstico , Catatonia/induzido quimicamente , Catatonia/diagnóstico , Metadona/intoxicação , Overdose de Drogas , Feminino , Humanos , Leucoencefalopatias/induzido quimicamente , Leucoencefalopatias/diagnóstico , Fatores de TempoRESUMO
INTRODUCTION: Clinical picture of severe glyphosate-surfactant poisoning is manifested by gastroenteritis, respiratory disturbances, altered mental status, hypotension refractory to the treatment, renal failure, shock. Single case report indicated possible neurotoxic sequels of glyphosate-surfactant exposure with white matter lesions and development of Parkinsonism. We described a patient with massive white matter damage which led to vigil coma and lethal outcome. CASE REPORT: A 56-year old woman ingested about 500 mL of herbicide containing glyphosate isopropylamine salt. The most prominent manifestation of poisoning included hypotension, coma, hyperkaliemia, respiratory and renal failure. The patient was treated in intensive care unit by symptomatic and supportive therapy including mechanical ventilation and hemodialysis. The patient survived the acute phase of poisoning, but she developed vigil coma. Nuclear magnetic imagining revealed extensive bilateral lesions of the brain stem white matter and pons. CONCLUSION: The outcome of reported poisoning may be the consequence of glyphosate-surfactant neurotoxic effect or/and ischemia, especially in the episodes of marked hypotension during hemodialysis. Considering recommendation of early hemodialysis as the treatment of choice, even before renal failure development, we point out the importance of careful planning of dialysis modality in hemodynamically instable patient and recommend continuous dialysis methods.
Assuntos
Glicina/análogos & derivados , Herbicidas/intoxicação , Síndromes Neurotóxicas/etiologia , Doença Aguda , Afasia Acinética/induzido quimicamente , Evolução Fatal , Feminino , Glicina/intoxicação , Humanos , Pessoa de Meia-Idade , GlifosatoRESUMO
Akinetic mutism is an uncommon clinical syndrome characterized by the inability to produce voluntary movements or speech without loss of awareness. Cerebrovascular diseases are the most frequent etiology. It has been reported in cyclosporine-related neurotoxicity, but it is exceptional as the presenting form of tacrolimus intoxication. We report the case of a 66-year-old man who underwent an orthotopic liver transplantation and was treated with intravenous methylprednisolone and tacrolimus. He had an uneventful postoperative course until the third day after surgery, when he developed acute onset mutism, akinesia, and waxy rigidity of passive limb movements. His arterial blood pressure and temperature were normal. Blood analysis and a magnetic resonance image of the brain showed no acute abnormalities. Serum levels of tacrolimus were 20.8 ng/mL, so it was substituted by cyclosporine and mycophenolate mofetil with progressive and complete recovery of akinetic mutism during the following days. Akinetic mutism is an exceptional manifestation of tacrolimus neurotoxicity, but early recognition of the syndrome and withdrawal of the drug are important to avoid persistent cerebral lesions.
Assuntos
Afasia Acinética/induzido quimicamente , Afasia Acinética/diagnóstico , Tacrolimo/efeitos adversos , Idoso , Humanos , Imunossupressores/efeitos adversos , Transplante de Fígado , MasculinoRESUMO
Butane inhalation can cause serious medical complications and is particularly toxic to the nervous system. This is a report of an acutely encephalopathic youth with prominent abulia. MRI revealed severe bithalamic injury attributed to butane toxicity. Clinical issues, including particular radiologic findings, related to butane inhalation are reviewed.
Assuntos
Butanos/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/complicações , Doenças Talâmicas/induzido quimicamente , Doenças Talâmicas/patologia , Doença Aguda , Administração por Inalação , Adolescente , Afasia Acinética/induzido quimicamente , Afasia Acinética/patologia , Butanos/administração & dosagem , Feminino , Lateralidade Funcional , Humanos , Imageamento por Ressonância MagnéticaRESUMO
Neuropsychiatric changes during exogenous corticosteroid administration are well-recognized. However, reports of neuropsychiatric reactions to corticosteroid replacement for Addison's disease are distinctively rare. We report on a patient with primary adrenocortical insufficiency, initially presenting with depressive symptoms, who developed akinetic mutism followed by acute manic illness shortly after the initiation of steroid replacement. Both disorders occurred with physiological doses of hydrocortisone and resolved spontaneously. The pathogenesis of the above neuropsychiatric reactions is discussed in the context of glucocorticoid receptor-related brain effects of glucocorticoids. In addition, this report points to the need for accurate psychiatric assessment of patients with Addison's disease upon introduction of replacement therapy.
