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2.
Virchows Arch ; 458(6): 649-57, 2011 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-21494762

RESUMO

On 15 June 1888, the German Emperor, Kaiser Friedrich III, died of laryngeal cancer. Three biopsies of his laryngeal lesion had been taken by the British laryngologist, Morel Mackenzie, in 1887 and diagnosed by Rudolf Virchow as "pachydermia verrucosa laryngis", confirming Mackenzie's assessment that the Kaiser's disease was benign. A fourth specimen coughed up by the patient was considered by Virchow to be nondiagnostic. A further specimen expectorated by the patient 3 months before his death was diagnosed as carcinoma by Wilhelm Waldeyer. The autopsy revealed squamous carcinoma in the larynx with a cervical lymph node metastasis. The discrepancies between the initial diagnoses and the final outcome of the Kaiser's disease gave rise to a never-ending medical controversy. Our investigations on this historical case were limited to the official German documents and publications and their English translations and to subsequent literature sources of the time, after having received confirmation that the histological slides and Virchow's original reports had been lost. Based on current surgical pathology knowledge, we propose that the tumour that challenged the diagnostic skills of the founder of pathology was hybrid verrucous carcinoma (HVC), an extremely rare, metastasizing variant of verrucous carcinoma (VC) composed of pure VC mixed with clusters of conventional squamous cell carcinoma. As we see it now, Virchow was therefore not totally wrong. Our retrospective evaluation suggests that Virchow's detailed description of the Kaiser's cancer preceded the paper that contributed to the full understanding of HVC of the larynx by 110 years.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Carcinoma Verrucoso/diagnóstico , Neoplasias Laríngeas/diagnóstico , Carcinoma de Células Escamosas/história , Carcinoma de Células Escamosas/patologia , Carcinoma Verrucoso/história , Carcinoma Verrucoso/patologia , Diagnóstico Diferencial , Erros de Diagnóstico , Alemanha , História do Século XIX , Humanos , Neoplasias Laríngeas/história , Neoplasias Laríngeas/patologia , Estudos Retrospectivos
3.
Gen Dent ; 59(6): 492-7, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-22313921

RESUMO

Two former U.S. presidents, Ulysses S. Grant and Grover Cleveland, were diagnosed with head and neck cancer in 1884 and 1893, respectively. A historical review of the risk factors, diagnoses, and treatments is examined and compared with modern-day interpretations. A comparison was made using the original diagnoses with today's equivalent diagnosis. Different treatment outcomes at the time of the original diagnoses relative to today's treatment are reviewed. Clinicians must be familiar with risk factors, signs, symptoms, diagnosis, and treatment of head and neck cancer.


Assuntos
Pessoas Famosas , Governo Federal/história , Neoplasias de Cabeça e Pescoço/história , Carcinoma de Células Escamosas/história , Carcinoma Verrucoso/história , História do Século XIX , Humanos , Masculino , Neoplasias Maxilares/história , Neoplasias da Língua/história , Estados Unidos
4.
N Y State Dent J ; 76(1): 42-5, 2010 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-20359065

RESUMO

Grover Cleveland rose from being the mayor of Buffalo to the governor of New York to the president of the United States. At the start of Cleveland's second term as president, the nation was involved in a severe financial crisis, the extent of which was not known by the general public. President Cleveland was to make a strong appeal to Congress in the coming months to repeal the Sherman Silver Purchase Act of 1890. He thought this would set the nation on the road to fiscal recovery. However, his vice president, Adlai Stevenson, strongly opposed repeal of the Sherman Act. Prior to scheduling his appearance before Congress, President Cleveland noticed a rough spot on his palate. A biopsy confirmed that it was cancer, and it was determined that surgery was needed. Cleveland and his advisors thought the nation would be thrown into a panic if the President's health did not remain a secret. A surgical team, which included a dentist, performed the surgery in secrecy while traveling aboard a yacht. A prosthetic obturator was fabricated by a New York prosthodontist to close the surgical defect. Cleveland recovered well, made a forceful speech before Congress, had the Sherman Act repealed and lived without a recurrence of his oral cancer for the rest of his life. The public remained unaware, for the most part, of the gravity of President Cleveland's health for decades.