Assuntos
Doença de Addison/tratamento farmacológico , Afasia Acinética/induzido quimicamente , Transtorno Bipolar/induzido quimicamente , Hidrocortisona/efeitos adversos , Doença de Addison/diagnóstico , Eletroencefalografia , Terapia de Reposição Hormonal/efeitos adversos , Humanos , Hidrocortisona/administração & dosagem , Masculino , Pessoa de Meia-IdadeRESUMO
A 35-year-old female ingested a lethal dose of potassium cyanide in a suicide attempt. She survived following antidote therapy and intensive care. Following artificial coma she presented with an agitative state for several days followed by akinetic mutism, buccofacial and ideomotoric aphasia. Severe rigid-akinetic syndrome, dysarthria, dysphagia and generalized dystonia developed weeks later. MRI revealed lesions in the caudate and lentiform nuclei, precentral cortex, and cerebellum. SPECT by [123-I] 2 beta-carbomethoxy-3-beta-(4-iodophenyl)-Tropan on two occasions revealed progressive loss of dopamine transporter suggestive of nigral neuronal apoptosis. Striatal and frontal hypometabolism and hypoperfusion were found by FDG-PET and HMPAO SPECT.
Assuntos
Afasia Acinética/induzido quimicamente , Afasia Acinética/diagnóstico , Cocaína/análogos & derivados , Imageamento por Ressonância Magnética , Tomografia por Emissão de Pósitrons , Cianeto de Potássio/intoxicação , Tomografia Computadorizada de Emissão de Fóton Único , Adulto , Distonia/induzido quimicamente , Distonia/diagnóstico , Feminino , Fluordesoxiglucose F18 , Humanos , Tentativa de Suicídio , Tecnécio Tc 99m ExametazimaRESUMO
A middle-aged man suffering from acute carbon monoxide intoxication was clinically assessed to be in an akinetic and mute state. In order to elucidate regional cerebral disturbances, brain metabolism was investigated with fluoro-deoxyglucose positron emission tomography ((18)FDG-PET) 5.5 months after intoxication. Significantly reduced metabolic rates of glucose were revealed in selected brain regions, especially in both the frontal and anterior cingulate cortices, as well as in the subcortical white matter. Frontal and cingulate cortices showed a preserved metabolism of 35-53%, whereas the regional glucose consumption in cerebral white matter was reduced by more than 70%. In contrast, other areas of the brain such as the sensory-motor cortex, parts of the temporal lobes, basal ganglia and brainstem disclosed normal metabolic values. This lesion topography is discussed in relation to the development of akinetic mutism in the present case and in comparison with recent reports on the topic. Considering a plausible pathophysiology, akinetic mutism appears to be based on a different structural neuropathology when compared with the locked-in syndrome and the vegetative state. It is suggested that akinetic mutism is regarded as a specific condition characterized by injury of the frontal neuronal systems which promote executive functions.
Assuntos
Afasia Acinética/induzido quimicamente , Intoxicação por Monóxido de Carbono/complicações , Lobo Frontal/metabolismo , Giro do Cíngulo/metabolismo , Doença Aguda , Adulto , Afasia Acinética/diagnóstico por imagem , Afasia Acinética/metabolismo , Fluordesoxiglucose F18 , Lobo Frontal/diagnóstico por imagem , Giro do Cíngulo/diagnóstico por imagem , Humanos , Masculino , Compostos Radiofarmacêuticos , Tomografia Computadorizada de EmissãoRESUMO
A case of cyclosporin A (Cys A)-induced posterior encephalopathy developed into persistent abulia despite rapid and marked improvement of abnormal T2- and FLAIR MRI hyperintense regions. Diffusion-weighted MRI signal intensity was also high at the onset. This change is atypical in Cys A-induced encephalopathy and was thought to predict poor recovery from the encephalopathy. Persistent abulia was probably due to marked hypoperfusion in the whole cortex including bilateral frontal lobes and basal ganglia as detected by SPECT. Apart from the breakdown of the blood-brain barrier, direct toxicity of Cys A to the brain may play a role in the pathogenesis of chronic, irreversible encephalopathy.
Assuntos
Afasia Acinética/induzido quimicamente , Isquemia Encefálica/induzido quimicamente , Encéfalo/irrigação sanguínea , Ciclosporina/efeitos adversos , Síndromes Neurotóxicas/etiologia , Afasia Acinética/diagnóstico , Isquemia Encefálica/diagnóstico , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Síndromes Neurotóxicas/diagnóstico , Tomografia Computadorizada de Emissão de Fóton ÚnicoRESUMO
BACKGROUND: Muromonab-CD3 (OKT3), a mouse monoclonal antibody directed against human T lymphocytes, is a potent immunosuppressive agent used to reverse and more recently to prevent allograft rejection, mostly in cardiac transplant recipients. Neurotoxicity from OKT3 usually manifests itself as a transient aseptic meningitis and remains uncommon. METHODS: The authors describe a dramatic neurologic syndrome after orthotopic heart transplant characterized by akinetic mutism, blepharospasm, anomic aphasia, and delirium. RESULTS: Magnetic resonance imaging (MRI) showed meningeal enhancement and single-photon emission computed tomography (SPECT) showed markedly reduced tracer uptake. Discontinuation of OKT3 resulted in resolution of this neuropsychiatric syndrome and reversal of abnormalities on neuroimaging that coincided with normalization of CD3+ lymphocyte count. CONCLUSIONS: In the initial posttransplant period, it remains difficult to attribute encephalopathic signs to toxicity of immunosuppressive drugs. However, MRI and cerebral perfusion studies may help support the diagnosis. More precise characterization of the prevalence of OKT3-associated encephalopathy could come from prospective SPECT studies.
Assuntos
Afasia Acinética/induzido quimicamente , Transplante de Coração , Imunossupressores/intoxicação , Muromonab-CD3/intoxicação , Neurotoxinas , Adulto , Afasia Acinética/fisiopatologia , Animais , Humanos , Imunossupressores/administração & dosagem , Imageamento por Ressonância Magnética , Masculino , Camundongos , Muromonab-CD3/administração & dosagem , Recuperação de Função Fisiológica , Tomografia Computadorizada de Emissão de Fóton ÚnicoRESUMO
We present serial neuropsychological, magnetic resonance (MR) imaging and EEG changes in a case of widespread CNS myelinopathy due to intravenous heroin overdose complicated by a period of prolonged unconsciousness. Following recovery from the acute overdose, the subject had the delayed onset of akinetic mutism with urinary incontinence. Sequential formal neuro-psychological assessments over 9 months showed evolution from severe global cerebral dysfunction to moderate disturbance of frontal lobe function. Almost complete resolution of diffuse white matter signal changes, accompanied by the development of a degree of volume loss, was evident on serial MR imaging over the same period, and generalized arrhythmic delta-range slowing on the EEG evolved int o a near normal pattern.
Assuntos
Encefalopatias/induzido quimicamente , Dependência de Heroína/complicações , Heroína/intoxicação , Entorpecentes/intoxicação , Afasia Acinética/induzido quimicamente , Afasia Acinética/patologia , Encefalopatias/patologia , Eletroencefalografia , Humanos , Injeções Intravenosas , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Recuperação de Função Fisiológica , Inconsciência/induzido quimicamente , Inconsciência/patologiaRESUMO
A 76-year-old man developed akinetic mutism after 3 days of receiving low-dosage baclofen. Electroencephalography showed a diffusely slow background with intermittent generalized sharp wave discharges. The condition resolved after discontinuing baclofen. To our knowledge, this is the first reported case of baclofen-induced akinetic mutism in a patient with normal renal function. The pathophysiology of this condition is unknown, but it may result from selective binding of the drug to the gamma-aminobutyric acid-B receptors located in the frontal lobes or thalamic nuclei, interrupting the thalamocortical limbic pathways.
Assuntos
Afasia Acinética/induzido quimicamente , Baclofeno/efeitos adversos , Agonistas GABAérgicos/efeitos adversos , Idoso , Humanos , MasculinoRESUMO
Chemotherapy of the central nervous system may cause neurotoxicity in children with acute lymphocytic leukemia. We evaluated regional blood flow in a 6-year-old child presenting with akinetic mutism, using 99mTc-HMPAO single photon emission tomography (SPECT) following high-dose intravenous methotrexate therapy. While findings in X-ray computerized tomography were decreased density in bilateral basal ganglia and thalamic nuclei with diffusely decreased attenuation of the periventricular white matter, a global, frontal dominant profoundly abnormal perfusion pattern involving both gray and white matter was observed in the SPECT study. Treatment of the central nervous system with high dose intravenous chemotherapy may cause profound abnormalities in white and gray matter blood flow and early assessment of the neurotoxicity may be identified by 99mTc-HMPAO SPECT in the pediatric age group.