Assuntos
Carcinoma Verrucoso/história , Pessoas Famosas , Neoplasias Palatinas/história , Carcinoma Verrucoso/cirurgia , Financiamento Governamental/história , Financiamento Governamental/legislação & jurisprudência , História do Século XIX , História do Século XX , Humanos , New York , Neoplasias Palatinas/cirurgia , Estados Unidos
5.
Am J Dermatopathol ; 28(5): 451-61, 2006 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-17012926

RESUMO

Professor Ian Aird, a renowned British surgeon of the mid-twentieth century, described a peculiar neoplasm of the foot in 3 patients under the term epithelioma cuniculatum, now more commonly called carcinoma cuniculatum. I will recount the life of Professor Aird and then summarize his original report emphasizing the clinical and more particularly the histopathologic criteria of epithelioma cuniculatum as described by Aird et al. Then I will summarize some of the subsequent reports of epithelioma (carcinoma) cuniculatum. Authors have grouped carcinoma cuniculatum with giant condyloma of the penis of Buschke-Loewenstein and oral verrucous carcinoma of Ackerman and similar neoplasms at other sites under the generic title "verrucous carcinoma." Although this classification has been accepted, I will stress that the clinical picture and histopathology described by Aird et al differ from those in later reports of carcinoma cuniculatum. These correspond to descriptions of the verrucous carcinomas of Buschke-Loewenstein and Ackerman. Finally, I will conclude that carcinoma cuniculatum as delineated by Aird and his colleagues is an extremely rare, indolent, nonmetastasizing squamous cell carcinoma composed of banal keratinocytes with unique clinical and histopathologic features that almost always arises on the foot. If a neoplasm on the foot has the characteristics of verrucous carcinoma that occurs at others sites, but not those of Aird et al, it should be called verrucous carcinoma of the foot, and not "epithelioma (carcinoma) cuniculatum."


Assuntos
Carcinoma Verrucoso/história , Carcinoma Verrucoso/patologia , Dermatologia/história , Patologia Cirúrgica/história , Neoplasias Cutâneas/história , Neoplasias Cutâneas/patologia , Pé/patologia , História do Século XX , Reino Unido
6.
Am J Dermatopathol ; 26(4): 334-41, 2004 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-15249863

RESUMO

In 1948, Lauren V. Ackerman described a neoplasm of the oral mucous membrane, which he thought represented a unique type of squamous cell carcinoma and that is now termed verrucous carcinoma of Ackerman. "Verrucous carcinoma" has also been used as a generic term under which are placed giant condyloma of Buschke-Loewenstein and carcinoma cuniculatum. This report will synopsize the life of Lauren Vedder Ackerman, review the original and subsequent report by Ackerman, and discuss some other reports of oral verrucous carcinoma. Because this review is directed to histopathologists, the histopathology will be emphasized. Other aspects of the neoplasm (eg, clinical picture, incidence, etiopathogenesis, and treatment) will not be discussed, or if so, only briefly. Giant condyloma acuminatum of Buschke-Loewenstein and carcinoma cuniculatum and studies that mention the occurrence of Ackerman's verrucous carcinoma in the pharynx, larynx, and esophagus will be mentioned only in the section on classification.


Assuntos
Carcinoma Verrucoso/história , Carcinoma Verrucoso/patologia , Dermatologia/história , Epônimos , Patologia Cirúrgica/história , Neoplasias Cutâneas/história , Neoplasias Cutâneas/patologia , História do Século XX , Humanos
9.
Am J Surg ; 176(5): 393-7, 1998 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-9874420

RESUMO

The salient clinical and pathological features of verrucous carcinoma, as first described by Ackerman in 1948, are reviewed. Two case reports are presented. The first concerns a personal experience with a patient who had five surgical procedures for multifocal oral verrucous carcinoma and remains alive and well 28 years after her initial treatment. The second report highlights the remarkable story of President Grover Cleveland's secret surgery for verrucous carcinoma of the palate in 1893. Current concepts about the management of this uncommon tumor are reviewed, as well as some recent investigations that deal with its etiology.


Assuntos
Carcinoma Verrucoso , Neoplasias de Cabeça e Pescoço , Carcinoma Verrucoso/etiologia , Carcinoma Verrucoso/história , Carcinoma Verrucoso/patologia , Carcinoma Verrucoso/cirurgia , Pessoas Famosas , Feminino , Neoplasias de Cabeça e Pescoço/etiologia , Neoplasias de Cabeça e Pescoço/história , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/cirurgia , História do Século XIX , Humanos , Masculino , Pessoa de Meia-Idade , Plantas Tóxicas , Tabaco sem Fumaça/efeitos adversos
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