Assuntos
Afasia Acinética/induzido quimicamente , Antimetabólitos Antineoplásicos/efeitos adversos , Encéfalo/irrigação sanguínea , Metotrexato/efeitos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico , Tomografia Computadorizada de Emissão de Fóton Único , Afasia Acinética/diagnóstico por imagem , Antimetabólitos Antineoplásicos/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Criança , Dominância Cerebral/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Lobo Frontal/irrigação sanguínea , Humanos , Infusões Intravenosas , Metotrexato/administração & dosagem , Fluxo Sanguíneo Regional/efeitos dos fármacos , Tecnécio Tc 99m ExametazimaRESUMO
Akinetic mutism (AM) is a rare, specific, unconscious state. An AM patient seems to be awake, lacks mental activity, is unable to speak, and does not respond to any environmental stimulus. Cyclical sleep and awake states are maintained, and incontinence is present. Various factors such as tumor, vascular events, drug use and radiotherapy are responsible for the development of AM. A 12-year-old epileptic patient displayed AM and diphenylhydantoin toxicity (DPH). She seemed awake, was unable to speak or to understand, and had no movements with either spontaneous or noxious stimuli. Her serum DPH level was greater than 40 micrograms/ml. Magnetic resonance imaging (MRI) showed mild cerebellar atrophy. All known causes of AM were excluded. The AM state in this patient was considered to be due to toxic DPH levels. She regained her motor and mental activity within two months after carbamazepine was administered to replace DPH. She was symptom-free when examined at the two-year follow-up. No similar adverse effect of DPH has been reported to date.
Assuntos
Afasia Acinética/induzido quimicamente , Anticonvulsivantes/intoxicação , Fenitoína/intoxicação , Afasia Acinética/complicações , Cerebelo/patologia , Criança , Epilepsia/complicações , Epilepsia/tratamento farmacológico , Feminino , HumanosRESUMO
Forty-six patients who were exposed to sarin consulted our hospital because of darkness of vision, and ocular pain, vomiting, dyspnea and headaches on June 27 and 28, 1994. Eighteen patients were admitted and 4 of them were in the critical state. There were 6 features: 1) depression of plasma cholinesterase activity (17 of 18 patients, 94%), 2) hypokalemia (4/18, 22%), 3) depression of triglyceride (12/18, 67%), 4) hypocapnia (5/17, 29%), 5) partial pressure of oxygen (PaO2) <80 mmHg, or requirement of O2 inhalation (15/18, 83%), 6) white blood cells (WBC) >9,000 per mm3 (13/18, 72%). Seventeen patients were discharged from hospital, but one patient is still suffering from akinetic mutism after two years.
Assuntos
Afasia Acinética/induzido quimicamente , Substâncias para a Guerra Química/intoxicação , Inibidores da Colinesterase/intoxicação , Coma/induzido quimicamente , Parada Cardíaca/induzido quimicamente , Hemoperfusão , Sarina/intoxicação , Violência , Adulto , Afasia Acinética/sangue , Fibrilação Atrial/sangue , Fibrilação Atrial/induzido quimicamente , Contagem de Células Sanguíneas/efeitos dos fármacos , Proteínas Sanguíneas/efeitos dos fármacos , Cátions/sangue , Substâncias para a Guerra Química/farmacologia , Inibidores da Colinesterase/farmacologia , Colinesterases/sangue , Colinesterases/deficiência , Coma/sangue , Dispneia/induzido quimicamente , Feminino , Cefaleia/sangue , Cefaleia/induzido quimicamente , Parada Cardíaca/sangue , Bloqueio Cardíaco/sangue , Bloqueio Cardíaco/induzido quimicamente , Humanos , Hipopotassemia/sangue , Hipopotassemia/induzido quimicamente , Hipóxia/sangue , Hipóxia/induzido quimicamente , Japão , Pessoa de Meia-Idade , Agonistas Muscarínicos/farmacologia , Agonistas Muscarínicos/intoxicação , Agonistas Nicotínicos/farmacologia , Agonistas Nicotínicos/intoxicação , Pressão Parcial , Intoxicação/terapia , Sarina/farmacologia , Triglicerídeos/sangue , Transtornos da Visão/induzido quimicamente , Vômito/induzido quimicamenteRESUMO
A case of leukoencephalopathy induced by tegafur, an antineoplastic derivative of 5-FU, is reported. The patient received 600 mg of tegafur p.o. for 16 days before excision of rectal cancer. After the operation, gait disturbance and mental abnormalities appeared. He became akinetic and mute within a few days following readministration of tegafur. Serial studies of brain CT, somatosensory evoked potentials (SEP) were made, and myelin basic proteins (MBP) in the cerebrospinal fluid were measured. The level of MBP was about twice the normal value and the central conduction time (CCT) of SEP was prolonged at admission. The value of MBP and CCT improved with recovery from akinetic mutism.